Biopsy specimens of 30 patients having a normal rectosigmoidal mucosa showed a DAO activity of 22.8 nmol/min g. In 12 UC patients the DAO activity was 2.7 nmol/min g (p = 0.01)
pubmed.ncbi.nlm.nih.gov/2115242/
pubmed.ncbi.nlm.nih.gov/2115242/
Diamine oxidase activities in the large bowel mucosa of ulcerative colitis patients - PubMed
The term colitis suggests mucosal inflammation as the key event. However, it may be that the disease starts with mucosal hyperproliferation, and inflammation of the impaired mucosa is a succeeding eve...
pubmed.ncbi.nlm.nih.gov
May 25, 2025 at 6:03 AM
Biopsy specimens of 30 patients having a normal rectosigmoidal mucosa showed a DAO activity of 22.8 nmol/min g. In 12 UC patients the DAO activity was 2.7 nmol/min g (p = 0.01)
pubmed.ncbi.nlm.nih.gov/2115242/
pubmed.ncbi.nlm.nih.gov/2115242/
Serotonin from enterochromaffin cells inhibits gastric acid and may act as an enterogastrone; it also stimulates mucus secretion in the stomach and colon
journals.sagepub.com/doi/abs/10.3...
journals.sagepub.com/doi/abs/10.3...
Action of Serotonin on the Gastrointestinal Tract - Herbert S. Ormsbee, Joseph D. Fondacaro, 1985
Serotonin is localized in the enterochromaffin cells of the gastrointestinal mucosa and within neurons in the enteric nervous system. It can be released into th...
journals.sagepub.com
May 9, 2025 at 3:31 AM
Serotonin from enterochromaffin cells inhibits gastric acid and may act as an enterogastrone; it also stimulates mucus secretion in the stomach and colon
journals.sagepub.com/doi/abs/10.3...
journals.sagepub.com/doi/abs/10.3...
The accumulation of Quorum Sensing signals throughout the gut is instrumental in regulating bacterial virulence during infection. This process also enables the regulation of behavior based on the location and stage of infection
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Quorum Sensing Modulates Bacterial Virulence and Colonization Dynamics During an Enteric Infection
Quorum Sensing (QS) is a form of cell-to-cell communication that enables bacteria to modify behaviour according to their population density. While QS has been proposed as a potential intervention agai...
www.biorxiv.org
March 7, 2025 at 1:24 AM
The accumulation of Quorum Sensing signals throughout the gut is instrumental in regulating bacterial virulence during infection. This process also enables the regulation of behavior based on the location and stage of infection
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
“Patients started on vedolizumab, should have their kidney function monitored routinely to assess for kidney injury with AIN/ATN being on the differential for AKi if it develops on this medication.”
PO-2260 #Kidneywk
Vedolizumab-Induced Acute Interstitial Nephritis and Acute Tubular Necrosis
Abdul Muzib, Rushang Parikh, @VBijol @nupuruppal @mala_sachdeva
https://asn.apprisor.org/epsView.cfm?LruJabE%2B6yo9tH46q3YNEDTlAv2lGxtr4ggl9qvwjQX4opGSJif8mmKvp8Cbs38%2Fh0BnjrpJgNg%3D
Vedolizumab-Induced Acute Interstitial Nephritis and Acute Tubular Necrosis
Abdul Muzib, Rushang Parikh, @VBijol @nupuruppal @mala_sachdeva
https://asn.apprisor.org/epsView.cfm?LruJabE%2B6yo9tH46q3YNEDTlAv2lGxtr4ggl9qvwjQX4opGSJif8mmKvp8Cbs38%2Fh0BnjrpJgNg%3D
February 24, 2025 at 6:10 AM
“Patients started on vedolizumab, should have their kidney function monitored routinely to assess for kidney injury with AIN/ATN being on the differential for AKi if it develops on this medication.”
Children exposed to indoor cats and dogs during foetal development and early infancy have fewer food allergies
Surprisingly, children exposed to hamsters had significantly greater incidence of nut allergies
journals.plos.org/plosone/arti...
Surprisingly, children exposed to hamsters had significantly greater incidence of nut allergies
journals.plos.org/plosone/arti...
Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children’s Study
The hygiene hypothesis suggests that pet exposure is effective in preventing allergic disease, and some studies have reported the beneficial effects of dog exposure during fetal development or early i...
journals.plos.org
February 24, 2025 at 5:43 AM
Children exposed to indoor cats and dogs during foetal development and early infancy have fewer food allergies
Surprisingly, children exposed to hamsters had significantly greater incidence of nut allergies
journals.plos.org/plosone/arti...
Surprisingly, children exposed to hamsters had significantly greater incidence of nut allergies
journals.plos.org/plosone/arti...
“With LGG supplementation, mucin 2 and 3A (MUC2 and MUC3A) gene expressions increased more than ninefolds (p = 0.046 and p = 0.008, respectively) at post-treatment”
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Lactobacillus GG is associated with mucin genes expressions in type 2 diabetes mellitus: a randomized, placebo-controlled trial - European Journal of Nutrition
Purpose Recent studies indicate that dysbiosis of gut microbiota and low-grade inflammation are important pathogenic determinants of type two diabetes mellitus (T2DM). The aim of this study is to inve...
link.springer.com
February 14, 2025 at 6:19 PM
“With LGG supplementation, mucin 2 and 3A (MUC2 and MUC3A) gene expressions increased more than ninefolds (p = 0.046 and p = 0.008, respectively) at post-treatment”
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Coconut water modulated the gut microbiome and was more effective than a placebo in the induction of clinical remission in patients with mild-moderate UC
gut.bmj.com/content/72/S...
gut.bmj.com/content/72/S...
IDDF2023-ABS-0162 Potassium-rich diet (coconut water) modulates gut microbiome and induces clinical remission in patients with mild to moderate ulcerative colitis: double blind randomized placebo-cont...
Background High potassium intake has been associated with decreased risk of inflammatory bowel disease (IBD), and urinary potassium levels have been correlated with disease activity in ulcerative coli...
gut.bmj.com
January 25, 2025 at 10:49 AM
Coconut water modulated the gut microbiome and was more effective than a placebo in the induction of clinical remission in patients with mild-moderate UC
gut.bmj.com/content/72/S...
gut.bmj.com/content/72/S...
2 weeks of B. infantis 35624 (Align) supplementation significantly increases methane, but not hydrogen, excretion after lactulose administration
pubmed.ncbi.nlm.nih.gov/29397491/
pubmed.ncbi.nlm.nih.gov/29397491/
Effect of Bifidobacterium infantis 35624 (Align) on the Lactulose Breath Test for Small Intestinal Bacterial Overgrowth - PubMed
This study found that 2 weeks of B. infantis 35624 (Align) supplementation affects LBT assessment for SIBO by significantly increasing methane, but not hydrogen, excretion after lactulose administrati...
pubmed.ncbi.nlm.nih.gov
January 6, 2025 at 8:58 PM
2 weeks of B. infantis 35624 (Align) supplementation significantly increases methane, but not hydrogen, excretion after lactulose administration
pubmed.ncbi.nlm.nih.gov/29397491/
pubmed.ncbi.nlm.nih.gov/29397491/
Intestinal inflammation severity negatively correlates with the amount of xanthurenic and kynurenic acids, which decreases colitis severity through effects on intestinal epithelial cells and T cells
gut.bmj.com/content/72/7...
gut.bmj.com/content/72/7...
Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases
Objective The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism end-produ...
gut.bmj.com
December 28, 2024 at 12:53 PM
Intestinal inflammation severity negatively correlates with the amount of xanthurenic and kynurenic acids, which decreases colitis severity through effects on intestinal epithelial cells and T cells
gut.bmj.com/content/72/7...
gut.bmj.com/content/72/7...
When fiber-fermenting microbes are present in an uninflamed gut, fermentation strengthens the intestinal barrier and reduces the inflammatory response. When the gut environment is inflammatory, β-fructans stimulate inflammation
www.gutmicrobiotaforhealth.com/is-dietary-f...
www.gutmicrobiotaforhealth.com/is-dietary-f...
Is dietary fiber beneficial or deleterious for patients with IBD?
