Marc Spehr
@marcspehr.bsky.social
Reposted by Marc Spehr
What if the DNA methylation enzyme DNMT1 isn’t just about DNA?
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...
A cytosolic function of DNMT1 controls neuronal morphogenesis via microtubule regulation
Proteins traditionally confined to a single cellular compartment are increasingly recognized to exert non-canonical functions in alternative domains. The DNA methyltransferase 1 (DNMT1), classically d...
www.biorxiv.org
October 20, 2025 at 9:09 AM
What if the DNA methylation enzyme DNMT1 isn’t just about DNA?
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...
Reposted by Marc Spehr
🚨 We are looking for 2 PhD students! 🧠🐸👃
Join the Manzini Lab @jlugiessen.bsky.social to explore the olfactory system in #aquatic #vertebrates.
We mainly use #amphibians, combining:
🔬 Imaging
👩🔬 Cell biology
🐝 Behavior
👉 bit.ly/neurophd
🌍 bit.ly/manzinilab
Please share!
#PhD #neuroscience #job
Join the Manzini Lab @jlugiessen.bsky.social to explore the olfactory system in #aquatic #vertebrates.
We mainly use #amphibians, combining:
🔬 Imaging
👩🔬 Cell biology
🐝 Behavior
👉 bit.ly/neurophd
🌍 bit.ly/manzinilab
Please share!
#PhD #neuroscience #job
August 22, 2025 at 8:15 AM
🚨 We are looking for 2 PhD students! 🧠🐸👃
Join the Manzini Lab @jlugiessen.bsky.social to explore the olfactory system in #aquatic #vertebrates.
We mainly use #amphibians, combining:
🔬 Imaging
👩🔬 Cell biology
🐝 Behavior
👉 bit.ly/neurophd
🌍 bit.ly/manzinilab
Please share!
#PhD #neuroscience #job
Join the Manzini Lab @jlugiessen.bsky.social to explore the olfactory system in #aquatic #vertebrates.
We mainly use #amphibians, combining:
🔬 Imaging
👩🔬 Cell biology
🐝 Behavior
👉 bit.ly/neurophd
🌍 bit.ly/manzinilab
Please share!
#PhD #neuroscience #job
Reposted by Marc Spehr
🌍 Open Call! RWTH Aachen University invites postdocs from outside the EU to apply for the “Port to Europe” Fellowship (24 months funding, all disciplines). Start your research journey at one of Europe’s top universities! 🚀 Deadline: Oct 5, 2025. 👉https://rwth-aachen.de/go/id/botjje/lidx/1
August 18, 2025 at 6:18 PM
🌍 Open Call! RWTH Aachen University invites postdocs from outside the EU to apply for the “Port to Europe” Fellowship (24 months funding, all disciplines). Start your research journey at one of Europe’s top universities! 🚀 Deadline: Oct 5, 2025. 👉https://rwth-aachen.de/go/id/botjje/lidx/1
Reposted by Marc Spehr
Studie von RWTH-Professorin und ihrem Team in der Fachzeitschrift Nature Communications veröffentlicht 📃💡: Die Forschenden untersuchen die Bedeutung des Enzyms DNMT1 für die Entstehung von Schizophrenie, Autismus und Epilepsie.
➡️ Mehr Infos: www.rwth-aachen.de/go/id/bouvms...
➡️ Mehr Infos: www.rwth-aachen.de/go/id/bouvms...
Studie liefert Hinweise auf Ursachen neuropsychiatrischer Erkrankungen | RWTH Aachen University | DE
Wenn wichtige molekulare Schalter der Genregulation im Gehirn fehlen oder nicht mehr funktionieren, kann das gravierende Folgen für die Entwicklung eines Menschen haben – mit möglichen Folgen wie Schizophrenie, Autismus und Epilepsie. Forschende der RWTH haben nun im Mausmodell untersucht, welche Rolle das Enzym DNMT1 dabei spielt. Die Ergebnisse wurden in der renommierten Fachzeitschrift Nature Communications veröffentlicht.
www.rwth-aachen.de
July 29, 2025 at 6:59 AM
Studie von RWTH-Professorin und ihrem Team in der Fachzeitschrift Nature Communications veröffentlicht 📃💡: Die Forschenden untersuchen die Bedeutung des Enzyms DNMT1 für die Entstehung von Schizophrenie, Autismus und Epilepsie.
