Michael Koeris
@koeris.bsky.social
Director of the Office of Biological Technologies of DARPA
Reposted by Michael Koeris
Good & detailed analysis of the US campaign in Venezuela, including the prospect of a war. "The risks of violence in any post-Maduro scenario should not be downplayed. Many senior military officers could resist regime change." www.crisisgroup.org/latin-americ...
Beware the Slide Toward Regime Change in Venezuela | International Crisis Group
The Trump administration is dispatching military assets to the Caribbean and sinking boats it claims ferry drugs. While it appears the deployment is part of a plan to depose Venezuelan President Nicol...
www.crisisgroup.org
October 25, 2025 at 11:53 AM
Good & detailed analysis of the US campaign in Venezuela, including the prospect of a war. "The risks of violence in any post-Maduro scenario should not be downplayed. Many senior military officers could resist regime change." www.crisisgroup.org/latin-americ...
Reposted by Michael Koeris
Kyle Muldoon thought he might never get to watch an Eagles game with his son KJ, who was born with a rare and fatal liver disease that was treated with an individual CRISPR therapy.
#STATSummit
#STATSummit
October 18, 2025 at 10:17 PM
Kyle Muldoon thought he might never get to watch an Eagles game with his son KJ, who was born with a rare and fatal liver disease that was treated with an individual CRISPR therapy.
#STATSummit
#STATSummit
Reposted by Michael Koeris
How does NATO monitor and defend its airspace? It operates a large, diverse & growing network of sensors & interceptors on air, sea and land—but also one with significant limitations when it comes to countering low-level drone incursions in peacetime.
www.economist.com/europe/2025/...
www.economist.com/europe/2025/...
A scary struggle with the Kremlin over Europe’s skies
Russian air incursions are testing NATO’s will to resist
www.economist.com
September 14, 2025 at 12:51 PM
How does NATO monitor and defend its airspace? It operates a large, diverse & growing network of sensors & interceptors on air, sea and land—but also one with significant limitations when it comes to countering low-level drone incursions in peacetime.
www.economist.com/europe/2025/...
www.economist.com/europe/2025/...
Reposted by Michael Koeris
'The ‘C’s’ between 1909 and 2024 fall into two distinct groups; former Joint Intelligence Committee (JIC) Chair Sir Percy Cradock talked of ‘sword men’ and ‘gown men’, reflecting the increasing civilianisation of SIS from the 1950s onwards' www.tandfonline.com/doi/full/10....
A, B, or C? The Foreign Office and the Politics of Choosing the Chief of SIS
This article explores the process whereby the Chief (‘C’) of Britain’s foreign intelligence agency, the Secret Intelligence Service (SIS or MI6) has been appointed, and the inter-departmental polit...
www.tandfonline.com
September 2, 2025 at 9:18 AM
'The ‘C’s’ between 1909 and 2024 fall into two distinct groups; former Joint Intelligence Committee (JIC) Chair Sir Percy Cradock talked of ‘sword men’ and ‘gown men’, reflecting the increasing civilianisation of SIS from the 1950s onwards' www.tandfonline.com/doi/full/10....
The Defense Advanced Research Projects Agency BTO (us!!!) is seeking disruptive solutions to defend U.S. agriculture (crops and livestock) against chemical/biological threats!
darpa.mil/research/progr…
darpa.mil/research/progr…
https://darpa.mil/research/progr…
June 14, 2025 at 4:58 PM
The Defense Advanced Research Projects Agency BTO (us!!!) is seeking disruptive solutions to defend U.S. agriculture (crops and livestock) against chemical/biological threats!
darpa.mil/research/progr…
darpa.mil/research/progr…
Reposted by Michael Koeris
ISW is seeking a full-time Middle East Security Program Researcher to provide timely open-source research and analysis of the geo-strategic dynamics of the Middle East region and how those dynamics will affect U.S. national security interests.
For more info & to apply: isw.pub/MiddleEastRe...
For more info & to apply: isw.pub/MiddleEastRe...
June 14, 2025 at 4:00 PM
ISW is seeking a full-time Middle East Security Program Researcher to provide timely open-source research and analysis of the geo-strategic dynamics of the Middle East region and how those dynamics will affect U.S. national security interests.
For more info & to apply: isw.pub/MiddleEastRe...
For more info & to apply: isw.pub/MiddleEastRe...
Reposted by Michael Koeris
4/ PRC is possibly conducting bathymetric surveys in the strategically significant Luzon Strait between Taiwan and the Philippines.
May 9, 2025 at 7:52 PM
4/ PRC is possibly conducting bathymetric surveys in the strategically significant Luzon Strait between Taiwan and the Philippines.
