LightNews LightNews
mattiaquattro.bsky.social
@mattiaquattro.bsky.social
180 followers 470 following 85 posts
Posts Replies Media Videos
Reposted
craigagoodman1.bsky.social
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
www.cell.com/cell-chemica...
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
Based on an acute exercise model, Yan et al. identify lactate as a positive regulator of autophagy in skeletal muscle. Lactate triggers muscle autophagy via K921 lactylation-dependent inactivation of ...
www.cell.com
November 12, 2025 at 4:33 PM
mattiaquattro.bsky.social
Dystrophinopathy in ACTION: The first 500 males enrolled in the Advanced Cardiac Therapies Improving Outcomes Network prospective dystrophinopathy registry - ScienceDirect www.sciencedirect.com/science/arti... @myoblue.bsky.social @cardiosky11.bsky.social
Dystrophinopathy in ACTION: The first 500 males enrolled in the Advanced Cardiac Therapies Improving Outcomes Network prospective dystrophinopathy registry
The Advanced Cardiac Therapies Improving Outcomes Network formed a dystrophinopathy registry to define cardiac diagnostics, management, and advanced t…
www.sciencedirect.com
November 11, 2025 at 7:23 PM
Reposted
uwidfellowship.bsky.social
Vaccines save lives in more ways than one.

Flu, COVID, HIV, HCV, and HZV were associated with an increased risk of major cardiovascular events. Vaccines may have important role in reducing the risk of cardiovascular disease… #IDSky #vaccine #COVID

www.ahajournals.org/doi/10.1161/...
Viral Infections and Risk of Cardiovascular Disease: Systematic Review and Meta‐Analysis | Journal of the American Heart Association
www.ahajournals.org
October 31, 2025 at 4:37 AM
Reposted
savestandard.bsky.social
Ohio house committee held a third hearing on permanent Daylight Saving Time. All written testimony opposed (thank you!). No oral testimony occurred (we spoke at the second hearing in May). No discussion or vote occurred. Tell your OH state reps NO on HCR 10!
October 29, 2025 at 2:11 AM
Reposted
nature.com
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government

www.nature.com/articles/d41...
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
www.nature.com
October 29, 2025 at 11:10 AM
mattiaquattro.bsky.social
Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy | Nature Communications www.nature.com/articles/s41... #myoblue @myoblue.bsky.social
Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy - Nature Communications
Defective neurotransmission is a hallmark of spinal muscular atrophy (SMA). Here, the authors show that local presynaptic Munc13-1synthesis is defective in SMA and that modification of the Munc13-1 mR...
www.nature.com
October 29, 2025 at 1:05 PM
Reposted
savestandard.bsky.social
PENNSYLVANIA State Rep Joe McAndrew files HR 349 for permanent Daylight Saving Time. Would put sunrise past 8am for 3 months, to nearly 9am. Tell your PA state reps NO on HR 349—and yes instead on HB 119 for permanent Standard Time! 🔗👇
Maps and photos of winter sunrise times in Pennsylvania. Permanent Standard Time keeps sunrise before 8am. Permanent DST keeps it dark long past 8am.
October 23, 2025 at 11:21 PM
Reposted
savestandard.bsky.social
Honestly, why do we even have Daylight Saving Time?
“Be Honest, Thank You” meme: • Woman: “Daylight Saving Time helps farmers, children, workers…” • Man: “Be honest.” • Woman: “I am being honest!” • Man: “Be honest! Why do we really have DST?” • Woman: “DST profits shopping malls, golf associations, and candy merchants.” • Man: “Thank you.”
October 21, 2025 at 10:43 PM
mattiaquattro.bsky.social
www.researchsquare.com/article/rs-7... intriguing preprint on myonuclei motility in muscular dystrophy, particularly in light of centronucleation and regeneration #myoblue
NuMA1 controls myonuclear motility in striated skeletal muscle through AMPK activity and is impaired in Duchenne Muscular Dystrophy
Skeletal muscle consists in a bundle of thousands post-mitotic multinucleated cells, called myofibers, in which myonuclei are evenly spaced and positioned at the periphery. This myonuclear positioning...
www.researchsquare.com
October 13, 2025 at 1:04 PM
mattiaquattro.bsky.social
Scientist on front lines of overdose crisis receives MacArthur 'genius' award : NPR www.npr.org/2025/10/08/n...
Scientist on front lines of overdose crisis receives MacArthur 'genius' award
Nabarun Dasgupta was recognized with a MacArthur "genius" award for work studying the deadly overdose crisis. He's also a front-line organizer, helping people survive.
www.npr.org
October 9, 2025 at 3:07 PM
mattiaquattro.bsky.social
How Trump's research cuts affect a 4-year-old in heart failure : NPR www.npr.org/2025/10/09/n... this is tragic
This 4-year-old's heart is failing. A federal grant that might help him was canceled
A Cornell University researcher has been developing an artificial heart for children for more than 20 years. Now, his research is on hold and his lab is shut down.
www.npr.org
October 9, 2025 at 3:05 PM
Reposted
savestandard.bsky.social
Canadians, tell your MPs and MLAs/MPPs/MNAs/MHAs to listen to sleep doctors, support permanent Standard Time and not permanent Daylight Saving Time!
Screenshot of article linked below.
October 6, 2025 at 6:41 PM
Reposted
seemagrewal.bsky.social
So sad to hear the news - John truly was an inspiration to so many, and one of a kind.

