Ufuk Günesdogan
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guenesdoganlab.bsky.social
Ufuk Günesdogan
@guenesdoganlab.bsky.social
160 followers 140 following 4 posts
Developmental and Stem Cell Biology lab at the University of Goettingen
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guenesdoganlab.bsky.social
Ufuk Günesdogan @guenesdoganlab.bsky.social · Jun 3
🚨Preprint alert!🚨 Great collaboration with the lab of Stefan Schoenfelder @stefanschoenfelder.bsky.social - we dissect the role of non-canonical enhancers in human pluripotent stem cells. 👇
Reposted by Ufuk Günesdogan
stemcellpodcast.com
We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉

Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
November 10, 2025 at 9:46 PM
Reposted by Ufuk Günesdogan
ferhatay.bsky.social
Our latest paper on comparative analysis of HiChIP data is now online! HiChIP is one of the most useful/practical assays to profile 3D genome organization and chromatin loops but has its challenges in the data analysis especially when it comes to comparative analysis.
November 4, 2025 at 10:58 PM
Reposted by Ufuk Günesdogan
stefanschoenfelder.bsky.social
🚨 Exciting conference for stem cell aficionados!
‘Frontiers in Stem Cell Innovation’ will bring together experts in stem cell biology from academia & industry to discuss key developments as well as challenges in regenerative medicine and disease modelling.
fisci2026.eventbrite.co.uk
Please repost 🙏
Frontiers in Stem Cell Innovation 2026
Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery
FISCI2026.eventbrite.co.uk
November 1, 2025 at 8:56 PM
Reposted by Ufuk Günesdogan
mariekeoudelaar.bsky.social
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
October 27, 2025 at 11:49 AM
Reposted by Ufuk Günesdogan
jengreitz.bsky.social
New preprint from our lab!

What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?

Find out here: www.biorxiv.org/content/10.1...

👇

1/
bioRxiv - An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq
September 19, 2025 at 3:03 AM
Reposted by Ufuk Günesdogan
gurdoninstitute.bsky.social
Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.
September 18, 2025 at 1:20 PM
Reposted by Ufuk Günesdogan
akispapantonis.bsky.social
Most read, I hear!
Here is your chance to read what @mariekeoudelaar.bsky.social and I had in mind when writing this together.
annualreviews.bsky.social Annual Reviews @annualreviews.bsky.social · Sep 9
The latest Annual Review of Genomics and Human Genetics is now online 🧬 Most read article so far is "Mechanisms of Enhancer-Mediated Gene Activation in the Context of the 3D Genome" @akispapantonis.bsky.social @mariekeoudelaar.bsky.social Check it out arevie.ws/47BZEJp
Full TOC: arevie.ws/4plCaPe
September 10, 2025 at 1:21 PM
Reposted by Ufuk Günesdogan
peiferlabunc.bsky.social
The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share
Dear Fly Community, In May 2025, the NIH terminated all grant funding to Harvard University, including the NHGRI grant that supported FlyBase. This grant also funded FlyBase teams at Indiana University (IU) and the University of Cambridge (UK), and as a result, their subawards were also canceled. The Cambridge team has secured support for one to two years through generous donations from the European fly community, emergency funding from the Wellcome Trust, and support from the University of Cambridge. At IU, funding has been secured for one year thanks to reserve funds from Thom Kaufman and a supplement from ORIP/NIH to the Bloomington Drosophila Stock Center (BDSC). Unfortunately, the situation at Harvard is far more critical. Harvard University had supported FlyBase staff since May but recently denied a request for extended bridge funding. As a result, all eight employees (four full-time and four part-time) were abruptly laid off, with termination dates ranging from August to mid-October depending on their positions. In addition, our curator at the University of New Mexico will leave her position at the end of August. This decision came as a shock, and we are urgently pursuing all possible funding options. To put the need into perspective: although FlyBase is free to use, it is not free to make. It takes large teams of people and millions of dollars a year to create FlyBase to support fly research (the last NHGRI grant supported us with more than 2 million USD per annum). To help sustain FlyBase operations, we have been reaching out to you to ask for your support. We have set up a donation site in Cambridge, UK, to which European labs have and can continue to contribute, and a new donation site at IU to which labs in the US and the rest of the world can contribute. We urge researchers to work with their grant administrators to contribute to FlyBase via these sites if at all possible, as more of the money will go to FlyBase. However, we appreciate that some fu… https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase Our immediate goals are: 1. To maintain core curation activities and keep the FlyBase website online 2. To complete integration with the Alliance of Genome Resources (The Alliance). Integration with the Alliance is essential for FlyBase’s long-term sustainability. For nearly a decade, NHGRI/NIH has supported the unification of Model Organism Databases (MODs) into the Alliance, which we aim to achieve by 2028. Therefore, securing bridge funding to sustain FlyBase over the next three years is crucial for successful integration and the long-term access to FlyBase data. At present, our remaining funds will allow us to keep the FlyBase website online for approximately one more year. Beyond that, its future is uncertain unless new funding is secured. We will, of course, continue pursuing additional grant opportunities as they arise. Given the uncertainty of future NIH or alternative funding sources, we are relying on the Fly community for support. Your contributions will directly help us retain the staff needed to complete this transition and to secure ongoing fly data curation into the Alliance beyond 2028. We at FlyBase are incredibly grateful for the outpouring of support from the community during this challenging time. Your encouragement has strengthened our resolve and underscores how vital this resource remains to Drosophila research worldwide. Sincerely, The FlyBase Team
August 23, 2025 at 12:18 PM
Reposted by Ufuk Günesdogan
vallierlab.bsky.social
So, we (Dylan Liabeuf and Anastasiia Maksiuk) are organising the first Berlin symposium on organoids. The objective is to bring together the Berlin organoid community and to develop further interactions.

