Gregor Bond
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gregorbond.bsky.social
Gregor Bond
@gregorbond.bsky.social
630 followers 580 following 90 posts
transplant nephrologist and psychotherapy student in Vienna (Austria)
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gregorbond.bsky.social
the cure for kidney week FOMO 😀

www.nephjc.com/news/kidneyw...
Kidney Week in Houston: Day 1 — NephJC
in this edition: Atacicept in IgAN; Albuminuria as a surrogate outcome, Renal Remission and additional CONFIDENCE analysis
www.nephjc.com
November 12, 2025 at 8:45 AM
Reposted by Gregor Bond
hswapnil.medsky.social
The second sibeprenlimab paper in @nejm.org

(At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!)

www.nejm.org/doi/full/10....
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial | NEJM
The cytokine A proliferation-inducing ligand (APRIL) is considered a key driver of the pathogenesis of IgA nephropathy. Sibeprenlimab, a humanized IgG2 monoclonal antibody, selectively binds to and...
www.nejm.org
November 8, 2025 at 5:03 PM
Reposted by Gregor Bond
hswapnil.medsky.social
And another ns-MRA

Balcinrenone added to Dapa in proteinuric CKD

#KidneyWK

@thelancet.com

www.thelancet.com/journals/lan...
Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinica...
In participants with chronic kidney disease at increased risk of disease progression, a fixed dose combination of balcinrenone and dapagliflozin was superior to dapagliflozin alone in reducing albumin...
www.thelancet.com
November 8, 2025 at 6:18 PM
Reposted by Gregor Bond
nejm.org
ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL

@asnkidney.bsky.social | #KidneyWk
American Society of Nephrology Kidney Week 2025 Original Article | Nov. 6, 2025 | NEJM.org A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy Figure 2A. Change from Baseline in 24-Hr Urinary Protein-to-Creatinine Ratio through Week 36. The NEJM identity sits at the bottom.
November 6, 2025 at 2:55 PM
Reposted by Gregor Bond
hswapnil.medsky.social
Eli Lilly continuing to hit it out the park

Selective amylin agonist as an alternative to GLP1RAs? #eloralintide

www.thelancet.com/journals/lan... in @thelancet.com

(Yeah I know it’s #KidneyWk but what do we do till Houston wakes up!)

cc @rnflex.bsky.social
Figure 2. Change in bodyweight (A) Mean percent change in bodyweight from baseline to week 48, shown as observed means and bars indicating SEs. The model-based estimates of the mean percent change in bodyweight and differences among treatment groups at week 48 with the corresponding p values (efficacy estimand only) and 95% CIs are shown in (B) (efficacy estimand) and (D) (treatment-regimen estimand); bars indicate SEs. Multiplicity adjustment was not performed, and p values should be interpreted as exploratory. (C) shows the percentage of participants with bodyweight reductions of at least 5%, 10%, 15%, 20%, 25%, and 30% from baseline to week 48. The percentage of participants is annotated above each bar, calculated with the use of Rubin's rules by combining the percentages of participants who met the thresholds in imputed datasets. *The model-based estimates and 95% CIs from a mixed model repeated measures analysis for the efficacy estimand are shown on the right, denoted by 48.
November 6, 2025 at 1:54 PM
Reposted by Gregor Bond
hswapnil.medsky.social
Another simultaneous publication from the afternoon session

Albuminuria as an acceptable surrogate outcome (per our discussion earlier today)

www.nature.com/articles/s41... in @naturemedicine.bsky.social @nature.com sadly paywalled

#KidneyWk
A meta-analysis of albuminuria as a surrogate endpoint for kidney failure - Nature Medicine
In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidne...
www.nature.com
November 6, 2025 at 10:49 PM
Reposted by Gregor Bond
hswapnil.medsky.social
a conservative dialysis strategy in possibly recovering AKI helps people recover faster!

jamanetwork.com/journals/jam...

