Abid Hussaini
@hussainilab.bsky.social
Associate Professor at Burke Neurological Institute at Weill Cornell Medicine
Systems Neuroscience + Neurodegeneration. 🧠
Focus on neuronal dysfunction in Alzheimer's disease. #entorhinalcortex #locuscoeruleus #dementia #memory #cognition
hussainilab.org
Systems Neuroscience + Neurodegeneration. 🧠
Focus on neuronal dysfunction in Alzheimer's disease. #entorhinalcortex #locuscoeruleus #dementia #memory #cognition
hussainilab.org
Reposted by Abid Hussaini
🚨New preprint alert!
The thalamus has long been seen as a relay of sensory signals to cortex.
But could it also generate its own structured activity?
Our study explores this question in the head-direction (HD) system.
Some explanation 🧵👇 1/13
www.biorxiv.org/content/10.1...
The thalamus has long been seen as a relay of sensory signals to cortex.
But could it also generate its own structured activity?
Our study explores this question in the head-direction (HD) system.
Some explanation 🧵👇 1/13
www.biorxiv.org/content/10.1...
Coherent dynamics of thalamic head-direction neurons irrespective of input
While the thalamus is known to relay and modulate sensory signals to the cortex, whether it also participates in active computation and intrinsic signal generation remains unresolved. The anterodorsal...
www.biorxiv.org
September 16, 2025 at 3:56 PM
🚨New preprint alert!
The thalamus has long been seen as a relay of sensory signals to cortex.
But could it also generate its own structured activity?
Our study explores this question in the head-direction (HD) system.
Some explanation 🧵👇 1/13
www.biorxiv.org/content/10.1...
The thalamus has long been seen as a relay of sensory signals to cortex.
But could it also generate its own structured activity?
Our study explores this question in the head-direction (HD) system.
Some explanation 🧵👇 1/13
www.biorxiv.org/content/10.1...
Reposted by Abid Hussaini
1/
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
September 17, 2025 at 7:33 PM
1/
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
🚨 New preprint! 🚨
Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇
📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩
#neuroskyence
Reposted by Abid Hussaini
Your brain doesn’t just passively track time ⏳ - it structures it.
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)
👉 www.science.org/doi/10.1126/...
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)
👉 www.science.org/doi/10.1126/...
Event structure sculpts neural population dynamics in the lateral entorhinal cortex
Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we...
www.science.org
June 26, 2025 at 6:06 PM
Your brain doesn’t just passively track time ⏳ - it structures it.
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)
👉 www.science.org/doi/10.1126/...
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)
👉 www.science.org/doi/10.1126/...
Reposted by Abid Hussaini
OK here it is, the moment you have all been waiting for! Our advert for 5 posts here at Glasgow: Cognitive neuroscience/psychology. Closing date May 12 - please spread the word
www.nature.com/naturecareer...
www.nature.com/naturecareer...
March 28, 2025 at 7:06 AM
OK here it is, the moment you have all been waiting for! Our advert for 5 posts here at Glasgow: Cognitive neuroscience/psychology. Closing date May 12 - please spread the word
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Reposted by Abid Hussaini
🚨 Neuromatch Academy Course Applications are OPEN for 2025!! 🚨
Get your application in early to be a student or teaching assistant for this year’s courses!
Applications are due Sunday, March 23.
Apply & learn more: neuromatch.io/courses/
#mlsky #compneurosky #ai #climatesolutions #ScienceEdu 🧪
Get your application in early to be a student or teaching assistant for this year’s courses!
Applications are due Sunday, March 23.
Apply & learn more: neuromatch.io/courses/
#mlsky #compneurosky #ai #climatesolutions #ScienceEdu 🧪
February 24, 2025 at 5:58 PM
🚨 Neuromatch Academy Course Applications are OPEN for 2025!! 🚨
Get your application in early to be a student or teaching assistant for this year’s courses!
Applications are due Sunday, March 23.
Apply & learn more: neuromatch.io/courses/
#mlsky #compneurosky #ai #climatesolutions #ScienceEdu 🧪
Get your application in early to be a student or teaching assistant for this year’s courses!
Applications are due Sunday, March 23.