➡️ Mehr Infos: www.rwth-aachen.de/go/id/bouvms...
➡️ Mehr Infos: www.rwth-aachen.de/go/id/bouvms...
Reposted by Marc Spehr
While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! See my article in Gen News. www.genengnews.com/topics/trans...
Why We Still Need Animal Research in a World of AI and Organoids
The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.
www.genengnews.com
July 12, 2025 at 2:56 AM
While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! See my article in Gen News. www.genengnews.com/topics/trans...
Reposted by Marc Spehr
Wir begrüßen Professorin @silkesachse.bsky.social als neue Leiterin des Lehrstuhls für #Neurobiologie und #Genetik! Sie kommt aus Jena zu uns (@mpi-ce.bsky.social) und erforscht den Geruchssinn von #Insekten.
➡️ www.uni-wuerzburg.de/aktuelles/ei...
➡️ www.uni-wuerzburg.de/aktuelles/ei...
May 21, 2025 at 9:08 AM
Wir begrüßen Professorin @silkesachse.bsky.social als neue Leiterin des Lehrstuhls für #Neurobiologie und #Genetik! Sie kommt aus Jena zu uns (@mpi-ce.bsky.social) und erforscht den Geruchssinn von #Insekten.
➡️ www.uni-wuerzburg.de/aktuelles/ei...
➡️ www.uni-wuerzburg.de/aktuelles/ei...
Reposted by Marc Spehr
🚨 Preprint alert! 🚨
Can mice estimate the distance to an odour source?
New work led by Cristina Marin and colleagues, jointly supervised by @andreas-t-schaefer.bsky.social at the @crick.ac.uk and myself.
Spoiler alert: Yes, they can!
Read the paper here: bit.ly/43A9tF9
Short 🧵 below
Can mice estimate the distance to an odour source?
New work led by Cristina Marin and colleagues, jointly supervised by @andreas-t-schaefer.bsky.social at the @crick.ac.uk and myself.
Spoiler alert: Yes, they can!
Read the paper here: bit.ly/43A9tF9
Short 🧵 below
May 18, 2025 at 8:41 AM
🚨 Preprint alert! 🚨
Can mice estimate the distance to an odour source?
New work led by Cristina Marin and colleagues, jointly supervised by @andreas-t-schaefer.bsky.social at the @crick.ac.uk and myself.
Spoiler alert: Yes, they can!
Read the paper here: bit.ly/43A9tF9
Short 🧵 below
Can mice estimate the distance to an odour source?
New work led by Cristina Marin and colleagues, jointly supervised by @andreas-t-schaefer.bsky.social at the @crick.ac.uk and myself.
Spoiler alert: Yes, they can!
Read the paper here: bit.ly/43A9tF9
Short 🧵 below
RFK Jr. & HHS: Last Week Tonight with John Oliver (HBO)
YouTube video by LastWeekTonight
youtu.be
April 28, 2025 at 4:23 PM
P.S.: If you cannot get enough of this, stop by at our poster at AChemS 2025 on Thursday morning.
www.jneurosci.org/content/45/1...
Excited to see this out (now in print).
A fantastic collaboration by former student Rudolf Degen and current PhD student Victoria Switacz, who did an amazing job closing the deal on this one.
Give it a read if you like, but beware - it's nerdy ephys at its best.
Excited to see this out (now in print).
A fantastic collaboration by former student Rudolf Degen and current PhD student Victoria Switacz, who did an amazing job closing the deal on this one.
Give it a read if you like, but beware - it's nerdy ephys at its best.
Ca2+-Activated Ion Channels Exert Opposite Effects in Different Signaling Compartments of Vomeronasal Sensory Neurons
In most mammals, conspecific chemical cues that drive innate social and sexual behavior are detected by the vomeronasal organ (VNO) and processed in the accessory olfactory bulb (AOB). Chemosensory st...
www.jneurosci.org
April 22, 2025 at 9:54 PM
P.S.: If you cannot get enough of this, stop by at our poster at AChemS 2025 on Thursday morning.
www.jneurosci.org/content/45/1...
Excited to see this out (now in print).
A fantastic collaboration by former student Rudolf Degen and current PhD student Victoria Switacz, who did an amazing job closing the deal on this one.
