Gautham SANKARA
@gauthamsankara.bsky.social
Scientist @ Institut Pasteur Mechanobiology ⚙️ + Cryo-ET 🧊 | Capturing battles 🛡️ between host & pathogen 🦠 | Science at intersection of physics 🔭 and life 🧬
Pinned
🔬 Dive into the invisible!
At Institut Pasteur, @gauthamsankara.bsky.social uses confocal microscopy to track E. coli division in real time — turning hours of bacterial life into seconds of insight.
Science, precision, innovation. #Research #Microbiology
At Institut Pasteur, @gauthamsankara.bsky.social uses confocal microscopy to track E. coli division in real time — turning hours of bacterial life into seconds of insight.
Science, precision, innovation. #Research #Microbiology
When cutting-edge tech, brilliant minds, and powerful science communication come together — that's Institut Pasteur! Grateful to be part of this inspiring community. #PasteurCommunity #ScienceLife
Reposted by Gautham SANKARA
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1
September 18, 2025 at 4:58 PM
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
The cell looks like Inkay Pokémon🔬 — yellow glowing arms, pink heart.
Under attack by cyan bacteria🦠, but it’s just vibing on the glass, dancing🪩, unaware of the aftermath☠️. #FluorescenceFriday #Microscopy #CellBiology #mechanobiology @pasteuredu.bsky.social #hostpathogeninteraction @pasteur.fr
Under attack by cyan bacteria🦠, but it’s just vibing on the glass, dancing🪩, unaware of the aftermath☠️. #FluorescenceFriday #Microscopy #CellBiology #mechanobiology @pasteuredu.bsky.social #hostpathogeninteraction @pasteur.fr
June 6, 2025 at 11:54 AM
The cell looks like Inkay Pokémon🔬 — yellow glowing arms, pink heart.
Under attack by cyan bacteria🦠, but it’s just vibing on the glass, dancing🪩, unaware of the aftermath☠️. #FluorescenceFriday #Microscopy #CellBiology #mechanobiology @pasteuredu.bsky.social #hostpathogeninteraction @pasteur.fr
Under attack by cyan bacteria🦠, but it’s just vibing on the glass, dancing🪩, unaware of the aftermath☠️. #FluorescenceFriday #Microscopy #CellBiology #mechanobiology @pasteuredu.bsky.social #hostpathogeninteraction @pasteur.fr
Reposted by Gautham SANKARA
🦠 The plague bacillus became less virulent, extending the duration of two major pandemics. @yersiniaunit.bsky.social @pierrelebury.bsky.social @mcmasteruniversity.bsky.social @ravneetksidhu.bsky.social
The plague bacillus became less virulent, prolonging the duration of two major pandemics
Scientists at the Institut Pasteur and McMaster University have discovered that the evolution of a gene in the bacterium that causes bubonic plague, Yersinia pestis, may have prolonged the duration of...
www.pasteur.fr
June 2, 2025 at 2:42 PM
🦠 The plague bacillus became less virulent, extending the duration of two major pandemics. @yersiniaunit.bsky.social @pierrelebury.bsky.social @mcmasteruniversity.bsky.social @ravneetksidhu.bsky.social
Reposted by Gautham SANKARA
A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-situ @jbuenrostro.bsky.social
May 29, 2025 at 7:14 PM
A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-situ @jbuenrostro.bsky.social
Reposted by Gautham SANKARA
Harvard president receives standing ovation during commencement.
May 29, 2025 at 11:40 PM
Harvard president receives standing ovation during commencement.
Reposted by Gautham SANKARA
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...
May 30, 2025 at 11:37 AM
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...
Reposted by Gautham SANKARA
The new issue is out! 👉 cell.com/cell/current
On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops
📷credit: Andreas Brunner.
On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops
📷credit: Andreas Brunner.
May 16, 2025 at 10:00 AM
The new issue is out! 👉 cell.com/cell/current
On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops
📷credit: Andreas Brunner.
On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops
📷credit: Andreas Brunner.
Reposted by Gautham SANKARA
Cohabitation shifts gut bacteria to protect the liver:
Sharing gut bacteria via cohabitation, notably Rikenellamicrofusus, boosts isoflavone conversion to biochanin-A, reducing liver injury from acetaminophen overdose by enhancing liver cell metabolism and defense
www.cell.com/cell-host-mi...
