Johannes Herpell
@herpell.bsky.social
Microbes | Plants | Ecology | Climbing | Cycling | Surfing
Postdoc @mpipz.bsky.social with @hacquardst.bsky.social | Views are my own
Postdoc @mpipz.bsky.social with @hacquardst.bsky.social | Views are my own
Reposted by Johannes Herpell
Great to see this really cool story (see quoted post) published in @newphyt.bsky.social!
nph.onlinelibrary.wiley.com/doi/full/10....
Congratulations @laravdijck.bsky.social, @parkergroup.bsky.social!
Plant-Scopoletin-Fungal Endophyte-Iron
#PlantScience #Coumarin #PlantImmunity #PlantNutrition
nph.onlinelibrary.wiley.com/doi/full/10....
Congratulations @laravdijck.bsky.social, @parkergroup.bsky.social!
Plant-Scopoletin-Fungal Endophyte-Iron
#PlantScience #Coumarin #PlantImmunity #PlantNutrition
August 21, 2025 at 8:56 AM
Great to see this really cool story (see quoted post) published in @newphyt.bsky.social!
nph.onlinelibrary.wiley.com/doi/full/10....
Congratulations @laravdijck.bsky.social, @parkergroup.bsky.social!
Plant-Scopoletin-Fungal Endophyte-Iron
#PlantScience #Coumarin #PlantImmunity #PlantNutrition
nph.onlinelibrary.wiley.com/doi/full/10....
Congratulations @laravdijck.bsky.social, @parkergroup.bsky.social!
Plant-Scopoletin-Fungal Endophyte-Iron
#PlantScience #Coumarin #PlantImmunity #PlantNutrition
Reposted by Johannes Herpell
How can we better understand the plant immune system? In my new @cp-cellhostmicrobe.bsky.social piece, I propose “immune cell states” as a framework for uniting molecular and cellular perspectives.
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
August 13, 2025 at 3:12 PM
How can we better understand the plant immune system? In my new @cp-cellhostmicrobe.bsky.social piece, I propose “immune cell states” as a framework for uniting molecular and cellular perspectives.
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Reposted by Johannes Herpell
Fascinating innate immune evasion strategy in SCIENCE #glycotime
𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘴𝘺𝘳𝘪𝘯𝘨𝘢𝘦 makes GLYCOSIRIN, a novel iminosugar that blocks plant glycosidases from degrading bacterial flagellin—hiding pathogens from plant immune sensors. New cryo-EM insights reveal exactly how this stealthy trick works
𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘴𝘺𝘳𝘪𝘯𝘨𝘢𝘦 makes GLYCOSIRIN, a novel iminosugar that blocks plant glycosidases from degrading bacterial flagellin—hiding pathogens from plant immune sensors. New cryo-EM insights reveal exactly how this stealthy trick works
Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology
The extracellular space (apoplast) in plants is a key battleground during microbial infections. To avoid recognition, the bacterial model phytopathogen Pseudomonas syringae pv. tomato DC3000 produces ...
www.science.org
April 18, 2025 at 5:00 AM
Fascinating innate immune evasion strategy in SCIENCE #glycotime
𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘴𝘺𝘳𝘪𝘯𝘨𝘢𝘦 makes GLYCOSIRIN, a novel iminosugar that blocks plant glycosidases from degrading bacterial flagellin—hiding pathogens from plant immune sensors. New cryo-EM insights reveal exactly how this stealthy trick works
𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘴𝘺𝘳𝘪𝘯𝘨𝘢𝘦 makes GLYCOSIRIN, a novel iminosugar that blocks plant glycosidases from degrading bacterial flagellin—hiding pathogens from plant immune sensors. New cryo-EM insights reveal exactly how this stealthy trick works
Reposted by Johannes Herpell
Nature research paper: Low overlap of transcription factor DNA binding and regulatory targets
https://go.nature.com/4jedGUz
https://go.nature.com/4jedGUz
Low overlap of transcription factor DNA binding and regulatory targets - Nature
A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between their binding sites on DNA and regulation of nearby genes.
go.nature.com
April 17, 2025 at 12:47 PM
Nature research paper: Low overlap of transcription factor DNA binding and regulatory targets
https://go.nature.com/4jedGUz
https://go.nature.com/4jedGUz
Would you like to study metabolite-based microbe-microbe or plant-microbe interactions but do not have the tools to?