Apply & learn more: neuromatch.io/courses/
#mlsky #compneurosky #ai #climatesolutions #ScienceEdu 🧪
Reposted by Abid Hussaini
Join us at #COSYNE2025 to explore recent advancements in large-scale training and analysis of brain data! 🧠🟦
We also made a starter pack with (most of) our speakers: go.bsky.app/Ss6RaEF
We also made a starter pack with (most of) our speakers: go.bsky.app/Ss6RaEF
March 10, 2025 at 9:21 PM
Join us at #COSYNE2025 to explore recent advancements in large-scale training and analysis of brain data! 🧠🟦
We also made a starter pack with (most of) our speakers: go.bsky.app/Ss6RaEF
We also made a starter pack with (most of) our speakers: go.bsky.app/Ss6RaEF
Reposted by Abid Hussaini
@burkeneurosci.bsky.social is excited to offer the NeuroAcademy program for high school students starting in July 2025. This 3-week, hands-on training course will introduce students to fundamental biological based neuroscience at the molecular and cellular levels.
NeuroAcademy
A 3-week summer enrichment program for high school students with the option of 1 of 2 sessions: July 7 - July 25, 2025 or July 28 - August 15, 2025.
buff.ly
March 1, 2025 at 4:00 PM
@burkeneurosci.bsky.social is excited to offer the NeuroAcademy program for high school students starting in July 2025. This 3-week, hands-on training course will introduce students to fundamental biological based neuroscience at the molecular and cellular levels.
Reposted by Abid Hussaini
"The researchers discovered that people who took longer to get to the REM stage of sleep were more likely to have biomarkers of Alzheimer’s disease."
Sleep should be sacred, you get the best sleep, apart from the tips in this article, in darkness and silence.
#sleep #brainhealth #alzheimers
Sleep should be sacred, you get the best sleep, apart from the tips in this article, in darkness and silence.
#sleep #brainhealth #alzheimers
Scientists Just Found A New Alzheimer's Warning Sign
A new study suggested that not getting enough REM sleep can be an early warning sign of Alzheimer's disease. Here's what a neurologist wants you to know.
www.yahoo.com
January 31, 2025 at 1:44 PM
"The researchers discovered that people who took longer to get to the REM stage of sleep were more likely to have biomarkers of Alzheimer’s disease."
Sleep should be sacred, you get the best sleep, apart from the tips in this article, in darkness and silence.
#sleep #brainhealth #alzheimers
Sleep should be sacred, you get the best sleep, apart from the tips in this article, in darkness and silence.
#sleep #brainhealth #alzheimers
Reposted by Abid Hussaini
*How* does the hippocampus encode the world around us? Leo Waschke and Fabian Kamp bring the 🔥, showing that single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans. Our latest in Nature Communications: www.nature.com/articles/s41...
Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans - Nature Communications
The hippocampus is thought to encode the content of stimuli, but how it does so is unknown. The authors show that when hippocampal spiking variability tracks the abstract building blocks of individual...
www.nature.com
January 13, 2025 at 7:37 PM
*How* does the hippocampus encode the world around us? Leo Waschke and Fabian Kamp bring the 🔥, showing that single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans. Our latest in Nature Communications: www.nature.com/articles/s41...
Reposted by Abid Hussaini
New work from our postdoc Elouise Koops just got published: #locuscoeruleus metabolism is elevated in preclinical Alzheimer’s disease, and provides resilience against cognitive decline! In collaboration with Joyita Dutta (UMass) alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease
INTRODUCTION Alterations in locus coeruleus’ (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across d...
alz-journals.onlinelibrary.wiley.com
November 28, 2024 at 12:29 AM
New work from our postdoc Elouise Koops just got published: #locuscoeruleus metabolism is elevated in preclinical Alzheimer’s disease, and provides resilience against cognitive decline! In collaboration with Joyita Dutta (UMass) alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Abid Hussaini
go.bsky.app/LdtUYZS
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet
November 12, 2024 at 9:00 PM
go.bsky.app/LdtUYZS
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet
Reposted by Abid Hussaini
I made a systems neuroscience starter pack, focused on experimentalists who study the brain at the level of populations of neurons!
Also want to be on the list? Reply or DM me a picture of your ephys rig or 2p setup and I'll add you 🤭
go.bsky.app/UiqX7ry
Also want to be on the list? Reply or DM me a picture of your ephys rig or 2p setup and I'll add you 🤭
go.bsky.app/UiqX7ry
November 11, 2024 at 7:50 AM
I made a systems neuroscience starter pack, focused on experimentalists who study the brain at the level of populations of neurons!
