Alessandra Magistrato
banner
magistratolab.bsky.social
Alessandra Magistrato
@magistratolab.bsky.social
Research Director, CNR-IOM @ SISSA,
Head of Laboratory for Computational Chemistry and Biochemistry
http://magistratogroup.wordpress.com
Our new work entitled 'Plasticity of the cytotoxic Nep1-like protein enables promiscuity in binding to its lipid receptor glycosylinositol phosphorylceramides' has been published on Science Advances!
In collaboration with Gregor Anderlu, NIC, Slo read 👇 www.science.org/doi/10.1126/...
Plasticity of the cytotoxic Nep1-like protein enables promiscuity in binding to its lipid receptor glycosylinositol phosphorylceramides
Microbial effectors Nep1-like proteins bind to different plant sphingolipids and disrupt di- and monocot model lipid membranes.
www.science.org
October 17, 2025 at 8:49 AM
Our new review entitled 'Decoding Spliceosome Dynamics through Computation and Experiment' has been published on Chemical Reviews @pubs.acs.org Congrats to @pokorna.bsky.social, Sebastian Fica and Jana Aupic! pubs.acs.org/doi/10.1021/...
Decoding Spliceosome Dynamics through Computation and Experiment
RNA splicing is orchestrated by a complex and exceptionally dynamic RNA–protein machine, called the spliceosome. Stepwise, large-scale structural and compositional remodeling of the spliceosome enable...
pubs.acs.org
October 14, 2025 at 8:51 AM
Almost at the end of the exciting @cecamevents.bsky.social conference 'RNA Modelling across scales' at SISSA, Trieste, Italy! 🎉 Fantastic speakers and great science. Organized with @bussigio.bsky.social @marcodevivo.bsky.social #RNA
May 21, 2025 at 7:22 PM
Reposted by Alessandra Magistrato
Our integrative approach using #MD and #cryoEM data to construct structural ensembles of #RNA just published on @natcomms.bsky.social doi.org/10.1038/s414... Lead by Elisa Posani, with @magistratolab.bsky.social @bonomimax.bsky.social @pjanos.bsky.social @navtejtoor.bsky.social and Daniel Haack 🎉
May 16, 2025 at 9:16 AM
Reposted by Alessandra Magistrato
Check out the speakers!
@rommieamaro.bsky.social @jessicaandreani.bsky.social @gauravbhardwaj.bsky.social @bonomimax.bsky.social @rocovino.bsky.social @arneelof.bsky.social Sergei Grudinin @magistratolab.bsky.social Christine Orengo @joanampereira.bsky.social Maya Topf, Sameer Velankar, Basile Wicky
May 9, 2025 at 10:38 AM
Just published our new paper on Identification of a new Small Rho GTPase Inhibitor Effective in Glioblastoma Human Cells. Check it out! www.sciencedirect.com/science/arti.... Excellent work done by
@angelaparis3.bsky.social , in collaboration with University of Trieste, University of Udine, CNR-IC
Identification of a new Small Rho GTPase Inhibitor Effective in Glioblastoma Human Cells
Glioblastoma (GBM) is the most common and lethal primary brain tumour. The prognosis for GBM patients remains poor due to rapid tumour recurrence and …
www.sciencedirect.com
May 5, 2025 at 11:54 AM
Reposted by Alessandra Magistrato
📢 Our article calling for a #FAIR database for #MolecularDynamics simulation data has now been peer-reviewed and published in @naturemethods.bsky.social

📖 Read it here: rdcu.be/ef6YX

📝 Support the statement: bit.ly/3zVS3qm

#MDDB #FAIRdata #collaboration
April 4, 2025 at 8:09 AM
We are sill accepting applications for poster presentations at the CECAM conference 'RNA Modelling Across Scales". Join us in the beautiful Trieste ☀️🏖️🏰! Apply now: www.cecam.org/workshop-det... Co-organized with @bussigio.bsky.social @marcodevivo.bsky.social
March 27, 2025 at 7:04 PM
Interested in understanding the molecular details of RNA–membrane association? Read our new paper just published in Nano Letters @acs.org. Excellent work done by sdimarco.bsky.social with Jana Aupic and @bussigio.bsky.social pubs.acs.org/doi/full/10....
#RNA #MembraneBiology #compchem #compbiol
All-Atom Simulations Elucidate the Molecular Mechanism Underlying RNA–Membrane Interactions
RNA–membrane interactions are starting to emerge as an important organizing force in both natural and synthetic biological systems. Notably, RNA molecules were recently discovered to be present on the...
pubs.acs.org
March 9, 2025 at 11:39 AM
Reposted by Alessandra Magistrato
Interested in #RNA modelling across multiple scales? Join us for the @cecamevents.bsky.social meeting at SISSA, Trieste, May 19-22! www.cecam.org/workshop-det... We still have slots for contributed talks. Deadline March 23. Co-organized with @magistratolab.bsky.social and @marcodevivo.bsky.social
CECAM - RNA modelling across scales
www.cecam.org
February 20, 2025 at 7:22 PM
Very proud to announce that a member of our group, Dr. Jana Aupič, has been awarded the prestigious "EuChemS ChemBioLife Young Investigator" prize! 🏅 This honors her hard work and exceptional contribution to chemical biology. Congratulations, Jana! 🌟✨ .
www.euchems.eu/divisions/ch...
News - EuChemS
WINNER ANNOUNCEMENT! “EuChemS ChemBioLife Young Investigator Award” 2024-2025 edition   We are proud to announce the winner of the EuChemS ChemBioLife Young Investigator Award  of the EuChemS Division...
www.euchems.eu
February 4, 2025 at 4:03 PM
Reposted by Alessandra Magistrato
Two PhD vivas just before the end of the year! Bea and Irene defended their theses in front of two committees of leading female researchers: @magistratolab.bsky.social, Laura Masgrau, Montse Terrazas, @elisafadda.bsky.social, Salomé Llabrés and Mercedes Alfonso-Prieto. Congrats to Irene and Bea!
December 23, 2024 at 9:40 AM
✨Great presentation of our work by @angelaparis3.bsky.social at Physics Day in Trieste!👏
December 13, 2024 at 3:17 PM
Just published in Journal of Chemical Information and Modeling our new study on the Mechanism of Rac1b: the Alternative Spliced Variant of Rac1 Small Rho GTPase. Great work by A. Parise and S. Cresca!
pubs.acs.org/doi/10.1021/...
Assessing the Mechanism of Rac1b: An All-Atom Simulation Study of the Alternative Spliced Variant of Rac1 Small Rho GTPase
The Rho GTPase family plays a key role in cell migration, cytoskeletal dynamics, and intracellular signaling. Rac1 and its splice variant Rac1b, characterized by the insertion of an Extraloop, are fre...
pubs.acs.org
December 9, 2024 at 3:33 PM