in @jama.com from #KidneyWk

Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury
This trial examines whether a conservative dialysis strategy can improve recovery of kidney function for patients with acute kidney injury who require dialysis.
jamanetwork.com
November 7, 2025 at 6:50 PM
Reposted by Gregor Bond
hswapnil.medsky.social
low dose Tac + Everolimus is not superior to Tac + MMF in older transplant recipients

in @asnpublications.bsky.social

another LBCT from #KidneyWk published

journals.lww.com/jasn/fulltex...
journals.lww.com
November 7, 2025 at 6:53 PM
gregorbond.bsky.social
jamesstein18.substack.com/p/my-hot-tak...
My Hot Take on PISCES, the New Fish Oil in Hemodialysis Study
I love when a new study challenges what we think we know.
jamesstein18.substack.com
November 12, 2025 at 8:20 AM
gregorbond.bsky.social
😲 too good to be true?

nothing except tx reduces death on hd
and now….

something safe, cheep and with more effect than tx (and more effect than in non hd)

waiting for the @freelyfiltered.bsky.social podcast covering this paper

www.nejm.org/doi/full/10....
Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis | NEJM
Cardiovascular disease is the leading cause of death in patients receiving hemodialysis, yet effective preventive therapies remain limited. Supplementation with n−3 polyunsaturated fatty acids, esp...
www.nejm.org
November 12, 2025 at 8:12 AM
Reposted by Gregor Bond
hswapnil.medsky.social
Natural history of RRT from the ERA registry

The visual abstract in this case tells a lot

academic.oup.com/ndt/advance-...

@ndt-era.bsky.social #NephSky
Visual abstract Sad story reflecting that most people start with HD and most of them die
November 4, 2025 at 1:39 AM
Reposted by Gregor Bond
hswapnil.medsky.social
Should we be screening every young child’s urine (as is done in some countries!)

@rheaultm.bsky.social and Oliver Gross make the case in @kireports.bsky.social

www.kireports.org/article/S246...

Main issue: we have therapeutic options!

#NephSky
Urine screening to early diagnose young individuals with CKD: a call for action
Alport syndrome is an inherited disorder of basement membranes leading to progressive chronic kidney disease, hearing loss, and ocular abnormalities in many affected patients. When the authors started...
www.kireports.org
October 25, 2025 at 1:05 AM
gregorbond.bsky.social
can viruses 🦠 be superheroes 🦸‍♂️ ?

PhD student Felix Herkner just published the statistical analysis plan
of the TTVguideIT trial 💪👏

Torque Teno virus guided immunosuppression #TTVguide

data cleaning until Q1/26
analysis Q2/26

trialsjournal.biomedcentral.com/articles/10....
Statistical analysis plan for TTVguideIT—a multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and Torque Teno virus-guided immuno...
Background Non-interventional studies indicate an association between Torque Teno Virus (TTV) load in peripheral blood and immunosuppression related outcomes in kidney transplant recipients. This make...
trialsjournal.biomedcentral.com
October 23, 2025 at 5:39 PM
Reposted by Gregor Bond
hswapnil.medsky.social
As expected, Iptacopan phase 3 in IgA nephropathy slows GFR decline

APPLAUSE-IgA

Adding another new medication we won’t be able to access or afford to our IgA armamentarium

#NephSky

www.novartis.com/news/media-r...
Novartis Fabhalta® (iptacopan) meets Phase III primary endpoint, slows kidney function decline in patients with IgA nephropathy (IgAN)
www.novartis.com
October 16, 2025 at 11:28 AM
Reposted by Gregor Bond
hswapnil.medsky.social
Big win for telitacicept in SLE (not lupus nephritis, yet)

www.nejm.org/doi/full/10....