Give it a read if you like, but beware - it's nerdy ephys at its best.
Excited to see this out (now in print).
A fantastic collaboration by former student Rudolf Degen and current PhD student Victoria Switacz, who did an amazing job closing the deal on this one.
Give it a read if you like, but beware - it's nerdy ephys at its best.
Ca2+-Activated Ion Channels Exert Opposite Effects in Different Signaling Compartments of Vomeronasal Sensory Neurons
In most mammals, conspecific chemical cues that drive innate social and sexual behavior are detected by the vomeronasal organ (VNO) and processed in the accessory olfactory bulb (AOB). Chemosensory st...
www.jneurosci.org
April 22, 2025 at 9:53 PM
www.jneurosci.org/content/45/1...
Excited to see this out (now in print).
A fantastic collaboration by former student Rudolf Degen and current PhD student Victoria Switacz, who did an amazing job closing the deal on this one.
Give it a read if you like, but beware - it's nerdy ephys at its best.
Excited to see this out (now in print).
A fantastic collaboration by former student Rudolf Degen and current PhD student Victoria Switacz, who did an amazing job closing the deal on this one.
Give it a read if you like, but beware - it's nerdy ephys at its best.
Reposted by Marc Spehr
Olfactory neuroscientists have known for a while that their stimuli stink. A new analysis illuminates the extent of the problem.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
Smell studies often use unnaturally high odor concentrations, analysis reveals
It’s time to fashion olfactory neuroscience stimuli based on odor concentrations in the wild, say study investigators Elizabeth Hong and Matt Wachowiak.
www.thetransmitter.org
April 16, 2025 at 2:26 PM
Olfactory neuroscientists have known for a while that their stimuli stink. A new analysis illuminates the extent of the problem.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
Reposted by Marc Spehr
This Week in The Journal #JNeurosci | The Neural Underpinnings of Waiting; Behavioral Outcomes from Neurofibromin Deficiency
www.jneurosci.org/content/45/1...
www.jneurosci.org/content/45/1...
This Week in The Journal
The Neural Underpinnings of Waiting
Qiang Zheng, Yujing Liu, Yue Huang, Jiaming Cao, Xuanning Wang, and Jianing Yu
(see article e1820242025)
Waiting is important for action control during motor ta...
www.jneurosci.org
April 16, 2025 at 5:53 PM
This Week in The Journal #JNeurosci | The Neural Underpinnings of Waiting; Behavioral Outcomes from Neurofibromin Deficiency
www.jneurosci.org/content/45/1...
www.jneurosci.org/content/45/1...
Reposted by Marc Spehr
Vorzeitige #Wehen und #Präeklampsie können bei einer #Schwangerschaft die #Gesundheit von Mutter und Baby gefährden. Forscher um @marcspehr.bsky.social von der @rwth.bsky.social und @physiologyiscool.bsky.social von @washumedicine.bsky.social zeigen einen zentralen Auslöser dieser Komplikationen.
Neue Ansätze zur Behandlung von Schwangerschaftskomplikationen
Forschende der RWTH Aachen haben gemeinsam mit einem Team aus St. Louis eine Studie veröffentlicht, die neue Wege für die Behandlung von Schwangerschaftskomplikationen eröffnen könnte.
dlvr.it
April 1, 2025 at 6:30 AM
Vorzeitige #Wehen und #Präeklampsie können bei einer #Schwangerschaft die #Gesundheit von Mutter und Baby gefährden. Forscher um @marcspehr.bsky.social von der @rwth.bsky.social und @physiologyiscool.bsky.social von @washumedicine.bsky.social zeigen einen zentralen Auslöser dieser Komplikationen.
A scientific excursion for us, and a fun collaboration with Polina Lishko and her team. In this new study, led on our end by Lina Kenzler and Jerome Schrőer, we address a molecular mechanism that controls uterine contractions in mice and humans.
Enjoy the read.
www.science.org/doi/10.1126/...
Enjoy the read.
www.science.org/doi/10.1126/...
Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function
Progesterone and progestins activate Kir7.1 to control uterine excitability, offering insights for preterm birth therapy.
www.science.org
March 6, 2025 at 9:20 PM
A scientific excursion for us, and a fun collaboration with Polina Lishko and her team. In this new study, led on our end by Lina Kenzler and Jerome Schrőer, we address a molecular mechanism that controls uterine contractions in mice and humans.
