Jordan Crameri
@jcrameri.bsky.social
Postdoctoral Research Fellow in the Kittler Lab at UCL, London | Mitochondrial neurobiology
Reposted by Jordan Crameri
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
From Biogenesis to Breakdown: How Protein Biogenesis and Quality Control Failures Drive Mitochondrial Disease
From Biogenesis to Breakdown: How Protein Biogenesis and Quality Control Failures Drive Mitochondrial Disease
Mitochondria rely on the coordinated function of over 1000 proteins, most of which are nuclear-encoded, synthesized in the cytosol, and imported into distinct mitochondrial sub-compartments. Thirte...
www.tandfonline.com
October 22, 2025 at 8:46 PM
From Biogenesis to Breakdown: How Protein Biogenesis and Quality Control Failures Drive Mitochondrial Disease
Reposted by Jordan Crameri
Online now - the Review "Interconnectivity of mitochondrial protein biogenesis and quality control" from @mitolab.bsky.social et al.
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
October 10, 2025 at 3:55 PM
Online now - the Review "Interconnectivity of mitochondrial protein biogenesis and quality control" from @mitolab.bsky.social et al.
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
#ProteinImport #Proteaes #Proteolysis #Proteostasis
Read it here: authors.elsevier.com/sd/article/S...
Reposted by Jordan Crameri
We noticed CII assembly factor SDHAF2 accumulates in some OXPHOS deficient cell lines but not others. New Dr Kugan cracked the case: CII assembly controls a balance btwn TCA cycle direction and protection from Q-pool stress to support ROS-meditated metabolic reprogramming in OXPHOS adapted cells.
Complex II assembly drives metabolic adaptation to OXPHOS dysfunction
Succinate dehydrogenase assembly dynamics maintains metabolic homeostasis during mitochondrial oxidative stress.
www.science.org
August 15, 2025 at 9:16 PM
We noticed CII assembly factor SDHAF2 accumulates in some OXPHOS deficient cell lines but not others. New Dr Kugan cracked the case: CII assembly controls a balance btwn TCA cycle direction and protection from Q-pool stress to support ROS-meditated metabolic reprogramming in OXPHOS adapted cells.
Reposted by Jordan Crameri
#Legionella pumps 100s of effector proteins into host cells, including to #mitochondria. @drdstojanovski.bsky.social &co show that effector LpPIP is a tail-anchored protein of the MOM that recruits protein phosphatase 1 to modulate the host mitochondrial P-proteome @plosbiology.org 🧪 plos.io/4f2T5kE
July 25, 2025 at 1:57 PM
#Legionella pumps 100s of effector proteins into host cells, including to #mitochondria. @drdstojanovski.bsky.social &co show that effector LpPIP is a tail-anchored protein of the MOM that recruits protein phosphatase 1 to modulate the host mitochondrial P-proteome @plosbiology.org 🧪 plos.io/4f2T5kE
Reposted by Jordan Crameri
Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d
Silencing mitochondrial gene expression in living cells
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...
scim.ag
May 23, 2025 at 7:23 PM
Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d
Reposted by Jordan Crameri
We're super proud to see our study showing utility of proteomics in ultra-rapid variant prioritisation for suspected mito and other rare diseases out in Genome Medicine (rdcu.be/endwE). Too many amazing collabs to thank, so here are the big ones @daniellahock.bsky.social @thorburnmito.bsky.social!
Cutting the diagnosis journey for children born with rare genetic diseases
Families can wait years for a diagnosis of a rare genetic disorder, but a new test can provide answers in days for a better understanding of the condition and potentially earlier treatment, finds new...
pursuit.unimelb.edu.au
May 23, 2025 at 12:57 AM
We're super proud to see our study showing utility of proteomics in ultra-rapid variant prioritisation for suspected mito and other rare diseases out in Genome Medicine (rdcu.be/endwE). Too many amazing collabs to thank, so here are the big ones @daniellahock.bsky.social @thorburnmito.bsky.social!
