Jeffrey Huang
@jkhuang.bsky.social
Scientist studying oligodendrocytes, remyelination, neuroinflammation, multiple sclerosis @Georgetown University. https://www.huang-lab.com/
Very happy to share that Zeeba @zeebamehrin.bsky.social's work on cellular senescence in EAE is now published in J Neuroinflammation! Congratulations, Zeeba, on this informative study! 😀https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-025-03425-3
Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelination - Journal of Neuroinflammation
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by immune cell-driven demyelination and progressive neurodegeneration. Senescent cells (SCs)...
jneuroinflammation.biomedcentral.com
April 8, 2025 at 3:32 PM
Very happy to share that Zeeba @zeebamehrin.bsky.social's work on cellular senescence in EAE is now published in J Neuroinflammation! Congratulations, Zeeba, on this informative study! 😀https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-025-03425-3
Reposted by Jeffrey Huang
Excited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41...
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Senescent-like microglia limit remyelination through the senescence associated secretory phenotype - Nature Communications
The impact of senescent cells on remyelination is unknown. Here, the authors show that treatment with senolytics following demyelination enhances remyelination in young, but not aged mice, and these e...
www.nature.com
March 7, 2025 at 1:57 PM
Excited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41...
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Congratulations Phil @philgrossphd.bsky.social and a huge thank you to all the lab members and collaborators for their contributions to our project on the role of senescence in remyelination, which has now been published in @naturecomms.bsky.social! 😀 www.nature.com/articles/s41...
Senescent-like microglia limit remyelination through the senescence associated secretory phenotype - Nature Communications
The impact of senescent cells on remyelination is unknown. Here, the authors show that treatment with senolytics following demyelination enhances remyelination in young, but not aged mice, and these e...
www.nature.com
March 7, 2025 at 3:52 PM
Congratulations Phil @philgrossphd.bsky.social and a huge thank you to all the lab members and collaborators for their contributions to our project on the role of senescence in remyelination, which has now been published in @naturecomms.bsky.social! 😀 www.nature.com/articles/s41...
Reposted by Jeffrey Huang
New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function - Nature Communications
Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...
www.nature.com
January 18, 2025 at 6:41 PM
New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jeffrey Huang
Dissecting the evolving cellular landscape of a remyelinating microenvironment https://www.biorxiv.org/content/10.1101/2024.12.25.630253v1
December 26, 2024 at 12:17 AM
Dissecting the evolving cellular landscape of a remyelinating microenvironment https://www.biorxiv.org/content/10.1101/2024.12.25.630253v1
Reposted by Jeffrey Huang
Excited to share our new work identifying PKC as a druggable target for modulating microglia in order to enhance myelin repair. 🧵 #remyelination #multiplesclerosis www.science.org/doi/10.1126/...
The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination
Protein kinase C modulation with bryostatin-1 enables innate immune cells in the central nervous system to promote myelin repair and regeneration.
www.science.org
January 8, 2025 at 7:49 PM
Excited to share our new work identifying PKC as a druggable target for modulating microglia in order to enhance myelin repair. 🧵 #remyelination #multiplesclerosis www.science.org/doi/10.1126/...
Congratulations to Phil, George, and Jingwen @PhilgrossPhD @thegliaguy @Jingwen_SMyelin on your doctoral hooding and graduation from @Georgetown! It’s been an incredible journey with you over the years. I’m so proud of your accomplishments.
January 11, 2025 at 10:36 PM
Congratulations to Phil, George, and Jingwen @PhilgrossPhD @thegliaguy @Jingwen_SMyelin on your doctoral hooding and graduation from @Georgetown! It’s been an incredible journey with you over the years. I’m so proud of your accomplishments.
Very proud that George Mechor @thegliaguy successfully defended his PhD thesis on the analysis of #remyelination via single nuc RNA-seq. We've learned that single cell studies are informative but an exhausting endeavor 😀. Congratulations Dr. Melchor on your remarkable
January 11, 2025 at 10:36 PM
Very proud that George Mechor @thegliaguy successfully defended his PhD thesis on the analysis of #remyelination via single nuc RNA-seq. We've learned that single cell studies are informative but an exhausting endeavor 😀. Congratulations Dr. Melchor on your remarkable
Are we close to a breakthrough for Multiple Sclerosis?Thanks @bbctanyabeckett @BBCTheInquiry for this informative program and the opportunity to discuss MS treatment and repair strategies with @tim_coetzee @TZiemssen @CShannonLowe. #MS #remyelination...