Also want to be on the list? Reply or DM me a picture of your ephys rig or 2p setup and I'll add you 🤭
go.bsky.app/UiqX7ry
Also want to be on the list? Reply or DM me a picture of your ephys rig or 2p setup and I'll add you 🤭
go.bsky.app/UiqX7ry
Reposted by Abid Hussaini
Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of APP NL-G-F mice https://www.biorxiv.org/content/10.1101/2024.11.26.624990v1
Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of APP NL-G-F mice https://www.biorxiv.org/content/10.1101/2024.11.26.624990v1
The progressive accumulation of amyloid beta (A{beta}) pathology in the brain has been associated wi
www.biorxiv.org
November 27, 2024 at 1:23 AM
Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of APP NL-G-F mice https://www.biorxiv.org/content/10.1101/2024.11.26.624990v1
Reposted by Abid Hussaini
Pleased to announce that Shuzo Sakata and I are recruiting for a PhD student to work on hippocampal-thalamic interactions in sleep using Neuropixels ephys: details in the link. Deadline Monday 6th January 2025. Come and work in beautiful Scotland!
www.gla.ac.uk/postgraduate...
www.gla.ac.uk/postgraduate...
https://gla.ac.uk/postgraduate/d…
November 7, 2024 at 12:12 PM
Pleased to announce that Shuzo Sakata and I are recruiting for a PhD student to work on hippocampal-thalamic interactions in sleep using Neuropixels ephys: details in the link. Deadline Monday 6th January 2025. Come and work in beautiful Scotland!
www.gla.ac.uk/postgraduate...
www.gla.ac.uk/postgraduate...
Reposted by Abid Hussaini
Someone had to do it! I created a starter pack for #Alzheimer’s #dementia #ADRD researchers on Bluesky. Please let me know who I left out! Hoping more and more of us will join Bluesky
go.bsky.app/22DpUEy
go.bsky.app/22DpUEy
November 15, 2024 at 6:18 PM
Someone had to do it! I created a starter pack for #Alzheimer’s #dementia #ADRD researchers on Bluesky. Please let me know who I left out! Hoping more and more of us will join Bluesky
go.bsky.app/22DpUEy
go.bsky.app/22DpUEy
Reposted by Abid Hussaini
Big update to the Aging Research starter pack. Many new folks joining every day, so challenging to keep up. Related starter packs by @brunetlab.bsky.social and @paigeonthebrain.bsky.social. Networks are built by self-reinforced expansion and amplification.
go.bsky.app/PcreQSa
go.bsky.app/PcreQSa
November 23, 2024 at 8:19 PM
Big update to the Aging Research starter pack. Many new folks joining every day, so challenging to keep up. Related starter packs by @brunetlab.bsky.social and @paigeonthebrain.bsky.social. Networks are built by self-reinforced expansion and amplification.
go.bsky.app/PcreQSa
go.bsky.app/PcreQSa
Reposted by Abid Hussaini
ertorres.bsky.social, Bill Rebeck, and I recently concluded our Research Topic on APOE4-associated heterogeneity in AD. Here’s our editorial summarizing the papers that were published: www.frontiersin.org/journals/agi... Thank you to all the contributors!
ertorres.bsky.social
ertorres.bsky.social
November 19, 2024 at 2:25 PM
ertorres.bsky.social, Bill Rebeck, and I recently concluded our Research Topic on APOE4-associated heterogeneity in AD. Here’s our editorial summarizing the papers that were published: www.frontiersin.org/journals/agi... Thank you to all the contributors!
Reposted by Abid Hussaini
Just published: "Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain", led by Jinyoung Kang and Margaret Schroeder! multiExR enables antibody staining of >20 proteins in a sample w/registration error down to 25 nm. www.nature.com/articles/s41...
Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain - Nature Communications
Mapping the nature of multiprotein nanostructures in cellular contexts remains challenging. Here, Kang and Schroeder et al. report multiplexed expansion revealing, a technique which expands proteins a...
www.nature.com
November 10, 2024 at 10:26 PM
Just published: "Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain", led by Jinyoung Kang and Margaret Schroeder! multiExR enables antibody staining of >20 proteins in a sample w/registration error down to 25 nm. www.nature.com/articles/s41...