Reposted by Jordan Crameri
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
March 13, 2025 at 7:20 PM
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
Reposted by Jordan Crameri
Ya-Ting Chang, @nanigrotjahn.bsky.social et al. @scripps.edu present a membrane-guided approach for identifying a subset of cytoplasmic #ribosomes oriented for protein import on the surface of #mitochondria in budding yeast using #cryoET: rupress.org/jcb/article/...
March 6, 2025 at 6:26 PM
Ya-Ting Chang, @nanigrotjahn.bsky.social et al. @scripps.edu present a membrane-guided approach for identifying a subset of cytoplasmic #ribosomes oriented for protein import on the surface of #mitochondria in budding yeast using #cryoET: rupress.org/jcb/article/...
Reposted by Jordan Crameri
Two complementary methods ( #singlemoleculeimaging of ribosomal populations, specialized ribosomes and associated mRNAs & affinity purification of subcellular ribosome populations) used to characterize ribosomes in subcellular space ➡️ www.science.org/doi/10.1126/...
A subcellular map of translational machinery composition and regulation at the single-molecule level
Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...
www.science.org
March 7, 2025 at 8:15 AM
Two complementary methods ( #singlemoleculeimaging of ribosomal populations, specialized ribosomes and associated mRNAs & affinity purification of subcellular ribosome populations) used to characterize ribosomes in subcellular space ➡️ www.science.org/doi/10.1126/...
Reposted by Jordan Crameri
Mitochondria a safe haven for aggregation-prone proteins? #neurodegeneration. #Parkinson. Find our latest manuscript in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Mitochondria serve as a Holdout Compartment for Aggregation-Prone Proteins hindering Efficient Ubiquitin-Dependent Degradation
The accumulation of protein aggregates has been causatively linked to the pathogenesis of neurodegenerative diseases. In this study, we have conducted a genome-wide CRISPR-Cas9 screen to identify cell...
www.biorxiv.org
March 6, 2025 at 11:51 AM
Mitochondria a safe haven for aggregation-prone proteins? #neurodegeneration. #Parkinson. Find our latest manuscript in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Reposted by Jordan Crameri
We are hiring! The Formosa Group is hiring a Research Officer to join our program on #Mitochondria, #Metabolism & #MitochondrialDisease at the Monash BDI!
💡If you're passionate about mitochondrial research or know someone who is, please share! Apply now: careers.pageuppeople.com/513/cw/en/jo...
💡If you're passionate about mitochondrial research or know someone who is, please share! Apply now: careers.pageuppeople.com/513/cw/en/jo...
Job Search
careers.pageuppeople.com
January 30, 2025 at 6:53 AM
We are hiring! The Formosa Group is hiring a Research Officer to join our program on #Mitochondria, #Metabolism & #MitochondrialDisease at the Monash BDI!
💡If you're passionate about mitochondrial research or know someone who is, please share! Apply now: careers.pageuppeople.com/513/cw/en/jo...
💡If you're passionate about mitochondrial research or know someone who is, please share! Apply now: careers.pageuppeople.com/513/cw/en/jo...
Reposted by Jordan Crameri
Nice to end the year with a paper! Very excited to share my first authorship in the @lancasterlab.bsky.social lab - making mouse organoids 🧠
Check it out: doi.org/10.1101/2024...
Check it out: doi.org/10.1101/2024...
Mouse brain organoids model in vivo neurodevelopment and function and capture differences to human
In the last decade since their emergence, brain organoids have offered an increasingly popular and powerful model for the study of early development and disease in humans. These 3D stem cell-derived m...
doi.org
December 31, 2024 at 7:38 PM
Nice to end the year with a paper! Very excited to share my first authorship in the @lancasterlab.bsky.social lab - making mouse organoids 🧠
Check it out: doi.org/10.1101/2024...
Check it out: doi.org/10.1101/2024...