Enjoy the read.
www.science.org/doi/10.1126/...
Enjoy the read.
www.science.org/doi/10.1126/...
Reposted by Marc Spehr
📣 Science matters!
#FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬
🔗 Read the full statement: loom.ly/cn7vJR4
#sciencematters #standupforscience #sciencenotsilence #scienceforall
#FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬
🔗 Read the full statement: loom.ly/cn7vJR4
#sciencematters #standupforscience #sciencenotsilence #scienceforall
March 5, 2025 at 2:14 PM
📣 Science matters!
#FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬
🔗 Read the full statement: loom.ly/cn7vJR4
#sciencematters #standupforscience #sciencenotsilence #scienceforall
#FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬
🔗 Read the full statement: loom.ly/cn7vJR4
#sciencematters #standupforscience #sciencenotsilence #scienceforall
Reposted by Marc Spehr
2024 marked the 10-year anniversary of the FENS-Kavli Network of Excellence. We warmly invite you to explore the 10-Year Report, showcasing its impact on science, mentoring, outreach, advocacy, and personal achievements. @fens.org @kavlifoundation.bsky.social fenskavlinetwork.org/fkne-10-year...
February 17, 2025 at 3:24 PM
2024 marked the 10-year anniversary of the FENS-Kavli Network of Excellence. We warmly invite you to explore the 10-Year Report, showcasing its impact on science, mentoring, outreach, advocacy, and personal achievements. @fens.org @kavlifoundation.bsky.social fenskavlinetwork.org/fkne-10-year...
Reposted by Marc Spehr
With the huge challenges facing scientists, I call on peer reviewers to reflect on their role as gatekeepers to trainee career development and scientific progress. You can maintain high standards for rigor while being kind and not demanding an extra year of studies for every paper revision.
February 12, 2025 at 3:43 PM
With the huge challenges facing scientists, I call on peer reviewers to reflect on their role as gatekeepers to trainee career development and scientific progress. You can maintain high standards for rigor while being kind and not demanding an extra year of studies for every paper revision.
Reposted by Marc Spehr
I am deeply grateful for this award, which not only recognizes my work but also reflects the invaluable contributions of my team, mentors, and supporters!
It inspires me to continue working with my lab to deepen our understanding of how we perceive and interpret our environment.
It inspires me to continue working with my lab to deepen our understanding of how we perceive and interpret our environment.
Mammals smell faster than they breathe: Paul Ehrlich and Ludwig Darmstaedter Early Career Award 2025 goes to Tobias Ackels @goetheuni.bsky.social @paulstiftung...
weiterlesen
weiterlesen
January 28, 2025 at 12:26 PM
I am deeply grateful for this award, which not only recognizes my work but also reflects the invaluable contributions of my team, mentors, and supporters!
It inspires me to continue working with my lab to deepen our understanding of how we perceive and interpret our environment.
It inspires me to continue working with my lab to deepen our understanding of how we perceive and interpret our environment.
Reposted by Marc Spehr
⏰ Last chance! Today is the final day to submit your #AChemS2025 abstract!
Submit now: achems.org/2025/abstrac...
Submit now: achems.org/2025/abstrac...
January 13, 2025 at 3:27 PM
⏰ Last chance! Today is the final day to submit your #AChemS2025 abstract!
Submit now: achems.org/2025/abstrac...
Submit now: achems.org/2025/abstrac...
Reposted by Marc Spehr
We are hiring!
We are looking for two PhD students interested in the regulation of habit formation. Habits are useful to decrease cognitive load, but carry the risk of becoming stereotyped and hard to control - it’s hard to shake a bad habit. The fruit fly Drosophila also forms habits and we […]
We are looking for two PhD students interested in the regulation of habit formation. Habits are useful to decrease cognitive load, but carry the risk of becoming stereotyped and hard to control - it’s hard to shake a bad habit. The fruit fly Drosophila also forms habits and we […]
Original post on mastodon.social
mastodon.social
January 7, 2025 at 12:43 PM
We are hiring!
