Judith Agudo
@judithagudo.bsky.social
Immigrant scientist. Mom of 3 boys. First gen. Immunology and stem cells are cool. Fighting cancer and autoimmunity. She/hers.
Anti-racist feminist, LGTBQIA rights. Climate change is too real.
Anti-racist feminist, LGTBQIA rights. Climate change is too real.
Pinned
Judith Agudo
@judithagudo.bsky.social
· Jun 13
CRI Announces 2025 Lloyd J. Old STARs: Five Bold Innovators Driving the Future of Cancer Immunotherapy - Cancer Research Institute
The Cancer Research Institute (CRI) proudly announces the 2025 class of Lloyd J. Old STARs—five rising scientific leaders poised to reshape cancer immunotherapy through daring, paradigm-shifting resea...
www.cancerresearch.org
Honored and excited to receive the CRI Lloyd Old STAR award. I can barely believe it! Thanks to everyone in my lab and all my collaborators at DFCI, HMS and beyond @cancerresearchinst.bsky.social
@dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social
@dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social
Reposted by Judith Agudo
In commentary published in Cancer Cell, @danafarber.bsky.social’s @judithagudo.bsky.social contends that integrating cancer cell phenotypic heterogeneity into spatial analyses is essential to reveal the mechanisms that generate TIME diversity and address resistance to immunotherapy. bit.ly/496Mc0Y.
November 7, 2025 at 3:30 PM
In commentary published in Cancer Cell, @danafarber.bsky.social’s @judithagudo.bsky.social contends that integrating cancer cell phenotypic heterogeneity into spatial analyses is essential to reveal the mechanisms that generate TIME diversity and address resistance to immunotherapy. bit.ly/496Mc0Y.
Reposted by Judith Agudo
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 1:26 PM
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Congrats! Indeed, so beautiful!
Our paper made the cover of Nature Immunology’s September issue! 🎉
Aren’t dendritic cells beautiful? 😍
SEM shows pDCs as they switch identity into cDC2-like cells.
Congrats to the whole team! 👏
🔗 www.nature.com/ni/volumes/2...
Aren’t dendritic cells beautiful? 😍
SEM shows pDCs as they switch identity into cDC2-like cells.
Congrats to the whole team! 👏
🔗 www.nature.com/ni/volumes/2...
September 4, 2025 at 11:05 AM
Congrats! Indeed, so beautiful!
Reposted by Judith Agudo
Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...
Interferons in health and disease
The cytokine messenger proteins known as interferons are central to protective immune
responses against infections, but they are also involved in inflammatory and autoimmune
diseases. This review maps...
www.cell.com
September 3, 2025 at 4:55 PM
Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...
Reposted by Judith Agudo
Bone appetite: bone-derived factors feed distant immune suppression
Bone appetite: bone-derived factors feed distant immune suppression
The site of metastatic disease influences treatment response. A recent study in Cancer Cell by Cheng et al. revealed that bone metastases systemically impair immune function, abrogating immunotherapy response. Bone metastases led to osteopontin (OPN) production, which suppressed immunity in distal lesions. This highlights a novel cross-organ communication hindering antitumor immunity.
dlvr.it
July 19, 2025 at 12:23 PM
Bone appetite: bone-derived factors feed distant immune suppression
www.sciencedirect.com/science/arti...
Stellar postdoc @debolina-ganguly.bsky.social and I wrote this spotlight for a super cool paper on the systemic effects of metatasis. The organ of metastatic diseases makes A BIG difference! Highly recommended paper in @cp-cancercell.bsky.social
Stellar postdoc @debolina-ganguly.bsky.social and I wrote this spotlight for a super cool paper on the systemic effects of metatasis. The organ of metastatic diseases makes A BIG difference! Highly recommended paper in @cp-cancercell.bsky.social
Bone appetite: bone-derived factors feed distant immune suppression
The site of metastatic disease influences treatment response. A recent study in Cancer Cell by Cheng et al. revealed that bone metastases systemically…
www.sciencedirect.com
July 18, 2025 at 1:44 PM
www.sciencedirect.com/science/arti...
