Isabel Puig Borreil
@ipuigborreil.bsky.social
Senior Investigator at @vhio.bsky.social . Co-founder of Oniria Tx. Investigating non-genetic #cancer persistence.
https://vhio.net/pf/stem-cells-cancer-group/
https://vhio.net/pf/stem-cells-cancer-group/
Pinned
DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
Cuesta-Borràs et al. show that chemotherapy induces a hypoxia response by increasing
DPPA3 levels in cancer cells, which in turn promotes a chemoresistant proliferative-delayed
state. Our findings ide...
www.cell.com
On this #WorldCancerDay, I want to revisit our published work on DPPA3 as a key regulator of therapy-resistant slow-cycling cancer cells that drive colorectal cancer persistence and relapse.
📝 Read our fully study here:
www.cell.com/cell-reports...
📝 Read our fully study here:
www.cell.com/cell-reports...
Reposted by Isabel Puig Borreil
Drug-tolerant persisters #DTP, a rare subpopulation of cancer cells, can survive therapy via reversible non-genetic mechanisms. @seansi.bsky.social lab provide their #perspective on the gaps and research paths still needed to bridge basic DTP research with the clinic. www.nature.com/articles/s41...
November 19, 2025 at 3:24 PM
Drug-tolerant persisters #DTP, a rare subpopulation of cancer cells, can survive therapy via reversible non-genetic mechanisms. @seansi.bsky.social lab provide their #perspective on the gaps and research paths still needed to bridge basic DTP research with the clinic. www.nature.com/articles/s41...
Reposted by Isabel Puig Borreil
Our latest paper in @natcomms.nature.com is here!
➡️Cx43 sensitizes BRAF-mutant tumors to BRAF/MEK inhibitors by impairing DNA repair
🔗Open access PDF: rdcu.be/euQkW
➡️Cx43 sensitizes BRAF-mutant tumors to BRAF/MEK inhibitors by impairing DNA repair
🔗Open access PDF: rdcu.be/euQkW
Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity
Nature Communications - Drug resistance remains a major challenge in cancer treatment. Here, the authors identify Connexin43 as target that enhances BRAF/MEKi efficacy by interfering with DNA...
rdcu.be
July 6, 2025 at 9:02 PM
Our latest paper in @natcomms.nature.com is here!
➡️Cx43 sensitizes BRAF-mutant tumors to BRAF/MEK inhibitors by impairing DNA repair
🔗Open access PDF: rdcu.be/euQkW
➡️Cx43 sensitizes BRAF-mutant tumors to BRAF/MEK inhibitors by impairing DNA repair
🔗Open access PDF: rdcu.be/euQkW
Reposted by Isabel Puig Borreil
What a fantastic conference we’ve had this week in Lyon, shining the spotlight on the rapidly evolving area of research that is cancer persister cells. Thank you to all participants, speakers and our wonderful Scientific Programme Committee 🤩
March 21, 2025 at 2:12 PM
What a fantastic conference we’ve had this week in Lyon, shining the spotlight on the rapidly evolving area of research that is cancer persister cells. Thank you to all participants, speakers and our wonderful Scientific Programme Committee 🤩
Many thanks to the organizers of "Persister Cells: From Bacteria to Cancer" @helloeacr.bsky.social for the opportunity to present our results on CRC persistence. Excited about our group’s strong representation which allowed us to establish new collaborations. Looking forward to next year’s event!
March 21, 2025 at 6:49 AM
Many thanks to the organizers of "Persister Cells: From Bacteria to Cancer" @helloeacr.bsky.social for the opportunity to present our results on CRC persistence. Excited about our group’s strong representation which allowed us to establish new collaborations. Looking forward to next year’s event!
Ready to start the EACR Conference_Persister Cells: from Bacteria to Cancer in Lyon!!!
@helloeacr.bsky.social @vhio.bsky.social
@helloeacr.bsky.social @vhio.bsky.social
March 18, 2025 at 12:38 PM
Ready to start the EACR Conference_Persister Cells: from Bacteria to Cancer in Lyon!!!
@helloeacr.bsky.social @vhio.bsky.social
@helloeacr.bsky.social @vhio.bsky.social
Reposted by Isabel Puig Borreil
Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
February 26, 2025 at 12:10 AM
Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Isabel Puig Borreil
Thanks to those who politely pointed out we initially made a list of Metastasis Researchers... we've now made a starter pack! ☺️
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
February 18, 2025 at 4:46 AM
Thanks to those who politely pointed out we initially made a list of Metastasis Researchers... we've now made a starter pack! ☺️
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
go.bsky.app/KasKkhK
Drop us a message or reply here to be added.
More to follow over the coming days.
🦋
Reposted by Isabel Puig Borreil
Interview and article related to the international day of the fight against cancer when I visited Spain last November. Thanks for a wonderful interview - in spanish.
www.cartv.es/aragonradio/...
www.cartv.es/aragonradio/...
