Manav Pathania
@manavpathania.bsky.social
Unravelling the biology of brain tumours like #DMG #DIPG #glioma in children and young people. CRUK Career Establishment Awardee. 🏳️🌈🇮🇳🇭🇰🇲🇾🇸🇬🇺🇲🇬🇧
https://www.pathanialab.com
https://www.pathanialab.com
Pinned
Manav Pathania
@manavpathania.bsky.social
· Nov 15
A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Models of pediatric high-grade glioma reveal genotype–phenotype associations, differences in cell type composition, and sensitivity to targeted and combination therapy approaches, making preclinical e...
doi.org
Hi Bluesky! I am a PI in the Dept of Oncology at the University of Cambridge, UK. Our lab develops mouse models of different types of brain tumours and uses these to explore targeted treatments, TME interactions, and the role of heterogeneity in resistance.
doi.org/10.1158/2159...
doi.org/10.1158/2159...
Please share or forward to anyone interested in joining our lab as a research assistant, details can be found via the link below
shorturl.at/x0cSs
shorturl.at/x0cSs
a penguin wearing a red bandana and a tie looks through binoculars
Alt: a penguin wearing a red bandana and a tie looks through binoculars
media.tenor.com
November 12, 2025 at 10:16 AM
Please share or forward to anyone interested in joining our lab as a research assistant, details can be found via the link below
shorturl.at/x0cSs
shorturl.at/x0cSs
Please share or forward to anyone interested in joining our lab for a postdoc, details can be found via the link below
shorturl.at/GMbW0
shorturl.at/GMbW0
a woman in a yellow wig and white sunglasses
ALT: a woman in a yellow wig and white sunglasses
media.tenor.com
November 10, 2025 at 6:49 PM
Please share or forward to anyone interested in joining our lab for a postdoc, details can be found via the link below
shorturl.at/GMbW0
shorturl.at/GMbW0
The Pathania lab will be moving to the Ludwig Institute in Oxford in early 2026. We'll be recruiting postdocs and research assistants soon, so keep an eye out for those job ads and reach out if you want to find out more about the science we have planned!
shorturl.at/thpyK
shorturl.at/thpyK
Ludwig Oxford welcomes Dr Manav Pathania
Ludwig Oxford is delighted to welcome Dr Manav Pathania as an Assistant Member of the Ludwig Institute for Cancer Research, Oxford Branch.
shorturl.at
November 4, 2025 at 6:57 PM
The Pathania lab will be moving to the Ludwig Institute in Oxford in early 2026. We'll be recruiting postdocs and research assistants soon, so keep an eye out for those job ads and reach out if you want to find out more about the science we have planned!
shorturl.at/thpyK
shorturl.at/thpyK
Reposted by Manav Pathania
🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off.
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
FlyBase secures funding for year, but future still uncertain
The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.
tinyurl.com
October 29, 2025 at 12:31 PM
🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off.
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2
tinyurl.com/FlyBase
Reposted by Manav Pathania
Yes, it was carefully hidden in the New England Journal of Medicine.
Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... )
1/2
Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... )
1/2
September 1, 2025 at 4:08 PM
Yes, it was carefully hidden in the New England Journal of Medicine.
Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... )
1/2
Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... )
1/2
Reposted by Manav Pathania
When mRNA vaccines are wrongly attacked, this is one of many examples of what you're missing.
A broad spectrum prevention strategy against viruses
www.science.org/doi/10.1126/...
A broad spectrum prevention strategy against viruses
www.science.org/doi/10.1126/...
August 13, 2025 at 7:04 PM
When mRNA vaccines are wrongly attacked, this is one of many examples of what you're missing.
A broad spectrum prevention strategy against viruses
www.science.org/doi/10.1126/...
A broad spectrum prevention strategy against viruses
www.science.org/doi/10.1126/...
Farewell for Carmo, RA extraordinaire! Good luck in your PhD at the Crick and thanks for all your hard work over the last 3 years!
July 17, 2025 at 8:21 PM
Farewell for Carmo, RA extraordinaire! Good luck in your PhD at the Crick and thanks for all your hard work over the last 3 years!
Reposted by Manav Pathania
WOW!!!!!😱😮
High-speed mapping of whole-mouse peripheral nerves at subcellular resolution: Cell www.cell.com/cell/fulltex...
High-speed mapping of whole-mouse peripheral nerves at subcellular resolution: Cell www.cell.com/cell/fulltex...
High-speed mapping of whole-mouse peripheral nerves at subcellular resolution
A high-speed pipeline enables whole-mouse imaging and mesoscopic analysis of peripheral
nerves using transgenic, immunostaining, and viral labeling, providing an effective
means to map body-wide struc...
www.cell.com
July 14, 2025 at 3:44 PM
WOW!!!!!😱😮
High-speed mapping of whole-mouse peripheral nerves at subcellular resolution: Cell www.cell.com/cell/fulltex...
High-speed mapping of whole-mouse peripheral nerves at subcellular resolution: Cell www.cell.com/cell/fulltex...
Reposted by Manav Pathania
A study in Nature Medicine shows the mechanisms driving amyloid-β clearance in both passively and actively Aβ immunized patients with Alzheimer’s disease. #alzsky 🧪
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease - Nature Medicine
Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.
go.nature.com
March 15, 2025 at 1:21 PM
A study in Nature Medicine shows the mechanisms driving amyloid-β clearance in both passively and actively Aβ immunized patients with Alzheimer’s disease. #alzsky 🧪
Reposted by Manav Pathania
Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length
👉 These mice, with humanized telomere regulation, represent a valuable model to study human aging and cancer.
www.nature.com/articles/s41...
