From growth charts to anemia thresholds, clinical standards assume a single human prototype. Why are we still using one-size-fits-all health metrics?

A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses ...

Many patients experience inadequate pain control due to limited options that are both efficacious and safe for treating moderate-to-severe acute pain; therefore, opioids are still frequently prescr...

Potential mechanism-based pharmacological treatment approaches could be developed by blocking promotors of nerve ingrowth, such as NGF, and promoting inhibitors of nerve ingrowth, like semaphorins, as...

We aimed to evaluate and compare the clinical benefits of platelet-rich plasma (PRP) injections compared to corticosteroid (CS) injections in patients…

PDF | Integrating artificial intelligence into biomedical human subjects research is transforming traditional experimental paradigms. This review... | Find, read and cite all the research you need on ...

PDF | Conventional human movement science often considers body parts and processes separately as belonging to complementary but distinct domains (motor... | Find, read and cite all the research you ne...

YouTube video by Madhur Mangalam

OBJECTIVE: To determine whether tailored interventions based on patients' psychological profiles enhanced the outcomes of interventions in people with non-specific low back pain (NSLBP), compared to usual care. DESIGN: Systematic review with meta-analysis. LITERATURE SEARCH: Embase, Cochrane, Medline, Web of Science, CINAHL, and PsycINFO were searched from their inception until November 2, 2023. STUDY SELECTION CRITERIA: We included randomized clinical trials (RCTs) that compared psychological interventions to any alternatives without psychological components in patients with NSLBP who were stratified based on their psychological risk factors using the cutoff of the questionnaires measuring a psychological construct. DATA SYNTHESIS: The outcomes were pain intensity and disability. The revised Cochrane risk-of-bias tool for randomized trials was used to evaluate the risk of bias. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to judge certainty of evidence. RESULTS: Twenty-nine trials were included, most presenting some concerns for the risk of bias. The certainty of evidence was mostly low, with moderate to substantial heterogeneity. Using psychological stratification, individuals who received a psychological intervention (versus usual care) reported lower pain intensity at short (MD -0.22, 95% confidence interval [CI] -0.41, -0.02) and mid-term (MD -0.37, 95% CI -0.57, -0.16). For disability, there was a larger improvement with psychological interventions versus usual care at short- (SMD -0.17; 95% CI -0.32, -0.02), mid- (SMD -0.16; 95% CI -0.28, -0.05), and long-term (SMD -0.17; 95% CI -0.29, -0.04) follow-ups. CONCLUSIONS: Psychological interventions had a positive impact, although small, on reducing pain intensity and disability in patients with low back pain and psychological risk factors.