Dietary fibers, known to regulate intestinal inflammation and gut barrier functions, have been avoided by patients with inflammatory bowel diseases (IBD) to avoid flare-ups. However, recent findings s...
www.gutmicrobiotaforhealth.com
December 20, 2024 at 4:49 AM
When fiber-fermenting microbes are present in an uninflamed gut, fermentation strengthens the intestinal barrier and reduces the inflammatory response. When the gut environment is inflammatory, β-fructans stimulate inflammation
www.gutmicrobiotaforhealth.com/is-dietary-f...
www.gutmicrobiotaforhealth.com/is-dietary-f...
Biofilms are present in more than 1/2 of all patients with IBS and 1/3 of patients with UC and implicates their involvement in disease pathogenesis and provides a strong basis for new diagnostic and treatment opportunities, as well as disease classification.”
www.gastrojournal.org/article/S001...
www.gastrojournal.org/article/S001...
DEFINE_ME
www.gastrojournal.org
December 11, 2024 at 1:45 PM
Biofilms are present in more than 1/2 of all patients with IBS and 1/3 of patients with UC and implicates their involvement in disease pathogenesis and provides a strong basis for new diagnostic and treatment opportunities, as well as disease classification.”
www.gastrojournal.org/article/S001...
www.gastrojournal.org/article/S001...
Cyberlindnera jadinii and Kluyveromyces lactis, two fungi used in food processes, have potential probiotic effects on gut inflammation
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Cyberlindnera jadinii and Kluyveromyces lactis, two fungi used in food processes, have potential probiotic effects on gut inflammation | mSystems
The food industry has always used many strains of microorganisms including fungi in
their production processes. These strains have been widely characterized for their
biotechnological value, but we st...
journals.asm.org
December 3, 2024 at 11:18 PM
Cyberlindnera jadinii and Kluyveromyces lactis, two fungi used in food processes, have potential probiotic effects on gut inflammation
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Akkermansia muciniphila resulted in stronger anti-commensal IgE coating and innate type-2 immune responses, exacerbating food allergy in fibre-deprived mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice - Nature Microbiology
The gut commensal Akkermansia muciniphila regulates food allergy symptoms in a diet-dependent manner in mice.
www.nature.com
November 23, 2024 at 9:20 PM
Akkermansia muciniphila resulted in stronger anti-commensal IgE coating and innate type-2 immune responses, exacerbating food allergy in fibre-deprived mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sialic acid plays a pivotal role in licensing Citrobacter rodentium’s transition from the intestinal lumen to a mucosal adherent niche
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Sialic acid plays a pivotal role in licensing Citrobacter rodentium’s transition from the intestinal lumen to a mucosal adherent niche | PNAS
Enteric bacterial pathogens pose significant threats to human health; however, the
mechanisms by which they infect the mammalian gut in the face of...
www.pnas.org
November 22, 2024 at 7:20 PM
Sialic acid plays a pivotal role in licensing Citrobacter rodentium’s transition from the intestinal lumen to a mucosal adherent niche
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Indigo Naturalis may not be able to induce complete "microbial remission,' but a combination treatment that includes probiotics containing members of the Firmicutes phylum that were not restored to normal levels may be beneficial for Ulcerative Colitis
www.gastrojournal.org/article/S001...
www.gastrojournal.org/article/S001...
DEFINE_ME
www.gastrojournal.org
November 22, 2024 at 10:58 AM
Indigo Naturalis may not be able to induce complete "microbial remission,' but a combination treatment that includes probiotics containing members of the Firmicutes phylum that were not restored to normal levels may be beneficial for Ulcerative Colitis
www.gastrojournal.org/article/S001...
www.gastrojournal.org/article/S001...
Expression of AHR in the GI tract has been shown to protect the mouse gut from insults such as DSS induced colitis and Citrobacter rodentium infection. Broccoli can be used as a natural source of AHR - consumption improved resistance to DSS colitis in mice
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming
In the face of mechanical, chemical, microbial, and immunologic pressure, intestinal homeostasis is maintained through balanced cellular turnover, pro…
www.sciencedirect.com
November 21, 2024 at 4:21 AM
Expression of AHR in the GI tract has been shown to protect the mouse gut from insults such as DSS induced colitis and Citrobacter rodentium infection. Broccoli can be used as a natural source of AHR - consumption improved resistance to DSS colitis in mice
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
(PFAS) exposure is associated with later occurrence of inflammatory bowel disease
www.cghjournal.org/article/S154...
www.cghjournal.org/article/S154...
