WORMoholic
@karoatarlab.com
We are all about immunology, host-helminth interactions and tissue regeneration. karoatarlab.com
Reposted by WORMoholic
Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...
September 25, 2025 at 7:28 AM
Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...
Reposted by WORMoholic
Just published in @AllergyEaaci
Led by @dsilvaanish66 in collaboration with @RothenbergLab @ChenVarol @AstraZeneca. We reveal a non-redundant and key role for TSLP in eosinophilic esophagitis (EoE)- a chronic allergic disease of the esophagus.
onlinelibrary.wiley.com/doi/10.1111/...
🧵👇
1/8
Led by @dsilvaanish66 in collaboration with @RothenbergLab @ChenVarol @AstraZeneca. We reveal a non-redundant and key role for TSLP in eosinophilic esophagitis (EoE)- a chronic allergic disease of the esophagus.
onlinelibrary.wiley.com/doi/10.1111/...
🧵👇
1/8
onlinelibrary.wiley.com
July 29, 2025 at 12:36 PM
Just published in @AllergyEaaci
Led by @dsilvaanish66 in collaboration with @RothenbergLab @ChenVarol @AstraZeneca. We reveal a non-redundant and key role for TSLP in eosinophilic esophagitis (EoE)- a chronic allergic disease of the esophagus.
onlinelibrary.wiley.com/doi/10.1111/...
🧵👇
1/8
Led by @dsilvaanish66 in collaboration with @RothenbergLab @ChenVarol @AstraZeneca. We reveal a non-redundant and key role for TSLP in eosinophilic esophagitis (EoE)- a chronic allergic disease of the esophagus.
onlinelibrary.wiley.com/doi/10.1111/...
🧵👇
1/8
Reposted by WORMoholic
Great to be a (small) part of this beautiful new study on global diversity of soil transmitted #helminths from @stephenrdoyle.bsky.social and colleagues 🧪 www.nature.com/articles/s41...
Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets - Nature Communications
This study analysed genetic data of soil-transmitted helminths from 27 countries, revealing diversity impacting molecular test accuracy and highlighting the need to adapt diagnostics for effective STH...
www.nature.com
July 11, 2025 at 10:48 AM
Great to be a (small) part of this beautiful new study on global diversity of soil transmitted #helminths from @stephenrdoyle.bsky.social and colleagues 🧪 www.nature.com/articles/s41...
Reposted by WORMoholic
🚨 New McSorley lab paper just out in Cell Reports!
Very happy to see this published - it has been a lot of work, and its turned into a really nice story.
In it, we show that HpARI+HpBARI can be used as vaccines
Tutorial thread below (1/16):
www.sciencedirect.com/science/arti...
Very happy to see this published - it has been a lot of work, and its turned into a really nice story.
In it, we show that HpARI+HpBARI can be used as vaccines
Tutorial thread below (1/16):
www.sciencedirect.com/science/arti...
Vaccination against helminth IL-33 modulators permits immune-mediated parasite ejection
The murine intestinal nematode Heligmosomoides polygyrus bakeri (Hpb) modulates the host immune response via the Hpb alarmin release inhibitor (HpARI)…
www.sciencedirect.com
May 22, 2025 at 10:42 AM
🚨 New McSorley lab paper just out in Cell Reports!
Very happy to see this published - it has been a lot of work, and its turned into a really nice story.
In it, we show that HpARI+HpBARI can be used as vaccines
Tutorial thread below (1/16):
www.sciencedirect.com/science/arti...
Very happy to see this published - it has been a lot of work, and its turned into a really nice story.
In it, we show that HpARI+HpBARI can be used as vaccines
Tutorial thread below (1/16):
www.sciencedirect.com/science/arti...
Reposted by WORMoholic
Take a look at our latest work from @ikinglab.bsky.social identifying an immune-stromal cell axis that mediates disease tolerance against intestinal infection. It's been a pleasure working with a truly collaborative team to make this project a reality.
authors.elsevier.com/c/1kznjL7PXu...
authors.elsevier.com/c/1kznjL7PXu...
authors.elsevier.com
April 22, 2025 at 5:06 PM
Take a look at our latest work from @ikinglab.bsky.social identifying an immune-stromal cell axis that mediates disease tolerance against intestinal infection. It's been a pleasure working with a truly collaborative team to make this project a reality.
authors.elsevier.com/c/1kznjL7PXu...
authors.elsevier.com/c/1kznjL7PXu...
Reposted by WORMoholic
I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection
Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…
www.sciencedirect.com
April 22, 2025 at 4:35 PM
I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A protective role for IFN-gamma during helminth infections—gotta love it!
Congrats @ikinglab.bsky.social and @susanwestfall.bsky.social
Really beautiful work, thank you for letting me be a small part of it #Medsky #immunosky 🪱
authors.elsevier.com/c/1kznjL7PXu...