Stellar postdoc @debolina-ganguly.bsky.social and I wrote this spotlight for a super cool paper on the systemic effects of metatasis. The organ of metastatic diseases makes A BIG difference! Highly recommended paper in @cp-cancercell.bsky.social
Stellar postdoc @debolina-ganguly.bsky.social and I wrote this spotlight for a super cool paper on the systemic effects of metatasis. The organ of metastatic diseases makes A BIG difference! Highly recommended paper in @cp-cancercell.bsky.social
Reposted by Judith Agudo
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue
stress and the formation of host-derived molecules that further tune immune responses.
We show that host-derived oxidi...
dlvr.it
July 17, 2025 at 3:35 PM
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Reposted by Judith Agudo
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 11, 2025 at 1:03 AM
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Reposted by Judith Agudo
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
July 10, 2025 at 10:27 PM
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social
Reposted by Judith Agudo
PICI Investigator @judithagudo.bsky.social, PhD, was recognized with the 2025 CRI Lloyd J. Old STAR Award, one of immuno-oncology’s highest honors from the Cancer Research Institute (CRI). Congratulations, Dr. Agudo!
www.cancerresearch.org/media-room/2...
www.cancerresearch.org/media-room/2...
June 17, 2025 at 2:46 AM
PICI Investigator @judithagudo.bsky.social, PhD, was recognized with the 2025 CRI Lloyd J. Old STAR Award, one of immuno-oncology’s highest honors from the Cancer Research Institute (CRI). Congratulations, Dr. Agudo!
www.cancerresearch.org/media-room/2...
www.cancerresearch.org/media-room/2...
Thanks to other support that enabled this recognition @parkerici.bsky.social the NYSCF and the department of defense breast cancer program
Honored and excited to receive the CRI Lloyd Old STAR award. I can barely believe it! Thanks to everyone in my lab and all my collaborators at DFCI, HMS and beyond @cancerresearchinst.bsky.social
@dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social
@dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social
CRI Announces 2025 Lloyd J. Old STARs: Five Bold Innovators Driving the Future of Cancer Immunotherapy - Cancer Research Institute
The Cancer Research Institute (CRI) proudly announces the 2025 class of Lloyd J. Old STARs—five rising scientific leaders poised to reshape cancer immunotherapy through daring, paradigm-shifting resea...
www.cancerresearch.org
June 13, 2025 at 5:27 PM
Thanks to other support that enabled this recognition @parkerici.bsky.social the NYSCF and the department of defense breast cancer program
Honored and excited to receive the CRI Lloyd Old STAR award. I can barely believe it! Thanks to everyone in my lab and all my collaborators at DFCI, HMS and beyond @cancerresearchinst.bsky.social
@dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social
@dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social
CRI Announces 2025 Lloyd J. Old STARs: Five Bold Innovators Driving the Future of Cancer Immunotherapy - Cancer Research Institute
The Cancer Research Institute (CRI) proudly announces the 2025 class of Lloyd J. Old STARs—five rising scientific leaders poised to reshape cancer immunotherapy through daring, paradigm-shifting resea...
www.cancerresearch.org
June 13, 2025 at 4:54 PM
Honored and excited to receive the CRI Lloyd Old STAR award. I can barely believe it! Thanks to everyone in my lab and all my collaborators at DFCI, HMS and beyond @cancerresearchinst.bsky.social
@dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social
@dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social
Reposted by Judith Agudo
NIH funding to HMS, including for ImmGen, has been terminated. This threatens tools used by 10,000+ immunologists globally. Please email support for ImmGen’s value to you to Immgen(at)gmail.com, your Senator (US), or US Embassy (abroad). Thanks The ImmGen Team #immgen #supportScience #NIHfunding
Gmail
Gmail is email that’s intuitive, efficient, and useful. 15 GB of storage, less spam, and mobile access.
gmail.com
June 3, 2025 at 8:58 PM
NIH funding to HMS, including for ImmGen, has been terminated. This threatens tools used by 10,000+ immunologists globally. Please email support for ImmGen’s value to you to Immgen(at)gmail.com, your Senator (US), or US Embassy (abroad). Thanks The ImmGen Team #immgen #supportScience #NIHfunding
Thanks @reinacampos.bsky.social for inviting me to @lji.org and UCSD. This has been a super fun visit! it is so amazing and energizing to meet in person!
