Ye Lab
@liye-tsri.bsky.social
Ye lab at Scripps Research and HHMI. Neuroscience, Metabolism, and Chemical Biology. Opinions are my own and do not reflect those of my employer.
Reposted by Ye Lab
What if we could see 3D #biodistribution of cancer drugs at the cellular level... throughout an entire model animal? ๐ง A new paper from Li Ye's lab @scripps.edu, Zhengyuan Pang & Verina Leung et al. introduce a technique for doing just that. (1/3) ๐งต
February 10, 2026 at 4:05 PM
What if we could see 3D #biodistribution of cancer drugs at the cellular level... throughout an entire model animal? ๐ง A new paper from Li Ye's lab @scripps.edu, Zhengyuan Pang & Verina Leung et al. introduce a technique for doing just that. (1/3) ๐งต
Thank you! @carolynbertozzi.bskyverified.social
December 22, 2025 at 8:46 PM
Thank you! @carolynbertozzi.bskyverified.social
Thrilled to share our latest work--combining CATCH with whole-body HYBRiD imaging, leveraging click chemistry to visualize and identify drug-targeted cells across organ systems. Led by a brilliant team: former PhD student Ben Pang and former undergrad Verina Leung.
Now online! Mapping cellular targets of covalent cancer drugs in the entire mammalian body
Mapping cellular targets of covalent cancer drugs in the entire mammalian body
vCATCH is a volumetric tissue labeling technique enabling cellular-resolution mapping of covalent drug targets throughout the entire mammalian body.
dlvr.it
December 22, 2025 at 8:46 PM
Thrilled to share our latest work--combining CATCH with whole-body HYBRiD imaging, leveraging click chemistry to visualize and identify drug-targeted cells across organ systems. Led by a brilliant team: former PhD student Ben Pang and former undergrad Verina Leung.
Reposted by Ye Lab
Fellows-to-Faculty awardee Chen Ran maps the senses of internal organs. Receiving this award โ which is currently open for apps โ has been crucial in enabling his work: https://www.simonsfoundation.org/autism-and-neuroscience-innovators-awardees-share-their-research-at-the-annual-retreat/ #science
December 21, 2025 at 7:17 PM
Fellows-to-Faculty awardee Chen Ran maps the senses of internal organs. Receiving this award โ which is currently open for apps โ has been crucial in enabling his work: https://www.simonsfoundation.org/autism-and-neuroscience-innovators-awardees-share-their-research-at-the-annual-retreat/ #science
Iโm sorry to say sd is not very sunny this week haha
November 13, 2025 at 11:52 PM
Iโm sorry to say sd is not very sunny this week haha
Reposted by Ye Lab
RIP Jim Watson. You inspired many of us to pursue a life in research. I wish you had made it easier for us to celebrate your legacy.
November 7, 2025 at 11:11 PM
RIP Jim Watson. You inspired many of us to pursue a life in research. I wish you had made it easier for us to celebrate your legacy.
Reposted by Ye Lab
Nothing beats the ceremony of dragging a grant from my pending folder to dead grant folder hahaha (sometimes it did give a big relief though)
November 9, 2025 at 6:17 AM
Nothing beats the ceremony of dragging a grant from my pending folder to dead grant folder hahaha (sometimes it did give a big relief though)
Nothing beats the ceremony of dragging a grant from my pending folder to dead grant folder hahaha (sometimes it did give a big relief though)
November 9, 2025 at 6:17 AM
Nothing beats the ceremony of dragging a grant from my pending folder to dead grant folder hahaha (sometimes it did give a big relief though)
Did aha approve the chips?
November 9, 2025 at 6:14 AM
Did aha approve the chips?
Deeply honored to receive this year's Tianqiao and Chrissy Chen Young Investigator Award from @sfn.org Grateful to all lab members and my mentors.
Congratulations to the 2025 SfN award & prize recipients!
Their dedication to advancing the understanding of the brain paves the way for future discoveries.
SfN looks forward to celebrating their achievements at #SfN25.
Learn about the recipients.
๐ vist.ly/4cni8
#neurosky
Their dedication to advancing the understanding of the brain paves the way for future discoveries.
SfN looks forward to celebrating their achievements at #SfN25.
Learn about the recipients.
๐ vist.ly/4cni8
#neurosky
November 3, 2025 at 8:55 PM
Deeply honored to receive this year's Tianqiao and Chrissy Chen Young Investigator Award from @sfn.org Grateful to all lab members and my mentors.
Reposted by Ye Lab
Come be my newest colleague! Scripps neuro is an energetic and supportive department, and uniquely benefits from proximity to our intimidatingly awesome chem and drug discovery programs. Happy to chat about my experiences here so far!
During these uncertain times, Iโm very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. Iโd especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 6:33 PM
Come be my newest colleague! Scripps neuro is an energetic and supportive department, and uniquely benefits from proximity to our intimidatingly awesome chem and drug discovery programs. Happy to chat about my experiences here so far!
Reposted by Ye Lab
The NIH has awarded a $14.2M Directorโs Transformative Research Award to a team led by Nobel Prize-winning neuroscientist @ardemp.bskyverified.social, Prof. @liye-tsri.bsky.social and Assoc. Prof. @xinjin.bsky.social to map interoception and build the first atlas of this hidden sixth sense.
Scripps Research-led team receives $14.2M NIH award to map the bodyโs โhidden sixth senseโ
www.scripps.edu
October 10, 2025 at 12:06 AM
The NIH has awarded a $14.2M Directorโs Transformative Research Award to a team led by Nobel Prize-winning neuroscientist @ardemp.bskyverified.social, Prof. @liye-tsri.bsky.social and Assoc. Prof. @xinjin.bsky.social to map interoception and build the first atlas of this hidden sixth sense.
