Frits Franssen
@fritsfranssen.bsky.social
Head of department of Respiratory Medicine, Maastricht University Medical Centre, the Netherlands / Fellow of ERS
Remote photoplethysmography (PPG) app-based prolonged opportunistic arrhythmia screening pathway for COPD doi.org/10.1183/2312...
November 2, 2025 at 7:50 PM
Remote photoplethysmography (PPG) app-based prolonged opportunistic arrhythmia screening pathway for COPD doi.org/10.1183/2312...
Natural disasters affecting respiratory health and the underlying mechanisms #ERS doi.org/10.1183/1399...
October 29, 2025 at 9:41 AM
Natural disasters affecting respiratory health and the underlying mechanisms #ERS doi.org/10.1183/1399...
Modeled evolution of the global economic and health burden of COPD from 2025 to 2050, considering trends in risk factors and an expanding population. Actions needed to reduce risk factors and improve treatments. #CHEST doi.org/10.1016/j.ch...
October 15, 2025 at 2:34 PM
Modeled evolution of the global economic and health burden of COPD from 2025 to 2050, considering trends in risk factors and an expanding population. Actions needed to reduce risk factors and improve treatments. #CHEST doi.org/10.1016/j.ch...
Pathophysiological mechanisms disrupting lung development. Early-life exposures, including genetic and epigenetic alterations, infections, oxidative stress, and inflammation, contribute to impaired lung development. doi.org/10.1146/annu... #worldlungday
September 25, 2025 at 7:27 AM
Pathophysiological mechanisms disrupting lung development. Early-life exposures, including genetic and epigenetic alterations, infections, oxidative stress, and inflammation, contribute to impaired lung development. doi.org/10.1146/annu... #worldlungday
Having had just 1 moderate exacerbation in the year prior to COPD diagnosis significantly increases the risk of future events, suggesting that placing patients with 0 or 1 moderate event in the same low risk of future exacerbation groups (A & B) in GOLD is not justified doi.org/10.1183/1399...
September 1, 2025 at 7:12 PM
Having had just 1 moderate exacerbation in the year prior to COPD diagnosis significantly increases the risk of future events, suggesting that placing patients with 0 or 1 moderate event in the same low risk of future exacerbation groups (A & B) in GOLD is not justified doi.org/10.1183/1399...
Multiple direct and indirect pathways increase risk of lung disease exacerbations during heat waves. Community preparedness and advocacy are needed, particularly to address greater adverse effects on vulnerable populations. doi.org/10.1164/rccm... @atsblueeditor.bsky.social
August 11, 2025 at 8:11 AM
Multiple direct and indirect pathways increase risk of lung disease exacerbations during heat waves. Community preparedness and advocacy are needed, particularly to address greater adverse effects on vulnerable populations. doi.org/10.1164/rccm... @atsblueeditor.bsky.social
New US study shows that COPD confers a 1.9-fold higher risk of intensive care unit admission or in-hospital mortality in adults hospitalized with RSV doi.org/10.1093/ofid... #virus #RSV
August 6, 2025 at 1:36 PM
New US study shows that COPD confers a 1.9-fold higher risk of intensive care unit admission or in-hospital mortality in adults hospitalized with RSV doi.org/10.1093/ofid... #virus #RSV
COPD patient survey shows that >20% of patients are not on maintenance therapy; leading reasons include that their COPD was not severe enough, and that their doctors had not recommended it. Action is needed for more effective and timely disease management. #COPDfoundation doi.org/10.15326/jco...
July 31, 2025 at 7:15 AM
COPD patient survey shows that >20% of patients are not on maintenance therapy; leading reasons include that their COPD was not severe enough, and that their doctors had not recommended it. Action is needed for more effective and timely disease management. #COPDfoundation doi.org/10.15326/jco...
Airway mucus plugs were previously associated with increased risk of exacerbations and mortality in COPD. Now, persistent and newly formed mucus plugs are associated with a faster decrease in lung function (FEV1) in this disease. @nejm.org www.nejm.org/doi/abs/10.1...
