Chris Lupton
@luptoncj.bsky.social
#CryoEM and structural biology at Monash University
Very well deserved! A great reward for a a lot of hard work 😊
Earlier this year, I was incredibly honoured to receive the Premier’s Award for Health and Medical Research in the Basic Science category.
This recognition is a huge testament to the amazing work of our entire team. 🙌💥🎉
Photography and video: @vicgovau.bsky.social
www.youtube.com/watch?v=9_Ht...
This recognition is a huge testament to the amazing work of our entire team. 🙌💥🎉
Photography and video: @vicgovau.bsky.social
www.youtube.com/watch?v=9_Ht...
August 6, 2025 at 2:43 AM
Very well deserved! A great reward for a a lot of hard work 😊
Reposted by Chris Lupton
Seed to sub-Å!
We just solved crambin at 0.85Å with #MicroED straight from spontaneous nanocrystals, phased ab-initio from a 5-res helix. Video shows diffraction ➜ ugly start map ➜ beautiful spheres. Preprint: www.biorxiv.org/content/10.1...
#StructuralBiology #CryoEM
We just solved crambin at 0.85Å with #MicroED straight from spontaneous nanocrystals, phased ab-initio from a 5-res helix. Video shows diffraction ➜ ugly start map ➜ beautiful spheres. Preprint: www.biorxiv.org/content/10.1...
#StructuralBiology #CryoEM
July 5, 2025 at 7:53 PM
Seed to sub-Å!
We just solved crambin at 0.85Å with #MicroED straight from spontaneous nanocrystals, phased ab-initio from a 5-res helix. Video shows diffraction ➜ ugly start map ➜ beautiful spheres. Preprint: www.biorxiv.org/content/10.1...
#StructuralBiology #CryoEM
We just solved crambin at 0.85Å with #MicroED straight from spontaneous nanocrystals, phased ab-initio from a 5-res helix. Video shows diffraction ➜ ugly start map ➜ beautiful spheres. Preprint: www.biorxiv.org/content/10.1...
#StructuralBiology #CryoEM
Awesome talk from @bradleyspicer.bsky.social telling us all about his work on insecticidal proteins. Very cool stuff! #lorneproteins2025
February 11, 2025 at 4:24 AM
Awesome talk from @bradleyspicer.bsky.social telling us all about his work on insecticidal proteins. Very cool stuff! #lorneproteins2025
Reposted by Chris Lupton
🚨 Save the Date! 🚨
I'm thrilled to announce the Prato Conference on Pore Forming Proteins, happening this June in the stunning city of Prato, Italy!
🙏 Please share or repost this to help us reach as many people as possible—especially those who would love to attend!
I'm thrilled to announce the Prato Conference on Pore Forming Proteins, happening this June in the stunning city of Prato, Italy!
🙏 Please share or repost this to help us reach as many people as possible—especially those who would love to attend!
January 16, 2025 at 10:41 PM
🚨 Save the Date! 🚨
I'm thrilled to announce the Prato Conference on Pore Forming Proteins, happening this June in the stunning city of Prato, Italy!
🙏 Please share or repost this to help us reach as many people as possible—especially those who would love to attend!
I'm thrilled to announce the Prato Conference on Pore Forming Proteins, happening this June in the stunning city of Prato, Italy!
🙏 Please share or repost this to help us reach as many people as possible—especially those who would love to attend!
Reposted by Chris Lupton
We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates - Nature Structural & Molecular Biology
Here the authors show that a gene-inactivating protein complex packs inactive genes into a dynamic and accessible structure. The study challenges the traditional views that restricted accessibility an...
www.nature.com
January 16, 2025 at 9:24 PM
We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...
Reposted by Chris Lupton
🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇
January 14, 2025 at 10:57 PM
🧵 1/ We’re excited to share that our new paper with @adrianbracken.bsky.social lab is out 🎉 In this study (which began over 10 years ago!), we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇
Very cool! 😁
The PDBs for our TSC structure are now available!
To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩
#cryoEM #mTORC1 #TSC
rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩
#cryoEM #mTORC1 #TSC
rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
December 7, 2024 at 3:34 AM
Very cool! 😁
Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex! Awesome effort from co-authors @charlesbj.bsky.social and Laura D'Andrea with @drellisdon.bsky.social doing the heavy lifting leading the project.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structure of the human TSC:WIPI3 lysosomal recruitment complex
The complete TSC structure reveals how lysosomal targeting proteins and phosphoinositides coordinate mTORC1 inhibition.
www.science.org
November 21, 2024 at 12:35 AM
Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex! Awesome effort from co-authors @charlesbj.bsky.social and Laura D'Andrea with @drellisdon.bsky.social doing the heavy lifting leading the project.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Chris Lupton
Our latest study is now online at Science Advances! We report the structure of the gigantic TSC:WIPI3 complex revealing new insights into lysosomal docking and dysregulation in disease. #cryoEM #mTOR 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 20, 2024 at 9:32 PM
Our latest study is now online at Science Advances! We report the structure of the gigantic TSC:WIPI3 complex revealing new insights into lysosomal docking and dysregulation in disease. #cryoEM #mTOR 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Chris Lupton
Excited to see our latest study published!
We report several structures of the intriguing LYCHOS (GPR155) protein revealing a chimeric structure of a GPCR and a PIN-like transporter domain #cryoEM #mTOR #GPCR #auxin
www.nature.com/articles/s41...
We report several structures of the intriguing LYCHOS (GPR155) protein revealing a chimeric structure of a GPCR and a PIN-like transporter domain #cryoEM #mTOR #GPCR #auxin
www.nature.com/articles/s41...
LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR - Nature
Cryo-electron microscopy structures of the human lysosomal transmembrane protein LYCHOS show that it comprises a transporter-like domain fused to a G-protein-coupled receptor, and that the transporter...
www.nature.com
October 9, 2024 at 9:10 AM
Excited to see our latest study published!
We report several structures of the intriguing LYCHOS (GPR155) protein revealing a chimeric structure of a GPCR and a PIN-like transporter domain #cryoEM #mTOR #GPCR #auxin
www.nature.com/articles/s41...
We report several structures of the intriguing LYCHOS (GPR155) protein revealing a chimeric structure of a GPCR and a PIN-like transporter domain #cryoEM #mTOR #GPCR #auxin
www.nature.com/articles/s41...
Reposted by Chris Lupton
🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in Science Advances.
Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council.
www.science.org/doi/10.1126/...
Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council.
www.science.org/doi/10.1126/...
November 20, 2024 at 9:48 PM
🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in Science Advances.
Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council.
www.science.org/doi/10.1126/...
Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council.
www.science.org/doi/10.1126/...
Reposted by Chris Lupton
Another really nice highlight of our recent work. Arun et al raise interesting points about membrane cross talk and next-steps for LYCHOS. www.cell.com/cell/abstrac...
Bound by the love for cholesterol: A transporter meets a GPCR
In a recent issue of Nature, Bayly-Jones et al. report the cryo-EM structures of a
lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique
fusion of a plant auxin-transporte...
www.cell.com
November 14, 2024 at 9:32 PM
Another really nice highlight of our recent work. Arun et al raise interesting points about membrane cross talk and next-steps for LYCHOS. www.cell.com/cell/abstrac...
Very cool to see our work on the #cryoEM structure of LYCHOS as the Editor's Choice in Science Signalling! Thanks @jffoley.bsky.social !!
November 14, 2024 at 1:36 AM
Very cool to see our work on the #cryoEM structure of LYCHOS as the Editor's Choice in Science Signalling! Thanks @jffoley.bsky.social !!