iSpy Explore
@ispyexplore.bsky.social
With support of the Leducq Foundation, the iSPY Explore Network, led by UC San Diego in partnership with Imperial College London (iSpy Life), unites 14 investigators from the USA, Australia, Brazil, and New Zealand to understand streptococcal immunity.
Reposted by iSpy Explore
New @plosbiology.org paper from Sumedha Ravishankar, PhD and the Cressida Madigan Lab applies the powerful and optically transparent zebrafish embryo model to study group B streptococcal transit of the blood-brain barrier.
Beautiful time-lapse confocal microscopy!
journals.plos.org/plosbiology/...
Beautiful time-lapse confocal microscopy!
journals.plos.org/plosbiology/...
July 4, 2025 at 1:26 AM
New @plosbiology.org paper from Sumedha Ravishankar, PhD and the Cressida Madigan Lab applies the powerful and optically transparent zebrafish embryo model to study group B streptococcal transit of the blood-brain barrier.
Beautiful time-lapse confocal microscopy!
journals.plos.org/plosbiology/...
Beautiful time-lapse confocal microscopy!
journals.plos.org/plosbiology/...
Reposted by iSpy Explore
Why did invasive #strepA infections increase in young children after the pandemic?
In this new @imperialinfect.bsky.social PREPRINT *not peer-reviewed* we look at antibody responses to #strepA and resp viruses in European children before and after the pandemic:
www.medrxiv.org/cgi/content/...
In this new @imperialinfect.bsky.social PREPRINT *not peer-reviewed* we look at antibody responses to #strepA and resp viruses in European children before and after the pandemic:
www.medrxiv.org/cgi/content/...
Immunity to Streptococcus pyogenes and Common Respiratory Viruses at Age 0-4 Years after COVID-19 restrictions: A Cross-Sectional Study
Importance The upsurge in invasive disease caused by Streptococcus pyogenes among children reported in several European countries during 2022-2023 has not been fully explained.
Objective To test the ...
www.medrxiv.org
April 25, 2025 at 5:16 PM
Why did invasive #strepA infections increase in young children after the pandemic?
In this new @imperialinfect.bsky.social PREPRINT *not peer-reviewed* we look at antibody responses to #strepA and resp viruses in European children before and after the pandemic:
www.medrxiv.org/cgi/content/...
In this new @imperialinfect.bsky.social PREPRINT *not peer-reviewed* we look at antibody responses to #strepA and resp viruses in European children before and after the pandemic:
www.medrxiv.org/cgi/content/...
Reposted by iSpy Explore
New preprint alert 🚨
My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens.
For paper: SSRN ssrn.com/abstract=519...
biorxiv : doi: doi.org/10.1101/2025...
My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens.
For paper: SSRN ssrn.com/abstract=519...
biorxiv : doi: doi.org/10.1101/2025...
April 4, 2025 at 12:01 AM
New preprint alert 🚨
My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens.
For paper: SSRN ssrn.com/abstract=519...
biorxiv : doi: doi.org/10.1101/2025...
My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens.
For paper: SSRN ssrn.com/abstract=519...
biorxiv : doi: doi.org/10.1101/2025...
Reposted by iSpy Explore
From 2013 to 2022, invasive group A Streptococcus infections increased in 10 US states, with higher incidence among older adults, American Indian or Alaska Native persons, and vulnerable groups. https://ja.ma/3G9OPT2
Invasive Group A Streptococcal Infections in 10 US States
This population-based surveillance study investigates trends in the incidence, characteristics, antimicrobial resistance, and outcomes of invasive group A Streptococcus infections among individuals in 10 US states.
ja.ma
April 7, 2025 at 4:00 PM
From 2013 to 2022, invasive group A Streptococcus infections increased in 10 US states, with higher incidence among older adults, American Indian or Alaska Native persons, and vulnerable groups. https://ja.ma/3G9OPT2
Reposted by iSpy Explore
Rheumatic heart disease arises from repeated Group A Strep infections, leading to autoimmune heart damage. New research advances knowledge of its progression, offering hope for better interventions.
Review by Adrien Lupieri et al, LeDucq Foundation PRIMA Network
www.frontiersin.org/journals/car...
Review by Adrien Lupieri et al, LeDucq Foundation PRIMA Network
www.frontiersin.org/journals/car...
March 13, 2025 at 11:14 PM
Rheumatic heart disease arises from repeated Group A Strep infections, leading to autoimmune heart damage. New research advances knowledge of its progression, offering hope for better interventions.
Review by Adrien Lupieri et al, LeDucq Foundation PRIMA Network
www.frontiersin.org/journals/car...
Review by Adrien Lupieri et al, LeDucq Foundation PRIMA Network
www.frontiersin.org/journals/car...
Reposted by iSpy Explore
🔥❤️🔥🔥❤️🔥 #LISSSD25 in Brisbane. Get in line (in pairs or chains) and get moving on your abstracts (open NOW).
if your research relates to any -ology of catalase negative Gram + cocci (starts with Strep*) with an impact on human health - you belong at #LISSSD25!!!!
www.lisssd2025.org/abstract-sub...
if your research relates to any -ology of catalase negative Gram + cocci (starts with Strep*) with an impact on human health - you belong at #LISSSD25!!!!
www.lisssd2025.org/abstract-sub...
Abstract Submission — LISSSD 2025
www.lisssd2025.org
November 19, 2024 at 10:22 PM
🔥❤️🔥🔥❤️🔥 #LISSSD25 in Brisbane. Get in line (in pairs or chains) and get moving on your abstracts (open NOW).
if your research relates to any -ology of catalase negative Gram + cocci (starts with Strep*) with an impact on human health - you belong at #LISSSD25!!!!
www.lisssd2025.org/abstract-sub...
if your research relates to any -ology of catalase negative Gram + cocci (starts with Strep*) with an impact on human health - you belong at #LISSSD25!!!!
www.lisssd2025.org/abstract-sub...
