Leon Aksman
@leonaksman.bsky.social
Asst. Prof of Research at USC's Laboratory of Neuroimaging, working on dementia progression
Reposted by Leon Aksman
For this who are unaware, the reason NIH now posts these data habitually on the data book site is… Jeremy Berg. He pioneered this openness as NIGMS Director.
Since there is some discussion that NIH institutes should not simply use paylines to determine which grants to fund, I thought I would share some old data.
These are plots of funding probability fas a function of percentile score for 9 institutes.
1/7
These are plots of funding probability fas a function of percentile score for 9 institutes.
1/7
September 26, 2025 at 3:14 PM
For this who are unaware, the reason NIH now posts these data habitually on the data book site is… Jeremy Berg. He pioneered this openness as NIGMS Director.
Reposted by Leon Aksman
🧠New paper alert!
We define PI-2620 tau PET cutpoints in a diverse cohort — summary of 🗝️ findings below ⬇️
675 adults:
• AB+ cognitively impaired (CI)
• AB– cognitively unimpaired (CU)
• 28% Hispanic, 31% NH Black, 41% NH White
🔗 Read it here:
(bit.ly/44RLVwe)
@victoriatennant.bsky.social
We define PI-2620 tau PET cutpoints in a diverse cohort — summary of 🗝️ findings below ⬇️
675 adults:
• AB+ cognitively impaired (CI)
• AB– cognitively unimpaired (CU)
• 28% Hispanic, 31% NH Black, 41% NH White
🔗 Read it here:
(bit.ly/44RLVwe)
@victoriatennant.bsky.social
July 8, 2025 at 7:00 PM
🧠New paper alert!
We define PI-2620 tau PET cutpoints in a diverse cohort — summary of 🗝️ findings below ⬇️
675 adults:
• AB+ cognitively impaired (CI)
• AB– cognitively unimpaired (CU)
• 28% Hispanic, 31% NH Black, 41% NH White
🔗 Read it here:
(bit.ly/44RLVwe)
@victoriatennant.bsky.social
We define PI-2620 tau PET cutpoints in a diverse cohort — summary of 🗝️ findings below ⬇️
675 adults:
• AB+ cognitively impaired (CI)
• AB– cognitively unimpaired (CU)
• 28% Hispanic, 31% NH Black, 41% NH White
🔗 Read it here:
(bit.ly/44RLVwe)
@victoriatennant.bsky.social
Reposted by Leon Aksman
🎉Congrats to PhD student, Amaryllis Tsiknia, who led our new paper bit.ly/3ZndVVh studying how diabetes relates to cortical thickness in Hispanic & non-Hispanic Black & White older adults!
Read more here: bit.ly/3GS0Ddj
More on our findings soon...
Read more here: bit.ly/3GS0Ddj
More on our findings soon...
🧠 Our new study finds a strong link between type 2 diabetes and brain atrophy in older adults—especially in memory-related regions. Managing blood sugar could be key to protecting brain health as we age.
Learn more 👉 bit.ly/3GS0Ddj
Learn more 👉 bit.ly/3GS0Ddj
USC Study Reveals Link Between Type 2 Diabetes and Brain Health in Older Adults from Various Populations
Related News USC study finds new evidence linking dementia to problems with the brain’s waste clearance system January 7, 2025 Calorie-free sweeteners can disrupt the brain’s appetite signals March 26...
bit.ly
May 15, 2025 at 5:27 PM
🎉Congrats to PhD student, Amaryllis Tsiknia, who led our new paper bit.ly/3ZndVVh studying how diabetes relates to cortical thickness in Hispanic & non-Hispanic Black & White older adults!
Read more here: bit.ly/3GS0Ddj
More on our findings soon...
Read more here: bit.ly/3GS0Ddj
More on our findings soon...
Reposted by Leon Aksman
Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community
Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia
www.nature.com/articles/s41...
Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia
www.nature.com/articles/s41...
Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community - Nature Medicine
In a community-based cohort of more than 2,000 older adults from Sweden, blood biomarkers for Alzheimer’s disease were able to predict dementia up to 16 years before disease onset.
www.nature.com
March 31, 2025 at 2:33 PM
Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community
Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia
www.nature.com/articles/s41...
Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia
www.nature.com/articles/s41...
Reposted by Leon Aksman
The crush of new grant cancellations hasn't let up.
If your grant was terminated (or your app was pulled) please use this Google Form👇 to submit details for tracking purposes.
Multiple advocacy efforts are moving forward, but we must must must know more about what grants were cancelled and why.
If your grant was terminated (or your app was pulled) please use this Google Form👇 to submit details for tracking purposes.
Multiple advocacy efforts are moving forward, but we must must must know more about what grants were cancelled and why.
Cancelled NIH grant information submission form
Please use this form to submit information identifying specific NIH grants that have been cancelled for any reason after January 20, 2025.
Data from this form will be used to update the Rescinded NIH...
forms.gle
March 21, 2025 at 3:32 AM
The crush of new grant cancellations hasn't let up.
If your grant was terminated (or your app was pulled) please use this Google Form👇 to submit details for tracking purposes.