@chesneau-g.bsky.social came up with a simple solution with great potential! Check out our new publication in @naturecomms.bsky.social and Guillaume’s 🧵 below for details👇
@chesneau-g.bsky.social came up with a simple solution with great potential! Check out our new publication in @naturecomms.bsky.social and Guillaume’s 🧵 below for details👇
🚨Excited to share our new publication! MetaFlowTrain, a highly parallelized and modular fluidic system to study exometabolite interactions between microbes-microbes-plants 🌱
@hacquardst.bsky.social @herpell.bsky.social S.Wolf S.Perin @mpipz.bsky.social
www.youtube.com/watch?v=gNUf...
🧵Thread 5/5:
@hacquardst.bsky.social @herpell.bsky.social S.Wolf S.Perin @mpipz.bsky.social
www.youtube.com/watch?v=gNUf...
🧵Thread 5/5:
MetaFlowTrain : A Highly-Parallelized and Modular Fluidic System.
YouTube video by Guillaume Chesneau
www.youtube.com
April 11, 2025 at 2:25 PM
Would you like to study metabolite-based microbe-microbe or plant-microbe interactions but do not have the tools to?
@chesneau-g.bsky.social came up with a simple solution with great potential! Check out our new publication in @naturecomms.bsky.social and Guillaume’s 🧵 below for details👇
@chesneau-g.bsky.social came up with a simple solution with great potential! Check out our new publication in @naturecomms.bsky.social and Guillaume’s 🧵 below for details👇
Reposted by Johannes Herpell
📣Paper Alert! 📣New publication out by @hacquardst.bsky.social and his team on the development of MetaFlowTrain – a new tool to study metabolic exchange and interactions within microbial communities @naturecomms.bsky.social 👏🥳Congratulations! 👉https://bit.ly/44jnM1H
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MetaFlowTrain: a highly parallelized and modular fluidic system for studying exometabolite-mediated inter-organismal interactions - Nature Communications
Metabolic interactions shape ecosystems but remain hard to study. Here, authors present MetaFlowTrain, a modular, low-cost fluidic system controlling metabolic fluxes between microbes, and show its va...
www.nature.com
April 10, 2025 at 2:17 PM
📣Paper Alert! 📣New publication out by @hacquardst.bsky.social and his team on the development of MetaFlowTrain – a new tool to study metabolic exchange and interactions within microbial communities @naturecomms.bsky.social 👏🥳Congratulations! 👉https://bit.ly/44jnM1H
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Johannes Herpell
We present MetaFlowTrain, an easy-to-build, highly parallelized, and cost-effective fluidic system for studying microbial exometabolites and their roles in modulating microbe–microbe–host interactions. Kudos to @chesneau-g.bsky.social @mpipz.bsky.social
Give it a try: www.nature.com/articles/s41...
Give it a try: www.nature.com/articles/s41...
April 10, 2025 at 9:59 AM
We present MetaFlowTrain, an easy-to-build, highly parallelized, and cost-effective fluidic system for studying microbial exometabolites and their roles in modulating microbe–microbe–host interactions. Kudos to @chesneau-g.bsky.social @mpipz.bsky.social
Give it a try: www.nature.com/articles/s41...
Give it a try: www.nature.com/articles/s41...
Reposted by Johannes Herpell
How did horses become so athletic? In part, a mutation that should have cut a key protein short instead makes it more sensitive to the stress of exercise. That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪🐴
a brown horse is running across a dry grass field .
ALT: a brown horse is running across a dry grass field .
media.tenor.com
March 28, 2025 at 5:24 PM
How did horses become so athletic? In part, a mutation that should have cut a key protein short instead makes it more sensitive to the stress of exercise. That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪🐴
Reposted by Johannes Herpell
Finally!
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Apoplastic barriers are essential for nodule formation and nitrogen fixation in Lotus japonicus
Establishment of the apoplastic root barrier known as the Casparian strip occurs early in root development. In legumes, this area overlaps with nitrogen-fixing nodule formation, which raises the possi...
www.science.org
March 21, 2025 at 5:53 AM
Finally!
