Gwen Knight
@gmknght.bsky.social
Prof of AMR research at London School of Hygiene and Tropical Medicine
Excited to say that we have a PhD project out on our age-sex research - looking at combinations of #AMR. With the fabulous @jodi-lindsay.bsky.social and Lanre Edun! Do get in touch for more information!
mrc-lid.lshtm.ac.uk/2026-27-proj...
mrc-lid.lshtm.ac.uk/2026-27-proj...
Projects - MRC London Intercollegiate Doctoral Training Partnership Studentships
2026-27 MRC LID POTENTIAL RESEARCH PROJECTS MRC LID is offering 40 distinct potential projects for...
mrc-lid.lshtm.ac.uk
November 10, 2025 at 4:05 PM
Excited to say that we have a PhD project out on our age-sex research - looking at combinations of #AMR. With the fabulous @jodi-lindsay.bsky.social and Lanre Edun! Do get in touch for more information!
mrc-lid.lshtm.ac.uk/2026-27-proj...
mrc-lid.lshtm.ac.uk/2026-27-proj...
Reposted by Gwen Knight
Drug-resistant infections in Europe set to rise as populations age, study suggests
@gmknght.bsky.social & Catrin Moore explain understanding demographics & infection trends will help design more effective ways of controlling & preventing drug-resistant infections.
www.lshtm.ac.uk/newsevents/n...
@gmknght.bsky.social & Catrin Moore explain understanding demographics & infection trends will help design more effective ways of controlling & preventing drug-resistant infections.
www.lshtm.ac.uk/newsevents/n...
November 5, 2025 at 11:54 AM
Drug-resistant infections in Europe set to rise as populations age, study suggests
@gmknght.bsky.social & Catrin Moore explain understanding demographics & infection trends will help design more effective ways of controlling & preventing drug-resistant infections.
www.lshtm.ac.uk/newsevents/n...
@gmknght.bsky.social & Catrin Moore explain understanding demographics & infection trends will help design more effective ways of controlling & preventing drug-resistant infections.
www.lshtm.ac.uk/newsevents/n...
How will population shifts affect the future burden of #AMR? 👶👩🦳 🧫
We use a new modelling framework to explore future projections of #AMR by age and by sex, as well as interventions for control, building on our earlier findings that AMR isn’t uniform across demographics.
doi.org/10.1371/jour...
We use a new modelling framework to explore future projections of #AMR by age and by sex, as well as interventions for control, building on our earlier findings that AMR isn’t uniform across demographics.
doi.org/10.1371/jour...
Combining demographic shifts with age-based resistance prevalence to estimate future antimicrobial resistance burden in Europe and implications for targets: A modelling study
Author summary Why was this study done? Infections caused by bacteria that are resistant to antibiotics are a major and growing threat to public health. Older adults and men are at higher risk of...
doi.org
November 5, 2025 at 12:06 PM
How will population shifts affect the future burden of #AMR? 👶👩🦳 🧫
We use a new modelling framework to explore future projections of #AMR by age and by sex, as well as interventions for control, building on our earlier findings that AMR isn’t uniform across demographics.
doi.org/10.1371/jour...
We use a new modelling framework to explore future projections of #AMR by age and by sex, as well as interventions for control, building on our earlier findings that AMR isn’t uniform across demographics.
doi.org/10.1371/jour...
Reposted by Gwen Knight
Agata Pacho and I published an article on self care and UTIs/AMR this week! In Sociology of Health and Illness:
onlinelibrary.wiley.com/doi/10.1111/.... @lshtmamrcentre.bsky.social
onlinelibrary.wiley.com/doi/10.1111/.... @lshtmamrcentre.bsky.social
onlinelibrary.wiley.com
October 24, 2025 at 2:19 PM
Agata Pacho and I published an article on self care and UTIs/AMR this week! In Sociology of Health and Illness:
onlinelibrary.wiley.com/doi/10.1111/.... @lshtmamrcentre.bsky.social
onlinelibrary.wiley.com/doi/10.1111/.... @lshtmamrcentre.bsky.social
Reposted by Gwen Knight
PhD opportunity in my lab: exploring how commensals and pathogens build biofilm communities on endotracheal (ventilator) tubes. Microbial ecology, medical microbiology and fancy imaging! Co-supervised with the fabulous Saskia Bakker and Jeremy Webb warwick.ac.uk/fac/cross_fa... #MicroSky
Dr Freya Harrison
Dr Freya Harrison
warwick.ac.uk
October 15, 2025 at 8:09 PM
PhD opportunity in my lab: exploring how commensals and pathogens build biofilm communities on endotracheal (ventilator) tubes. Microbial ecology, medical microbiology and fancy imaging! Co-supervised with the fabulous Saskia Bakker and Jeremy Webb warwick.ac.uk/fac/cross_fa... #MicroSky
Reposted by Gwen Knight
🚀 Exciting news!