DEFINE_ME
www.cghjournal.org
November 19, 2024 at 2:30 AM
(PFAS) exposure is associated with later occurrence of inflammatory bowel disease
www.cghjournal.org/article/S154...
www.cghjournal.org/article/S154...
Reposted
go.bsky.app/JShNP99
Post below to get added to the list if you are an IBD researcher, educator, or advocate!
Post below to get added to the list if you are an IBD researcher, educator, or advocate!
November 16, 2024 at 12:59 PM
go.bsky.app/JShNP99
Post below to get added to the list if you are an IBD researcher, educator, or advocate!
Post below to get added to the list if you are an IBD researcher, educator, or advocate!
Gleeson et al. investigated this interaction in patients with and without IgA nephropathy and in mice to show that Akkermansia muciniphila, a species of mucin-degrading bacteria, contributed to autoimmune kidney disease
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis
Gut microbiota dysbiosis in IgA nephropathy increases mucin-degrading bacteria, resulting in auto-antigen generation.
www.science.org
November 17, 2024 at 7:35 PM
Gleeson et al. investigated this interaction in patients with and without IgA nephropathy and in mice to show that Akkermansia muciniphila, a species of mucin-degrading bacteria, contributed to autoimmune kidney disease
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Lower ultra-short-term HRV correlates with worse mucosal healing in ulcerative colitis.
bmcgastroenterol.biomedcentral.com/articles/10....
bmcgastroenterol.biomedcentral.com/articles/10....
Lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis - BMC Gastroenterology
Background Psychological stress has been proved to be a risk factor for exacerbation for ulcerative colitis (UC). However, traditional approaches of quantifying psychological stress using psychologica...
bmcgastroenterol.biomedcentral.com
November 17, 2024 at 2:59 PM
Lower ultra-short-term HRV correlates with worse mucosal healing in ulcerative colitis.
bmcgastroenterol.biomedcentral.com/articles/10....
bmcgastroenterol.biomedcentral.com/articles/10....
Betaine Ameliorates Acute Severe Ulcerative Colitis (ASUC) by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis
onlinelibrary.wiley.com/doi/abs/10.1...
onlinelibrary.wiley.com/doi/abs/10.1...
Betaine Ameliorates Acute Sever Ulcerative Colitis by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis
Betaine as a methyl donor in dietary nutrient is abundant in sugar beets, which can be a potential therapeutic compound to repair damaged colonic barrier for the treatment of ASUC by its antioxidant ....
onlinelibrary.wiley.com
November 14, 2024 at 3:23 AM
Betaine Ameliorates Acute Severe Ulcerative Colitis (ASUC) by Inhibiting Oxidative Stress Induced Inflammatory Pyroptosis
onlinelibrary.wiley.com/doi/abs/10.1...
onlinelibrary.wiley.com/doi/abs/10.1...
Although fibers are typically beneficial in individuals with normal microbial fermentative potential, some dietary fibers (FOS and Inulin) have detrimental effects in select patients with active IBD who lack fermentative microbe activities
www.gastrojournal.org/article/S001...
www.gastrojournal.org/article/S001...
DEFINE_ME
www.gastrojournal.org
November 14, 2024 at 3:22 AM
Although fibers are typically beneficial in individuals with normal microbial fermentative potential, some dietary fibers (FOS and Inulin) have detrimental effects in select patients with active IBD who lack fermentative microbe activities
www.gastrojournal.org/article/S001...
www.gastrojournal.org/article/S001...
Propyzamide, sold by Corteva, amplifies intestinal inflammation through the AHR–NF-κB–C/EBPβ signaling, highlighting its role as an environmental factor in Inflammatory Bowel Disease:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Identification of environmental factors that promote intestinal inflammation - Nature
The herbicide propyzamide increases inflammation in the small and large intestine, and the AHR–NF-κB–C/EBPβ signalling axis—which operates in T cells and dendritic cells to promote intestinal inflamma...
www.nature.com
November 14, 2024 at 3:21 AM
Propyzamide, sold by Corteva, amplifies intestinal inflammation through the AHR–NF-κB–C/EBPβ signaling, highlighting its role as an environmental factor in Inflammatory Bowel Disease:
www.nature.com/articles/s41...
www.nature.com/articles/s41...