Congrats @ikinglab.bsky.social and @susanwestfall.bsky.social
Really beautiful work, thank you for letting me be a small part of it #Medsky #immunosky 🪱
authors.elsevier.com/c/1kznjL7PXu...
April 22, 2025 at 3:58 PM
A protective role for IFN-gamma during helminth infections—gotta love it!
Congrats @ikinglab.bsky.social and @susanwestfall.bsky.social
Really beautiful work, thank you for letting me be a small part of it #Medsky #immunosky 🪱
authors.elsevier.com/c/1kznjL7PXu...
Congrats @ikinglab.bsky.social and @susanwestfall.bsky.social
Really beautiful work, thank you for letting me be a small part of it #Medsky #immunosky 🪱
authors.elsevier.com/c/1kznjL7PXu...
Reposted by WORMoholic
🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share
a purple octopus with big eyes is crawling on the ground in the ocean .
ALT: a purple octopus with big eyes is crawling on the ground in the ocean .
media.tenor.com
April 21, 2025 at 6:11 PM
🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share
Reposted by WORMoholic
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Immunity
www.cell.com/immunity/ful...
Immunity
www.cell.com/immunity/ful...
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut
microbial and immune environment, disrupting tissue homeostasis. IL-22 production
by group 3 innate lymphoid cells (I...
www.cell.com
April 16, 2025 at 6:51 PM
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Immunity
www.cell.com/immunity/ful...
Immunity
www.cell.com/immunity/ful...
Reposted by WORMoholic
The microbiota regulates intestinal goblet cell response and mucin production during enteric parasitic infection via the TLR2-SPDEF axis
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
April 16, 2025 at 8:59 PM
The microbiota regulates intestinal goblet cell response and mucin production during enteric parasitic infection via the TLR2-SPDEF axis
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
So cool
'Here, we developed a probe that can fluorogenically label mouse gut microbiota in situ after gavage, and the use of two-photon microscopy enabled us to directly visualize the bacteria translocated into blood vessels and liver in real-time.'
#Immunology #Immunosky
www.pnas.org/doi/10.1073/...
#Immunology #Immunosky
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
March 31, 2025 at 5:12 AM
So cool
We have a new baby! We are going to have some beautiful images soon 🪱🔬🧪
March 18, 2025 at 10:04 AM
We have a new baby! We are going to have some beautiful images soon 🪱🔬🧪
Reposted by WORMoholic
Preprint 📢📢
Epithelial cell-derived cytokines such as TSLP snd IL-33 likely have key roles in the initiation of allergic diseases. We show that despite co-upregulation/expression of IL-33 and TSLP in EoE, TSLP has a dominant role.
www.biorxiv.org/content/10.1...
Epithelial cell-derived cytokines such as TSLP snd IL-33 likely have key roles in the initiation of allergic diseases. We show that despite co-upregulation/expression of IL-33 and TSLP in EoE, TSLP has a dominant role.
www.biorxiv.org/content/10.1...
Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitis
Rationale: Thymic stromal lymphopoietin (TSLP) and IL-33 are alarmins implicated in EoE pathogenesis by activating multiple cells including mast cells (MCs). Whether TSLP or IL-33 have a role in EoE a...
www.biorxiv.org
March 3, 2025 at 1:24 AM
Preprint 📢📢
Epithelial cell-derived cytokines such as TSLP snd IL-33 likely have key roles in the initiation of allergic diseases. We show that despite co-upregulation/expression of IL-33 and TSLP in EoE, TSLP has a dominant role.
www.biorxiv.org/content/10.1...
Epithelial cell-derived cytokines such as TSLP snd IL-33 likely have key roles in the initiation of allergic diseases. We show that despite co-upregulation/expression of IL-33 and TSLP in EoE, TSLP has a dominant role.
www.biorxiv.org/content/10.1...
Help a new PI!
Started working on my first Intro to Immunology course lectures. Any suggestions on the best story/ historic perspective to make my students LOVE immunology above all? Jenner and Pasteur are the obvious fathers but maybe someone found another intriguing option? #Immunosky 🧪
Started working on my first Intro to Immunology course lectures. Any suggestions on the best story/ historic perspective to make my students LOVE immunology above all? Jenner and Pasteur are the obvious fathers but maybe someone found another intriguing option? #Immunosky 🧪
February 16, 2025 at 1:05 PM
Help a new PI!
Started working on my first Intro to Immunology course lectures. Any suggestions on the best story/ historic perspective to make my students LOVE immunology above all? Jenner and Pasteur are the obvious fathers but maybe someone found another intriguing option? #Immunosky 🧪
Started working on my first Intro to Immunology course lectures. Any suggestions on the best story/ historic perspective to make my students LOVE immunology above all? Jenner and Pasteur are the obvious fathers but maybe someone found another intriguing option? #Immunosky 🧪
Reposted by WORMoholic
Hello, Bluesky! ☀️
We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.
