Liz Worthey
@lizworthey.bsky.social
#AssociateProf #CompBio #Omics #WomenInScience #LGBTQ+Ally #Scottish #PrecisionMedicine #HealthCare #MDx #ME/CFS #RareDisease #Informatics #SciFiNerd #LongCovidAffected
sites.uab.edu/cgds/ she/her
sites.uab.edu/cgds/ she/her
Pinned
Liz Worthey
@lizworthey.bsky.social
· Nov 30
Thought I'd collect names for an ME/CFS Starter Pack: patients, advocates, researchers. For #diagnostics and #treatment for #ME/CFS, #LongCOVID, #Fibromyalgia, #POTS, and other related multisystem diseases. Send me a note to include.
Reposted by Liz Worthey
This ought to be engraved somewhere.
September 23, 2025 at 2:56 AM
This ought to be engraved somewhere.
Reposted by Liz Worthey
An unarmed veteran was attacked from behind, sustaining injuries and being dragged into a Portland ice building.
August 15, 2025 at 3:27 PM
An unarmed veteran was attacked from behind, sustaining injuries and being dragged into a Portland ice building.
Reposted by Liz Worthey
We have some bandwidth and so I’m interested in expanding the nbr of ME/CFS patients whose genomes we analyze. If you have data and would be interested in signing up to our protocol (we have found interesting findings in some, but not all people) please reach out and I can explain. #ME/CFS #Genomics
August 15, 2025 at 8:58 PM
We have some bandwidth and so I’m interested in expanding the nbr of ME/CFS patients whose genomes we analyze. If you have data and would be interested in signing up to our protocol (we have found interesting findings in some, but not all people) please reach out and I can explain. #ME/CFS #Genomics
Reposted by Liz Worthey
Choose Europe for Science: EU comes together to attract top research talent research-and-innovation.ec.europa.eu/news/all-res...
Choose Europe for Science: EU comes together to attract top research talent
Research and innovation news alert: The European Union is stepping up to become the world’s most attractive destination for researchers and innovators.
research-and-innovation.ec.europa.eu
May 24, 2025 at 4:11 PM
Choose Europe for Science: EU comes together to attract top research talent research-and-innovation.ec.europa.eu/news/all-res...
AM: 1,715 combinations with nominally significant impacts were identified in UK Biobank study. Two clinically relevant examples of effect heterogeneity were seen: 1) BMA -T2D attenuates with age, 2) LDL cholesterol exacerbates with increased urate. Study just published #ESHG2025
May 25, 2025 at 9:43 AM
AM: 1,715 combinations with nominally significant impacts were identified in UK Biobank study. Two clinically relevant examples of effect heterogeneity were seen: 1) BMA -T2D attenuates with age, 2) LDL cholesterol exacerbates with increased urate. Study just published #ESHG2025
AM: Resid-Strat, DR by G, DR by X, and Raw-Strat methods were all tested in term of impact on Type 1 error. Each method was found to be differentially affected by collider biases #ESHG2025
May 25, 2025 at 9:40 AM
AM: Resid-Strat, DR by G, DR by X, and Raw-Strat methods were all tested in term of impact on Type 1 error. Each method was found to be differentially affected by collider biases #ESHG2025
AM: discussing sources of collider bias - biases that occur when an exposure and outcome (or factors causing these) each influence a common third variable #ESHG2025
May 25, 2025 at 9:37 AM
AM: discussing sources of collider bias - biases that occur when an exposure and outcome (or factors causing these) each influence a common third variable #ESHG2025
AM: Asking: In precision medicine in patients with cardiovascular disease - how can we systematically identify patients differentially effected by a broad range of clinical variables and risk modifiers #ESHG2025
May 25, 2025 at 9:34 AM
AM: Asking: In precision medicine in patients with cardiovascular disease - how can we systematically identify patients differentially effected by a broad range of clinical variables and risk modifiers #ESHG2025
CA: Collectively these measurements account for 70% of variation, allowing generation of an accurate time of day prediction that acts as a proxy for internal circadian time #ESHG2025
May 25, 2025 at 9:30 AM
CA: Collectively these measurements account for 70% of variation, allowing generation of an accurate time of day prediction that acts as a proxy for internal circadian time #ESHG2025
CA: Oscillation measure developed seen to be highly correlated with sleep questionnaire data and propensity to work night shifts due to sleep cycle shift #ESHG2025
May 25, 2025 at 9:27 AM
CA: Oscillation measure developed seen to be highly correlated with sleep questionnaire data and propensity to work night shifts due to sleep cycle shift #ESHG2025
CA: Proteomics explains 68% of circadian effect (despite being a smaller dataset), NMR 39%, Biochemistry 13%, and cell counts 6% #ESHG2025
May 25, 2025 at 9:26 AM
CA: Proteomics explains 68% of circadian effect (despite being a smaller dataset), NMR 39%, Biochemistry 13%, and cell counts 6% #ESHG2025
CA: Variety of plasma omics available for analysis. Time of day effect seen across all these datasets; to variable degrees when pre-regressed with age, PCs, fasting, and other technical covariates #ESHG2025
May 25, 2025 at 9:22 AM
CA: Variety of plasma omics available for analysis. Time of day effect seen across all these datasets; to variable degrees when pre-regressed with age, PCs, fasting, and other technical covariates #ESHG2025
CA: circadian dysregulation alters the difference between external and internal time and can be measured by melatonin levels in the saliva #ESHG2025
May 25, 2025 at 9:19 AM
CA: circadian dysregulation alters the difference between external and internal time and can be measured by melatonin levels in the saliva #ESHG2025
LU: Studied incidence of T2D in individuals with melatonin prescription - individuals with the risk variant were seen to have higher risk of disease when supplemented with melatonin #ESHG2025
May 25, 2025 at 9:12 AM
LU: Studied incidence of T2D in individuals with melatonin prescription - individuals with the risk variant were seen to have higher risk of disease when supplemented with melatonin #ESHG2025
LU: Effect of MTNR1B variant effect varies over the day - assoc higher glucose in the am and lower in the pm - homozygous carriers showed 0.5mmol/l higher levels in the am than pm compared to non carriers - replicated to FinnGen, Estonian biobank #ESHG2025
May 25, 2025 at 9:10 AM
LU: Effect of MTNR1B variant effect varies over the day - assoc higher glucose in the am and lower in the pm - homozygous carriers showed 0.5mmol/l higher levels in the am than pm compared to non carriers - replicated to FinnGen, Estonian biobank #ESHG2025
LU: Performed Regenie testing on UK Biobank data. Identified signal at common variants at CRY2 and MTNR1B loci - signals only seen when variation over the day is considered, not in analyses without this concept #ESHG2025
May 25, 2025 at 9:07 AM
LU: Performed Regenie testing on UK Biobank data. Identified signal at common variants at CRY2 and MTNR1B loci - signals only seen when variation over the day is considered, not in analyses without this concept #ESHG2025