Manuel González-Guerrero
@manuelgg1977.bsky.social
Metals in plant-microbe interactions @CBGP (UPM-INIA/CSIC)
Reposted by Manuel González-Guerrero
1/ It is my pleasure to share the latest preprint of the team: "Symbiotic diversification relies on an ancestral gene network in plants"
doi.org/10.1101/2025...
Here, we identified and functionally validated a novel master regulator of intracellular symbioses!
A thread ...
#PlantScience
doi.org/10.1101/2025...
Here, we identified and functionally validated a novel master regulator of intracellular symbioses!
A thread ...
#PlantScience
Symbiotic diversification relies on an ancestral gene network in plants
Symbioses have been fundamental to colonization of terrestrial ecosystems by plants and their evolution. Emergence of the ancient arbuscular mycorrhizal symbiosis was followed by the diversification o...
doi.org
November 4, 2025 at 8:06 AM
1/ It is my pleasure to share the latest preprint of the team: "Symbiotic diversification relies on an ancestral gene network in plants"
doi.org/10.1101/2025...
Here, we identified and functionally validated a novel master regulator of intracellular symbioses!
A thread ...
#PlantScience
doi.org/10.1101/2025...
Here, we identified and functionally validated a novel master regulator of intracellular symbioses!
A thread ...
#PlantScience
Reposted by Manuel González-Guerrero
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Manuel González-Guerrero
Having a PhD means you can find the word “unfortunately” in an email faster that the search function
October 28, 2025 at 3:58 AM
Having a PhD means you can find the word “unfortunately” in an email faster that the search function
New lab preprint: GrxD transfers the catalytic [2Fe2S] cluster to NifU. www.biorxiv.org/content/10.1...
Azotobacter vinelandii glutaredoxin D delivers the core [Fe2S2] cluster to nitrogenase cofactor scaffold protein NifU
The scaffold protein NifU plays a central role in assembling the precursor [Fe4S4] clusters required for nitrogenase to function. The synthesis of these precursors depends on a catalytic [Fe2S2] group...
www.biorxiv.org
October 22, 2025 at 4:06 AM
New lab preprint: GrxD transfers the catalytic [2Fe2S] cluster to NifU. www.biorxiv.org/content/10.1...
Reposted by Manuel González-Guerrero
Dear funding agencies,
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
October 14, 2025 at 7:24 PM
Dear funding agencies,
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
Reposted by Manuel González-Guerrero
New Article: "A mobile DELLA controls Medicago truncatula root cortex patterning to host arbuscular mycorrhizal fungi" rdcu.be/eJO9O
Mobile transcriptional regulators DELLA and SHORT-ROOT control the number of root inner cortex cell layers able to host symbiotic AMF.
Mobile transcriptional regulators DELLA and SHORT-ROOT control the number of root inner cortex cell layers able to host symbiotic AMF.
October 7, 2025 at 11:05 AM
New Article: "A mobile DELLA controls Medicago truncatula root cortex patterning to host arbuscular mycorrhizal fungi" rdcu.be/eJO9O
Mobile transcriptional regulators DELLA and SHORT-ROOT control the number of root inner cortex cell layers able to host symbiotic AMF.
Mobile transcriptional regulators DELLA and SHORT-ROOT control the number of root inner cortex cell layers able to host symbiotic AMF.
Reposted by Manuel González-Guerrero
EPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis https://www.biorxiv.org/content/10.1101/2025.09.29.679184v1
October 1, 2025 at 11:03 PM
EPP1 couples receptor activation to cytoplasmic signaling in root nodule symbiosis https://www.biorxiv.org/content/10.1101/2025.09.29.679184v1
Reposted by Manuel González-Guerrero
Pleased to announce that our book on the evolution of biological agency is now available, thanks to @templetonfdn.bsky.social It condenses +2 years of discussions between a philosopher and a biochemist, including our conversations in the Jardí Botànic @uv.es
@ehu.eus @i2sysbio.es @dicv.csic.es
@ehu.eus @i2sysbio.es @dicv.csic.es
October 1, 2025 at 4:33 PM
Pleased to announce that our book on the evolution of biological agency is now available, thanks to @templetonfdn.bsky.social It condenses +2 years of discussions between a philosopher and a biochemist, including our conversations in the Jardí Botànic @uv.es
@ehu.eus @i2sysbio.es @dicv.csic.es
@ehu.eus @i2sysbio.es @dicv.csic.es
Reposted by Manuel González-Guerrero
Amazing work by the Santiago lab @unil.bsky.social. The malectin-LRR receptor kinase IGP1 senses cello-oligomers to alert the plant immune system & enhance disease resistance. Very nice discovery & mechanism.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 30, 2025 at 2:18 PM
Amazing work by the Santiago lab @unil.bsky.social. The malectin-LRR receptor kinase IGP1 senses cello-oligomers to alert the plant immune system & enhance disease resistance. Very nice discovery & mechanism.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Manuel González-Guerrero
Cecilia Payne-Gaposchkin ✨ figured out what stars are made of ✨ when she was just 25. 🔭🧪
Her PhD thesis basically established the Harvard astro department — at a time when Harvard didn't officially allow woman students.