Investigación en ‘células durmientes’ para apoyar el Día Mundial Contra el Cáncer
Aragón Radio, la Radio Autonómica de Aragón
www.cartv.es
February 5, 2025 at 12:58 PM
Interview and article related to the international day of the fight against cancer when I visited Spain last November. Thanks for a wonderful interview - in spanish.
www.cartv.es/aragonradio/...
www.cartv.es/aragonradio/...
On this #WorldCancerDay, I want to revisit our published work on DPPA3 as a key regulator of therapy-resistant slow-cycling cancer cells that drive colorectal cancer persistence and relapse.
📝 Read our fully study here:
www.cell.com/cell-reports...
📝 Read our fully study here:
www.cell.com/cell-reports...
DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
Cuesta-Borràs et al. show that chemotherapy induces a hypoxia response by increasing
DPPA3 levels in cancer cells, which in turn promotes a chemoresistant proliferative-delayed
state. Our findings ide...
www.cell.com
February 4, 2025 at 8:05 PM
On this #WorldCancerDay, I want to revisit our published work on DPPA3 as a key regulator of therapy-resistant slow-cycling cancer cells that drive colorectal cancer persistence and relapse.
📝 Read our fully study here:
www.cell.com/cell-reports...
📝 Read our fully study here:
www.cell.com/cell-reports...
Reposted by Isabel Puig Borreil
Opening the genetic gates in colon cancer!
This month’s cover features work by Linda Resar, Cindy Sears & team @harvardmed.bsky.social on an epigenetic gatekeeper of Wnt signaling in colon cancer: https://www.jci.org/articles/view/184442
This month’s cover features work by Linda Resar, Cindy Sears & team @harvardmed.bsky.social on an epigenetic gatekeeper of Wnt signaling in colon cancer: https://www.jci.org/articles/view/184442
February 3, 2025 at 5:14 PM
Opening the genetic gates in colon cancer!
This month’s cover features work by Linda Resar, Cindy Sears & team @harvardmed.bsky.social on an epigenetic gatekeeper of Wnt signaling in colon cancer: https://www.jci.org/articles/view/184442
This month’s cover features work by Linda Resar, Cindy Sears & team @harvardmed.bsky.social on an epigenetic gatekeeper of Wnt signaling in colon cancer: https://www.jci.org/articles/view/184442
Reposted by Isabel Puig Borreil
We are still looking for a #PhDstudent to join the @ERC_Research project #DORMATRIX, modeling #breastcancer #dormancy with novel #biomaterials. Bioengineers, (bio)chemists or similar.
@biogipuzkoa @Ikerbasque. More info & apply until 15/02 👉 bit.ly/3Wkd2eQ
@biogipuzkoa @Ikerbasque. More info & apply until 15/02 👉 bit.ly/3Wkd2eQ
February 2, 2025 at 6:46 PM
We are still looking for a #PhDstudent to join the @ERC_Research project #DORMATRIX, modeling #breastcancer #dormancy with novel #biomaterials. Bioengineers, (bio)chemists or similar.
@biogipuzkoa @Ikerbasque. More info & apply until 15/02 👉 bit.ly/3Wkd2eQ
@biogipuzkoa @Ikerbasque. More info & apply until 15/02 👉 bit.ly/3Wkd2eQ
Enormemente agradecida de ser una de las afortunadas en liderar uno de los proyectos de I+D+I en salud del ISCIII @saludisciii.bsky.social y contribuir en el avance de la investigación en el campo de la persistencia del cáncer.
📣 El Instituto Acreditado #VallHebron es el centro que más proyectos de I+D+I en salud ha recibido del Instituto de Salud Carlos III con más de 8 millones de euros.
🔬 Once investigadores del VHIO han sido seleccionados en esta convocatoria ➡️ https://linke.to/IDISalud_VHIO
🔬 Once investigadores del VHIO han sido seleccionados en esta convocatoria ➡️ https://linke.to/IDISalud_VHIO
February 2, 2025 at 7:47 PM
Enormemente agradecida de ser una de las afortunadas en liderar uno de los proyectos de I+D+I en salud del ISCIII @saludisciii.bsky.social y contribuir en el avance de la investigación en el campo de la persistencia del cáncer.
Hello BlueSky community!!!
I'm excited to be here and connect with all of you! Looking forward to sharing ideas, discussing science, and collaborating.
Let's advance cancer research together!
I'm excited to be here and connect with all of you! Looking forward to sharing ideas, discussing science, and collaborating.
Let's advance cancer research together!
February 2, 2025 at 7:15 PM
Hello BlueSky community!!!
I'm excited to be here and connect with all of you! Looking forward to sharing ideas, discussing science, and collaborating.
Let's advance cancer research together!
I'm excited to be here and connect with all of you! Looking forward to sharing ideas, discussing science, and collaborating.
Let's advance cancer research together!