George Wood
@gwoodrna.bsky.social
PostDoc @ University of Cambridge, Department of Pathology
Interested in RNA biology and infection
👨🔬 | 🏳️🌈 | he/him
Interested in RNA biology and infection
👨🔬 | 🏳️🌈 | he/him
Our new paper is out in @natcomms.nature.com! We uncover how the Salmonella SPI-1 injectisome reshapes macrophage translation, resulting in a sustained decrease in inflammatory gene expression. Grateful to all my co-authors and collaborators for an incredible team effort!
The Salmonella pathogenicity island 1 injectisome reprograms host cell translation to evade the inflammatory response - Nature Communications
In this work, authors show that Salmonella uses its SPI-1 injectisome to infect macrophages, triggering rapid translational upregulation of transcription factors, such as EGR1 which suppresses the inf...
www.nature.com
November 6, 2025 at 11:18 AM
Our new paper is out in @natcomms.nature.com! We uncover how the Salmonella SPI-1 injectisome reshapes macrophage translation, resulting in a sustained decrease in inflammatory gene expression. Grateful to all my co-authors and collaborators for an incredible team effort!
Reposted by George Wood
Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11
Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11
Ravenhill et al. employ subcellular proteomics to quantify the movement of >9,000 proteins during infection with the model RNA virus Sendai. In addition to known controls, CRTC2 and CRTC3 translocate to the nucleus, triggering a transcriptional program…
dlvr.it
February 8, 2025 at 1:35 PM
Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11
Excited to share our currently in-press article describing an improved dual-reporter system for real-time measurement of translational recoding across diverse cell types and contexts!
@jmolbiol.bsky.social
@jmolbiol.bsky.social
An RNA-Based Dual-Fluorescence Reporter System Reveals Cell Type-Specific and Temporal Dynamics of −1 Programmed Ribosomal Frameshifting
Translational recoding events, such as programmed ribosomal frameshifting (PRF), are critical regulatory processes that enable the production of multi…
www.sciencedirect.com
August 8, 2025 at 12:25 PM
Excited to share our currently in-press article describing an improved dual-reporter system for real-time measurement of translational recoding across diverse cell types and contexts!
@jmolbiol.bsky.social
@jmolbiol.bsky.social
Reposted by George Wood
Happy share this latest study from the team. Here we look at placental macrophage biology across pregnany and their interaction with Listeria monocytogenes.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Interactions between placental Hofbauer cells and L. monocytogenes change throughout gestation
Gestational changes in Hofbauer cells alter their interactions with Listeria monocytogenes.
www.science.org
July 21, 2025 at 8:27 AM
Happy share this latest study from the team. Here we look at placental macrophage biology across pregnany and their interaction with Listeria monocytogenes.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...