www.cam.ac.uk/research/new...
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
October 7, 2025 at 4:02 PM
Reposted
nature.com
Public health decisions must be made in line with the consensus of experts

go.nature.com/46Oxl8p
Weaponizing uncertainty in science and in public health puts people in harm’s way
Those who cite scientific studies to support policies should take care to tell the whole story, especially when it’s complex.
go.nature.com
October 3, 2025 at 2:01 PM
Reposted
johanneshaushofer.com
"Jane" (2017), directed by Brett Morgen, with music by Philip Glass, and based on unseen footage discovered shortly before, is one of the most enchanting films I've ever seen. Goodbye Jane Goodall, and thank you.

www.youtube.com/watch?v=FRlU...
Official Film Trailer: JANE | National Geographic
YouTube video by National Geographic
www.youtube.com
October 2, 2025 at 1:58 AM
Reposted
emmawilson.bsky.social
This piece by @olivia.science et al is a fantastic read for anyone navigating AI in academia — I’ve included it in the reading for the lecture I’m giving to MSc students later this week
olivia.science Olivia Guest · Ολίβια Γκεστ @olivia.science · Sep 6
Finally! 🤩 Our position piece: Against the Uncritical Adoption of 'AI' Technologies in Academia:
doi.org/10.5281/zeno...

