Masaru Kanekiyo
@kanekiyom.bsky.social
All views/posts are my own; vaccines for life; proteins are beautiful; vaccine design; viral immunity; host-vaccine interface; vaccine immunologist; cat dad
ORCiD: 0000-0001-5767-1532
ORCiD: 0000-0001-5767-1532
Just out📢 Our new paper published in @natmicrobiol.nature.com describes highly potent cross-neutralizing human monoclonal antibodies against H5Nx influenza viruses. Close collaboration with Sara Andrews lab and Tongqing Zhou lab at the VRC. Link to the article: rdcu.be/eKV9T 1/2
October 14, 2025 at 3:10 PM
Just out📢 Our new paper published in @natmicrobiol.nature.com describes highly potent cross-neutralizing human monoclonal antibodies against H5Nx influenza viruses. Close collaboration with Sara Andrews lab and Tongqing Zhou lab at the VRC. Link to the article: rdcu.be/eKV9T 1/2
Reposted by Masaru Kanekiyo
Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques https://www.biorxiv.org/content/10.1101/2025.02.21.639368v1
February 27, 2025 at 4:16 PM
Functional, Immunogenetic, and Structural Convergence in Influenza Immunity between Humans and Macaques https://www.biorxiv.org/content/10.1101/2025.02.21.639368v1
Reposted by Masaru Kanekiyo
Also last week in @science.org : @kanekiyom.bsky.social, Douglas Reed, Simon Barratt-Boyes, & colleagues show pre-exposure broadly neutralizing #antibody ( #bnAb ) #prophylaxis against a conserved supersite on #influenza #hemagglutinin (HA) stem protects #macaques against #H5N1 infection! #BirdFlu
Pre-exposure antibody prophylaxis protects macaques from severe influenza
Influenza virus pandemics and seasonal epidemics have claimed countless lives. Recurrent zoonotic spillovers of influenza viruses with pandemic potential underscore the need for effective countermeasu...
www.science.org
February 6, 2025 at 6:31 PM
Also last week in @science.org : @kanekiyom.bsky.social, Douglas Reed, Simon Barratt-Boyes, & colleagues show pre-exposure broadly neutralizing #antibody ( #bnAb ) #prophylaxis against a conserved supersite on #influenza #hemagglutinin (HA) stem protects #macaques against #H5N1 infection! #BirdFlu
Reposted by Masaru Kanekiyo
Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies https://www.biorxiv.org/content/10.1101/2024.11.27.625426v1
Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies https://www.biorxiv.org/content/10.1101/2024.11.27.625426v1
Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed mill
www.biorxiv.org
December 3, 2024 at 7:15 PM
Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies https://www.biorxiv.org/content/10.1101/2024.11.27.625426v1
📢Hot off the press! Our latest work studying #influenza broadly neutralizing antibody development in humanized mice. Huge thanks to everyone involved in the study🙏 #NIAID #VRC #Ragon #Scripps www.cell.com/cell-reports...
Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem
Ataca et al. describe a pathway to generate cross-reactive B cells against influenza
hemagglutinin by engaging a subdominant immunoglobulin germline-encoded motif through
prime-boost vaccination in IG...
www.cell.com
November 23, 2024 at 5:14 AM
📢Hot off the press! Our latest work studying #influenza broadly neutralizing antibody development in humanized mice. Huge thanks to everyone involved in the study🙏 #NIAID #VRC #Ragon #Scripps www.cell.com/cell-reports...
Hot off the press! Our latest paper on #influenza neuraminidase (NA) antibodies has just been published in Immunity. Lederhofer et al. Isolated and characterized human antibodies to the NA ‘dark side’ that are broadly cross-reactive and protective. www.cell.com/immunity/ful...
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase
Influenza neuraminidase (NA) is underappreciated as a vaccine target owing to its
incomplete epitope landscape. Lederhofer et al. isolated human monoclonal antibodies
to NA underside (i.e., dark side)...
www.cell.com
March 1, 2024 at 4:31 PM
Hot off the press! Our latest paper on #influenza neuraminidase (NA) antibodies has just been published in Immunity. Lederhofer et al. Isolated and characterized human antibodies to the NA ‘dark side’ that are broadly cross-reactive and protective. www.cell.com/immunity/ful...