👉 These mice, with humanized telomere regulation, represent a valuable model to study human aging and cancer.
www.nature.com/articles/s41...
Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length - Nature Communications
Mice models often fail to reflect human telomere biology. Here, the authors engineer a mouse strain with a humanized mTert gene, restoring telomere length regulation to a human-like pattern. This mode...
www.nature.com
February 14, 2025 at 1:23 AM
Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length
👉 These mice, with humanized telomere regulation, represent a valuable model to study human aging and cancer.
www.nature.com/articles/s41...
👉 These mice, with humanized telomere regulation, represent a valuable model to study human aging and cancer.
www.nature.com/articles/s41...
Reposted by Manav Pathania
From a journalist friend: Just spreading the word. The CDC is purging data, so people should archive their favorite CDC datasets today, namely ones around race/ethnic diversity, LGBTQ, and reproductive health. Also health data involving climate. The youth risk behavior survey has already gone down.
January 31, 2025 at 3:43 PM
From a journalist friend: Just spreading the word. The CDC is purging data, so people should archive their favorite CDC datasets today, namely ones around race/ethnic diversity, LGBTQ, and reproductive health. Also health data involving climate. The youth risk behavior survey has already gone down.
Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding
Glioblastoma is a highly aggressive primary brain tumor with glioblastoma stem cells (GSCs) enforcing the intra-tumoral hierarchy. Plasma cells (PCs) …
www.sciencedirect.com
January 15, 2025 at 11:57 AM
Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Merry Christmas!
December 26, 2024 at 12:20 PM
Merry Christmas!
Rounding out the year with the team
December 17, 2024 at 4:27 PM
Rounding out the year with the team
Reposted by Manav Pathania
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Regulation of human interferon signaling by transposon exonization
Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.
www.cell.com
December 12, 2024 at 6:57 PM
I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪
Reposted by Manav Pathania
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...
November 27, 2024 at 10:17 PM
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...
Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma - Nature
The prodrug gliocidin effectively kills glioblastoma cells by targeting de novo purine synthesis, improving survival in mouse models.
www.nature.com
November 21, 2024 at 1:20 PM
Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Happy International Day of LGBQTIA+ People in STEM! Proud to advocate for the enriching benefits of diversity, of experiences and viewpoints, IRL and on this platform.
November 18, 2024 at 8:22 PM
Happy International Day of LGBQTIA+ People in STEM! Proud to advocate for the enriching benefits of diversity, of experiences and viewpoints, IRL and on this platform.
Hi Bluesky! I am a PI in the Dept of Oncology at the University of Cambridge, UK. Our lab develops mouse models of different types of brain tumours and uses these to explore targeted treatments, TME interactions, and the role of heterogeneity in resistance.
doi.org/10.1158/2159...
doi.org/10.1158/2159...
A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Models of pediatric high-grade glioma reveal genotype–phenotype associations, differences in cell type composition, and sensitivity to targeted and combination therapy approaches, making preclinical e...
doi.org
November 15, 2024 at 6:12 PM
Hi Bluesky! I am a PI in the Dept of Oncology at the University of Cambridge, UK. Our lab develops mouse models of different types of brain tumours and uses these to explore targeted treatments, TME interactions, and the role of heterogeneity in resistance.
doi.org/10.1158/2159...
doi.org/10.1158/2159...
Reposted by Manav Pathania
Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas
Incredible study now out in Nature, with long-term remission for pediatric glioma
Michelle Monje, Crystal Mackall et al
Well done to all the authors for this true tour de force!
🧪⚕️🩺
www.nature.com/articles/s41...
Incredible study now out in Nature, with long-term remission for pediatric glioma
Michelle Monje, Crystal Mackall et al
Well done to all the authors for this true tour de force!
🧪⚕️🩺
www.nature.com/articles/s41...
November 14, 2024 at 7:16 PM
Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas
Incredible study now out in Nature, with long-term remission for pediatric glioma
Michelle Monje, Crystal Mackall et al
Well done to all the authors for this true tour de force!
🧪⚕️🩺
www.nature.com/articles/s41...
Incredible study now out in Nature, with long-term remission for pediatric glioma
Michelle Monje, Crystal Mackall et al
Well done to all the authors for this true tour de force!
🧪⚕️🩺
www.nature.com/articles/s41...
I reserved my first Bluesky post to mark another enjoyable and successful collaboration with the Jabado and Kleinman labs! Congrats to @selinjessa.bsky.social, Bhavyaa and Antonella on this cool paper!
doi.org/10.1158/0008...
doi.org/10.1158/0008...
FOXR2 targets LHX6+/DLX+ neural lineages to drive CNS neuroblastoma
Abstract. Central nervous system neuroblastoma with FOXR2 activation (NB-FOXR2) is a high-grade tumor of the brain hemispheres and a newly identified molecular entity. Tumors express dual neuronal and...
doi.org
November 7, 2024 at 11:17 AM
I reserved my first Bluesky post to mark another enjoyable and successful collaboration with the Jabado and Kleinman labs! Congrats to @selinjessa.bsky.social, Bhavyaa and Antonella on this cool paper!
doi.org/10.1158/0008...
doi.org/10.1158/0008...