Reposted by Michael Koeris
We’ve now seen ground-based missile use, tho’ Pakistan’s Fateh is a non-nuclear tactical ballistic missile & not in same category as some longer range systems. As for nuc signalling, it depends whether you believe Pakistan’s earlier statement or the def minister’s later one
bsky.app/profile/shas...
bsky.app/profile/shas...
Things we have not (yet) seen in this crisis:
- Fighter jets crossing the border/LoC
- Use of ground-based dual-capable missiles
- Nuclear signalling of a sort we previously saw in in 1990 & 1999 (at least not publicly)
- Large-scale mobilisation of ground forces, as in 2001/02
- Fighter jets crossing the border/LoC
- Use of ground-based dual-capable missiles
- Nuclear signalling of a sort we previously saw in in 1990 & 1999 (at least not publicly)
- Large-scale mobilisation of ground forces, as in 2001/02
May 10, 2025 at 7:40 AM
We’ve now seen ground-based missile use, tho’ Pakistan’s Fateh is a non-nuclear tactical ballistic missile & not in same category as some longer range systems. As for nuc signalling, it depends whether you believe Pakistan’s earlier statement or the def minister’s later one
bsky.app/profile/shas...
bsky.app/profile/shas...
Reposted by Michael Koeris
Things we have not (yet) seen in this crisis:
- Fighter jets crossing the border/LoC
- Use of ground-based dual-capable missiles
- Nuclear signalling of a sort we previously saw in in 1990 & 1999 (at least not publicly)
- Large-scale mobilisation of ground forces, as in 2001/02
- Fighter jets crossing the border/LoC
- Use of ground-based dual-capable missiles
- Nuclear signalling of a sort we previously saw in in 1990 & 1999 (at least not publicly)
- Large-scale mobilisation of ground forces, as in 2001/02
May 9, 2025 at 6:44 PM
Things we have not (yet) seen in this crisis:
- Fighter jets crossing the border/LoC
- Use of ground-based dual-capable missiles
- Nuclear signalling of a sort we previously saw in in 1990 & 1999 (at least not publicly)
- Large-scale mobilisation of ground forces, as in 2001/02
- Fighter jets crossing the border/LoC
- Use of ground-based dual-capable missiles
- Nuclear signalling of a sort we previously saw in in 1990 & 1999 (at least not publicly)
- Large-scale mobilisation of ground forces, as in 2001/02
Reposted by Michael Koeris
Indonesia names Ray Dalio and Jeffrey Sachs as sovereign wealth fund advisers
https://www.ft.com/content/d90a401b-d086-44a9-b00a-adf46f00f450
https://www.ft.com/content/d90a401b-d086-44a9-b00a-adf46f00f450
Indonesia names Ray Dalio and Jeffrey Sachs as sovereign wealth fund advisers
Investors voice concern over governance at fund expected to manage state assets
www.ft.com
March 24, 2025 at 8:37 AM
Indonesia names Ray Dalio and Jeffrey Sachs as sovereign wealth fund advisers
https://www.ft.com/content/d90a401b-d086-44a9-b00a-adf46f00f450
https://www.ft.com/content/d90a401b-d086-44a9-b00a-adf46f00f450
Reposted by Michael Koeris
Check out our latest Hot Plasmids post, featuring cool new tools like self-labeling constructs from @dozenoaks.bsky.social, an improved voltage sensor from @michaelzlin.bsky.social, prime editing in dicot plants, and more!
blog.addgene.org/hot...
blog.addgene.org/hot...
Hot Plasmids: Winter 2025
Check out the latest Hot Plasmids, viral vectors, and antibodies in the Addgene repository!
blog.addgene.org
March 11, 2025 at 6:00 PM
Check out our latest Hot Plasmids post, featuring cool new tools like self-labeling constructs from @dozenoaks.bsky.social, an improved voltage sensor from @michaelzlin.bsky.social, prime editing in dicot plants, and more!
blog.addgene.org/hot...
blog.addgene.org/hot...
