Haider Manzer
@haidermanzer.bsky.social
Postdoc in the Zackular lab at CHOP. PhD from the Doran Lab. Interested in early life host-pathogen interactions. BWF PDEP Fellow. He/Him.
Reposted by Haider Manzer
Thrilled to share @alex-dobrila.bsky.social’s new review in Infection & Immunity on how butyrate shapes C. difficile pathogenesis. A must-read for those interested in microbiome–pathogen interactions. 👉 journals.asm.org/doi/10.1128/...
The emerging view on the roles of butyrate in Clostridioides difficile pathogenesis | Infection and Immunity
The Centers for Disease Control and Prevention classifies Clostridioides difficile as an urgent threat to the nation’s health, as it causes 450,000 infections, 15,000 deaths, and 1 billion dollars in excess healthcare costs per year in the United States (1, 2). Most C. difficile infections (CDIs) occur in healthcare settings, where CDI is the most common cause of infectious diarrhea (3). Known and suspected risk factors for CDI include antibiotics, proton pump inhibitors, impaired immune function, advanced age, and diet, all of which are associated with dysbiotic gastrointestinal (GI) microbiomes (4–6). Though most CDIs are associated with antibiotic treatment, 22% of individuals with community-acquired CDI have no recent history of antibiotic use. Factors affecting persistent and recurrent CDIs remain poorly defined (7, 8). Despite the morbidity and mortality caused by C. difficile, up to 15% of healthy adults are asymptomatic carriers of toxigenic C. difficile (9), highlighting the gaps in our understanding of C. difficile.
journals.asm.org
September 24, 2025 at 5:08 PM
Thrilled to share @alex-dobrila.bsky.social’s new review in Infection & Immunity on how butyrate shapes C. difficile pathogenesis. A must-read for those interested in microbiome–pathogen interactions. 👉 journals.asm.org/doi/10.1128/...
Reposted by Haider Manzer
Excited to share our recent review in which @rcglover.bsky.social, @joeyzacks.bsky.social, @bordenlacy.bsky.social, and I discuss current advances in our understanding of immunity to C. difficile infection and what it will take to develop an effective vaccine 💉
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Immune Aspects of Clostridioides difficile Infection and Vaccine Development
www.sciencedirect.com
August 28, 2025 at 9:27 PM
Excited to share our recent review in which @rcglover.bsky.social, @joeyzacks.bsky.social, @bordenlacy.bsky.social, and I discuss current advances in our understanding of immunity to C. difficile infection and what it will take to develop an effective vaccine 💉
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Haider Manzer
Excited to share this collaborative study with @ritatamayo.bsky.social showing that E. faecalis influences C. diff morphology through the phase variable CmrRST system! This work was co-led by the amazing team of @ashleyweiss.bsky.social and Jilarie Santos-Santiago!
Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1
July 26, 2025 at 3:08 AM
Excited to share this collaborative study with @ritatamayo.bsky.social showing that E. faecalis influences C. diff morphology through the phase variable CmrRST system! This work was co-led by the amazing team of @ashleyweiss.bsky.social and Jilarie Santos-Santiago!
Reposted by Haider Manzer
I’m excited to share my recent study from the labs of @joeyzacks.bsky.social and @ritatamayo.bsky.social on the impact of E.faecalis on phase variable behaviors in C.difficile. This work was achieved through amazing co-leadership with PhD candidate Jilarie Santos-Santiago.
Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1
August 12, 2025 at 11:12 PM
I’m excited to share my recent study from the labs of @joeyzacks.bsky.social and @ritatamayo.bsky.social on the impact of E.faecalis on phase variable behaviors in C.difficile. This work was achieved through amazing co-leadership with PhD candidate Jilarie Santos-Santiago.
I’m extremely honored to be included with this amazing group of scientists as a recipient of the 2025 BWF PDEP award!
BWF is proud to announce the 2025 recipients of its Postdoctoral Diversity Enrichment Program (PDEP), which provides critical support to postdoctoral researchers pursuing careers in biomedical and medical research. www.bwfund.org/news/bwf-ann... #bwfpdep
BWF Announces 2025 Postdoctoral Diversity Enrichment Program Recipients - Burroughs Wellcome Fund
Research Triangle Park, N.C. — The Burroughs Wellcome Fund (BWF) is proud to announce the 2025 recipients of its Postdoctoral Diversity Enrichment Program (PDEP), which provides critical support to…
www.bwfund.org
July 9, 2025 at 4:30 PM
I’m extremely honored to be included with this amazing group of scientists as a recipient of the 2025 BWF PDEP award!