Reposted by Ye Lab
Finally out: our recent work with Nick Betley is a view into how the brain reshapes its behavior in the face of competing survival needs- and also a potential angle on treatment targets for enduring pain.
A brief rundown...
www.nature.com/articles/s41...
A brief rundown...
www.nature.com/articles/s41...
A parabrachial hub for need-state control of enduring pain - Nature
Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.
www.nature.com
October 9, 2025 at 1:15 PM
Finally out: our recent work with Nick Betley is a view into how the brain reshapes its behavior in the face of competing survival needs- and also a potential angle on treatment targets for enduring pain.
A brief rundown...
www.nature.com/articles/s41...
A brief rundown...
www.nature.com/articles/s41...
Reposted by Ye Lab
Coming to #SfN2025 in San Diego? Come join our Neuroscience Symposium a day before on Nov 13! Hear from a fantastic speaker lineup and interact with vibrant audience in our community and beyond.
Free registration link: www.eventbrite.com/e/dorris-neu...
Free registration link: www.eventbrite.com/e/dorris-neu...
October 8, 2025 at 2:56 PM
Coming to #SfN2025 in San Diego? Come join our Neuroscience Symposium a day before on Nov 13! Hear from a fantastic speaker lineup and interact with vibrant audience in our community and beyond.
Free registration link: www.eventbrite.com/e/dorris-neu...
Free registration link: www.eventbrite.com/e/dorris-neu...
What a small world!!! We left the island the next morning.
July 2, 2025 at 11:15 PM
What a small world!!! We left the island the next morning.
We were likely both at this place last night!
July 2, 2025 at 5:20 AM
We were likely both at this place last night!
Congrats to @xinjin.bsky.social @tinakim-neuro.bsky.social and many others!
Love seeing friends and colleagues #slay! Congrats to @moriel-z.bsky.social @utah.edu for becoming a @hhmi.org Hrabowski scholar! Also congrats to @tinakim-neuro.bsky.social @xinjin.bsky.social @doctheagrif.bsky.social www.hhmi.org/programs/fre...
The 2025 Freeman Hrabowski Scholars | HHMI
Freeman Hrabowski Scholars areย outstanding early career faculty who have the potential to become leaders in their research fields.
www.hhmi.org
June 20, 2025 at 2:06 AM
Congrats to @xinjin.bsky.social @tinakim-neuro.bsky.social and many others!
Reposted by Ye Lab
Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.
โArdem Patapoutianโs story is not just the American dream, it is the dream of American science.โ
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
โArdem Patapoutianโs story is not just the American dream, it is the dream of American science.โ
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear Itโs Dimming
www.nytimes.com
June 3, 2025 at 10:58 AM
Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.
โArdem Patapoutianโs story is not just the American dream, it is the dream of American science.โ
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
โArdem Patapoutianโs story is not just the American dream, it is the dream of American science.โ
Read the article here. No subscription required:
www.nytimes.com/2025/06/03/u...
Reposted by Ye Lab
Congrats to Assist. Prof. Chen Ran (@chenran.bsky.social), one of just 15 selected as a 2025 Searle Scholar! ๐
His work on how visceral signals are encoded in the brain was recognized for its potential to elucidate disease mechanisms & inform new therapeutics. More: ow.ly/HtLM50VN8sN
His work on how visceral signals are encoded in the brain was recognized for its potential to elucidate disease mechanisms & inform new therapeutics. More: ow.ly/HtLM50VN8sN
May 6, 2025 at 11:00 PM
Congrats to Assist. Prof. Chen Ran (@chenran.bsky.social), one of just 15 selected as a 2025 Searle Scholar! ๐
His work on how visceral signals are encoded in the brain was recognized for its potential to elucidate disease mechanisms & inform new therapeutics. More: ow.ly/HtLM50VN8sN
His work on how visceral signals are encoded in the brain was recognized for its potential to elucidate disease mechanisms & inform new therapeutics. More: ow.ly/HtLM50VN8sN
Reposted by Ye Lab
Congratulations to @chenran.bsky.social on being named a Searle Scholar!
searlescholars.org/2025/04/14/s...
searlescholars.org/2025/04/14/s...
SEARLE SCHOLARS PROGRAM NAMES 15 SCIENTISTS AS SEARLE SCHOLARS FOR 2025
Members of the new class of Searle Scholars pursue ground-breaking research in chemistry and the biomedical sciences. Each receives an award of $300,000 in flexible funding to support his, her, or โฆ
searlescholars.org
April 19, 2025 at 11:56 PM
Congratulations to @chenran.bsky.social on being named a Searle Scholar!
searlescholars.org/2025/04/14/s...
searlescholars.org/2025/04/14/s...
Reposted by Ye Lab
Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Interoceptive processing in the nucleus of the solitary tract
The interoceptive nervous system continuously monitors the status of visceral organs to synthesize internal perceptions and regulate behavioral and phโฆ
www.sciencedirect.com
April 16, 2025 at 4:02 AM
Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Ye Lab
Great collaboration with @liye-tsri.bsky.social @dlipomi.bsky.social, and Jonathan Long labs and led by Yu Wang and Yunxiao Zhang 2/2
March 6, 2025 at 7:12 PM
Great collaboration with @liye-tsri.bsky.social @dlipomi.bsky.social, and Jonathan Long labs and led by Yu Wang and Yunxiao Zhang 2/2