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Reposted by Johannes Herpell
📣Paper Alert! New publication @science.org by the group of @tonnigrubeandersen.bsky.social @mpipz.bsky.social, colleagues @ucph.bsky.social & others on the Casparian strip and its role in metabolic trade between plants & bacteria. 👏Learn more 👉https://bit.ly/4bJe4Yd
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Apoplastic barriers are essential for nodule formation and nitrogen fixation in Lotus japonicus
Establishment of the apoplastic root barrier known as the Casparian strip occurs early in root development. In legumes, this area overlaps with nitrogen-fixing nodule formation, which raises the possi...
www.science.org
March 21, 2025 at 9:52 AM
📣Paper Alert! New publication @science.org by the group of @tonnigrubeandersen.bsky.social @mpipz.bsky.social, colleagues @ucph.bsky.social & others on the Casparian strip and its role in metabolic trade between plants & bacteria. 👏Learn more 👉https://bit.ly/4bJe4Yd
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Johannes Herpell
We're looking for a postdoc to join the lab to work on cell-to-cell communication via the apoplast. Candidate must be brave, as they will have to lead us (me) away from the plasmodesmata-lands we've inhabited for so long!
www.jic.ac.uk/vacancies/po...
www.jic.ac.uk/vacancies/po...
Postdoctoral Researcher (Faulkner Group) | John Innes Centre
An exciting opportunity has arisen for a Postdoctoral Researcher to join the Faulkner Group at the John Innes Centre, working on cutting-edge science in the field of Cell & Developmental Biology.
www.jic.ac.uk
March 11, 2025 at 11:57 AM
We're looking for a postdoc to join the lab to work on cell-to-cell communication via the apoplast. Candidate must be brave, as they will have to lead us (me) away from the plasmodesmata-lands we've inhabited for so long!
www.jic.ac.uk/vacancies/po...
www.jic.ac.uk/vacancies/po...
Reposted by Johannes Herpell
Poke bacteria with a sharp needle and they poke back in just a few seconds!
Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage!
Collaboration with Rod Lim's lab @biozentrum.unibas.ch
www.science.org/doi/10.1126/...
Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage!
Collaboration with Rod Lim's lab @biozentrum.unibas.ch
www.science.org/doi/10.1126/...
March 5, 2025 at 10:41 PM
Poke bacteria with a sharp needle and they poke back in just a few seconds!
Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage!
Collaboration with Rod Lim's lab @biozentrum.unibas.ch
www.science.org/doi/10.1126/...
Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage!
Collaboration with Rod Lim's lab @biozentrum.unibas.ch
www.science.org/doi/10.1126/...
Reposted by Johannes Herpell
🧪 Homo erectus crafted specialized tools out of the bones of elephants and hippos. Read all about it in my latest for Nature. #scicom #paleo www.nature.com/articles/d41...
Ancient humans used bone tools one million years earlier than thought
Objects discovered in Tanzania and dated to 1.5 million years ago help to rewrite human ancestors’ use of carved bone implements.
www.nature.com
March 5, 2025 at 4:24 PM
🧪 Homo erectus crafted specialized tools out of the bones of elephants and hippos. Read all about it in my latest for Nature. #scicom #paleo www.nature.com/articles/d41...
Reposted by Johannes Herpell
Wow, cAMP production appears to be the key for activating canonical auxin signalling, not AUX/IAA degradation!
Also annoying - I need to revise quite a many teaching slides to update auxin signalling 😀
www.nature.com/articles/s41...
Also annoying - I need to revise quite a many teaching slides to update auxin signalling 😀
www.nature.com/articles/s41...
TIR1-produced cAMP as a second messenger in transcriptional auxin signalling - Nature
cAMP produced by the TIR1/AFB receptors of the main endogenous developmental plant hormone auxin acts as a true second messenger, revising the established paradigm of transcriptional auxin signalling.
www.nature.com
March 5, 2025 at 4:39 PM
Wow, cAMP production appears to be the key for activating canonical auxin signalling, not AUX/IAA degradation!
Also annoying - I need to revise quite a many teaching slides to update auxin signalling 😀
www.nature.com/articles/s41...
Also annoying - I need to revise quite a many teaching slides to update auxin signalling 😀
www.nature.com/articles/s41...
Reposted by Johannes Herpell
🚨New paper published in @nature.com! Using pan-genetics across the Solanum genus🍅🥔🍆we reveal why gene duplications🧬are major contingencies in crop engineering. My postdoc work in the Lippman lab @CSHL, collab. with @katiejenike.bsky.social @mikeschatz.bsky.social chatz.bsky.social and many others!