April 10, 2025 at 2:58 AM
Thanks @reinacampos.bsky.social for inviting me to @lji.org and UCSD. This has been a super fun visit! it is so amazing and energizing to meet in person!
Reposted by Judith Agudo
I look forward to hosting @judithagudo.bsky.social at LJI, please join us! snacks and **Free parking**
Coming up Apr. 9 @ 12 PM - from the LJI & UC San Diego Program in Immunology:
Dr. Judith Agudo of the Dana-Farber Cancer Institute presents research on "Dissecting Immune Evasion: How heterogeneous phenotypes protect targeted cells"
More info: bit.ly/41N1T9B #Immunology @ucsdhealthsci.bsky.social
Dr. Judith Agudo of the Dana-Farber Cancer Institute presents research on "Dissecting Immune Evasion: How heterogeneous phenotypes protect targeted cells"
More info: bit.ly/41N1T9B #Immunology @ucsdhealthsci.bsky.social
March 26, 2025 at 8:48 PM
I look forward to hosting @judithagudo.bsky.social at LJI, please join us! snacks and **Free parking**
Going through Green Card application now with current climate, just to add to the uncertainty on funding in research. I need some positive thoughts!
March 16, 2025 at 1:57 PM
Going through Green Card application now with current climate, just to add to the uncertainty on funding in research. I need some positive thoughts!
Reposted by Judith Agudo
We report today that the structurally complex PAMP LPS can be broken down to a simple pattern that is detected by the innate immune receptor caspase-11. This pattern is a lipid containing a negative charged headgroup + acyl chain ≥14 carbons.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules
A bacterial sensory protein detects self- and nonself-lipids by similar mechanisms.
www.science.org
March 8, 2025 at 2:39 PM
We report today that the structurally complex PAMP LPS can be broken down to a simple pattern that is detected by the innate immune receptor caspase-11. This pattern is a lipid containing a negative charged headgroup + acyl chain ≥14 carbons.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Judith Agudo
Thrilled for Johan Garaude’s @inserm.fr new work in Nature! I’m proud to see this Blander lab alumnus shine. His group shows bacterial cAMP accumulation signals death, fueling macrophage recycling—a fresh live-vs-dead immune twist. Stellar work with huge impact! www.nature.com/articles/s41...
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
www.nature.com
March 7, 2025 at 10:34 PM
Thrilled for Johan Garaude’s @inserm.fr new work in Nature! I’m proud to see this Blander lab alumnus shine. His group shows bacterial cAMP accumulation signals death, fueling macrophage recycling—a fresh live-vs-dead immune twist. Stellar work with huge impact! www.nature.com/articles/s41...
Reposted by Judith Agudo
So excited to see how quickly #StandUpForScience has grown from a single rally to rallies in 32 cities in 27 states and counting! Let's go! Thank you for your leadership @standupforscience.bsky.social!
They also opened up a donation page 🧪
standupforscience2025.org/local-event-...
They also opened up a donation page 🧪
standupforscience2025.org/local-event-...
Local Event Information
Below are the state capitals and major cities (alphabetized by state) hosting official Stand Up for Science events. If your city is listed, a confirmed site leader—backed by our core team—is active…
standupforscience2025.org
February 26, 2025 at 2:53 PM
So excited to see how quickly #StandUpForScience has grown from a single rally to rallies in 32 cities in 27 states and counting! Let's go! Thank you for your leadership @standupforscience.bsky.social!
They also opened up a donation page 🧪
standupforscience2025.org/local-event-...
They also opened up a donation page 🧪
standupforscience2025.org/local-event-...