Info:
www.bihealth.org/en/notices/b...

Free registration:
www.bihealth.org/en/news/even...
Berlin Organoid Symposium - News - BIH at Charité
The Berlin Organoid Symposium will highlight recent advances in the field, covering topics from fundamental organoid biology to translational applications. By uniting scientists from various instituti...
www.bihealth.org
August 22, 2025 at 5:06 AM
Reposted by Ufuk Günesdogan
ambystoma22.bsky.social
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
H3K4me3 amplifies transcription at intergenic active regulatory elements
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
August 20, 2025 at 1:29 AM
Reposted by Ufuk Günesdogan
stadtfeldlab.bsky.social
Excited to share our new study in @cp-devcell.bsky.social dissecting how the brain-associated transcription factor OTX2 drives anteriorization of the mammalian gut by enhancer remodeling using stem cell-based models. #development #enhancers #patterning #stemcells

www.cell.com/developmenta...
Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm
Correct patterning of emerging tissues in the developing embryo is essential for the formation of functional organ systems. Using genetic tools for controlled protein depletion, Ee et al. identify the...
www.cell.com
August 19, 2025 at 6:14 PM
Reposted by Ufuk Günesdogan
schuhlab.bsky.social
Great honor to be nominated as one of the top 10 Falling Walls Foundation Science Breakthroughs of the Year 2025 in the Life Sciences. A big thank you to @ovarylab.bsky.social & @tabeamarx.bsky.social for their outstanding contributions, & to everyone else who helped move this project forward.
mpi-nat.bsky.social MPI for Multidisciplinary Sciences @mpi-nat.bsky.social · Aug 14
Keeping our fingers crossed for you, Melina @schuhlab.bsky.social!
We are thrilled that our director has been nominated for the Falling Walls Foundation Science Breakthroughs of the Year 2025 in the Life Sciences category with her project “Breaking the Wall of Invisible Ovulation”. 🥂
August 14, 2025 at 11:33 AM
Reposted by Ufuk Günesdogan
radaiglesiaslab.bsky.social
Excited to share the latest work from the lab led by @eharo84.bsky.social, in which we have used synthetic biology to explore the mechanisms by which different types of long-range enhancers ensure robust and precise developmental gene expression

www.biorxiv.org/content/10.1...
Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts
Enhancers are non-coding cis-regulatory elements that control the expression of distally located genes in a tissue- and time-specific manner. Recent studies indicate that enhancers can differ in their...
www.biorxiv.org
August 11, 2025 at 2:56 PM
Reposted by Ufuk Günesdogan
marta-shahbazi.bsky.social
🤩 Very excited to share our new work! We have derived euploid and aneuploid trophoblast organoids and extra-embryonic mesoderm cell lines from early human embryos. In doing so, we have characterised the tissue requirements for their specification. If you want to know more, continue reading….
August 9, 2025 at 8:03 AM
Reposted by Ufuk Günesdogan
sarawickstrom.bsky.social
Check out this exciting meeting and register! Fantastic line-up of speakers on cell biology of the nucleus and a great venue 🔥
events.embl.org EMBL Events @events.embl.org · Jul 31
📢 Abstract submission deadline reminder for 'Cell biology of the nucleus'!