I wrote this little profile to mark the 100th anniversary of her thesis:
Her PhD thesis basically established the Harvard astro department — at a time when Harvard didn't officially allow woman students.
I wrote this little profile to mark the 100th anniversary of her thesis:
September 24, 2025 at 9:14 AM
Cecilia Payne-Gaposchkin ✨ figured out what stars are made of ✨ when she was just 25. 🔭🧪
Her PhD thesis basically established the Harvard astro department — at a time when Harvard didn't officially allow woman students.
I wrote this little profile to mark the 100th anniversary of her thesis:
Her PhD thesis basically established the Harvard astro department — at a time when Harvard didn't officially allow woman students.
I wrote this little profile to mark the 100th anniversary of her thesis:
Reposted by Manuel González-Guerrero
a new mRNA therapy apparently can cut the rate of Huntington's disease progression by ~75%. yet more miracle shit www.bbc.com/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.com
September 24, 2025 at 1:34 PM
a new mRNA therapy apparently can cut the rate of Huntington's disease progression by ~75%. yet more miracle shit www.bbc.com/news/article...
Reposted by Manuel González-Guerrero
LinkedIn anuncia que a partir del 3 de noviembre usará nuestros datos para entrenar su IA. Para autoexcluirte puedes ir a Configuración > Privacidad de datos > Datos para mejorar la IA generativa.
September 18, 2025 at 7:21 PM
LinkedIn anuncia que a partir del 3 de noviembre usará nuestros datos para entrenar su IA. Para autoexcluirte puedes ir a Configuración > Privacidad de datos > Datos para mejorar la IA generativa.
Reposted by Manuel González-Guerrero
"The death of truth is the ultimate victory of evil. When truth leaves us, when we let it slip away, when it is ripped from our hands, we become vulnerable to the appetite of whatever monster screams at us the loudest."
-Mon Mothma (Andor)
-Mon Mothma (Andor)
May 7, 2025 at 3:15 PM
"The death of truth is the ultimate victory of evil. When truth leaves us, when we let it slip away, when it is ripped from our hands, we become vulnerable to the appetite of whatever monster screams at us the loudest."
-Mon Mothma (Andor)
-Mon Mothma (Andor)
Reposted by Manuel González-Guerrero
#Viewpoint: Harnessing hyperaccumulator #plants to recover technology-critical #metals: where are we at?
Elizabeth Rylott & Antony van der Ent
👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue
Elizabeth Rylott & Antony van der Ent
👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue
April 14, 2025 at 9:25 AM
#Viewpoint: Harnessing hyperaccumulator #plants to recover technology-critical #metals: where are we at?
Elizabeth Rylott & Antony van der Ent
👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue
Elizabeth Rylott & Antony van der Ent
👇
📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
#LatestIssue
Reposted by Manuel González-Guerrero
Super happy to have our work published in one of my favourite journals @newphyt.bsky.social Amazing effort by Jiayu Zhou and colleagues from @utrechtpmi.bsky.social and UvA. You can find it here: nph.onlinelibrary.wiley.com/doi/10.1111/... @cornepieterse.bsky.social
Arabidopsis root defense barriers support beneficial interactions with rhizobacterium Pseudomonas simiae WCS417
Plant roots interact with pathogenic and beneficial microbes in the soil. While root defense barriers block pathogens, their roles in facilitating beneficial plant–microbe associations are understud...
nph.onlinelibrary.wiley.com
September 8, 2025 at 10:39 AM
Super happy to have our work published in one of my favourite journals @newphyt.bsky.social Amazing effort by Jiayu Zhou and colleagues from @utrechtpmi.bsky.social and UvA. You can find it here: nph.onlinelibrary.wiley.com/doi/10.1111/... @cornepieterse.bsky.social
Reposted by Manuel González-Guerrero
Gift link: www.nytimes.com/2025/08/24/o...
Opinion | America First? Not When It Comes to Your Health.
www.nytimes.com
August 24, 2025 at 5:50 PM
Gift link: www.nytimes.com/2025/08/24/o...
Reposted by Manuel González-Guerrero
This is the definition of a failed social media platform.
August 20, 2025 at 1:41 PM
This is the definition of a failed social media platform.
Reposted by Manuel González-Guerrero
"En las tres autonomías golpeadas se sigue reduciendo impuestos a quien no lo necesita y eso resta recursos para prevenir catástrofes."
@fernandohvalls.bsky.social
Hartos www.lavanguardia.com/opinion/2025...
@fernandohvalls.bsky.social
Hartos www.lavanguardia.com/opinion/2025...
Hartos, por Fernando H. Valls
Una parte de España empieza a estar harta y otra ya se hartó hace tiempo. Con León, Orense, Zamora, Salamanca y Cáceres ardiendo prácticamente por los cuatro
www.lavanguardia.com
August 20, 2025 at 6:39 AM
"En las tres autonomías golpeadas se sigue reduciendo impuestos a quien no lo necesita y eso resta recursos para prevenir catástrofes."