Solanum pan-genetics reveals paralogues as contingencies in crop engineering - Nature
Gene duplication and subsequent paralogue diversification are major obstacles to genotype-to-phenotype predictability.
nature.com
March 5, 2025 at 4:43 PM
🚨New paper published in @nature.com! Using pan-genetics across the Solanum genus🍅🥔🍆we reveal why gene duplications🧬are major contingencies in crop engineering. My postdoc work in the Lippman lab @CSHL, collab. with @katiejenike.bsky.social @mikeschatz.bsky.social chatz.bsky.social and many others!
Reposted by Johannes Herpell
📌Vacancy at the University of Amsterdam!
Join us at the Green Life Sciences with three open positions by my colleagues. 🌱🌻
1/3
PhD position on "Microbial Host Preference in Plant Stress Resilience" in the group of Dr. Kathrin Wippel: werkenbij.uva.nl/en/vacancies...
Join us at the Green Life Sciences with three open positions by my colleagues. 🌱🌻
1/3
PhD position on "Microbial Host Preference in Plant Stress Resilience" in the group of Dr. Kathrin Wippel: werkenbij.uva.nl/en/vacancies...
Vacancy — PhD Candidate Microbial Host Preference in Plant Stress Resilience
Are you an early-career researcher with a passion for plant science? Would you like to apply your enthusiasm to a highly relevant project in the field of plant-microbiome interactions? Then we have th...
werkenbij.uva.nl
February 24, 2025 at 4:53 PM
📌Vacancy at the University of Amsterdam!
Join us at the Green Life Sciences with three open positions by my colleagues. 🌱🌻
1/3
PhD position on "Microbial Host Preference in Plant Stress Resilience" in the group of Dr. Kathrin Wippel: werkenbij.uva.nl/en/vacancies...
Join us at the Green Life Sciences with three open positions by my colleagues. 🌱🌻
1/3
PhD position on "Microbial Host Preference in Plant Stress Resilience" in the group of Dr. Kathrin Wippel: werkenbij.uva.nl/en/vacancies...
Reposted by Johannes Herpell
Congratulations to Jana Ordon and all coauthors!!! Our new study is published in @natureplants.bsky.social
"Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota" (0/n)
rdcu.be/eauzt
"Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota" (0/n)
rdcu.be/eauzt
Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota
Nature Plants - The authors show that immunosuppression is highly conserved in the bacterial order Xanthomonadales. This feature, which preceded their specialization as host-adapted pathogens,...
rdcu.be
February 20, 2025 at 9:44 AM
Congratulations to Jana Ordon and all coauthors!!! Our new study is published in @natureplants.bsky.social
"Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota" (0/n)
rdcu.be/eauzt
"Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota" (0/n)
rdcu.be/eauzt
Reposted by Johannes Herpell
Please read here about our collaborative work with Ag Kudla @uni-muenster.de on the phosphocode of these two Calcium-dependent kinases. With the power of MS-based functional #proteomics www.science.org/doi/10.1126/...
A bi-kinase module sensitizes and potentiates plant immune signaling
Mutual activation of a Ca2+ sensing bi-kinase module potentiates NADPH oxidase activation to facilitate systemic immunity.
www.science.org
February 18, 2025 at 10:24 AM
Please read here about our collaborative work with Ag Kudla @uni-muenster.de on the phosphocode of these two Calcium-dependent kinases. With the power of MS-based functional #proteomics www.science.org/doi/10.1126/...
Reposted by Johannes Herpell
Happy to share this viewpoint, written together with @fabriceroux7.bsky.social and Fabienne Vailleau @lipme-toulouse.bsky.social
nph.onlinelibrary.wiley.com/doi/10.1111/...
1/4
nph.onlinelibrary.wiley.com/doi/10.1111/...
1/4
Building microbial synthetic communities: get inspired by the design of synthetic plant communities
In the last decade, the generation of host-associated microbial culture collections has allowed the fine disentangling of complex relationships between commensal microbes and their hosts, and within-...
nph.onlinelibrary.wiley.com
February 17, 2025 at 4:25 PM
Happy to share this viewpoint, written together with @fabriceroux7.bsky.social and Fabienne Vailleau @lipme-toulouse.bsky.social
nph.onlinelibrary.wiley.com/doi/10.1111/...
1/4
nph.onlinelibrary.wiley.com/doi/10.1111/...
1/4
Reposted by Johannes Herpell
I’m super happy to have a great part of my PhD work (under the wonderful supervision of C. Libourel @pierremarcdelaux.bsky.social & @maximebonhomme.bsky.social) now out in @naturegenet.bsky.social !
Here’s a little thread (1/18)
www.nature.com/articles/s41...