Before packing your bags and leaving for your summer vacation, there is one important task left to do: submit your abstract for #EESNucleus ✍️

Deadline is 26 August: https://s.embl.org/ees25-07-bl
August 1, 2025 at 6:42 AM
Reposted by Ufuk Günesdogan
eileen-furlong.bsky.social
To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
embl.wd103.myworkdayjobs.com
July 30, 2025 at 1:41 PM
guenesdoganlab.bsky.social
Delighted to see this work published! Congrats to Chris Todd and everyone involved - happy to have been part of the team.
July 30, 2025 at 8:54 AM
Reposted by Ufuk Günesdogan
dev-journal.bsky.social
Save the Date!

Development has teamed up with the Wellcome-funded consortium the Human Developmental Biology Initiative to co-organise a meeting on #HumanDevelopment.

📅7 - 9 Sep 2026
📍University of Warwick, UK

Register your interest for #HumanDev26: www.biologists.com/meetings/dev...
Human Development: Stem Cells, Models, Embryos. 7 - 9 September 2026 University of Warwick, UK. Resgiter your interest. #HumanDev26. Image credit: Susanna Narkilahti, Tampere University, Finland
July 11, 2025 at 7:46 AM
Reposted by Ufuk Günesdogan
sonnenlab.bsky.social
Please pread the word.

We have just launched the Hubrecht International PhD Program (HIPP).

Are you looking for a PhD position in molecular and developmental biology or related subject in an international, very supportive and collaborative environment?

Then apply to the HIPP!! 👇
hubrechtinstitute.bsky.social Hubrecht Institute @hubrechtinstitute.bsky.social · Jul 10
🧬 Looking for a PhD position in molecular or developmental biology? 🔬

✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
July 10, 2025 at 6:56 PM
Reposted by Ufuk Günesdogan
vgzt2021.bsky.social
Join the VGZT Eastern KEYNOTE lecture ☀️☕ TOMORROW

🗓️ Wednesday July 09
⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET

Featuring:
1) Maithreyi Narasimha
👉Positioning tissues during Drosophila morphogenesis

Jose Silva @josesilvalab.bsky.social
👉From founder cells to organogenesis-stage embryo model
July 8, 2025 at 10:54 AM
Reposted by Ufuk Günesdogan
gscnoffice.bsky.social
GSCN Conference (15. - 17. Oct 2025 in Munich)! Extended Deadline: 21 July 2025. Submit your abstract for an oral presentation & get an early bird ticket by 21.7.! Save on registration and secure your spot in the scientific program. Register and submit your abstract here: ➙ gscn-conferences.org
July 7, 2025 at 12:12 PM
Reposted by Ufuk Günesdogan
evgenykvon.bsky.social
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 2, 2025 at 4:17 PM
Reposted by Ufuk Günesdogan
bulutkarslioglu.bsky.social
⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
June 23, 2025 at 7:51 AM
Reposted by Ufuk Günesdogan
gurdoninstitute.bsky.social
🌟Congratulations to Azim Surani @gurdoninstitute.bsky.social @cam.ac.uk for receiving the 2025 Kyoto Prize - Basic Sciences. Azim's research fundamentally advanced our understanding of developmental biology🔬🧬 www.gurdon.cam.ac.uk/kyoto-prize-...
#KyotoPrize #AzimSurani #DevelopmentalBiology
June 20, 2025 at 10:46 AM
Reposted by Ufuk Günesdogan
robertife.bsky.social
Our review on ➡️"Histone modifications in development" is out 🍾 in 🔖 Development @dev-journal.bsky.social urnal.bsky.social‬
Read more about histone tail and globular domain modifications during development: journals.biologists.com/dev/article/...
dev-journal.bsky.social Development @dev-journal.bsky.social · Jun 18
Histone modifications in development

Read this 'Development at a Glance' article by Yu-Hao Liu and @robertife.bsky.social, summarising the role of selected histone modifications during development.
journals.biologists.com/dev/article/...
A panel of the 'Histone modifications in development' poster, showing 'histone globular domain modifications in mouse and human development;.
June 19, 2025 at 10:22 AM