@fernandohvalls.bsky.social
Hartos www.lavanguardia.com/opinion/2025...
@fernandohvalls.bsky.social
Hartos www.lavanguardia.com/opinion/2025...
Reposted by Manuel González-Guerrero
New prepint ‼️
We studied how the 3 T6SSs of P. putida shape the rhizobiota of tomato plants. Spoiler alert: K2- and K3-T6SS do not kill E. coli, but they are functional in the rhizosphere. In collaboration with the lab of Prof. Marta Martin & Rafael Rivilla @uam.es
www.biorxiv.org/content/10.1...
We studied how the 3 T6SSs of P. putida shape the rhizobiota of tomato plants. Spoiler alert: K2- and K3-T6SS do not kill E. coli, but they are functional in the rhizosphere. In collaboration with the lab of Prof. Marta Martin & Rafael Rivilla @uam.es
www.biorxiv.org/content/10.1...
August 15, 2025 at 1:07 PM
New prepint ‼️
We studied how the 3 T6SSs of P. putida shape the rhizobiota of tomato plants. Spoiler alert: K2- and K3-T6SS do not kill E. coli, but they are functional in the rhizosphere. In collaboration with the lab of Prof. Marta Martin & Rafael Rivilla @uam.es
www.biorxiv.org/content/10.1...
We studied how the 3 T6SSs of P. putida shape the rhizobiota of tomato plants. Spoiler alert: K2- and K3-T6SS do not kill E. coli, but they are functional in the rhizosphere. In collaboration with the lab of Prof. Marta Martin & Rafael Rivilla @uam.es
www.biorxiv.org/content/10.1...
Open PhD position in our lab to work on copper-proteins in symbiotic nitrogen fixation: www.cbgp.upm.es/archivos/var...
www.cbgp.upm.es
August 12, 2025 at 8:43 AM
Open PhD position in our lab to work on copper-proteins in symbiotic nitrogen fixation: www.cbgp.upm.es/archivos/var...
Reposted by Manuel González-Guerrero
1. "'Trusting the experts is not a feature of either a science or democracy," Kennedy said."
It's literally a vital feature of both science and of representative democracy.
I've written a fair bit about trust in expertise as a vital mechanism in the collective epistemology of science.
It's literally a vital feature of both science and of representative democracy.
I've written a fair bit about trust in expertise as a vital mechanism in the collective epistemology of science.
RFK Jr. in interview with Scripps News: ‘Trusting the experts is not science’
HHS Secretary RFK Jr. sat down with Scripps News for a wide-ranging interview, discussing mRNA vaccine funding policy changes and a recent shooting at the Centers for Disease Control and Prevention.
www.scrippsnews.com
August 12, 2025 at 4:48 AM
1. "'Trusting the experts is not a feature of either a science or democracy," Kennedy said."
It's literally a vital feature of both science and of representative democracy.
I've written a fair bit about trust in expertise as a vital mechanism in the collective epistemology of science.
It's literally a vital feature of both science and of representative democracy.
I've written a fair bit about trust in expertise as a vital mechanism in the collective epistemology of science.
Reposted by Manuel González-Guerrero
Very excited that our work on directional symplastic transport in differentiated root is now published!A developmental switch controls cell-to-cell transport in roots via pectin-linked plasmodesmata changes: Molecular Plant www.cell.com/molecular-pl...
July 22, 2025 at 9:52 AM
Very excited that our work on directional symplastic transport in differentiated root is now published!A developmental switch controls cell-to-cell transport in roots via pectin-linked plasmodesmata changes: Molecular Plant www.cell.com/molecular-pl...
Reposted by Manuel González-Guerrero
[🚨Pre-print alert🚨] Excited to share our findings on the enigmatic ericoid mycorrhizal symbiosis.
🔴For the first time we provide evidence that ericoid mycorrhizae evolved from ancestral
arbuscular mycorrhizae through the co-option nutrient-dependent regulation 👇!
www.biorxiv.org/content/10.1...
🔴For the first time we provide evidence that ericoid mycorrhizae evolved from ancestral
arbuscular mycorrhizae through the co-option nutrient-dependent regulation 👇!
www.biorxiv.org/content/10.1...
Leafy liverwort genomes shed light on the evolution of ericoid symbiosis
Mycorrhizal symbiosis has been fundamental to colonization of terrestrial ecosystems by plants, influencing population dynamics, biogeography, and their evolution. The emergence of the ancient arbuscu...
www.biorxiv.org
April 2, 2025 at 11:59 AM
[🚨Pre-print alert🚨] Excited to share our findings on the enigmatic ericoid mycorrhizal symbiosis.
🔴For the first time we provide evidence that ericoid mycorrhizae evolved from ancestral
arbuscular mycorrhizae through the co-option nutrient-dependent regulation 👇!
www.biorxiv.org/content/10.1...
🔴For the first time we provide evidence that ericoid mycorrhizae evolved from ancestral
arbuscular mycorrhizae through the co-option nutrient-dependent regulation 👇!
www.biorxiv.org/content/10.1...