Reposted by iSpy Explore
Abstract submission extended 72h until Wed Feb 5th 1159 pm 🇦🇺 EDT. >300 abstracts submitted so far! Get yours in! mailchi.mp/f0e900990ac5...
February 3, 2025 at 2:14 AM
Abstract submission extended 72h until Wed Feb 5th 1159 pm 🇦🇺 EDT. >300 abstracts submitted so far! Get yours in! mailchi.mp/f0e900990ac5...
Reposted by iSpy Explore
Following relaxation of #COVID19 restrictions surges in infections from respiratory pathogens like RSV and #StrepA have been seen in many countries including Aotearoa New Zealand.
Did waning immunity contribute? We explored this concept in our latest work, see 🧵 academic.oup.com/jid/advance-...
Did waning immunity contribute? We explored this concept in our latest work, see 🧵 academic.oup.com/jid/advance-...
Decline of antibodies to major viral and bacterial respiratory pathogens during the COVID-19 pandemic
Antibodies to respiratory syncytial virus and Group A Streptococcus waned significantly in a longitudinal cohort throughout the pandemic. This waning may h
academic.oup.com
December 15, 2024 at 10:17 PM
Following relaxation of #COVID19 restrictions surges in infections from respiratory pathogens like RSV and #StrepA have been seen in many countries including Aotearoa New Zealand.
Did waning immunity contribute? We explored this concept in our latest work, see 🧵 academic.oup.com/jid/advance-...
Did waning immunity contribute? We explored this concept in our latest work, see 🧵 academic.oup.com/jid/advance-...
Reposted by iSpy Explore
📣Research Technician job alert! Needed to support our #iSpyLIFE field work and #strep biobanking. www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
January 16, 2025 at 2:16 AM
📣Research Technician job alert! Needed to support our #iSpyLIFE field work and #strep biobanking. www.imperial.ac.uk/jobs/search-...
Reposted by iSpy Explore
INVASIVE GROUP A STREP HAS BEEN AROUND A LONG TIME
Hippocrates
5th century BC
EPIDEMICS III
“Early in the spring—at the same time as the cold snaps which occurred—were many malignant cases of erysipelas, some from a known exciting cause and some not. Many died—and many suffered pain in the throat”
Hippocrates
5th century BC
EPIDEMICS III
“Early in the spring—at the same time as the cold snaps which occurred—were many malignant cases of erysipelas, some from a known exciting cause and some not. Many died—and many suffered pain in the throat”
December 22, 2024 at 6:53 AM
INVASIVE GROUP A STREP HAS BEEN AROUND A LONG TIME
Hippocrates
5th century BC
EPIDEMICS III
“Early in the spring—at the same time as the cold snaps which occurred—were many malignant cases of erysipelas, some from a known exciting cause and some not. Many died—and many suffered pain in the throat”
Hippocrates
5th century BC
EPIDEMICS III
“Early in the spring—at the same time as the cold snaps which occurred—were many malignant cases of erysipelas, some from a known exciting cause and some not. Many died—and many suffered pain in the throat”
Reposted by iSpy Explore
Hey Group A Strep Fans
New in Nature Communications from Di Tang in Johan Malmström Lab in Lund Sweden
Streptolysin O binds plasminogen, inducing conformational shifts that enhance plasminogen activation, revealing a conserved role beyond its cytolytic activity!
www.nature.com/articles/s41...
New in Nature Communications from Di Tang in Johan Malmström Lab in Lund Sweden
Streptolysin O binds plasminogen, inducing conformational shifts that enhance plasminogen activation, revealing a conserved role beyond its cytolytic activity!
www.nature.com/articles/s41...
November 28, 2024 at 6:37 AM
Hey Group A Strep Fans
New in Nature Communications from Di Tang in Johan Malmström Lab in Lund Sweden
Streptolysin O binds plasminogen, inducing conformational shifts that enhance plasminogen activation, revealing a conserved role beyond its cytolytic activity!
www.nature.com/articles/s41...
New in Nature Communications from Di Tang in Johan Malmström Lab in Lund Sweden
Streptolysin O binds plasminogen, inducing conformational shifts that enhance plasminogen activation, revealing a conserved role beyond its cytolytic activity!
www.nature.com/articles/s41...
Reposted by iSpy Explore
This #StrepA paper was a LONG labour of love from a great team 😊 Equal first & senior author credits buried at the very end, so I want to highlight the critical contributions of Dr Hannah Frost & @njmoreland.bsky.social & Dr Danika Hill @precisionvaxlab.bsky.social rdcu.be/d2gBV
Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections
Nature Communications - Streptococcus pyogenes is a deadly bacteria without a vaccine. Here, researchers measured antibodies in serum and saliva from a strep throat human challenge trial. Baseline...
rdcu.be
December 3, 2024 at 10:37 PM
This #StrepA paper was a LONG labour of love from a great team 😊 Equal first & senior author credits buried at the very end, so I want to highlight the critical contributions of Dr Hannah Frost & @njmoreland.bsky.social & Dr Danika Hill @precisionvaxlab.bsky.social rdcu.be/d2gBV
We're live! The iSPY Explore Network is on a mission to uncover immune correlates of streptococcal infection. Join us on this exciting journey of discovery! #StrepResearch #iSPYExplore #UCSanDiego
December 18, 2024 at 4:36 AM
We're live! The iSPY Explore Network is on a mission to uncover immune correlates of streptococcal infection. Join us on this exciting journey of discovery! #StrepResearch #iSPYExplore #UCSanDiego