Reposted by Haider Manzer
Congratulations to @haidermanzer.bsky.social on being awarded the @bwfund.bsky.social Postdoc Diversity Enrichment Program Award!! So well deserved - we are very proud here in the Zackular Lab!
BWF is proud to announce the 2025 recipients of its Postdoctoral Diversity Enrichment Program (PDEP), which provides critical support to postdoctoral researchers pursuing careers in biomedical and medical research. www.bwfund.org/news/bwf-ann... #bwfpdep
BWF Announces 2025 Postdoctoral Diversity Enrichment Program Recipients - Burroughs Wellcome Fund
Research Triangle Park, N.C. — The Burroughs Wellcome Fund (BWF) is proud to announce the 2025 recipients of its Postdoctoral Diversity Enrichment Program (PDEP), which provides critical support to…
www.bwfund.org
July 9, 2025 at 4:26 PM
Congratulations to @haidermanzer.bsky.social on being awarded the @bwfund.bsky.social Postdoc Diversity Enrichment Program Award!! So well deserved - we are very proud here in the Zackular Lab!
Reposted by Haider Manzer
Incredibly honored to be selected as a @bwfund.bsky.social Investigator in the Pathogenesis of Infectious Disease. Thank you to @bwfund.bsky.social for supporting our work - I am thrilled to join this amazing community! And special thank you to my AMAZING team (past & present) for getting us here!
Announcing the 2025 Investigators in the Pathogenesis of Infectious Disease www.bwfund.org/news/announc... #bwfpath
Announcing the 2025 Investigators in the Pathogenesis of Infectious Disease - Burroughs Wellcome Fund
DURHAM, N.C. – The Burroughs Wellcome Fund proudly announces the 2025 Investigators in the Pathogenesis of Infectious Disease (PATH) award recipients. This year’s cohort represents a diverse group of…
www.bwfund.org
May 23, 2025 at 5:22 PM
Incredibly honored to be selected as a @bwfund.bsky.social Investigator in the Pathogenesis of Infectious Disease. Thank you to @bwfund.bsky.social for supporting our work - I am thrilled to join this amazing community! And special thank you to my AMAZING team (past & present) for getting us here!
Reposted by Haider Manzer
Excited to share our new work in @aga-gastro.bsky.social! We show that dietary fiber alters the window of susceptibility to C. difficile following antibiotic exposure. This really fantastic study was co-led by an amazing team @rinniehewlett.bsky.social @alhecht.bsky.social and Amanda PeBenito.
Dietary fiber modulates the window of susceptibility to Clostridioides difficile infection
Clostridioides difficile epidemiology is rapidly evolving, and understanding the factors
that contribute to one’s risk of C. difficile infection (CDI) is urgently needed.
Based on our observations in ...
www.gastrojournal.org
May 16, 2025 at 9:20 PM
Excited to share our new work in @aga-gastro.bsky.social! We show that dietary fiber alters the window of susceptibility to C. difficile following antibiotic exposure. This really fantastic study was co-led by an amazing team @rinniehewlett.bsky.social @alhecht.bsky.social and Amanda PeBenito.
Reposted by Haider Manzer
Important: if a bug does not make the WHO's priority list, this does not mean it is not relevant. We present arguments why investment in R&D for surveillance, control and treatment of C. difficile (CDI) is of critical importance: www.sciencedirect.com/science/arti...
Clostridioides difficile is a bacterial priority pathogen
www.sciencedirect.com
May 14, 2025 at 7:40 AM
Important: if a bug does not make the WHO's priority list, this does not mean it is not relevant. We present arguments why investment in R&D for surveillance, control and treatment of C. difficile (CDI) is of critical importance: www.sciencedirect.com/science/arti...
Reposted by Haider Manzer
New preprint out! Here, we find that glycolipids and lipoteichoic acid alanylation are critical for Group B Strep survival against neutrophil killing during diabetic wound infection. We also define GBS-neutrophil interactions in this niche.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Global genome analysis identifies glycolipids and lipoteichoic acid alanylation as contributors to Group B streptococcal diabetic wound infection
Individuals with diabetes frequently develop chronic, hyper-inflammatory, non-healing wounds, which are the leading cause of all non-traumatic amputations. Group B Streptococcus (GBS) is a prominent b...
www.biorxiv.org
May 5, 2025 at 4:19 PM
New preprint out! Here, we find that glycolipids and lipoteichoic acid alanylation are critical for Group B Strep survival against neutrophil killing during diabetic wound infection. We also define GBS-neutrophil interactions in this niche.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Haider Manzer
ASM stands firm in its commitment to diversity, equity and inclusion, as such efforts are critical to advancing the microbial sciences for everyone. Read our statement: asm.org/Press-Releas...