We are looking for two PhD students interested in the regulation of habit formation. Habits are useful to decrease cognitive load, but carry the risk of becoming stereotyped and hard to control - it’s hard to shake a bad habit. The fruit fly Drosophila also forms habits and we […]
We are looking for two PhD students interested in the regulation of habit formation. Habits are useful to decrease cognitive load, but carry the risk of becoming stereotyped and hard to control - it’s hard to shake a bad habit. The fruit fly Drosophila also forms habits and we […]
Reposted by Marc Spehr
🎉✨ Happy New Year ! ✨🎉
Wishing you a year filled with inspiration, discovery, & happiness! Here's to making 2025 remarkable together.
#happynewyear #thanks #community
@wisocologne.bsky.social
@unibonn.bsky.social
@dzne.science
@mpinb.mpg.de
@fz_juelich
@rwth.bsky.social
@UniklinikBonn
@DLR-PT
Wishing you a year filled with inspiration, discovery, & happiness! Here's to making 2025 remarkable together.
#happynewyear #thanks #community
@wisocologne.bsky.social
@unibonn.bsky.social
@dzne.science
@mpinb.mpg.de
@fz_juelich
@rwth.bsky.social
@UniklinikBonn
@DLR-PT
January 2, 2025 at 11:06 AM
🎉✨ Happy New Year ! ✨🎉
Wishing you a year filled with inspiration, discovery, & happiness! Here's to making 2025 remarkable together.
#happynewyear #thanks #community
@wisocologne.bsky.social
@unibonn.bsky.social
@dzne.science
@mpinb.mpg.de
@fz_juelich
@rwth.bsky.social
@UniklinikBonn
@DLR-PT
Wishing you a year filled with inspiration, discovery, & happiness! Here's to making 2025 remarkable together.
#happynewyear #thanks #community
@wisocologne.bsky.social
@unibonn.bsky.social
@dzne.science
@mpinb.mpg.de
@fz_juelich
@rwth.bsky.social
@UniklinikBonn
@DLR-PT
Reposted by Marc Spehr
There's a movement in neuroscience suggesting we should be pursuing bigger bets with larger teams. I think there's a case for doing a bit of this, but I think it's a bad idea to prioritise it for two reasons, and a good case for saying we should be moving in the exact opposite direction. 🧠🧪
December 18, 2024 at 2:50 PM
There's a movement in neuroscience suggesting we should be pursuing bigger bets with larger teams. I think there's a case for doing a bit of this, but I think it's a bad idea to prioritise it for two reasons, and a good case for saying we should be moving in the exact opposite direction. 🧠🧪
Reposted by Marc Spehr
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...
www.nytimes.com/2024/12/09/h...
December 9, 2024 at 11:19 PM
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...
www.nytimes.com/2024/12/09/h...
Reposted by Marc Spehr
On Giving Tuesday, please consider making a donation to a nonprofit like AChemS (@achems.bsky.social) that supports academic scientific research, which is essential for building new knowledge about how our bodies work!
December 3, 2024 at 7:23 PM
On Giving Tuesday, please consider making a donation to a nonprofit like AChemS (@achems.bsky.social) that supports academic scientific research, which is essential for building new knowledge about how our bodies work!
Reposted by Marc Spehr
Check out our new review in PLoS Biology on how dynamic odour information can help mammals to navigate through their environment.
Led by the fantastic Anantu Sunil & Olivia Pedroncini, this also marks my first last author publication from the University of Bonn!
journals.plos.org/plosbiology/...
Led by the fantastic Anantu Sunil & Olivia Pedroncini, this also marks my first last author publication from the University of Bonn!
journals.plos.org/plosbiology/...
How do mammals convert dynamic odor information into neural maps for landscape navigation?
Odors contain complex spatiotemporal information that guide animal behavior, but how this information is processed is not fully understood. This Essay discusses recent advances in mammalian olfactory ...
journals.plos.org
November 22, 2024 at 9:32 AM
Check out our new review in PLoS Biology on how dynamic odour information can help mammals to navigate through their environment.
Led by the fantastic Anantu Sunil & Olivia Pedroncini, this also marks my first last author publication from the University of Bonn!
journals.plos.org/plosbiology/...
Led by the fantastic Anantu Sunil & Olivia Pedroncini, this also marks my first last author publication from the University of Bonn!
journals.plos.org/plosbiology/...