January 11, 2025 at 10:36 PM
Are we close to a breakthrough for Multiple Sclerosis?Thanks @bbctanyabeckett @BBCTheInquiry for this informative program and the opportunity to discuss MS treatment and repair strategies with @tim_coetzee @TZiemssen @CShannonLowe. #MS #remyelination...
Very excited that Phil Gross @PSGrossScience @georgetown #IPN #GUBiology has successfully defended his PhD thesis on the role of cellular senescence in CNS remyelination. Next stop a postdoc at the NIH. Congratulations Dr. Gross! 🎉🎉🎉🍾🍾🍾
January 11, 2025 at 10:36 PM
Very excited that Phil Gross @PSGrossScience @georgetown #IPN #GUBiology has successfully defended his PhD thesis on the role of cellular senescence in CNS remyelination. Next stop a postdoc at the NIH. Congratulations Dr. Gross! 🎉🎉🎉🍾🍾🍾
Ancient DNA helps trace multiple sclerosis origins in European descendants https://www.washingtonpost.com/science/2024/01/10/ancient-dna-multiple-sclerosis-european-ancestry/
January 11, 2025 at 10:36 PM
Ancient DNA helps trace multiple sclerosis origins in European descendants https://www.washingtonpost.com/science/2024/01/10/ancient-dna-multiple-sclerosis-european-ancestry/
Congratulations to @Jingwen_SMyelin on the publication of her manuscript showing the effect of myeloid cell derived aromatic alpha-keto acids (AKAs) in remyelination. Big thanks to @thegliaguy, @Meng2Fu, @PavanBhargavaMD and everyone who contributed!...
January 11, 2025 at 10:36 PM
Congratulations to @Jingwen_SMyelin on the publication of her manuscript showing the effect of myeloid cell derived aromatic alpha-keto acids (AKAs) in remyelination. Big thanks to @thegliaguy, @Meng2Fu, @PavanBhargavaMD and everyone who contributed!...
Very proud that my brilliant grad student @Jingwen_SMyelin successfully defended her PhD thesis today on the effect of aromatic amino acid metabolism in #remyelination. Congratulations Dr. Hu! 😀 #MultipleSclerosis #GUBiology @Georgetown
January 11, 2025 at 10:36 PM
Very proud that my brilliant grad student @Jingwen_SMyelin successfully defended her PhD thesis today on the effect of aromatic amino acid metabolism in #remyelination. Congratulations Dr. Hu! 😀 #MultipleSclerosis #GUBiology @Georgetown
Dr. Anthony Fauci To Join Georgetown Faculty as Distinguished University Professor - Georgetown University https://www.georgetown.edu/news/dr-anthony-fauci-to-join-georgetown-faculty-as-distinguished-university-professor/
Dr. Anthony Fauci To Join Georgetown Faculty as Distingui...
Dr. Fauci will serve as a Distinguished University Profes...
www.georgetown.edu
January 11, 2025 at 10:36 PM
Dr. Anthony Fauci To Join Georgetown Faculty as Distinguished University Professor - Georgetown University https://www.georgetown.edu/news/dr-anthony-fauci-to-join-georgetown-faculty-as-distinguished-university-professor/
Proud of @lauren_rosko for receiving the @ASNeurochem Marian Kies Award for outstanding graduate research at #ASN2023. Congratulations Lauren!!! 😀
January 11, 2025 at 10:36 PM
Proud of @lauren_rosko for receiving the @ASNeurochem Marian Kies Award for outstanding graduate research at #ASN2023. Congratulations Lauren!!! 😀
Excited to see @lauren_rosko's PhD work published in @SfNJournals. Cerebral creatine deficiency syndrome is a rare disease that affects CNS development. Lauren found that oligodendrocytes are the major producers of creatine in adult CNS. Congratulations!...
January 11, 2025 at 10:42 PM
Excited to see @lauren_rosko's PhD work published in @SfNJournals. Cerebral creatine deficiency syndrome is a rare disease that affects CNS development. Lauren found that oligodendrocytes are the major producers of creatine in adult CNS. Congratulations!...
