Hafting-Fyhn Lab
@hafting.bsky.social
Systems neuroscience at University of Oslo
No GPS in the head? Path integration by entorhinal grid cells without the grid pattern. Interesting paper from Heidelberg. www.nature.com/articles/s41...
Grid cells accurately track movement during path integration-based navigation despite switching reference frames - Nature Neuroscience
Grid cells do not maintain a stable pattern during a self-motion-based task, but track animal movement in multiple local reference frames and reanchor to task-relevant objects, thus estimating local r...
www.nature.com
October 30, 2025 at 4:03 PM
No GPS in the head? Path integration by entorhinal grid cells without the grid pattern. Interesting paper from Heidelberg. www.nature.com/articles/s41...
Reposted by Hafting-Fyhn Lab
New paper out with @hafting.bsky.social and @markandermann.bsky.social lab on reactivations and memory consolidation : www.science.org/doi/10.1126/...
Local inhibitory circuits mediate cortical reactivations and memory consolidation
Reducing inhibitory activity after training prevents cortical reactivations and memory consolidation.
www.science.org
June 2, 2025 at 3:54 PM
New paper out with @hafting.bsky.social and @markandermann.bsky.social lab on reactivations and memory consolidation : www.science.org/doi/10.1126/...
Great talk by David Olson UCDavis yesterday at UCSD. Impressive voyage through drug discovery, chemistry and systems neuroscience. www.science.org/doi/10.1126/...
May 22, 2025 at 7:13 PM
Great talk by David Olson UCDavis yesterday at UCSD. Impressive voyage through drug discovery, chemistry and systems neuroscience. www.science.org/doi/10.1126/...
Reposted by Hafting-Fyhn Lab
Harvard today, your institution tomorrow.
It's all part of the Project 2025 plan to destroy high education in America.
All leading US universities depend on federal funding and tuition dollars from international students. They severely curtailed the former. Now they're eliminating the latter.
It's all part of the Project 2025 plan to destroy high education in America.
All leading US universities depend on federal funding and tuition dollars from international students. They severely curtailed the former. Now they're eliminating the latter.
May 22, 2025 at 6:38 PM
Harvard today, your institution tomorrow.
It's all part of the Project 2025 plan to destroy high education in America.
All leading US universities depend on federal funding and tuition dollars from international students. They severely curtailed the former. Now they're eliminating the latter.
It's all part of the Project 2025 plan to destroy high education in America.
All leading US universities depend on federal funding and tuition dollars from international students. They severely curtailed the former. Now they're eliminating the latter.
New preprint out in eLife! Neurons in medical entorhinal cortex (MEC) develop responses to visual cues and reward as mice learn a visual Go/NoGo task. elifesciences.org/reviewed-pre...
May 13, 2025 at 6:03 PM
New preprint out in eLife! Neurons in medical entorhinal cortex (MEC) develop responses to visual cues and reward as mice learn a visual Go/NoGo task. elifesciences.org/reviewed-pre...
Reposted by Hafting-Fyhn Lab
Check out the full paper here: www.nature.com/articles/s41...
Goal-specific hippocampal inhibition gates learning - Nature
Parvalbumin-positive interneurons in the hippocampal CA3 substantially reduce firing on approach to and at goal locations while food-deprived mice learn to find food.
www.nature.com
April 9, 2025 at 6:28 PM
Check out the full paper here: www.nature.com/articles/s41...
Knockout of aggrecan in PV+ interneurons eliminate the expression of PNNs labeled by WFA. KO animals showed similar long-term memory as controls, but showed lower level of anxiety-related behavior in an open field and zero maze. www.nature.com/articles/s41...
Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function - Molecular Psychiatry
Molecular Psychiatry - Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function
www.nature.com
February 3, 2025 at 2:39 AM
Knockout of aggrecan in PV+ interneurons eliminate the expression of PNNs labeled by WFA. KO animals showed similar long-term memory as controls, but showed lower level of anxiety-related behavior in an open field and zero maze. www.nature.com/articles/s41...
Reposted by Hafting-Fyhn Lab
Fascinating new study: The visual cortex in people (like me!! 👋) with #aphantasia processes visual info but doesn’t translate it into conscious images. This disconnect explains why they can “know” details (like layouts) without “seeing” them—mental pictures don’t fully form. (Can confirm!)
People who can’t picture images in their ‘mind’s eye’ still represent them in their brains
Imaging study of people with aphantasia reveals differences—but not a complete deficit—in visual processing area
www.science.org
January 11, 2025 at 10:33 AM
Fascinating new study: The visual cortex in people (like me!! 👋) with #aphantasia processes visual info but doesn’t translate it into conscious images. This disconnect explains why they can “know” details (like layouts) without “seeing” them—mental pictures don’t fully form. (Can confirm!)
