Kenneth A. Jacobson
@kajacobson.bsky.social
medicinal chemist interested in G protein-coupled receptors
irp.nih.gov/blog/post/20...
Photoswitchable A3 adenosine receptor agonist, from the NIH Intramural Research Program, University of Barcelona and University of Pennsylvania
Photoswitchable A3 adenosine receptor agonist, from the NIH Intramural Research Program, University of Barcelona and University of Pennsylvania
Experimental Psoriasis Drug Comes With An ‘On-Off’ Switch | NIH Intramural Research Program
irp.nih.gov
April 3, 2025 at 8:19 PM
irp.nih.gov/blog/post/20...
Photoswitchable A3 adenosine receptor agonist, from the NIH Intramural Research Program, University of Barcelona and University of Pennsylvania
Photoswitchable A3 adenosine receptor agonist, from the NIH Intramural Research Program, University of Barcelona and University of Pennsylvania
IB-MECA (our prototypical A3 adenosine receptor agonist, in currently in Phase 3 clinical trial for psoriasis) was modified chemically for photopharmacology, to be turned on and off (repeatedly) with different colored light. Protected in a mouse psoriasis model. pubs.acs.org/doi/10.1021/...
Photoswitchable Diazocine Derivative for Adenosine A3 Receptor Activation in Psoriasis
Incorporating photoisomerizable moieties within drugs offers the possibility of rapid and reversible light-dependent switching between active and inactive configurations. Here, we developed a photoswi...
pubs.acs.org
December 17, 2024 at 4:11 PM
IB-MECA (our prototypical A3 adenosine receptor agonist, in currently in Phase 3 clinical trial for psoriasis) was modified chemically for photopharmacology, to be turned on and off (repeatedly) with different colored light. Protected in a mouse psoriasis model. pubs.acs.org/doi/10.1021/...