Here’s a little thread (1/18)
www.nature.com/articles/s41...
The Marchantia polymorpha pangenome reveals ancient mechanisms of plant adaptation to the environment - Nature Genetics
Pangenome analyses of 133 wild accessions of the model bryophyte Marchantia polymorpha identify adaptive features and provide insights into the mechanisms of plant adaptation to the terrestrial enviro...
www.nature.com
February 17, 2025 at 10:29 AM
I’m super happy to have a great part of my PhD work (under the wonderful supervision of C. Libourel @pierremarcdelaux.bsky.social & @maximebonhomme.bsky.social) now out in @naturegenet.bsky.social !
Here’s a little thread (1/18)
www.nature.com/articles/s41...
Here’s a little thread (1/18)
www.nature.com/articles/s41...
Reposted by Johannes Herpell
We continue to build the Plant Microbiome Starter Pack. Please let us know if you or others are missing! go.bsky.app/QG4wCyf
February 17, 2025 at 7:47 AM
We continue to build the Plant Microbiome Starter Pack. Please let us know if you or others are missing! go.bsky.app/QG4wCyf
Reposted by Johannes Herpell
Have a look at our new story on how Bacterial Cellulose works miracles in plant wound healing by activating regeneration via concurrent activation of ROS, defense and cytokinin signalling. In collaboration with @cbgpmadrid.bsky.social @icmabcsic.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Exogenous bacterial cellulose induces plant tissue regeneration through the regulation of cytokinin and defense networks
Bacterial cellulose application concurrently targets cytokinin- and ROS-associated defense responses to induce plant regeneration.
www.science.org
February 12, 2025 at 10:21 PM
Have a look at our new story on how Bacterial Cellulose works miracles in plant wound healing by activating regeneration via concurrent activation of ROS, defense and cytokinin signalling. In collaboration with @cbgpmadrid.bsky.social @icmabcsic.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Johannes Herpell
🔊Paper Alert - New publication out @nature.com by the Parker Lab @mpipz.bsky.social and colleagues at Westlake University on the fine tuning of plant immunity regulation 🌿🪴Congratulations 👏 👏 Learn more here 👉 bit.ly/3WZjrfw #plantsci #immunity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Balanced plant helper NLR activation by a modified host protein complex - Nature
In Arabidopsis, mechanisms for NRG1A activation by recognition of a modified host EDS1–SAG101 complex, and NRG1A inhibition by NRG1C through sequestration of activated EDS1–SAG101, show activation and...
www.nature.com
February 13, 2025 at 9:23 AM
🔊Paper Alert - New publication out @nature.com by the Parker Lab @mpipz.bsky.social and colleagues at Westlake University on the fine tuning of plant immunity regulation 🌿🪴Congratulations 👏 👏 Learn more here 👉 bit.ly/3WZjrfw #plantsci #immunity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Johannes Herpell
Evolution of interorganismal strigolactone biosynthesis in seed plants www.science.org/doi/10.1126/...
Evolution of interorganismal strigolactone biosynthesis in seed plants
Strigolactones (SLs) are methylbutenolide molecules derived from β-carotene through an intermediate carlactonoic acid (CLA). Canonical SLs act as signals to microbes and plants, whereas noncanonical S...
www.science.org
January 17, 2025 at 7:43 PM
Evolution of interorganismal strigolactone biosynthesis in seed plants www.science.org/doi/10.1126/...
Reposted by Johannes Herpell
I'm very happy to report that Matt Schechter's PhD work is now online as a pre-print:
"Ribosomal protein phylogeography offers quantitative insights into the efficacy of genome-resolved surveys of microbial communities", www.biorxiv.org/content/10.1...
Here's a little 🧵 about it.
"Ribosomal protein phylogeography offers quantitative insights into the efficacy of genome-resolved surveys of microbial communities", www.biorxiv.org/content/10.1...
Here's a little 🧵 about it.
January 17, 2025 at 3:31 PM
I'm very happy to report that Matt Schechter's PhD work is now online as a pre-print:
"Ribosomal protein phylogeography offers quantitative insights into the efficacy of genome-resolved surveys of microbial communities", www.biorxiv.org/content/10.1...
Here's a little 🧵 about it.
"Ribosomal protein phylogeography offers quantitative insights into the efficacy of genome-resolved surveys of microbial communities", www.biorxiv.org/content/10.1...
Here's a little 🧵 about it.