Follow us for updates on ERC funding, research policy, and our grantees' discoveries.
We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.
Follow us for updates on ERC funding, research policy, and our grantees' discoveries.
February 7, 2025 at 8:16 AM
Hello, Bluesky! ☀️
We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.
Follow us for updates on ERC funding, research policy, and our grantees' discoveries.
We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.
Follow us for updates on ERC funding, research policy, and our grantees' discoveries.
Reposted by WORMoholic
#Immunology by First release now @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
December 19, 2024 at 8:08 PM
#Immunology by First release now @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
🤯
Advances in microscopy mean we can now do more than just observe biology—we can control it. But how far can we really push this in mammalian cells with all their (beautiful but annoying) heterogeneity? 🧪🔬(🧵)
December 17, 2024 at 8:56 PM
🤯
Interesting!
How does the immune system make "decisions" at mucosal barriers? My new perspective explores how seeing strategic cell interactions through the lens of game theory could reveal fresh insights into mucosal immune homeostasis and disease. 🧵 1/7
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Organismal mucosal immunology: A perspective through the eyes of game theory
In complex organisms, functional units must interact cohesively to maintain homeostasis, especially within mucosal barriers that house diverse, specia…
www.sciencedirect.com
December 15, 2024 at 6:20 PM
Interesting!
Open minds and close friends is always important, science is no exception 🧪
The good idea comes when one person feels comfortable enough to say something that might make them look stupid and their friend is open enough to recognize its potential.
December 8, 2024 at 5:44 AM
Open minds and close friends is always important, science is no exception 🧪
Reposted by WORMoholic
We know everything about IL-33 already, right?
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
December 1, 2024 at 11:12 PM
We know everything about IL-33 already, right?
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
When a fungal commensal ruins over a year of your postdoc at least you get a chance to be part of a very cool paper. Was great to be included in this interesting story 🧪 🪱🍄🟫
Check out this landmark paper, hot off the press from Iliyan Iliev’s group (not on Bluesky, yet). www.nature.com/articles/s41... Very grateful to be a part of it!
Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature
Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.
www.nature.com
November 28, 2024 at 4:46 AM
When a fungal commensal ruins over a year of your postdoc at least you get a chance to be part of a very cool paper. Was great to be included in this interesting story 🧪 🪱🍄🟫
Reposted by WORMoholic
#MedSky🧪 #ImmunoSky #IDsky #academicsky #publichealth An excellent #Clinicalperspectives of The “danger theory of immunity” ,Immunogenetics of danger signals & Nuancing the danger theory of immunity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 27, 2024 at 5:09 PM
#MedSky🧪 #ImmunoSky #IDsky #academicsky #publichealth An excellent #Clinicalperspectives of The “danger theory of immunity” ,Immunogenetics of danger signals & Nuancing the danger theory of immunity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Beautiful
🎵"It's just another #Mucus Monday". This week, we look inside to see how the magic happens. TEM image of a goblet cell producing mucus. The nucleus on top, below that the ER and below it the Golgi producing mucus-filled granules. #immunosky 🧪 🧫 🔬 🦠
November 25, 2024 at 5:33 PM
Beautiful
Reposted by WORMoholic
Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out!
@vivianlilab.bsky.social @kingscollegelondon.bsky.social
www.cell.com/cell-reports...
@vivianlilab.bsky.social @kingscollegelondon.bsky.social
www.cell.com/cell-reports...
IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells
The crosstalk between immune and epithelial cells is vital to maintain intestinal
homeostasis. Lebrusant-Fernandez et al. identify NKT cells in the small intestine
as key regulators of epithelial biol...
www.cell.com
November 24, 2024 at 11:00 AM
Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out!
@vivianlilab.bsky.social @kingscollegelondon.bsky.social
www.cell.com/cell-reports...
@vivianlilab.bsky.social @kingscollegelondon.bsky.social
www.cell.com/cell-reports...
Reposted by WORMoholic
My lab in Aberdeen, in the stunning North East of Scotland, will soon be recruiting for a post-doc to studying immune-ECM interactions in the lung. If you love IL-13, Hyaluronan, ECM biology, pulmonary immune responses....Get in touch and keep an eye out for the position.
November 13, 2024 at 8:30 AM
My lab in Aberdeen, in the stunning North East of Scotland, will soon be recruiting for a post-doc to studying immune-ECM interactions in the lung. If you love IL-13, Hyaluronan, ECM biology, pulmonary immune responses....Get in touch and keep an eye out for the position.