When efforts on DEIB are at risk, all help is great. Plus, I love the bame of these awards. Sharing for those that may benefit, applying for a job requires preparation💪🏿💪🏾💪🏽💪🏼💪🏻
🌟 Postdocs on the Job Market! 🌟
JEDI awards celebrate justice, equity, diversity, & inclusion in science & can give you expert feedback on your job application & CV before they're scrutinized by search committees.
Let us help you shine!
Next Deadline: March 10th
lifescienceeditors.org/apply/
JEDI awards celebrate justice, equity, diversity, & inclusion in science & can give you expert feedback on your job application & CV before they're scrutinized by search committees.
Let us help you shine!
Next Deadline: March 10th
lifescienceeditors.org/apply/
JEDI Award - Life Science Editors Foundation
Our Justice, Equity, Diversity and Inclusion (JEDI) awards provide Feedback on Your Scientific Writing from one of our expert volunteers. These awards are offered quarterly to scientists facing unfair...
lifescienceeditors.org
February 25, 2025 at 1:06 PM
When efforts on DEIB are at risk, all help is great. Plus, I love the bame of these awards. Sharing for those that may benefit, applying for a job requires preparation💪🏿💪🏾💪🏽💪🏼💪🏻
Reposted by Judith Agudo
"… it is the words and actions of all members of the scientific community … that form the collective voice of science …," writes @holdenthorp.bsky.social in a new #ScienceEditorial. scim.ag/4hR6ux0
February 24, 2025 at 7:08 PM
"… it is the words and actions of all members of the scientific community … that form the collective voice of science …," writes @holdenthorp.bsky.social in a new #ScienceEditorial. scim.ag/4hR6ux0
Reposted by Judith Agudo
2 PhD students recently met at a conference & Trump's slashing of research & science bound them
With only 3 other scientists they started a movement that's growing around the country
On March 7 in Washington DC, and state capitals, "Stand Up for Science" will take place
All details below & bravo!
With only 3 other scientists they started a movement that's growing around the country
On March 7 in Washington DC, and state capitals, "Stand Up for Science" will take place
All details below & bravo!
‘I really wanted something to happen.’ The students behind the Stand Up for Science protests
New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies
www.science.org
February 23, 2025 at 1:29 AM
2 PhD students recently met at a conference & Trump's slashing of research & science bound them
With only 3 other scientists they started a movement that's growing around the country
On March 7 in Washington DC, and state capitals, "Stand Up for Science" will take place
All details below & bravo!
With only 3 other scientists they started a movement that's growing around the country
On March 7 in Washington DC, and state capitals, "Stand Up for Science" will take place
All details below & bravo!
Reposted by Judith Agudo
Funny that the $4B they want to save is the same amount SpaceX got last year in gov't contracts. That even paid the SpaceX CEO $4M! Rockets might be cool and all, but if choosing between rockets and life-saving medicine..You know, maybe the rich guy who wants to play with rockets should pay himself.
'The plan applied to $9 billion of the $35 billion in grants issued to research institutions. That quarter of the total research funding supports so-called indirect costs (...)
The Trump administration said it wanted to cut such funds roughly in half, by about $4 billion.'
The Trump administration said it wanted to cut such funds roughly in half, by about $4 billion.'
Court Halt on Trump Cuts for Medical Research Is Extended Nationwide
The federal order temporarily halts the Trump administration’s plans to slash $4 billion in overhead costs for research at universities and medical centers into diseases like cancer.
www.nytimes.com
February 12, 2025 at 11:51 AM
Funny that the $4B they want to save is the same amount SpaceX got last year in gov't contracts. That even paid the SpaceX CEO $4M! Rockets might be cool and all, but if choosing between rockets and life-saving medicine..You know, maybe the rich guy who wants to play with rockets should pay himself.
Reposted by Judith Agudo
Speak up!!! Please email & call you Congress Reps today to oppose these cuts to NIH-especially if you are a scientist living in a red state. Here’s where to find them: www.congress.gov/members/find...
www.congress.gov
February 15, 2025 at 4:13 PM
Speak up!!! Please email & call you Congress Reps today to oppose these cuts to NIH-especially if you are a scientist living in a red state. Here’s where to find them: www.congress.gov/members/find...