Liora Katz
@likatz.bsky.social
Associate Professor
Diabetes, obesity and metabolism institute
Mount Sinai, NY
Diabetes, obesity and metabolism institute
Mount Sinai, NY
Excited to share our Commentary in JCI. Exploring how SIRT2 regulates human beta cell proliferation
www.jci.org/articles/vie...
@jci.org
www.jci.org/articles/vie...
@jci.org
October 10, 2025 at 1:06 PM
Excited to share our Commentary in JCI. Exploring how SIRT2 regulates human beta cell proliferation
www.jci.org/articles/vie...
@jci.org
www.jci.org/articles/vie...
@jci.org
Reposted by Liora Katz
Reposted by Liora Katz
A molecular glue’ compound led to potent ChREBPα/14-3-3 PPI stabilization, retained ChREBPα in the cytoplasm, and efficiently protected β-cells from glucolipotoxicity while maintaining β-cell identity. @naturecomms.bsky.social www.nature.com/articles/s41...
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity - Nature Communications
Targeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, s...
www.nature.com
March 2, 2025 at 12:01 PM
A molecular glue’ compound led to potent ChREBPα/14-3-3 PPI stabilization, retained ChREBPα in the cytoplasm, and efficiently protected β-cells from glucolipotoxicity while maintaining β-cell identity. @naturecomms.bsky.social www.nature.com/articles/s41...
Excited to share our work in @naturecomms.bsky.social
We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41...
#DiabetesResearch #BetaCells
We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41...
#DiabetesResearch #BetaCells
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity - Nature Communications
Targeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, s...
www.nature.com
March 2, 2025 at 12:03 PM
Excited to share our work in @naturecomms.bsky.social
We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41...
#DiabetesResearch #BetaCells
We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41...
#DiabetesResearch #BetaCells
Reposted by Liora Katz
✨NYC Stand Up for Science Rally: March 7 (12-3pm)✨ This event is a call to protect publicly funded science from political interference and to reaffirm that diversity, equity, inclusion, and access are essential to scientific progress. @standupforscience.bsky.social (permit pending for location)
February 27, 2025 at 8:19 PM
✨NYC Stand Up for Science Rally: March 7 (12-3pm)✨ This event is a call to protect publicly funded science from political interference and to reaffirm that diversity, equity, inclusion, and access are essential to scientific progress. @standupforscience.bsky.social (permit pending for location)
Making America great means supporting research that saves lives, improves health, and drives new technology. Freezing NIH funding hurts all of us. Let’s tell our leaders to INCREASE funding for the NIH and keep America at the forefront of science and innovation!
Scientific advancements aside, this is economically irresponsible
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
January 23, 2025 at 3:22 PM
Making America great means supporting research that saves lives, improves health, and drives new technology. Freezing NIH funding hurts all of us. Let’s tell our leaders to INCREASE funding for the NIH and keep America at the forefront of science and innovation!
Happy to be a part of this amazing interdiciplinary reseach group!
New work led by Liora Katz at Mt. Sinai along with colleagues of a non-degrading molecular glue between a TF (ChREBP) and a 14-3-3 protein which effectively traps the TF in the nucleus, thereby preventing activation of its target genes in the nucleus. Congratulations!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity
The Carbohydrate Response Element Binding Protein (ChREBP) is a glucose-responsive transcription factor (TF) with two major splice isoforms (α and β). In chronic hyperglycemia and glucolipotoxicity, C...
www.biorxiv.org
January 5, 2025 at 3:20 PM
Happy to be a part of this amazing interdiciplinary reseach group!
Reposted by Liora Katz
New work led by Liora Katz at Mt. Sinai along with colleagues of a non-degrading molecular glue between a TF (ChREBP) and a 14-3-3 protein which effectively traps the TF in the nucleus, thereby preventing activation of its target genes in the nucleus. Congratulations!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity
The Carbohydrate Response Element Binding Protein (ChREBP) is a glucose-responsive transcription factor (TF) with two major splice isoforms (α and β). In chronic hyperglycemia and glucolipotoxicity, C...
www.biorxiv.org
November 22, 2024 at 1:04 PM
New work led by Liora Katz at Mt. Sinai along with colleagues of a non-degrading molecular glue between a TF (ChREBP) and a 14-3-3 protein which effectively traps the TF in the nucleus, thereby preventing activation of its target genes in the nucleus. Congratulations!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...