In this preprint we see how activity in entorhinal cortex change during learning a non-spatial visual association task. Neurons in the MEC initially exhibited weak responses to visual cues but gradually developed strong tuning toward the rewarded trials. doi.org/10.1101/2024...
Task and Behavior-Related Variables Are Encoded by the Postrhinal and Medial Entorhinal Cortex During Non-Spatial Associative Learning
The medial entorhinal cortex (MEC) is pivotal in spatial computations and episodic memory. In particular, an animal’s position can be decoded from the activity of entorhinal grid cells. However, it re...
doi.org
January 10, 2025 at 9:48 PM
In this preprint we see how activity in entorhinal cortex change during learning a non-spatial visual association task. Neurons in the MEC initially exhibited weak responses to visual cues but gradually developed strong tuning toward the rewarded trials. doi.org/10.1101/2024...
Interesting study indicating that even a bit of air pollution (PM2.5) slow down marathon performance. Average Chicago Marathon times 8 minutes faster in a low-pollution year 2019 (~3 micrograms/cubic meter) than in a high-pollution year (~20 mi-g/m3). link.springer.com/article/10.1...
Running on Fumes: An Analysis of Fine Particulate Matter’s Impact on Finish Times in Nine Major US Marathons, 2003–2019 - Sports Medicine
Background Under controlled conditions and in some observational studies of runners, airborne fine particulate matter smaller than 2.5 microns in diameter (PM2.5) is associated with exercise performan...
link.springer.com
January 10, 2025 at 7:12 PM
Interesting study indicating that even a bit of air pollution (PM2.5) slow down marathon performance. Average Chicago Marathon times 8 minutes faster in a low-pollution year 2019 (~3 micrograms/cubic meter) than in a high-pollution year (~20 mi-g/m3). link.springer.com/article/10.1...
Reposted by Hafting-Fyhn Lab
I wish more people were literate enough to truly be able to read & understand this graph, and to be upset by it. Because it's upsetting! We pay SO MUCH MORE for healthcare, and have worse outcomes & lower life-expectancy. The data is clear: We are coming in last in the race for health & well-being.
December 8, 2024 at 12:14 AM
I wish more people were literate enough to truly be able to read & understand this graph, and to be upset by it. Because it's upsetting! We pay SO MUCH MORE for healthcare, and have worse outcomes & lower life-expectancy. The data is clear: We are coming in last in the race for health & well-being.
BioRxiv: Knockout of ACAN in PV+ cells inhibit formation of WFA positiv perineuronal nets (PNNs) around PV+ cells. ACAN KO mice show lower level of anxiety-related behavior. In the morris watermaze they employ bolder search strategy, but long-term memory is the same. doi.org/10.1101/2024...
Deciphering the Role of Aggrecan in Parvalbumin Interneurons: Unexpected Outcomes from a Conditional ACAN Knockout That Eliminates WFA+ Perineuronal Nets
The transition from juvenile to adult is accompanied by the maturation of inhibitory parvalbumin-positive (PV+) neurons and reduced plasticity. This transition involves the formation of perineuronal n...
doi.org
November 19, 2024 at 7:25 AM
BioRxiv: Knockout of ACAN in PV+ cells inhibit formation of WFA positiv perineuronal nets (PNNs) around PV+ cells. ACAN KO mice show lower level of anxiety-related behavior. In the morris watermaze they employ bolder search strategy, but long-term memory is the same. doi.org/10.1101/2024...
Finally, recording from freely swimming larval zebrafish reveals place code. I wonder how it is in salmon returning to their natal creek. www.nature.com/articles/s41...
A population code for spatial representation in the zebrafish telencephalon - Nature
Using a tracking microscope for freely moving animals, the authors discover a population of place cells in the zebrafish brain and demonstrate that a non-amniote brain is capable of integrating alloth...
www.nature.com
November 14, 2024 at 1:01 AM
Finally, recording from freely swimming larval zebrafish reveals place code. I wonder how it is in salmon returning to their natal creek. www.nature.com/articles/s41...
New preprint together with the Andermann lab– Cortical reactivations modulated by local inhibitory circuits mediate memory consolidation biorxiv.org/content/10.110…
biorxiv.org
October 29, 2024 at 8:07 PM
New preprint together with the Andermann lab– Cortical reactivations modulated by local inhibitory circuits mediate memory consolidation biorxiv.org/content/10.110…
FENS Regional Meeting 2025
Welcome to the FENS Regional Meeting 2025 — in Oslo, Norway.
frm2025oslo.no
October 28, 2024 at 6:22 PM