Reposted by Michael Koeris
pcDNA3-Y392C-WLS-HA-IRES-GFP
Depositor: Joseph Gleeson
Purpose: Expression of WLS-HA protein (Y392C mutant)
www.addgene.org/178062/
Depositor: Joseph Gleeson
Purpose: Expression of WLS-HA protein (Y392C mutant)
www.addgene.org/178062/
March 11, 2025 at 8:00 PM
pcDNA3-Y392C-WLS-HA-IRES-GFP
Depositor: Joseph Gleeson
Purpose: Expression of WLS-HA protein (Y392C mutant)
www.addgene.org/178062/
Depositor: Joseph Gleeson
Purpose: Expression of WLS-HA protein (Y392C mutant)
www.addgene.org/178062/
Reposted by Michael Koeris
‘Game changer’: German spending plans lift bond market’s growth forecasts
https://www.ft.com/content/f54f6eb2-5858-443b-9c07-1ddeb22f126b
https://www.ft.com/content/f54f6eb2-5858-443b-9c07-1ddeb22f126b
‘Game changer’: German spending plans lift bond market’s growth forecasts
Chancellor-in-waiting Merz’s promise to do ‘whatever it takes’ pushes Bund yields sharply higher in anticipation of more issuance
www.ft.com
March 8, 2025 at 1:09 PM
‘Game changer’: German spending plans lift bond market’s growth forecasts
https://www.ft.com/content/f54f6eb2-5858-443b-9c07-1ddeb22f126b
https://www.ft.com/content/f54f6eb2-5858-443b-9c07-1ddeb22f126b
Reposted by Michael Koeris
Europe needs Friedrich Merz to succeed | Opinion
https://www.ft.com/content/61eef114-b42d-4532-ac74-d13eeaa01ea8
https://www.ft.com/content/61eef114-b42d-4532-ac74-d13eeaa01ea8
Europe needs Friedrich Merz to succeed | Opinion
The first moves by Germany’s chancellor-designate are bold and encouraging
www.ft.com
February 24, 2025 at 6:38 PM
Europe needs Friedrich Merz to succeed | Opinion
https://www.ft.com/content/61eef114-b42d-4532-ac74-d13eeaa01ea8
https://www.ft.com/content/61eef114-b42d-4532-ac74-d13eeaa01ea8
Reposted by Michael Koeris
Big Tech’s AI ambitions deliver funding boost to nuclear reactor race
https://www.ft.com/content/2d84198e-7eeb-4154-bbf2-9a469b0cc700
https://www.ft.com/content/2d84198e-7eeb-4154-bbf2-9a469b0cc700
Big Tech’s AI ambitions deliver funding boost to nuclear reactor race
Developers of advanced microreactors have raised at least $1.5bn over the past year as demand soars
www.ft.com
February 19, 2025 at 11:09 AM
Big Tech’s AI ambitions deliver funding boost to nuclear reactor race
https://www.ft.com/content/2d84198e-7eeb-4154-bbf2-9a469b0cc700
https://www.ft.com/content/2d84198e-7eeb-4154-bbf2-9a469b0cc700
Fantastic work by @kexinhuang.bsky.social at Stanford (arXiv: 2502.09858)
Validation of hypotheses for experimental planning and verification based on the falsification principle by Karl Popper.
The Future just most a lot closer!!!
Validation of hypotheses for experimental planning and verification based on the falsification principle by Karl Popper.
The Future just most a lot closer!!!
https://github.com/snap-stanford/POPPER”
February 19, 2025 at 10:43 AM
Fantastic work by @kexinhuang.bsky.social at Stanford (arXiv: 2502.09858)
Validation of hypotheses for experimental planning and verification based on the falsification principle by Karl Popper.
The Future just most a lot closer!!!
Validation of hypotheses for experimental planning and verification based on the falsification principle by Karl Popper.
The Future just most a lot closer!!!
Reposted by Michael Koeris
Michael Lauer, deputy director of the National Institutes of Health’s extramural research, will leave the agency at the end of the week.
Second top NIH official, who oversaw awarding of research grants, departs abruptly
Michael Lauer, deputy director of the National Institutes of Health’s extramural research, will leave the agency at the end of the week.
buff.ly
February 14, 2025 at 1:15 AM
Michael Lauer, deputy director of the National Institutes of Health’s extramural research, will leave the agency at the end of the week.
It’s been a tough few years. But innovation doesn’t stop. Science still advances, improvements and breakthroughs will still happen. The pace is different but it’s not gone.
I know it’s tough to see @adamfeuerstein.bsky.social and we at DARPA BTO still believe & will get after it.
#stayInTheFight
I know it’s tough to see @adamfeuerstein.bsky.social and we at DARPA BTO still believe & will get after it.
#stayInTheFight
Biotech is in a dark place.
The market offers one beatdown after another. Sentiment is lousy and the bad mood is relentless, to the point where people are seriously wondering if a sector turnaround is ever possible.
Sorry, but it's just depressing out there...
www.statnews.com/2025/02/13/b...
The market offers one beatdown after another. Sentiment is lousy and the bad mood is relentless, to the point where people are seriously wondering if a sector turnaround is ever possible.
Sorry, but it's just depressing out there...
www.statnews.com/2025/02/13/b...
Biotech is in a dark place
Biotech and drug stocks, collectively, are down an average of 16% over the past three months. The closely watched XBI index is down 19% in the same time period.
www.statnews.com
February 13, 2025 at 10:27 PM
It’s been a tough few years. But innovation doesn’t stop. Science still advances, improvements and breakthroughs will still happen. The pace is different but it’s not gone.
I know it’s tough to see @adamfeuerstein.bsky.social and we at DARPA BTO still believe & will get after it.
#stayInTheFight
I know it’s tough to see @adamfeuerstein.bsky.social and we at DARPA BTO still believe & will get after it.
#stayInTheFight
Reposted by Michael Koeris
Ready to jump into base editing? Check out our updated CRISPR 101 blog post "Cytosine and Adenine Base Editors"!
blog.addgene.org/sin...
blog.addgene.org/sin...
CRISPR 101: Cytosine and Adenine Base Editors
An overview of cytosine and adenine base transition editors, which make precise changes in DNA bases without causing double-strand breaks.
blog.addgene.org
February 13, 2025 at 3:02 PM
Ready to jump into base editing? Check out our updated CRISPR 101 blog post "Cytosine and Adenine Base Editors"!
blog.addgene.org/sin...
blog.addgene.org/sin...
Reposted by Michael Koeris
We're hiring here at DARPA! A "Program Manager" is effectively an intrapreneur and we're going after Synthetic Biology #SynBio super hard.
Please fwd to interested people!
www.linkedin.com/posts/mkoeri...
Please fwd to interested people!
www.linkedin.com/posts/mkoeri...
Michael Koeris on LinkedIn: Thank you Jeffrey S. Buguliskis for the interview and patience as I go on…
Thank you Jeffrey S. Buguliskis for the interview and patience as I go on and on about SCIENCE and of course especially Synthetic Biology!
Many sciences are…
www.linkedin.com
February 6, 2025 at 11:27 PM
We're hiring here at DARPA! A "Program Manager" is effectively an intrapreneur and we're going after Synthetic Biology #SynBio super hard.
Please fwd to interested people!
www.linkedin.com/posts/mkoeri...
Please fwd to interested people!
www.linkedin.com/posts/mkoeri...
Reposted by Michael Koeris
🎉🎉 Congrats! 🥳
If you're interested in unveiling the NATURA way, you can find the plasmids here: www.addgene.org/browse/artic...
If you're interested in unveiling the NATURA way, you can find the plasmids here: www.addgene.org/browse/artic...
February 6, 2025 at 7:45 PM
🎉🎉 Congrats! 🥳
If you're interested in unveiling the NATURA way, you can find the plasmids here: www.addgene.org/browse/artic...
If you're interested in unveiling the NATURA way, you can find the plasmids here: www.addgene.org/browse/artic...
Reposted by Michael Koeris
The CRISPR companies are not OK
Today, in @statnews.com - a must-read story from my colleague @jasonmast.bsky.social
www.statnews.com/2025/02/06/c...
Today, in @statnews.com - a must-read story from my colleague @jasonmast.bsky.social
www.statnews.com/2025/02/06/c...
The CRISPR companies are not OK
Gene editing promised a revolution, but biotech layoffs, stock slumps, and industry struggles reveal a stark reality: CRISPR is hard to do profitably.
www.statnews.com
February 6, 2025 at 3:14 PM
The CRISPR companies are not OK
Today, in @statnews.com - a must-read story from my colleague @jasonmast.bsky.social
www.statnews.com/2025/02/06/c...
Today, in @statnews.com - a must-read story from my colleague @jasonmast.bsky.social
www.statnews.com/2025/02/06/c...
We're hiring here at DARPA! A "Program Manager" is effectively an intrapreneur and we're going after Synthetic Biology #SynBio super hard.
Please fwd to interested people!
www.linkedin.com/posts/mkoeri...
Please fwd to interested people!
www.linkedin.com/posts/mkoeri...
Michael Koeris on LinkedIn: Thank you Jeffrey S. Buguliskis for the interview and patience as I go on…
Thank you Jeffrey S. Buguliskis for the interview and patience as I go on and on about SCIENCE and of course especially Synthetic Biology!
Many sciences are…
www.linkedin.com
February 6, 2025 at 11:27 PM
We're hiring here at DARPA! A "Program Manager" is effectively an intrapreneur and we're going after Synthetic Biology #SynBio super hard.
Please fwd to interested people!
www.linkedin.com/posts/mkoeri...
Please fwd to interested people!
www.linkedin.com/posts/mkoeri...
Reposted by Michael Koeris
What happens to bacterial genomes when they're cloned into yeast? Do they transcribe, do they get silenced, do they get packaged away from the rest of the DNA? This cool study congrats to the Koszul lab team at Pasteur for this great work.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
www.science.org
February 6, 2025 at 11:09 PM
What happens to bacterial genomes when they're cloned into yeast? Do they transcribe, do they get silenced, do they get packaged away from the rest of the DNA? This cool study congrats to the Koszul lab team at Pasteur for this great work.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...