Multiple advocacy efforts are moving forward, but we must must must know more about what grants were cancelled and why.
If your grant was terminated (or your app was pulled) please use this Google Form👇 to submit details for tracking purposes.
Multiple advocacy efforts are moving forward, but we must must must know more about what grants were cancelled and why.
Reposted by Leon Aksman
Some good-ish news from NIH
“Federal Register notices for study sections run by CSR (but not those by ICs) will start being permitted again”
As far as I know, the timing for this is not clear, but I will be checking the Federal Register.
“Federal Register notices for study sections run by CSR (but not those by ICs) will start being permitted again”
As far as I know, the timing for this is not clear, but I will be checking the Federal Register.
a man in a red suit and tie is holding a piece of paper that says breaking news on it
ALT: a man in a red suit and tie is holding a piece of paper that says breaking news on it
media.tenor.com
February 24, 2025 at 4:38 PM
Some good-ish news from NIH
“Federal Register notices for study sections run by CSR (but not those by ICs) will start being permitted again”
As far as I know, the timing for this is not clear, but I will be checking the Federal Register.
“Federal Register notices for study sections run by CSR (but not those by ICs) will start being permitted again”
As far as I know, the timing for this is not clear, but I will be checking the Federal Register.
Reposted by Leon Aksman
41/47 (87%) of NIH study sections are cancelled this week
Frustrating to see all this good research stalled (& not funded)
You can search for study sections that ‘did not meet as scheduled’ here with ones with * ⤵️
www.csr.nih.gov/RevPanelsAnd...
Frustrating to see all this good research stalled (& not funded)
You can search for study sections that ‘did not meet as scheduled’ here with ones with * ⤵️
www.csr.nih.gov/RevPanelsAnd...
Review Dates
www.csr.nih.gov
February 20, 2025 at 2:03 AM
41/47 (87%) of NIH study sections are cancelled this week
Frustrating to see all this good research stalled (& not funded)
You can search for study sections that ‘did not meet as scheduled’ here with ones with * ⤵️
www.csr.nih.gov/RevPanelsAnd...
Frustrating to see all this good research stalled (& not funded)
You can search for study sections that ‘did not meet as scheduled’ here with ones with * ⤵️
www.csr.nih.gov/RevPanelsAnd...
Reposted by Leon Aksman
What can we do to get Science Magazine to drop their paywall for a while, while all this critically important news is being reported on? The public needs to know. Great journalists are covering these stories. where will they and the magazine be without the scientists and the research?
February 16, 2025 at 10:29 AM
What can we do to get Science Magazine to drop their paywall for a while, while all this critically important news is being reported on? The public needs to know. Great journalists are covering these stories. where will they and the magazine be without the scientists and the research?
Reposted by Leon Aksman
These cases are just incredible
February 13, 2025 at 7:39 PM
These cases are just incredible
Reposted by Leon Aksman
I just wanted to share that I received the NoA for the second year of my R21 today. I know people are feeling anxious and I just hope some good news from the NIH can help. Hang in there - we'll get through this! ❤️
January 27, 2025 at 8:13 PM
I just wanted to share that I received the NoA for the second year of my R21 today. I know people are feeling anxious and I just hope some good news from the NIH can help. Hang in there - we'll get through this! ❤️
Reposted by Leon Aksman
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
scim.ag
January 22, 2025 at 11:28 PM
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
I got a lot of insights into how AI might work in scientific research from this convo:
www.theatlantic.com/podcasts/arc...
www.theatlantic.com/podcasts/arc...
The Scientist vs. the Machine
What happened when AI took over these researchers’ jobs?
www.theatlantic.com
January 14, 2025 at 10:08 PM
I got a lot of insights into how AI might work in scientific research from this convo:
www.theatlantic.com/podcasts/arc...
www.theatlantic.com/podcasts/arc...
Reposted by Leon Aksman
The importance of sleep microarchitecture- in addition to total sleep time - for cognition
academic.oup.com/sleep/articl...
academic.oup.com/sleep/articl...
Obstructive sleep apnea, cognitive impairment, and dementia: is sleep microstructure an important feature?
Obstructive sleep apnea (OSA) and dementia are both prevalent conditions in the aging population [1, 2]. Scientific evidence indicates that OSA is associat
academic.oup.com
January 6, 2025 at 4:29 PM
The importance of sleep microarchitecture- in addition to total sleep time - for cognition
academic.oup.com/sleep/articl...
academic.oup.com/sleep/articl...
Reposted by Leon Aksman
A Nature Aging paper identifies 13 proteins linked to brain aging. Changes in the concentrations of these blood proteins may peak at 57, 70, and 78 years old, and suggest that these ages may be important for potential interventions in the brain aging process. https://go.nature.com/3ZvGLSy 🧪
December 10, 2024 at 3:21 PM
A Nature Aging paper identifies 13 proteins linked to brain aging. Changes in the concentrations of these blood proteins may peak at 57, 70, and 78 years old, and suggest that these ages may be important for potential interventions in the brain aging process. https://go.nature.com/3ZvGLSy 🧪
Reposted by Leon Aksman
