Kellianne
@kelliannealexa1.bsky.social
Postdoctoral Researcher working in the Young-Pearse lab @ Brigham and Women’s Hospital & Harvard Medical School. Neuroscientist and stem cell biologist studying the blood brain barrier in Alzheimer’s Disease.
Reposted by Kellianne
Congratulations to Dr. Zach Augur, who successfully defended his PhD thesis on Friday!! Zach had an amazing defense which highlighted his incredible productivity in the lab, culminating in 3 first-author publications throughout his thesis work!
October 18, 2025 at 3:18 PM
Congratulations to Dr. Zach Augur, who successfully defended his PhD thesis on Friday!! Zach had an amazing defense which highlighted his incredible productivity in the lab, culminating in 3 first-author publications throughout his thesis work!
Reposted by Kellianne
Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!!
link.springer.com/epdf/10.1007...
link.springer.com/epdf/10.1007...
Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis
link.springer.com
October 15, 2025 at 2:08 PM
Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!!
link.springer.com/epdf/10.1007...
link.springer.com/epdf/10.1007...
Reposted by Kellianne
New TYP lab publication from co-authors
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons - Acta Neuropathologica Communications
Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral scleros...
link.springer.com
September 8, 2025 at 2:13 PM
New TYP lab publication from co-authors
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Reposted by Kellianne
Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
July 10, 2025 at 9:48 PM
Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
Reposted by Kellianne
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures
Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes,
and neurons to investigate intercellular communication across different environmental
and genetic contexts. Transcr...
www.cell.com
June 5, 2025 at 12:49 AM
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Reposted by Kellianne
Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
GBM-Masterpreis - Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V.
gbm-online.de
May 30, 2025 at 11:06 AM
Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
Reposted by Kellianne
We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!
June 4, 2025 at 2:09 AM
We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!
Excited to be back @umasschan.bsky.social for the Boston interactive glial group meeting! So many great talks!
Some TYP members attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student @gizemterzioglu.bsky.social & postdoc @kelliannealexa1.bsky.social gave amazing short talks, Master's student Emma & postdoc @heuerwego.bsky.social got great poster traffic!
May 14, 2025 at 10:08 PM
Excited to be back @umasschan.bsky.social for the Boston interactive glial group meeting! So many great talks!
Reposted by Kellianne
New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response
to accumulated neuropathology, thereby dampening inflammatory signaling between microglia
and astrocytes. Using s...
www.cell.com
April 30, 2025 at 3:56 PM
New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
Reposted by Kellianne
Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!
April 11, 2025 at 11:50 PM
Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!
Truly grateful for the opportunity to share my work at the CSHL Brain Barriers meeting! It’s been amazing to hear about all the exciting and innovative research happening across the community 🧠🚪🩸 #cshlbbb
Congratulations to TYP lab postdoc @kelliannealexa1.bsky.social on an amazing talk at the Cold Spring Harbor Barriers meeting!! Keep a lookout for all the cool work Kellie is doing with iPSC models of the BBB!
April 10, 2025 at 7:19 PM
Truly grateful for the opportunity to share my work at the CSHL Brain Barriers meeting! It’s been amazing to hear about all the exciting and innovative research happening across the community 🧠🚪🩸 #cshlbbb
Reposted by Kellianne
Congratulations to TYP lab Postdoctoral Research Fellow @heuerwego.bsky.social on being awarded a @brightfocus.bsky.social Alzheimer's Disease Research Fellowship! Sarah is using iPSCs to determine the cellular impacts of ABCA7 mutations in Alzheimer's disease!
April 10, 2025 at 12:15 PM
Congratulations to TYP lab Postdoctoral Research Fellow @heuerwego.bsky.social on being awarded a @brightfocus.bsky.social Alzheimer's Disease Research Fellowship! Sarah is using iPSCs to determine the cellular impacts of ABCA7 mutations in Alzheimer's disease!
Reposted by Kellianne
Proud of our amazing postdoc @kelliannealexa1.bsky.social who gave a fantastic talk today on her work with neuronal hyperexcitability and modeling blood-brain-barrier dysfunction in Alzheimer's disease today as part of the BWH Neuroscience Seminar Series!
March 6, 2025 at 12:41 AM
Proud of our amazing postdoc @kelliannealexa1.bsky.social who gave a fantastic talk today on her work with neuronal hyperexcitability and modeling blood-brain-barrier dysfunction in Alzheimer's disease today as part of the BWH Neuroscience Seminar Series!
Congrats @alexlish.bsky.social! You should be super proud of the work you’ve accomplished! Can’t wait to see what you do next!
Congratulations to the newly minted PhD @alexlish.bsky.social on successfully defending her thesis today! Be on the lookout for all the amazing things to come from Dr. Lish!
February 28, 2025 at 10:20 PM
Congrats @alexlish.bsky.social! You should be super proud of the work you’ve accomplished! Can’t wait to see what you do next!
Congrats @zacharyrmurphy.bsky.social!!!
Congratulations to PhD student @zacharyrmurphy.bsky.social for passing his preliminary exams and officially becoming a PhD candidate through the Harvard BBS program! Zack is excited to get started on his project using stem cell models to investigate sex differences in AD!
February 21, 2025 at 2:48 AM
Congrats @zacharyrmurphy.bsky.social!!!
Reposted by Kellianne
New TYP lab publication out today in Glia, led by talented previous PhD student Hyo Lee! Our first big analysis of induced Astrocytes from 44 individuals in the ROSMAP cohort.
You can find it here: onlinelibrary.wiley.com/doi/10.1002/...
You can find it here: onlinelibrary.wiley.com/doi/10.1002/...
Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease
Generation and characterization of induced pluripotent stem cell (iPSC)-derived astrocytes from 44 aged humans reveals congruence of gene expression profiles between astrocyte cultures and brain and ...
onlinelibrary.wiley.com
February 4, 2025 at 2:27 PM
New TYP lab publication out today in Glia, led by talented previous PhD student Hyo Lee! Our first big analysis of induced Astrocytes from 44 individuals in the ROSMAP cohort.
You can find it here: onlinelibrary.wiley.com/doi/10.1002/...
You can find it here: onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Kellianne
Happy #FluorescenceFriday and inaugural bluesky post- some beautiful microglia-neuron-astrocyte co-cultures from TYP lab postdoc @heuerwego.bsky.social!
January 10, 2025 at 4:07 PM
Happy #FluorescenceFriday and inaugural bluesky post- some beautiful microglia-neuron-astrocyte co-cultures from TYP lab postdoc @heuerwego.bsky.social!
The elf has arrived at the TYP lab in style—complete with a sleigh and hippo-reindeer! 🎅🛷 #ElfInTheLab #LabLife #ElvesBehavingBadly
December 13, 2024 at 2:33 PM
The elf has arrived at the TYP lab in style—complete with a sleigh and hippo-reindeer! 🎅🛷 #ElfInTheLab #LabLife #ElvesBehavingBadly
Reposted by Kellianne
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
Reposted by Kellianne
Now that half of SciTwitter is here…
Come be my colleague!
The Dept of Cell Biology @EmoryUniversity is recruiting a developmental cell biologist.
🔬Do you study mechanisms of development using cell biological (and other) approaches? Join us!🔬
TY for RT!
jobs.sciencecareers.org/job/664684/t...
Come be my colleague!
The Dept of Cell Biology @EmoryUniversity is recruiting a developmental cell biologist.
🔬Do you study mechanisms of development using cell biological (and other) approaches? Join us!🔬
TY for RT!
jobs.sciencecareers.org/job/664684/t...
Tenure-track Faculty position in Cell and Developmental Biology - Atlanta, Georgia job with Emory University | 664684
This search is open to investigators conducting mechanistic studies of developmental cell biology using genetically tractable model organisms.
jobs.sciencecareers.org
November 12, 2024 at 6:37 PM
Now that half of SciTwitter is here…
Come be my colleague!
The Dept of Cell Biology @EmoryUniversity is recruiting a developmental cell biologist.
🔬Do you study mechanisms of development using cell biological (and other) approaches? Join us!🔬
TY for RT!
jobs.sciencecareers.org/job/664684/t...
Come be my colleague!
The Dept of Cell Biology @EmoryUniversity is recruiting a developmental cell biologist.
🔬Do you study mechanisms of development using cell biological (and other) approaches? Join us!🔬
TY for RT!
jobs.sciencecareers.org/job/664684/t...
Reposted by Kellianne
📔 New review in Neuropharmacology, "Strategies to dissect microglia-synaptic interactions during aging and in #Alzheimer's disease" by Sarah Heuer, Erik Bloss & Gareth Howell:
🧪🤝🖥️ 🧬 ⑂ #jaxresearch #ScientificResearchPublishing
#alzsky #Neuroscience
doi.org/10.1016/j.ne...
🧪🤝🖥️ 🧬 ⑂ #jaxresearch #ScientificResearchPublishing
#alzsky #Neuroscience
doi.org/10.1016/j.ne...
May 30, 2024 at 12:53 PM
📔 New review in Neuropharmacology, "Strategies to dissect microglia-synaptic interactions during aging and in #Alzheimer's disease" by Sarah Heuer, Erik Bloss & Gareth Howell:
🧪🤝🖥️ 🧬 ⑂ #jaxresearch #ScientificResearchPublishing
#alzsky #Neuroscience
doi.org/10.1016/j.ne...
🧪🤝🖥️ 🧬 ⑂ #jaxresearch #ScientificResearchPublishing
#alzsky #Neuroscience
doi.org/10.1016/j.ne...
Reposted by Kellianne
What happens in our brains to bring about such decline and why does it vary so much between individuals? JAX's Erik Bloss, Gareth Howell & Sarah Heuer examined the effects of aging in mouse neurons & synapses, with findings in a new Aging Cell paper #Neuroscience 🧪🤝🖥️ 🧬:
www.jax.org/news-and-ins...
www.jax.org/news-and-ins...
Sharp as a tack or vague and forgetful?
Erik Bloss, Gareth Howell and predoctoral associate Sarah Heuer are examining the effects of aging in mouse neurons and synapses.
www.jax.org
January 10, 2024 at 8:10 PM
What happens in our brains to bring about such decline and why does it vary so much between individuals? JAX's Erik Bloss, Gareth Howell & Sarah Heuer examined the effects of aging in mouse neurons & synapses, with findings in a new Aging Cell paper #Neuroscience 🧪🤝🖥️ 🧬:
www.jax.org/news-and-ins...
www.jax.org/news-and-ins...
Reposted by Kellianne
PhD student: "please don't be excited yet, these are just preliminary results, I still need to repeat the experiment multiple times"
PI:
PI:
November 13, 2024 at 8:28 PM
PhD student: "please don't be excited yet, these are just preliminary results, I still need to repeat the experiment multiple times"
PI:
PI:
Fluorescence Friday! Ipsc derived endothelial cells (green/ red- tight junction proteins, blue-nucleus) #Bloodbrainbarrier #ipsc #stem #neuroscience
November 15, 2024 at 10:32 PM
Fluorescence Friday! Ipsc derived endothelial cells (green/ red- tight junction proteins, blue-nucleus) #Bloodbrainbarrier #ipsc #stem #neuroscience