Michael Thompson
@hepatocrinologist.bsky.social
Pediatric endocrinology physician scientist, liver disease researcher, husband, father
Reposted by Michael Thompson
Cristina Llorente et al NATURE
GI tract immune “gates” called goblet cell antigen passages (GAPs) need the muscarinic acetylcholine receptor M4
Alcohol silences M4 allowing bacteria to leak to the liver
Repurposing M4 agonists may restore innate immunity and prevent alcoholic liver disease
🧵1/2
GI tract immune “gates” called goblet cell antigen passages (GAPs) need the muscarinic acetylcholine receptor M4
Alcohol silences M4 allowing bacteria to leak to the liver
Repurposing M4 agonists may restore innate immunity and prevent alcoholic liver disease
🧵1/2
August 27, 2025 at 11:53 AM
Cristina Llorente et al NATURE
GI tract immune “gates” called goblet cell antigen passages (GAPs) need the muscarinic acetylcholine receptor M4
Alcohol silences M4 allowing bacteria to leak to the liver
Repurposing M4 agonists may restore innate immunity and prevent alcoholic liver disease
🧵1/2
GI tract immune “gates” called goblet cell antigen passages (GAPs) need the muscarinic acetylcholine receptor M4
Alcohol silences M4 allowing bacteria to leak to the liver
Repurposing M4 agonists may restore innate immunity and prevent alcoholic liver disease
🧵1/2
Lucky to be supported by a great society!
For August, the ASIP calendar features the 2024 Sanfilippo Visiting Lectureship Program Awardees: Drs. de la Puente (USD), Love-Rutledge (UA, Huntsville), Parry (@uncg.edu), and Thompson (@washumedicine.bsky.social)
August 14, 2025 at 9:21 PM
Lucky to be supported by a great society!
Great society. Great meeting. Can’t miss. @asipath.bsky.social
We're heading down South! #Pathobiology2026 will take place from May 16 to 19 at the Luminary Hotel & Co. Caloosa Sound Convention Center in Fort Myers, FL! Mark your calendar—more information will be available soon
August 7, 2025 at 12:45 AM
Great society. Great meeting. Can’t miss. @asipath.bsky.social
Reposted by Michael Thompson
We're heading down South! #Pathobiology2026 will take place from May 16 to 19 at the Luminary Hotel & Co. Caloosa Sound Convention Center in Fort Myers, FL! Mark your calendar—more information will be available soon
August 6, 2025 at 6:15 PM
We're heading down South! #Pathobiology2026 will take place from May 16 to 19 at the Luminary Hotel & Co. Caloosa Sound Convention Center in Fort Myers, FL! Mark your calendar—more information will be available soon
Exciting study assessing the infant gut microbiome in the US! Early life shifts could be a driver of non-communicable disease susceptibility. @commsbio.nature.com
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Bifidobacterium deficit in United States infants drives prevalent gut dysbiosis - Communications Biology
The My Baby Biome Study demonstrates that three gut microbiome community clusters exist in infants in the United States. These compositions vary on the prevalence and abundance of Bifidobacterium and ...
www.nature.com
June 25, 2025 at 3:59 PM
Exciting study assessing the infant gut microbiome in the US! Early life shifts could be a driver of non-communicable disease susceptibility. @commsbio.nature.com
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Michael Thompson
He's right. "Nothing short of devastating"
By @holdenthorp.bsky.social @science.org
www.science.org/doi/10.1126/...
By @holdenthorp.bsky.social @science.org
www.science.org/doi/10.1126/...
June 5, 2025 at 8:41 PM
He's right. "Nothing short of devastating"
By @holdenthorp.bsky.social @science.org
www.science.org/doi/10.1126/...
By @holdenthorp.bsky.social @science.org
www.science.org/doi/10.1126/...
Looking forward to this session tomorrow morning!!! @asipath.bsky.social
These speakers from @ohsunews.bsky.social and @uoregon.bsky.social are leaders in the field studying how developmental programming applies to offspring #MetabolicDisease and provide insight on how early life events contribute to #pathophysiology! Full #Pathobiology2025 program bit.ly/3yOeuxu
April 28, 2025 at 5:20 AM
Looking forward to this session tomorrow morning!!! @asipath.bsky.social
First couple days of #pathobiology2025 have been great. Always appreciate the supportive and trainee forward environment of @asipath.bsky.social!!
April 27, 2025 at 9:54 PM
First couple days of #pathobiology2025 have been great. Always appreciate the supportive and trainee forward environment of @asipath.bsky.social!!
Reposted by Michael Thompson
Early-onset colorectal cancer has doubled in 20 years—why?
New 𝘕𝘢𝘵𝘶𝘳𝘦 study from Díaz-Gay et al Ludmil Alexandrov lab here @UCSanDiego discovers mutational clues:
Exposure to bacteria-derived colibactin leaves a genetic imprint, especially in tumors from young people and high-incidence countries
New 𝘕𝘢𝘵𝘶𝘳𝘦 study from Díaz-Gay et al Ludmil Alexandrov lab here @UCSanDiego discovers mutational clues:
Exposure to bacteria-derived colibactin leaves a genetic imprint, especially in tumors from young people and high-incidence countries
Damage from gut bacteria may play a role in the rise in colon cancer in young adults
Scientists have a new clue in the mystery of why younger people are getting more colon cancer. It may have to do with a toxin produced by a common gut microbe.
www.npr.org
April 25, 2025 at 6:48 PM
Early-onset colorectal cancer has doubled in 20 years—why?
New 𝘕𝘢𝘵𝘶𝘳𝘦 study from Díaz-Gay et al Ludmil Alexandrov lab here @UCSanDiego discovers mutational clues:
Exposure to bacteria-derived colibactin leaves a genetic imprint, especially in tumors from young people and high-incidence countries
New 𝘕𝘢𝘵𝘶𝘳𝘦 study from Díaz-Gay et al Ludmil Alexandrov lab here @UCSanDiego discovers mutational clues:
Exposure to bacteria-derived colibactin leaves a genetic imprint, especially in tumors from young people and high-incidence countries
Reposted by Michael Thompson
Steve Kerr wore a Harvard basketball shirt after the Warriors’ win tonight: “Yes, this is me supporting Harvard. Way to go. Way to stand up to the bully.”
April 16, 2025 at 7:09 AM
Steve Kerr wore a Harvard basketball shirt after the Warriors’ win tonight: “Yes, this is me supporting Harvard. Way to go. Way to stand up to the bully.”
Reposted by Michael Thompson
We've greatly underestimated the role of the gut microbiome in fatty liver disease (MASLD). This open-access outstanding review @jclinical-invest.bsky.social is illuminating
www.jci.org/articles/vie...
www.jci.org/articles/vie...
April 6, 2025 at 4:50 PM
We've greatly underestimated the role of the gut microbiome in fatty liver disease (MASLD). This open-access outstanding review @jclinical-invest.bsky.social is illuminating
www.jci.org/articles/vie...
www.jci.org/articles/vie...