If you are at #SfN2022 and interested in MS, remyelination, senescence, and immunometabolism, checkout my grad students posters
George Melchor 11/12 Diversity poster session 6:30-8:30pm
Phillip Gross 11/14 8-9am #G14
Mia Cozart 11/14 11-12am #B29
Zeeba Manavi 11/16 10-11am #N14
George Melchor 11/12 Diversity poster session 6:30-8:30pm
Phillip Gross 11/14 8-9am #G14
Mia Cozart 11/14 11-12am #B29
Zeeba Manavi 11/16 10-11am #N14
January 11, 2025 at 10:42 PM
Had a great time at the inspiring @mssociety Ambassadors Ball w my awesome grad students :) @thegliaguy @Zeebamehrin @PSGrossScience @MiaCozart3 @Georgetown #EndMS
January 11, 2025 at 10:42 PM
Had a great time at the inspiring @mssociety Ambassadors Ball w my awesome grad students :) @thegliaguy @Zeebamehrin @PSGrossScience @MiaCozart3 @Georgetown #EndMS
Dear Twitter friends, George @thegliaguy, who is a PhD student in my lab, has lost his niece in the recent shooting in Uvalde, TX. To support the families of Robb Elementary at Uvalde, you can buy a t-shirt and donate to this fundraiser. Thx....
January 11, 2025 at 10:42 PM
Dear Twitter friends, George @thegliaguy, who is a PhD student in my lab, has lost his niece in the recent shooting in Uvalde, TX. To support the families of Robb Elementary at Uvalde, you can buy a t-shirt and donate to this fundraiser. Thx....
Proud of Jingwen @JingwenHu10 and Phil @PSGrossScience @Georgetown for presenting their PhD work on #remyelination at #ASN2022! Well done!
January 11, 2025 at 10:42 PM
Proud of Jingwen @JingwenHu10 and Phil @PSGrossScience @Georgetown for presenting their PhD work on #remyelination at #ASN2022! Well done!
Petition to 1. Enforcing a no-fly zone over Ukraine and 2. The immediate expulsion of Russia from the SWIFT system. #StandWithUkraine @UnitedHelpUA https://resist.bot/petitions/PVMJHK
Ukraine No Fly Zone
Text SIGN PVMJHK to 50409 to send this to your officials.
resist.bot
January 11, 2025 at 10:42 PM
Petition to 1. Enforcing a no-fly zone over Ukraine and 2. The immediate expulsion of Russia from the SWIFT system. #StandWithUkraine @UnitedHelpUA https://resist.bot/petitions/PVMJHK
Petition to ask NATO to close the airspace over Ukraine. #StandWithUkraine @UnitedHelpUA https://www.openpetition.eu/petition/online/people-around-the-world-ask-nato-to-close-the-airspace-over-ukraine
People around the world ask NATO to close the airspace ov...
We, people around the world, are asking NATO member state...
www.openpetition.eu
January 11, 2025 at 10:42 PM
Petition to ask NATO to close the airspace over Ukraine. #StandWithUkraine @UnitedHelpUA https://www.openpetition.eu/petition/online/people-around-the-world-ask-nato-to-close-the-airspace-over-ukraine
Please follow and support United Help Ukraine @UnitedHelpUA, an amazing DC based organization run by Maryna Baydyuk, a neuroscientist and professor at @georgetown university, and group of volunteers that send medical supplies & hum aide to people in Ukraine. #StandWithUkraine️
January 11, 2025 at 10:47 PM
Please follow and support United Help Ukraine @UnitedHelpUA, an amazing DC based organization run by Maryna Baydyuk, a neuroscientist and professor at @georgetown university, and group of volunteers that send medical supplies & hum aide to people in Ukraine. #StandWithUkraine️
Sad to see what’s happening in Ukraine. My thoughts are with my Ukrainian friends, colleagues, and their families. If you’d like to help people on the ground, please donate to my friend and colleague Maryna Baydyuk’s DC based foundation https://unitedhelpukraine.org/....
United Help Ukraine: Supporting Ukraine Since 2014
United Help Ukraine supports the Ukrainian people by prov...
unitedhelpukraine.org
January 11, 2025 at 10:47 PM
Sad to see what’s happening in Ukraine. My thoughts are with my Ukrainian friends, colleagues, and their families. If you’d like to help people on the ground, please donate to my friend and colleague Maryna Baydyuk’s DC based foundation https://unitedhelpukraine.org/....
Epstein-Barr virus and multiple sclerosis https://www.science.org/doi/10.1126/science.abm7930
January 11, 2025 at 10:47 PM
Epstein-Barr virus and multiple sclerosis https://www.science.org/doi/10.1126/science.abm7930