BAFF + APRIL FTW

#nephSky #Lupus
A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus | NEJM
Telitacicept, a new dual inhibitor of the cytokines B-lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligand), showed efficacy in adults with active systemic lupus erythematosus (S...
www.nejm.org
October 16, 2025 at 1:04 AM
gregorbond.bsky.social
viruses 🦠 can be superheroes 🦸‍♀️

Felix Herkner present
the statistical analysis plan
of the TTVguideIT trial
at the Austrian Transplant Congress

Torque Teni Virus guided immunosuppression #TTVguide
October 16, 2025 at 6:47 PM
gregorbond.bsky.social
happy to speak about TT virus 🦠 @Italien 🇮🇹 micro biology congress

TTV based immune monotoring
#TTVguide
September 21, 2025 at 1:17 PM
gregorbond.bsky.social
mhm that makes me curiouse to have a look at the calculations of the DSMB that led to the termination of the trial; must have been a tought decision
September 2, 2025 at 9:11 AM
gregorbond.bsky.social
well written; as a kidney doc I would just not agree that protein is bad for your kidneys
August 31, 2025 at 7:59 PM
gregorbond.bsky.social
August 25, 2025 at 9:38 PM
gregorbond.bsky.social
>7.000 kidney transplant recipients
on SGLT2 inhibitors & GLP-1RAs

▶️ better survival, cardiovascular & kidney outcomes, weight loss, lower HbA1c

no safety risks
tinyurl.com/4p6fdybn
SGLT2 Inhibitors and GLP-1 Receptor Agonists in Kidney... : Transplantation
ovascular and kidney benefits in non-KT recipients, but evidence in KT recipients remains limited. This systematic review and meta-analysis provide updated evidence on the efficacy and safety of SGLT2...
tinyurl.com
August 25, 2025 at 9:36 PM
Reposted by Gregor Bond
kidneyboy.bsky.social
I use a cool programmable calculator called Soulver that works on and syncs across my iPhone, iPad, and Mac.

I just created a formula to calculate the sodium after any combination of IV fluids and urine output based on Edelman.
sNa = 105 = 105 tbw = 50 = 50 = D5W_In = 0 = 0 NS_In = 1000 = 1,000 LR_In = 0 = 0 Hypertonic_In = 200 = 200 tK_In = 40 = 40 Kwater_In = 400 = 400 urine_Na = 10 = 10 urine_K = 10 = 10 urine_Vol = 6000 = 6,000 = final_Na = (eK_x_eNa + tNaIn + tK_In - urine_lytes)/(tbw + tWaterIn - urine_L) = 119.00438596 = eK_x_eNa =sNa × tbw = 5,250 tNaIn = (NS_In × .154) + ( Hypertonic_In × 0.513) + (LR_In × 0.13) = 256.6 tWaterIn = (D5W_In + NS_In + Hypertonic_In + Kwater_In)/1000 = 1.6 urine_lytes = (urine_Na + urine_K) × urine_L = 120 urine_L = urine_Vol/1000 = 6 = = = = Total: 13568.2043859649
July 25, 2025 at 2:12 AM
Reposted by Gregor Bond
ttvguidetx.bsky.social
Last week, our team around @gregorbond.bsky.social from @meduniwien.ac.at took part in the "Kinderuni Wien" - Vienna’s Children’s University - to bring science to life for curious kids aged 7 to 12, where the kids learnt that some viruses like TTV can also be superheroes. #TTVguide
gregorbond.bsky.social Gregor Bond @gregorbond.bsky.social · Jul 17
I had great fun at kids university @meduniwien.ac.at today 😁

viruses 🦠 can be superheroes 🦸‍♀️

🙏 @sebastiankaps.bsky.social
and @fredhaupenthal.bsky.social for your support

#ttvguide
July 22, 2025 at 6:11 AM
gregorbond.bsky.social
I had great fun at kids university @meduniwien.ac.at today 😁

viruses 🦠 can be superheroes 🦸‍♀️

🙏 @sebastiankaps.bsky.social
and @fredhaupenthal.bsky.social for your support

#ttvguide
July 17, 2025 at 9:02 PM