Sharing gut bacteria via cohabitation, notably Rikenellamicrofusus, boosts isoflavone conversion to biochanin-A, reducing liver injury from acetaminophen overdose by enhancing liver cell metabolism and defense
www.cell.com/cell-host-mi...
May 13, 2025 at 2:15 PM
Cohabitation shifts gut bacteria to protect the liver:
Sharing gut bacteria via cohabitation, notably Rikenellamicrofusus, boosts isoflavone conversion to biochanin-A, reducing liver injury from acetaminophen overdose by enhancing liver cell metabolism and defense
www.cell.com/cell-host-mi...
Sharing gut bacteria via cohabitation, notably Rikenellamicrofusus, boosts isoflavone conversion to biochanin-A, reducing liver injury from acetaminophen overdose by enhancing liver cell metabolism and defense
www.cell.com/cell-host-mi...
Reposted by Gautham SANKARA
Major depressive disorder is a complex condition that cannot be fully explained by any one single established biological or environmental pathway www.nature.com/articles/s41...
May 13, 2025 at 7:54 PM
Major depressive disorder is a complex condition that cannot be fully explained by any one single established biological or environmental pathway www.nature.com/articles/s41...
Reposted by Gautham SANKARA
This week in Science, researchers delve into the #mathematics that shapes growing rose petals. 🌹
Explore our latest issue—featuring a new print design: scim.ag/42DasUT
Explore our latest issue—featuring a new print design: scim.ag/42DasUT
May 1, 2025 at 6:05 PM
This week in Science, researchers delve into the #mathematics that shapes growing rose petals. 🌹
Explore our latest issue—featuring a new print design: scim.ag/42DasUT
Explore our latest issue—featuring a new print design: scim.ag/42DasUT
Reposted by Gautham SANKARA
How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z
May 2, 2025 at 12:35 PM
How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z
Watching fission yeast divide is cool🦠. But showing it with a kymograph? Even cooler 😎, shows it all—mitosis, cell wall—packed into spatiotemporal magic🪄. Flattening time into 2D just makes it easier to understand. #FluorescenceFriday @pasteur.fr @pasteuredu.bsky.social #Microscopy #Microbiology🔬
May 2, 2025 at 10:48 AM
Watching fission yeast divide is cool🦠. But showing it with a kymograph? Even cooler 😎, shows it all—mitosis, cell wall—packed into spatiotemporal magic🪄. Flattening time into 2D just makes it easier to understand. #FluorescenceFriday @pasteur.fr @pasteuredu.bsky.social #Microscopy #Microbiology🔬
When cutting-edge tech, brilliant minds, and powerful science communication come together — that's Institut Pasteur! Grateful to be part of this inspiring community. #PasteurCommunity #ScienceLife
🔬 Dive into the invisible!
At Institut Pasteur, @gauthamsankara.bsky.social uses confocal microscopy to track E. coli division in real time — turning hours of bacterial life into seconds of insight.
Science, precision, innovation. #Research #Microbiology
At Institut Pasteur, @gauthamsankara.bsky.social uses confocal microscopy to track E. coli division in real time — turning hours of bacterial life into seconds of insight.
Science, precision, innovation. #Research #Microbiology
April 28, 2025 at 10:56 AM
When cutting-edge tech, brilliant minds, and powerful science communication come together — that's Institut Pasteur! Grateful to be part of this inspiring community. #PasteurCommunity #ScienceLife
Reposted by Gautham SANKARA
Now online! Tissue geometry spatiotemporally drives bacterial infections
Tissue geometry spatiotemporally drives bacterial infections
Tissue-geometry-regulated cellular traction forces trigger the activation of Piezo1 and its co-localization with bacteria to facilitate the formation of specific bacterial invasion patterns to promote infection.
dlvr.it
April 21, 2025 at 6:51 PM
Now online! Tissue geometry spatiotemporally drives bacterial infections
Reposted by Gautham SANKARA
An origami-inspired ‘metamaterial’ has been engineered to have properties not found in natural materials — enabling it to undergo large, reversible deformations
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Shapeshifting origami material shrinks when twisted
An origami-inspired ‘metamaterial’ has been engineered to have properties not found in natural materials — enabling it to undergo large, reversible deformations.
www.nature.com
April 24, 2025 at 11:24 AM
An origami-inspired ‘metamaterial’ has been engineered to have properties not found in natural materials — enabling it to undergo large, reversible deformations
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Gautham SANKARA
New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...
April 23, 2025 at 2:04 PM
New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...
Reposted by Gautham SANKARA
😱 A very hungry #PacManoid ate the original post 🍬🍬🍬
Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!
Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...
Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!
Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...
Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
April 19, 2025 at 8:49 AM
😱 A very hungry #PacManoid ate the original post 🍬🍬🍬
Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!
Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...
Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again!
Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st...
Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
Reposted by Gautham SANKARA
Flocking and active solid behavior of epithelial cells in our new study in @pnas.org
Great work of Y. Shen, J. O'Byrne and
@andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez!
| PNAS www.pnas.org/doi/10.1073/...
Great work of Y. Shen, J. O'Byrne and
@andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez!
| PNAS www.pnas.org/doi/10.1073/...
April 19, 2025 at 2:11 PM
Flocking and active solid behavior of epithelial cells in our new study in @pnas.org
Great work of Y. Shen, J. O'Byrne and
@andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez!
| PNAS www.pnas.org/doi/10.1073/...
Great work of Y. Shen, J. O'Byrne and
@andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez!
| PNAS www.pnas.org/doi/10.1073/...
Fission yeast doing the splits— Microtubule push nucleus from inside, while cell membrane finishes the party. Shout-out @pasteur.fr and #PFAM course for the science vibes! #FluorescenceFriday #Microscopy #CellBiology @pasteuredu.bsky.social
April 4, 2025 at 10:24 AM
Fission yeast doing the splits— Microtubule push nucleus from inside, while cell membrane finishes the party. Shout-out @pasteur.fr and #PFAM course for the science vibes! #FluorescenceFriday #Microscopy #CellBiology @pasteuredu.bsky.social
Wrapping up two weeks of Principles and Applications of Fluorescence Microscopy #PAFM at @pasteur.fr
Hands-on with the FV4000 confocal microscope, chasing glowing E. coli colonies. #FluorescenceFriday #Microscopy
Hands-on with the FV4000 confocal microscope, chasing glowing E. coli colonies. #FluorescenceFriday #Microscopy
March 21, 2025 at 3:31 PM
Wrapping up two weeks of Principles and Applications of Fluorescence Microscopy #PAFM at @pasteur.fr
Hands-on with the FV4000 confocal microscope, chasing glowing E. coli colonies. #FluorescenceFriday #Microscopy
Hands-on with the FV4000 confocal microscope, chasing glowing E. coli colonies. #FluorescenceFriday #Microscopy
Sunny days in Paris, and this cell’s matching the vibe 🌞 Focal adhesions flaring up rocket TIRF 🚀 #FluorescenceFriday @pasteur.fr #Microscopy #cellbiology #biophysics #mechanobiology #hostpathogeninteraction
March 7, 2025 at 10:40 AM
Sunny days in Paris, and this cell’s matching the vibe 🌞 Focal adhesions flaring up rocket TIRF 🚀 #FluorescenceFriday @pasteur.fr #Microscopy #cellbiology #biophysics #mechanobiology #hostpathogeninteraction
Cells in motion remains in motion😇 #FluorescenceFriday
@pasteur.fr #Microscopy #cellbiology #biophysics #mechanobiology #hostpathogeninteraction
@pasteur.fr #Microscopy #cellbiology #biophysics #mechanobiology #hostpathogeninteraction
February 28, 2025 at 10:42 AM
Cells in motion remains in motion😇 #FluorescenceFriday
@pasteur.fr #Microscopy #cellbiology #biophysics #mechanobiology #hostpathogeninteraction
@pasteur.fr #Microscopy #cellbiology #biophysics #mechanobiology #hostpathogeninteraction
Reposted by Gautham SANKARA
Our methods paper made it to bioRxiv:
doi.org/10.1101/2025...
Full #cryoET workflows for #plant tissues. Plus some general tricks and tweaks on serial Lift-Out and cryo-FLM. 🧪🧵1/5
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM #CLEM
doi.org/10.1101/2025...
Full #cryoET workflows for #plant tissues. Plus some general tricks and tweaks on serial Lift-Out and cryo-FLM. 🧪🧵1/5
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM #CLEM
February 19, 2025 at 6:06 AM
Our methods paper made it to bioRxiv:
doi.org/10.1101/2025...
Full #cryoET workflows for #plant tissues. Plus some general tricks and tweaks on serial Lift-Out and cryo-FLM. 🧪🧵1/5
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM #CLEM
doi.org/10.1101/2025...
Full #cryoET workflows for #plant tissues. Plus some general tricks and tweaks on serial Lift-Out and cryo-FLM. 🧪🧵1/5
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM #CLEM