Our Centre Director @katholt.bsky.social will be speaking at #AMR2026 on “AMRrules: Interpretive Standards for AMR Genotypes.”
Don’t miss her insights🧬✨
📅 23–25 March 2026
🔗 bit.ly/3SWzJUm
#MicroSky #AMR #Genomics
Our Centre Director @katholt.bsky.social will be speaking at #AMR2026 on “AMRrules: Interpretive Standards for AMR Genotypes.”
Don’t miss her insights🧬✨
📅 23–25 March 2026
🔗 bit.ly/3SWzJUm
#MicroSky #AMR #Genomics
October 14, 2025 at 1:24 PM
🚀 Exciting news!
Our Centre Director @katholt.bsky.social will be speaking at #AMR2026 on “AMRrules: Interpretive Standards for AMR Genotypes.”
Don’t miss her insights🧬✨
📅 23–25 March 2026
🔗 bit.ly/3SWzJUm
#MicroSky #AMR #Genomics
Our Centre Director @katholt.bsky.social will be speaking at #AMR2026 on “AMRrules: Interpretive Standards for AMR Genotypes.”
Don’t miss her insights🧬✨
📅 23–25 March 2026
🔗 bit.ly/3SWzJUm
#MicroSky #AMR #Genomics
Reposted by Gwen Knight
Understanding patterns of #TB exposure and transmission is needed for targeted prevention strategies. In our latest pre-print, @petedodd24.bsky.social and I estimated the proportion of TB exposure to and transmission from sex and age groups for 177 countries.
bit.ly/4nbV492
bit.ly/4nbV492
A global analysis of patterns of tuberculosis exposure and transmission
Tuberculosis (TB) is a major public health concern and the leading infectious cause of mortality globally. The disease exhibits strong prevalence patterns by age and sex, but the implications of these...
www.medrxiv.org
October 12, 2025 at 12:51 PM
Understanding patterns of #TB exposure and transmission is needed for targeted prevention strategies. In our latest pre-print, @petedodd24.bsky.social and I estimated the proportion of TB exposure to and transmission from sex and age groups for 177 countries.
bit.ly/4nbV492
bit.ly/4nbV492
Reposted by Gwen Knight
I don't want to seem too cynical, but I wrote this 4 years ago: "...it will come as little surprise if a similar report in a year's time will be almost indistinguishable from the current version."
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Antimicrobial resistance: plus ça change
This issue marks the first anniversary of The Lancet Microbe. This has been a year
of profound change during which the world has experienced the most consequential infectious
disease outbreak of the p...
www.thelancet.com
October 14, 2025 at 9:18 AM
I don't want to seem too cynical, but I wrote this 4 years ago: "...it will come as little surprise if a similar report in a year's time will be almost indistinguishable from the current version."
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Great to see accounting for age and sex in the #AMR estimates from the latest WHO #AMR global burden report out today! www.who.int/publications...
Global antibiotic resistance surveillance report 2025
This new WHO report presents a global analysis of antibiotic resistance prevalence and trends, drawing on more than 23 million bacteriologically confirmed cases of bloodstream infections, urinary trac...
www.who.int
October 13, 2025 at 11:27 AM
Great to see accounting for age and sex in the #AMR estimates from the latest WHO #AMR global burden report out today! www.who.int/publications...
Reposted by Gwen Knight
In a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...
Do no harm - re-evaluating the risks of overtreatment in community-wide tuberculosis screening
Background Community-wide screening is a crucial strategy to end tuberculosis (TB), but a common concern is potential harm from overtreatment following false positive diagnoses. However, current refer...
www.medrxiv.org
October 7, 2025 at 9:17 AM
In a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...
Reposted by Gwen Knight
Sepsis claims a life every 3 seconds.
Ahead of #WorldSepsisDay, @jhenryc.bsky.social @lshtm.bsky.social shares 5 Facts × 5 Actions to tackle sepsis 🩺 & AMR 🦠—from empowering frontline workers 👩⚕️ to strengthening diagnostics 🔍 & integrating national response plans 🌍
👉 bit.ly/3Vh4NiG
Ahead of #WorldSepsisDay, @jhenryc.bsky.social @lshtm.bsky.social shares 5 Facts × 5 Actions to tackle sepsis 🩺 & AMR 🦠—from empowering frontline workers 👩⚕️ to strengthening diagnostics 🔍 & integrating national response plans 🌍
👉 bit.ly/3Vh4NiG
World Sepsis Day 2025: 5 Facts x 5 Actions to tackle sepsis and antimicrobial
World Sepsis Day 2025: 5 Facts x 5 Actions to tackle sepsis and antimicrobial resistance | LSHTM
bit.ly
September 12, 2025 at 10:14 AM
Sepsis claims a life every 3 seconds.
Ahead of #WorldSepsisDay, @jhenryc.bsky.social @lshtm.bsky.social shares 5 Facts × 5 Actions to tackle sepsis 🩺 & AMR 🦠—from empowering frontline workers 👩⚕️ to strengthening diagnostics 🔍 & integrating national response plans 🌍
👉 bit.ly/3Vh4NiG
Ahead of #WorldSepsisDay, @jhenryc.bsky.social @lshtm.bsky.social shares 5 Facts × 5 Actions to tackle sepsis 🩺 & AMR 🦠—from empowering frontline workers 👩⚕️ to strengthening diagnostics 🔍 & integrating national response plans 🌍
👉 bit.ly/3Vh4NiG
Reposted by Gwen Knight
Congratulations to Jody Phelan for receiving the prestigious @esmyco.bsky.social Gertrud Meissner Award for his groundbreaking work on drug resistant tuberculosis 👏🌍
Read more 👉 bit.ly/4mfGDjW
Read more 👉 bit.ly/4mfGDjW
Jody Phelan receives Gertrud Meissner Award | LSHTM
Jody Phelan receives Gertrud Meissner Award | LSHTM
bit.ly
July 28, 2025 at 2:12 PM
Congratulations to Jody Phelan for receiving the prestigious @esmyco.bsky.social Gertrud Meissner Award for his groundbreaking work on drug resistant tuberculosis 👏🌍
Read more 👉 bit.ly/4mfGDjW
Read more 👉 bit.ly/4mfGDjW
Unfortunately, we're going to have to reschedule this talk - if you have a free hour then do go back and check our some of our past seminars across the #AMR disciplines!
www.lshtm.ac.uk/research/cen...
www.lshtm.ac.uk/research/cen...
July 9, 2025 at 9:26 AM
Unfortunately, we're going to have to reschedule this talk - if you have a free hour then do go back and check our some of our past seminars across the #AMR disciplines!
www.lshtm.ac.uk/research/cen...
www.lshtm.ac.uk/research/cen...
Really looking forward to hear this high level overview of #AMR policy from a great female scientist!
Tomorrow - UK - lunch time 👩💻
Tomorrow - UK - lunch time 👩💻
🎙️ Join Prof Dame Sally Davies, for an insightful seminar on global action against AMR.
In this seminar, she will share updates on the UN High-Level AMR agenda, the evidence panel & what’s next for global policy.
📅 9 July 2025
🕰️ 13:00 BST
📍 Online
🔗 bit.ly/4kVSVgP
In this seminar, she will share updates on the UN High-Level AMR agenda, the evidence panel & what’s next for global policy.
📅 9 July 2025
🕰️ 13:00 BST
📍 Online
🔗 bit.ly/4kVSVgP
July 8, 2025 at 2:10 PM
Really looking forward to hear this high level overview of #AMR policy from a great female scientist!
Tomorrow - UK - lunch time 👩💻
Tomorrow - UK - lunch time 👩💻
A Friday reminder of this talk next Wednesday.
I'm looking forward to welcoming our students to the @lshtm.bsky.social @lshtmamrcentre.bsky.social #AMR short course and then having this seminar from Prof Dame Sally Davies!