We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical
thinking, expertise, academic freedom, & scientific integrity.
1/n
Abstract: Under the banner of progress, products have been uncritically adopted or even imposed on users — in past centuries with tobacco and combustion engines, and in the 21st with social media. For these collective blunders, we now regret our involvement or apathy as scientists, and society struggles to put the genie back in the bottle. Currently, we are similarly entangled with artificial intelligence (AI) technology. For example, software updates are rolled out seamlessly and non-consensually, Microsoft Office is bundled with chatbots, and we, our students, and our employers have had no say, as it is not considered a valid position to reject AI technologies in our teaching and research. This is why in June 2025, we co-authored an Open Letter calling on our employers to reverse and rethink their stance on uncritically adopting AI technologies. In this position piece, we expound on why universities must take their role seriously toa) counter the technology industry’s marketing, hype, and harm; and to b) safeguard higher education, critical thinking, expertise, academic freedom, and scientific integrity. We include pointers to relevant work to further inform our colleagues. Figure 1. A cartoon set theoretic view on various terms (see Table 1) used when discussing the superset AI (black outline, hatched background): LLMs are in orange; ANNs are in magenta; generative models are in blue; and finally, chatbots are in green. Where these intersect, the colours reflect that, e.g. generative adversarial network (GAN) and Boltzmann machine (BM) models are in the purple subset because they are both generative and ANNs. In the case of proprietary closed source models, e.g. OpenAI’s ChatGPT and Apple’s Siri, we cannot verify their implementation and so academics can only make educated guesses (cf. Dingemanse 2025). Undefined terms used above: BERT (Devlin et al. 2019); AlexNet (Krizhevsky et al. 2017); A.L.I.C.E. (Wallace 2009); ELIZA (Weizenbaum 1966); Jabberwacky (Twist 2003); linear discriminant analysis (LDA); quadratic discriminant analysis (QDA). Table 1. Below some of the typical terminological disarray is untangled. Importantly, none of these terms are orthogonal nor do they exclusively pick out the types of products we may wish to critique or proscribe. Protecting the Ecosystem of Human Knowledge: Five Principles
September 30, 2025 at 3:59 PM
Reposted
savestandard.bsky.social
“Most people would experience the least circadian burden under permanent Standard Time, which prioritizes morning light.” #DitchDST #SaveStandardTime
Screenshot of headline from Astronomy magazine. Article is linked below.
September 25, 2025 at 9:03 PM
Reposted
josephwgordon.bsky.social
www.nature.com/articles/s44...
Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α - Nature Cardiovascular Research
Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.
www.nature.com
September 24, 2025 at 1:32 PM
Reposted
drphilipskiba.bsky.social
Many of us have been saying this for a long time. The only question is whether LLM’s are now “too big to fail” given the massive investments currently at risk.
September 21, 2025 at 6:42 PM
mattiaquattro.bsky.social
The future of gene therapy: Safer vectors, sharper focus: Molecular Therapy www.cell.com/molecular-th... sobering commentary on the present challenges in AAV-based gene therapy @myoblue.bsky.social
The future of gene therapy: Safer vectors, sharper focus
While low-dose adeno-associated virus (AAV) gene therapy has been generally well tolerated, multiple recent reports have documented fatalities associated with high-dose AAV vectors. These events have ...
www.cell.com
September 16, 2025 at 1:41 PM
Reposted
jci.org
Elegant functional genomics that helps explain increases in cholesterol & atherosclerosis after menopause.

@mattiaquattro.bsky.social & team discover a nonrare variant encoding the human glucocorticoid receptor that increases cholesterol & promotes atherosclerosis

buff.ly/rQEt53L
September 8, 2025 at 1:20 PM
mattiaquattro.bsky.social
Time-restricted feeding mediated synchronization of circadian rhythms to sustain cardiovascular health - @jmccardiology.bsky.social www.jmcc-online.com/article/S002... excited to share this review on time-restricted feeding in our JMCC special issue on #circadian biology #cardiosky
Time-restricted feeding mediated synchronization of circadian rhythms to sustain cardiovascular health
Circadian rhythm is critical in maintaining metabolic homeostasis, including cardiac health, with disruptions often leading to adverse cardiac outcomes. Time-restricted feeding/eating (TRF/TRE) is a d...
www.jmcc-online.com
September 5, 2025 at 6:17 PM
mattiaquattro.bsky.social
A brief history of circadian time in the heart - @jmccardiology.bsky.social www.jmcc-online.com/article/S002... excited to share this excellent historical perspective on our JMCC special issue on #circadian biology #cardiosky
A brief history of circadian time in the heart
This review tracks the discovery of circadian biology in cardiovascular science, starting with early clinical observations of daily changes in heart rate, blood pressure, and cardiovascular events. Th...
www.jmcc-online.com
September 5, 2025 at 6:16 PM
mattiaquattro.bsky.social
Circadian transcriptional repressors REV-ERBα/β and E4BP4 regulate cardiac function - @jmccardiology.bsky.social www.jmcc-online.com/article/S002... excited to share this new contribution to our JMCC special issue on #circadian biology #cardiosky
Circadian transcriptional repressors REV-ERBα/β and E4BP4 regulate cardiac function
Circadian rhythms are an endogenous timekeeping system with a period of approximately 24 h that regulate many aspects of body physiology to maintain organismal health. Dysregulation of circadian rhyth...
www.jmcc-online.com
September 5, 2025 at 6:14 PM
Reposted
physiciandemocracy.medsky.social
In 1900, 31% of all deaths were children under the age of 5. Today it’s 0.7%. Vaccines, medications, and modern science are the reason why. Trust the science, it’s been proven to work safely and efficiently time and time again.
September 4, 2025 at 12:07 AM