Jacob A Hoffman
jahoffman1.bsky.social
Jacob A Hoffman
@jahoffman1.bsky.social
PhD - Penn - Wilson Lab - AAVxGlycobiology

MIT - Novo Nordisk AI Postdoctoral Fellow - Belcher Lab
Reposted by Jacob A Hoffman
🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
Ever wondered how gene therapies know where to go? Screening AAV vector libraries across different species I uncovered evidence of altered #glycan profiles between mouse, NHP and human liver, with implications for translation of #AAV #genetherapy

pubmed.ncbi.nlm.nih.gov/39001819/

Enjoy!
Modulation of AAV9 Galactose Binding Yields Novel Gene Therapy Vectors and Predicts Cross-Species Differences in Glycan Avidity - PubMed
Effective use of adeno-associated viruses (AAVs) for clinical gene therapy is limited by their propensity to accumulate in and transduce the liver. This natural liver tropism is associated with severe...
pubmed.ncbi.nlm.nih.gov
November 19, 2024 at 2:20 PM
Hi @bsky.app #glycobiology community! Seems pretty sweet over here
November 19, 2024 at 3:11 AM