Reposted by Jordan Crameri
Excited to reveal specific reactive oxygen species as sentinel molecules that control localized protein degradation at #mitochondria to adjust electron transport chain abundance, with many implications for the role of ROS in development and disease.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reactive oxygen species control protein degradation at the mitochondrial import gate
This work identifies reactive oxygen species released by the electron transport chain as sentinel molecules that regulate localized protein degradation at mitochondrial TOM complexes, a mechanism that controls mitochondrial protein import and adjusts the abundance of the electron transport chain to cellular needs.
www.cell.com
December 6, 2024 at 7:07 AM
Excited to reveal specific reactive oxygen species as sentinel molecules that control localized protein degradation at #mitochondria to adjust electron transport chain abundance, with many implications for the role of ROS in development and disease.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
What an amazing time AussieMit 2024 was! Was honoured to get the chance to present our recently published work on TIMM50 associated mitochondrial disease. Looking forward to the next event with everyone in 2026!
#Mitochondria #AussieMit #MitochondrialDisease #Mito
#Mitochondria #AussieMit #MitochondrialDisease #Mito
December 6, 2024 at 2:57 AM
What an amazing time AussieMit 2024 was! Was honoured to get the chance to present our recently published work on TIMM50 associated mitochondrial disease. Looking forward to the next event with everyone in 2026!
#Mitochondria #AussieMit #MitochondrialDisease #Mito
#Mitochondria #AussieMit #MitochondrialDisease #Mito
Was fortunate to speak with the MDHS team at @Unimelb recently about mitochondrial disease and the importance of basic research in developing novel therapeutics and personalized medicines!
Read here: biomedicalsciences.unimelb.edu.au/news-and-eve...
#Mitochondria #Unimelb #BasicResearch
Read here: biomedicalsciences.unimelb.edu.au/news-and-eve...
#Mitochondria #Unimelb #BasicResearch
Illuminate Tomorrow – This World Mitochondrial Disease week we are illuminating tomorrow’s leaders in Mito research
Illuminate Tomorrow – This World Mitochondrial Disease week we are illuminating tomorrow’s leaders in Mito research
biomedicalsciences.unimelb.edu.au
December 4, 2024 at 11:45 PM
Was fortunate to speak with the MDHS team at @Unimelb recently about mitochondrial disease and the importance of basic research in developing novel therapeutics and personalized medicines!
Read here: biomedicalsciences.unimelb.edu.au/news-and-eve...
#Mitochondria #Unimelb #BasicResearch
Read here: biomedicalsciences.unimelb.edu.au/news-and-eve...
#Mitochondria #Unimelb #BasicResearch
Reposted by Jordan Crameri
Scientific colour maps 8.0
· Perceptually uniform
· Perceptually ordered
· Colour-blind friendly
· Readable as B&W print
· Widely compatible
· Versioned & citable
fabiocrameri.ch/colourmaps
#useBatlow #Dataviz #SciArt #EduSky #OpenSource
1/n
· Perceptually uniform
· Perceptually ordered
· Colour-blind friendly
· Readable as B&W print
· Widely compatible
· Versioned & citable
fabiocrameri.ch/colourmaps
#useBatlow #Dataviz #SciArt #EduSky #OpenSource
1/n
October 5, 2023 at 1:15 PM
Scientific colour maps 8.0
· Perceptually uniform
· Perceptually ordered
· Colour-blind friendly
· Readable as B&W print
· Widely compatible
· Versioned & citable
fabiocrameri.ch/colourmaps
#useBatlow #Dataviz #SciArt #EduSky #OpenSource
1/n
· Perceptually uniform
· Perceptually ordered
· Colour-blind friendly
· Readable as B&W print
· Widely compatible
· Versioned & citable
fabiocrameri.ch/colourmaps
#useBatlow #Dataviz #SciArt #EduSky #OpenSource
1/n
Reposted by Jordan Crameri
The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 25, 2024 at 12:19 PM
The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Cannot wait to hear about all the fantastic work happening in the Aussie mito community this year at AussieMit 2024!
AussieMit 2024 takes place 26 – 29 November at the Melbourne Museum, Melbourne, VIC.
The AussieMit 2024 program and conference booklet are available here: aussiemit.com.au/program/
#MitochondrialDisease #Mitochondria #Mito
The AussieMit 2024 program and conference booklet are available here: aussiemit.com.au/program/
#MitochondrialDisease #Mitochondria #Mito
November 22, 2024 at 6:51 AM
Cannot wait to hear about all the fantastic work happening in the Aussie mito community this year at AussieMit 2024!