ASM’s Commitment to Diversity, Equity and Inclusion
The American Society for Microbiology stands firm in its commitment to diversity, equity and inclusion, as such efforts are critical to advancing the microbial sciences for everyone.
asm.org
February 15, 2025 at 12:34 AM
ASM stands firm in its commitment to diversity, equity and inclusion, as such efforts are critical to advancing the microbial sciences for everyone. Read our statement: asm.org/Press-Releas...
Reposted by Haider Manzer
Excited to share our latest work led by Josh Soto Ocaña & Elliot Friedman in mBio today! Together with Gary Wu's team at UPenn, we suggest metals may be an important nutritional factor shaping early life microbial ecology in infants.
Metal availability shapes early life microbial ecology and community succession | mBio
Early life represents a critical window for microbial colonization of the human gastrointestinal
tract. Surprisingly, we still know little about the rules that govern the successful
colonization of in...
journals.asm.org
October 23, 2024 at 4:30 PM
Excited to share our latest work led by Josh Soto Ocaña & Elliot Friedman in mBio today! Together with Gary Wu's team at UPenn, we suggest metals may be an important nutritional factor shaping early life microbial ecology in infants.
Reposted by Haider Manzer
We are in our fifth year of NSURP, and we couldn't have done it without the mentors. You all help make this program great. We are once again calling on you. Visit NSURP.org to sign up as a mentor today. This is a great mentorship opportunity for trainees. Looking forward to seeing you this summer!
March 27, 2024 at 5:24 PM
We are in our fifth year of NSURP, and we couldn't have done it without the mentors. You all help make this program great. We are once again calling on you. Visit NSURP.org to sign up as a mentor today. This is a great mentorship opportunity for trainees. Looking forward to seeing you this summer!
Reposted by Haider Manzer
I’m so excited to see my undergraduate lab’s work published in #NatureMicrobiology ! It was a pleasure to work on this project with Dr. Brantley Hall and Dr. Xiaofang Xiang, and congratulations to the entire team! www.nature.com/articles/s41...
BilR is a gut microbial enzyme that reduces bilirubin to urobilinogen - Nature Microbiology
BilR is identified as a bilirubin reductase encoded by gut bacteria, which reduces bilirubin to urobilinogen.
www.nature.com
January 9, 2024 at 9:09 PM
I’m so excited to see my undergraduate lab’s work published in #NatureMicrobiology ! It was a pleasure to work on this project with Dr. Brantley Hall and Dr. Xiaofang Xiang, and congratulations to the entire team! www.nature.com/articles/s41...
Reposted by Haider Manzer
December 13, 2023 at 3:38 PM
Reposted by Haider Manzer
Excited to share the latest from our lab, led by Alex Smith, out in mBio! Alex shows how Enterococci take advantage of C. diff toxin-mediated damage to thrive in the gut. Fun collaborative study with @dariavantyne.bsky.social Boone Prentice, Ahmed Moustafa, and team! journals.asm.org/doi/10.1128/...
December 11, 2023 at 3:40 PM
Excited to share the latest from our lab, led by Alex Smith, out in mBio! Alex shows how Enterococci take advantage of C. diff toxin-mediated damage to thrive in the gut. Fun collaborative study with @dariavantyne.bsky.social Boone Prentice, Ahmed Moustafa, and team! journals.asm.org/doi/10.1128/...
I’m using my first Bluesky post to announce that my third thesis chapter is out! This one was so much fun to work on with Kelly Doran. I’ve always been fascinated by bacterial DNA methylation regulating gene expression, and got to study how it impacts GBS vaginal colonization:
Identification of a DNA-cytosine methyltransferase that impacts global transcription to promote grou...
Group B Streptococcus (GBS) colonizes the female reproductive tract (FRT) in one-third of women, and carriage
leads to numerous adverse pregnancy outcomes including the preterm premature rupture
of me...
journals.asm.org
November 1, 2023 at 12:16 PM
I’m using my first Bluesky post to announce that my third thesis chapter is out! This one was so much fun to work on with Kelly Doran. I’ve always been fascinated by bacterial DNA methylation regulating gene expression, and got to study how it impacts GBS vaginal colonization: