Joel Miesfeld
@joelmiesfeld.bsky.social
Assistant Professor, Ophthalmology and Visual Sciences, Medical College of Wisconsin. Visual systems development, gene regulation, RGCs, dev bio and more. Views are my own.
https://www.mcw.edu/departments/ophthalmology-eye-institute/research/miesfeld-lab
https://www.mcw.edu/departments/ophthalmology-eye-institute/research/miesfeld-lab
Are you or do you know a current undergraduate student who wants to pursue research? Our Summer Program for Undergraduate Research (SPUR) application is now open! (reposting from the MCW Grad school X account)
Apply here: admissions.mcw.edu/register/sum...
Apply here: admissions.mcw.edu/register/sum...
October 29, 2025 at 2:19 PM
Are you or do you know a current undergraduate student who wants to pursue research? Our Summer Program for Undergraduate Research (SPUR) application is now open! (reposting from the MCW Grad school X account)
Apply here: admissions.mcw.edu/register/sum...
Apply here: admissions.mcw.edu/register/sum...
Reposted by Joel Miesfeld
Today’s speaker in our DRN external seminar series is Dr Ryan MacDonald @macdonaldlab.bsky.social (University College London)
Sponsored by the Physiological Society
@physoc.bsky.social
Host: Emily Noël
@noelresearchlab.bsky.social
All welcome!
Sponsored by the Physiological Society
@physoc.bsky.social
Host: Emily Noël
@noelresearchlab.bsky.social
All welcome!
October 29, 2025 at 9:34 AM
Today’s speaker in our DRN external seminar series is Dr Ryan MacDonald @macdonaldlab.bsky.social (University College London)
Sponsored by the Physiological Society
@physoc.bsky.social
Host: Emily Noël
@noelresearchlab.bsky.social
All welcome!
Sponsored by the Physiological Society
@physoc.bsky.social
Host: Emily Noël
@noelresearchlab.bsky.social
All welcome!
Reposted by Joel Miesfeld
You are a postdoc looking for an opportunity to present your latest work and discuss with leaders in the field? Apply to the early career scientists seminar series @ircm.bsky.social ! If selected, we pay for your expenses to come spend a day with us and give a seminar! www.ircm.qc.ca/en/news-deta...
Call for applications: A fifth edition for the Early-Career Scientist Seminar Series
www.ircm.qc.ca
October 22, 2025 at 2:12 PM
You are a postdoc looking for an opportunity to present your latest work and discuss with leaders in the field? Apply to the early career scientists seminar series @ircm.bsky.social ! If selected, we pay for your expenses to come spend a day with us and give a seminar! www.ircm.qc.ca/en/news-deta...
Reposted by Joel Miesfeld
For people with hemophilia A, a simple cut or bump can cause excessive bleeding or bruising.
MCW’s Dr. David A. Wilcox is working with colleagues to develop a new #GeneTherapy that could transform how patients with the disease are treated. #Research
Learn more: www.mcw.edu/mcwknowledge...
MCW’s Dr. David A. Wilcox is working with colleagues to develop a new #GeneTherapy that could transform how patients with the disease are treated. #Research
Learn more: www.mcw.edu/mcwknowledge...
New Gene Therapy for Severe Hemophilia A Developed and Tested at MCW Achieves Promising Results
A decades-long effort and a fruitful collaboration could lead to a better quality of life for patients with this genetic blood disease.
www.mcw.edu
October 21, 2025 at 2:58 PM
For people with hemophilia A, a simple cut or bump can cause excessive bleeding or bruising.
MCW’s Dr. David A. Wilcox is working with colleagues to develop a new #GeneTherapy that could transform how patients with the disease are treated. #Research
Learn more: www.mcw.edu/mcwknowledge...
MCW’s Dr. David A. Wilcox is working with colleagues to develop a new #GeneTherapy that could transform how patients with the disease are treated. #Research
Learn more: www.mcw.edu/mcwknowledge...
Reposted by Joel Miesfeld
New preprints from the lab (3)! www.biorxiv.org/content/10.1...
October 10, 2025 at 3:01 PM
New preprints from the lab (3)! www.biorxiv.org/content/10.1...
Reposted by Joel Miesfeld
New preprints from the lab!! (2)
Uncoupling Neocortical Neuron Fate and Migration via a Let-7-RBX2 Axis https://www.biorxiv.org/content/10.1101/2025.09.11.675676v1
September 17, 2025 at 1:49 AM
New preprints from the lab!! (2)
Reposted by Joel Miesfeld
🎉 New preprints from the lab! (1) www.biorxiv.org/content/10.1...
Novel Roles of Sonic Hedgehog Signaling in Retinal Patterning and Neurogenesis During Mammalian Eye Development
The Sonic Hedgehog (Shh) signaling pathway is essential for the patterning, growth, and morphogenesis of many tissues. During early eye development, Shh is critical for the formation of the two optic ...
www.biorxiv.org
September 17, 2025 at 1:43 AM
🎉 New preprints from the lab! (1) www.biorxiv.org/content/10.1...
Reposted by Joel Miesfeld
Damaged retinal ganglion cells can lead to blindness. MCW’s Dr. Joel Miesfeld is conducting #research into the development of these cells to better identify ways to help them regenerate after damage. Learn more: www.mcw.edu/mcwknowledge...
#Ophthalmology #VisionHealth #MCWKnowledge
#Ophthalmology #VisionHealth #MCWKnowledge
Preventing Blindness by Untangling the Genetic Network of Vision Neurons
Dr. Joel Miesfeld’s lab studies the mechanisms behind retinal ganglion cells to better understand vision development.
www.mcw.edu
September 17, 2025 at 3:34 PM
Damaged retinal ganglion cells can lead to blindness. MCW’s Dr. Joel Miesfeld is conducting #research into the development of these cells to better identify ways to help them regenerate after damage. Learn more: www.mcw.edu/mcwknowledge...
#Ophthalmology #VisionHealth #MCWKnowledge
#Ophthalmology #VisionHealth #MCWKnowledge
A big thanks to the NEI for supporting my new R01 and MCW for highlighting the research focus. We’ve already made some interesting discoveries and I’m excited to see how the research progresses for years to come. www.mcw.edu/mcwknowledge...
Preventing Blindness by Untangling the Genetic Network of Vision Neurons
Dr. Joel Miesfeld’s lab studies the mechanisms behind retinal ganglion cells to better understand vision development.
www.mcw.edu
September 16, 2025 at 2:05 PM
A big thanks to the NEI for supporting my new R01 and MCW for highlighting the research focus. We’ve already made some interesting discoveries and I’m excited to see how the research progresses for years to come. www.mcw.edu/mcwknowledge...
Reposted by Joel Miesfeld
Check out this 40x confocal image of a transgenic zebrafish eye showing UV (red) and blue cones (green), key for color vision. Zebrafish use UV vision for prey detection and navigation!
Got interesting data or images? Send your science with a brief description to be featured!
Got interesting data or images? Send your science with a brief description to be featured!
August 12, 2025 at 5:27 PM
Check out this 40x confocal image of a transgenic zebrafish eye showing UV (red) and blue cones (green), key for color vision. Zebrafish use UV vision for prey detection and navigation!
Got interesting data or images? Send your science with a brief description to be featured!
Got interesting data or images? Send your science with a brief description to be featured!
Reposted by Joel Miesfeld
Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…
TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl
August 6, 2025 at 3:19 AM
Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…
Reposted by Joel Miesfeld
🎉 MCW grad students: come to the GSA Welcome Social on Aug 22, 5–8 PM at Hoyt Park!
🥪 Free Jimmy John’s, 🎲 games, ☀️ good vibes
📝 RSVP by Aug 20 by scanning the QR code!
🥪 Free Jimmy John’s, 🎲 games, ☀️ good vibes
📝 RSVP by Aug 20 by scanning the QR code!
August 5, 2025 at 1:33 PM
🎉 MCW grad students: come to the GSA Welcome Social on Aug 22, 5–8 PM at Hoyt Park!
🥪 Free Jimmy John’s, 🎲 games, ☀️ good vibes
📝 RSVP by Aug 20 by scanning the QR code!
🥪 Free Jimmy John’s, 🎲 games, ☀️ good vibes
📝 RSVP by Aug 20 by scanning the QR code!
Should have included these two co-organizers in the original post @icanhasmiranda.bsky.social @aoiplab.bsky.social
July 24, 2025 at 8:19 PM
Should have included these two co-organizers in the original post @icanhasmiranda.bsky.social @aoiplab.bsky.social
Reposted by Joel Miesfeld
Beautiful morning in Madison at #izfc2025! Grad student @nicholashaghani.bsky.social will talk today on models of ASD-DM candidate genes in the disease models session #genomejoggers
July 10, 2025 at 12:22 PM
Beautiful morning in Madison at #izfc2025! Grad student @nicholashaghani.bsky.social will talk today on models of ASD-DM candidate genes in the disease models session #genomejoggers
Reposted by Joel Miesfeld
🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here:
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
tol2kit for kwan lab
tol2kitkwan.genetics.utah.edu
July 7, 2025 at 6:01 PM
🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here:
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing
Reposted by Joel Miesfeld
Madison-based Exact Sciences' story illustrates that basic research — combined with hard work, strong teams and enough money — can pay off in many ways.
Tom Still: Cancer tests continue to propel Exact Sciences, even in time of research cuts
Madison-based Exact Sciences' story illustrates that basic research — combined with hard work, strong teams and enough money — can pay off in many ways.
madison.com
June 17, 2025 at 11:45 AM
Madison-based Exact Sciences' story illustrates that basic research — combined with hard work, strong teams and enough money — can pay off in many ways.
Reposted by Joel Miesfeld
Meet your 2025–26 GSA Officers & Reps! 👋
We’re here to keep you in the loop, host fun events 🎉, and represent your voice.
Stay tuned for news, meeting reminders📅, monthly pet pics 🐾, science highlights 🔬 & more!
Got ideas? DM or email us anytime! 😊
We’re here to keep you in the loop, host fun events 🎉, and represent your voice.
Stay tuned for news, meeting reminders📅, monthly pet pics 🐾, science highlights 🔬 & more!
Got ideas? DM or email us anytime! 😊
June 16, 2025 at 3:04 PM
Meet your 2025–26 GSA Officers & Reps! 👋
We’re here to keep you in the loop, host fun events 🎉, and represent your voice.
Stay tuned for news, meeting reminders📅, monthly pet pics 🐾, science highlights 🔬 & more!
Got ideas? DM or email us anytime! 😊
We’re here to keep you in the loop, host fun events 🎉, and represent your voice.
Stay tuned for news, meeting reminders📅, monthly pet pics 🐾, science highlights 🔬 & more!
Got ideas? DM or email us anytime! 😊
Reposted by Joel Miesfeld
If you love Daniocell, but wish it could generate analyses specific to YOUR genes & cell types of interest, check out DaniocellDesktop - a new point-and-click app for Mac and Windows that enables reanalysis of the Daniocell data without programming: daniocell.nichd.nih.gov/desktop/ (1/4)
June 13, 2025 at 2:30 PM
If you love Daniocell, but wish it could generate analyses specific to YOUR genes & cell types of interest, check out DaniocellDesktop - a new point-and-click app for Mac and Windows that enables reanalysis of the Daniocell data without programming: daniocell.nichd.nih.gov/desktop/ (1/4)
Reposted by Joel Miesfeld
“Our results suggest that some axons regenerate along tracts of degenerating myelin debris. However, the topography of re-innervation is different after regeneration, suggesting that new axon tracts are created to restore functional vision.”
New work from @pennylamphd.bsky.social et al. 🐠
New work from @pennylamphd.bsky.social et al. 🐠
See-through science: Danionella cerebrum as a model for neuroregeneration https://www.biorxiv.org/content/10.1101/2025.05.13.653880v1
June 2, 2025 at 5:23 PM
“Our results suggest that some axons regenerate along tracts of degenerating myelin debris. However, the topography of re-innervation is different after regeneration, suggesting that new axon tracts are created to restore functional vision.”
New work from @pennylamphd.bsky.social et al. 🐠
New work from @pennylamphd.bsky.social et al. 🐠
Reposted by Joel Miesfeld
See-through science: Danionella cerebrum as a model for neuroregeneration https://www.biorxiv.org/content/10.1101/2025.05.13.653880v1
May 17, 2025 at 3:15 PM
See-through science: Danionella cerebrum as a model for neuroregeneration https://www.biorxiv.org/content/10.1101/2025.05.13.653880v1
Reposted by Joel Miesfeld
Dr. Kevin Emmerich, my former graduate student, will be presenting a summary of his thesis work as a finalist for the 2024 Outstanding Paper Prize from Development. Webinar is next Wednesday, May 28th:
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Development's 2024 outstanding paper prize
We introduced our Outstanding Paper Prize in 2022 (Briscoe et al., 2023). Each year since then, reviewing the papers shortlisted by our editors, and selecting the finalists and overall winner has beco...
journals.biologists.com
May 22, 2025 at 11:50 AM
Dr. Kevin Emmerich, my former graduate student, will be presenting a summary of his thesis work as a finalist for the 2024 Outstanding Paper Prize from Development. Webinar is next Wednesday, May 28th:
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted by Joel Miesfeld
May 16, 2025 at 9:24 PM
Reposted by Joel Miesfeld
Stop by A0265 today and say hi to @minagaffney.bsky.social - she’s sharing results from our AO corrected visual acuity project, made possible by a collaboration with @roordalab.bsky.social and Will Tuten.
May 7, 2025 at 2:34 PM
Stop by A0265 today and say hi to @minagaffney.bsky.social - she’s sharing results from our AO corrected visual acuity project, made possible by a collaboration with @roordalab.bsky.social and Will Tuten.