Reposted by Abid Hussaini
4) - Increased buildup of amyloid-beta protein, but not tau, in some COVID-19 patients, hinting the virus may trigger an immune response involving amyloid.
The findings indicate severe COVID-19 can induce broad brain changes ...
The findings indicate severe COVID-19 can induce broad brain changes ...
November 16, 2024 at 6:02 AM
4) - Increased buildup of amyloid-beta protein, but not tau, in some COVID-19 patients, hinting the virus may trigger an immune response involving amyloid.
The findings indicate severe COVID-19 can induce broad brain changes ...
The findings indicate severe COVID-19 can induce broad brain changes ...
Reposted by Abid Hussaini
For anyone interested, I wrote this piece recently:
www.thetransmitter.org/sex-differen...
#Alzheimers #womensbrainhealth
www.thetransmitter.org/sex-differen...
#Alzheimers #womensbrainhealth
Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research
New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.
www.thetransmitter.org
November 17, 2024 at 2:25 AM
For anyone interested, I wrote this piece recently:
www.thetransmitter.org/sex-differen...
#Alzheimers #womensbrainhealth
www.thetransmitter.org/sex-differen...
#Alzheimers #womensbrainhealth
Reposted by Abid Hussaini
Our new preprint exploring route planning in London taxi drivers, revealing how they exploit regional boundaries (e.g. Soho) to make more efficient choices
+ performance increases with experience / age (over 30 years...)
Study led by @cgahnstrom.bsky.social
www.biorxiv.org/content/10.1...
+ performance increases with experience / age (over 30 years...)
Study led by @cgahnstrom.bsky.social
www.biorxiv.org/content/10.1...
November 4, 2024 at 12:17 PM
Reposted by Abid Hussaini
Not sure if we've hit critical mass here on bsky yet, but the lab is hiring!
We've gotten some good news grants recently, and now have some funded projects that are looking for people to champion them.
All projects use Holographic Optogenetics to study motor systems.
oldenburglab.com/positions/
We've gotten some good news grants recently, and now have some funded projects that are looking for people to champion them.
All projects use Holographic Optogenetics to study motor systems.
oldenburglab.com/positions/
Positions, Oldenburg Lab
Join the lab We are looking for curious, motivated, and talented people from all different backgrounds to join our team at all levels.
oldenburglab.com
August 13, 2024 at 4:57 PM
Not sure if we've hit critical mass here on bsky yet, but the lab is hiring!
We've gotten some good news grants recently, and now have some funded projects that are looking for people to champion them.
All projects use Holographic Optogenetics to study motor systems.
oldenburglab.com/positions/
We've gotten some good news grants recently, and now have some funded projects that are looking for people to champion them.
All projects use Holographic Optogenetics to study motor systems.
oldenburglab.com/positions/
Reposted by Abid Hussaini
Entorhinal grid-like codes for visual space during memory formation
Neat study from Isabelle Wagner's new group:
www.biorxiv.org/content/10.1...
Neat study from Isabelle Wagner's new group:
www.biorxiv.org/content/10.1...
October 1, 2024 at 3:44 PM
Entorhinal grid-like codes for visual space during memory formation
Neat study from Isabelle Wagner's new group:
www.biorxiv.org/content/10.1...
Neat study from Isabelle Wagner's new group:
www.biorxiv.org/content/10.1...
Reposted by Abid Hussaini
Interested in large scale approaches to large scale spatial navigation?
Come see my talk on our new ManySpaces collaboration: 10/8, 1:30 pm eastern.
Come see my talk on our new ManySpaces collaboration: 10/8, 1:30 pm eastern.
@stevenmweisberg.bsky.social will preview ManySpaces—
We're excited to report that our 2024 conference schedule is now on our website! Check out the amazing line up of presenters and Big Team Science groups. bigteamscienceconference.github.io/program/
#OpenScience #TeamScience #SciSky #PsychSci
#OpenScience #TeamScience #SciSky #PsychSci
September 25, 2024 at 4:48 PM
Interested in large scale approaches to large scale spatial navigation?
Come see my talk on our new ManySpaces collaboration: 10/8, 1:30 pm eastern.
Come see my talk on our new ManySpaces collaboration: 10/8, 1:30 pm eastern.