I'm looking forward to welcoming our students to the @lshtm.bsky.social @lshtmamrcentre.bsky.social #AMR short course and then having this seminar from Prof Dame Sally Davies!
Very excited for this event on the 9th July!
It's part of our #AMR short course but open to everyone as it's online. Do join in and here what the amazing Prof Dame Sally Davies has to stay on the current status of global action on #AMR! @lshtmamrcentre.bsky.social
It's part of our #AMR short course but open to everyone as it's online. Do join in and here what the amazing Prof Dame Sally Davies has to stay on the current status of global action on #AMR! @lshtmamrcentre.bsky.social
🎙️ Join Prof Dame Sally Davies, for an insightful seminar on global action against AMR.
In this seminar, she will share updates on the UN High-Level AMR agenda, the evidence panel & what’s next for global policy.
📅 9 July 2025
🕰️ 13:00 BST
📍 Online
🔗 bit.ly/4kVSVgP
In this seminar, she will share updates on the UN High-Level AMR agenda, the evidence panel & what’s next for global policy.
📅 9 July 2025
🕰️ 13:00 BST
📍 Online
🔗 bit.ly/4kVSVgP
July 4, 2025 at 3:19 PM
A Friday reminder of this talk next Wednesday.
I'm looking forward to welcoming our students to the @lshtm.bsky.social @lshtmamrcentre.bsky.social #AMR short course and then having this seminar from Prof Dame Sally Davies!
I'm looking forward to welcoming our students to the @lshtm.bsky.social @lshtmamrcentre.bsky.social #AMR short course and then having this seminar from Prof Dame Sally Davies!
Reposted by Gwen Knight
In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials.
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
July 4, 2025 at 11:25 AM
In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials.
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
Reposted by Gwen Knight
LSHTM's Director writes to UK Government about #Gaza public health catastrophe
Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster:
👉 www.lshtm.ac.uk/newsevents/n...
Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster:
👉 www.lshtm.ac.uk/newsevents/n...
June 20, 2025 at 1:32 PM
LSHTM's Director writes to UK Government about #Gaza public health catastrophe
Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster:
👉 www.lshtm.ac.uk/newsevents/n...
Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster:
👉 www.lshtm.ac.uk/newsevents/n...
Reposted by Gwen Knight
I'm super happy to share this preprint on ‘Distribution of capsule and O types in #Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage’
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage
Background: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against 70% of K. pneumoniae infections, could aver...
doi.org
July 1, 2025 at 9:45 AM
I'm super happy to share this preprint on ‘Distribution of capsule and O types in #Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage’
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Gwen Knight
One week left to submit your abstract to @microbiologysociety.org meeting on “Understanding and Predicting Microbial Evolutionary Dynamics” at Liverpool 26-27 November
Lots of spaces for ECR talks and posters!
microbiologysociety.org/event/societ...
Lots of spaces for ECR talks and posters!
microbiologysociety.org/event/societ...
microbiologysociety.org
June 30, 2025 at 10:03 AM
One week left to submit your abstract to @microbiologysociety.org meeting on “Understanding and Predicting Microbial Evolutionary Dynamics” at Liverpool 26-27 November
Lots of spaces for ECR talks and posters!
microbiologysociety.org/event/societ...
Lots of spaces for ECR talks and posters!
microbiologysociety.org/event/societ...
The complexity of #AMR is rarely understated but few studies tackle the selection vs. transmission challenge.
That's what makes this this analysis from 2020 led by @juliethebatgirl.bsky.social so great - look how much could be done with well linked hospital data ... doi.org/10.7554/eLif....
That's what makes this this analysis from 2020 led by @juliethebatgirl.bsky.social so great - look how much could be done with well linked hospital data ... doi.org/10.7554/eLif....
Metapopulation ecology links antibiotic resistance, consumption, and patient transfers in a network of hospital wards
Patterns of antibiotic use and the connectivity between wards are independently associated with the incidence of antimicrobial-resistant infections in hospital networks.
doi.org
June 30, 2025 at 10:53 AM
The complexity of #AMR is rarely understated but few studies tackle the selection vs. transmission challenge.
That's what makes this this analysis from 2020 led by @juliethebatgirl.bsky.social so great - look how much could be done with well linked hospital data ... doi.org/10.7554/eLif....
That's what makes this this analysis from 2020 led by @juliethebatgirl.bsky.social so great - look how much could be done with well linked hospital data ... doi.org/10.7554/eLif....
Reposted by Gwen Knight
In this blog, our Student Liaison Officer @lshtm.bsky.social, Brandon Hill, explores the often-overlooked intersection between #AMR and #LGBTQ+ health, highlighting the need for more inclusive data and policies to address health inequities.
Read more 👇
bit.ly/3HYkp7e
Read more 👇
bit.ly/3HYkp7e
Exploring the social determinants of AMR | LSHTM
Exploring the social determinants of AMR | LSHTM
bit.ly
June 26, 2025 at 12:16 PM
In this blog, our Student Liaison Officer @lshtm.bsky.social, Brandon Hill, explores the often-overlooked intersection between #AMR and #LGBTQ+ health, highlighting the need for more inclusive data and policies to address health inequities.
Read more 👇
bit.ly/3HYkp7e
Read more 👇
bit.ly/3HYkp7e
Great to see this review of modelling for IPC & healthcare epi. - we had great discussions at the Think Tank!
Key points: determine pathway to infection, make sure the model fits to data then can use it to lead to evidence development on interventions 👩💻🏥
pubmed.ncbi.nlm.nih.gov/39228083/
Key points: determine pathway to infection, make sure the model fits to data then can use it to lead to evidence development on interventions 👩💻🏥
pubmed.ncbi.nlm.nih.gov/39228083/
Expanding the use of mathematical modeling in healthcare epidemiology and infection prevention and control - PubMed
During the coronavirus disease 2019 pandemic, mathematical modeling has been widely used to understand epidemiological burden, trends, and transmission dynamics, to facilitate policy decisions, and, t...
pubmed.ncbi.nlm.nih.gov
June 24, 2025 at 11:26 AM
Great to see this review of modelling for IPC & healthcare epi. - we had great discussions at the Think Tank!
Key points: determine pathway to infection, make sure the model fits to data then can use it to lead to evidence development on interventions 👩💻🏥
pubmed.ncbi.nlm.nih.gov/39228083/
Key points: determine pathway to infection, make sure the model fits to data then can use it to lead to evidence development on interventions 👩💻🏥
pubmed.ncbi.nlm.nih.gov/39228083/
So great to see this 🦣 effort finally published!
Massive congratulations to Nichola Naylor (#AMR economist extraordinaire) and the rest of the team!
Do check out the amazing resources behind this estimates that can be used for other economic assessments for #AMR.
gh.bmj.com/content/10/6...
Massive congratulations to Nichola Naylor (#AMR economist extraordinaire) and the rest of the team!
Do check out the amazing resources behind this estimates that can be used for other economic assessments for #AMR.
gh.bmj.com/content/10/6...
The global economic burden of antibiotic-resistant infections and the potential impact of bacterial vaccines: a modelling study
Introduction Antibiotic resistance (ABR) may increase hospital costs, utility loss and mortality risk per patient. Understanding these losses at national, regional and global scales is necessary for e...
gh.bmj.com
June 20, 2025 at 2:13 PM
So great to see this 🦣 effort finally published!
Massive congratulations to Nichola Naylor (#AMR economist extraordinaire) and the rest of the team!
Do check out the amazing resources behind this estimates that can be used for other economic assessments for #AMR.
gh.bmj.com/content/10/6...
Massive congratulations to Nichola Naylor (#AMR economist extraordinaire) and the rest of the team!
Do check out the amazing resources behind this estimates that can be used for other economic assessments for #AMR.
gh.bmj.com/content/10/6...
Great combination of modelling and experimental data to better understand dynamic antibiotic exposure and #AMR
And "fitness seascapes" 🌊
doi.org/10.1126/scia...
And "fitness seascapes" 🌊
doi.org/10.1126/scia...
doi.org
June 19, 2025 at 9:37 AM
Great combination of modelling and experimental data to better understand dynamic antibiotic exposure and #AMR
And "fitness seascapes" 🌊
doi.org/10.1126/scia...
And "fitness seascapes" 🌊
doi.org/10.1126/scia...