May 28, 2025 at 11:15 AM
Airway mucus plugs were previously associated with increased risk of exacerbations and mortality in COPD. Now, persistent and newly formed mucus plugs are associated with a faster decrease in lung function (FEV1) in this disease. @nejm.org www.nejm.org/doi/abs/10.1...
Newly proposed diagnostic schema for COPD using major and minor criteria classifies individuals as having this disease beyond airflow limitation and identifies individuals at increased risk for poor outcomes. doi:10.1001/jama.2025.7358
@jama.com
@jama.com
May 26, 2025 at 2:27 PM
Newly proposed diagnostic schema for COPD using major and minor criteria classifies individuals as having this disease beyond airflow limitation and identifies individuals at increased risk for poor outcomes. doi:10.1001/jama.2025.7358
@jama.com
@jama.com
Pulmonary rehabilitation is an evidence-based, personalized, comprehensive intervention that improves physical and psychological function and reduces healthcare consumption in people with chronic respiratory conditions #PRweek2025 #COPD
March 11, 2025 at 8:38 PM
Pulmonary rehabilitation is an evidence-based, personalized, comprehensive intervention that improves physical and psychological function and reduces healthcare consumption in people with chronic respiratory conditions #PRweek2025 #COPD
Almost 31% of persons hospitalized with severe RSV infection has underlying COPD and in-hospital mortality in this group may be as high as 18%. Preventive vaccins are available but need to be implemented. www.springernature.com/gp/open-rese...
February 26, 2025 at 3:36 PM
Almost 31% of persons hospitalized with severe RSV infection has underlying COPD and in-hospital mortality in this group may be as high as 18%. Preventive vaccins are available but need to be implemented. www.springernature.com/gp/open-rese...
Targeting T2 inflammation or epithelial-derived alarmins represents a step forward in precision medicine for the treatment of a subset of COPD... www.sciencedirect.com/science/arti...
February 21, 2025 at 2:18 PM
Targeting T2 inflammation or epithelial-derived alarmins represents a step forward in precision medicine for the treatment of a subset of COPD... www.sciencedirect.com/science/arti...
Theoretical framework illustrating the potential impact of body composition on COPD exacerbation risk; from our latest editorial in Respirology #felipemachado doi.org/10.1111/resp...
February 19, 2025 at 11:20 AM
Theoretical framework illustrating the potential impact of body composition on COPD exacerbation risk; from our latest editorial in Respirology #felipemachado doi.org/10.1111/resp...
Hard to comprehend and even harder to accept: a 46.3%, or 35 year, loss of life expectancy in the Gaza Strip during the period October, 2023, to September, 2024. Touched by this @thelancet.bsky.social paper. doi.org/10.1016/S014...
February 12, 2025 at 9:03 PM
Hard to comprehend and even harder to accept: a 46.3%, or 35 year, loss of life expectancy in the Gaza Strip during the period October, 2023, to September, 2024. Touched by this @thelancet.bsky.social paper. doi.org/10.1016/S014...
New meta-analysis shows a significant 20% reduction in all-cause mortality with ICS-containing therapies versus non-ICS containing inhaler therapies in COPD. Future research should identify patient subgroups most likely to benefit while minimizing adverse effects. doi.org/10.1080/1747...
February 12, 2025 at 7:56 PM
New meta-analysis shows a significant 20% reduction in all-cause mortality with ICS-containing therapies versus non-ICS containing inhaler therapies in COPD. Future research should identify patient subgroups most likely to benefit while minimizing adverse effects. doi.org/10.1080/1747...
The worldwide prevalence of shortness of breath in adults is approx. 14%, with a wide variation across sites. Furthermore, it is strongly associated with spirometric obstruction and restriction. #BOLD www.sciencedirect.com/science/arti...
February 6, 2025 at 12:27 PM
The worldwide prevalence of shortness of breath in adults is approx. 14%, with a wide variation across sites. Furthermore, it is strongly associated with spirometric obstruction and restriction. #BOLD www.sciencedirect.com/science/arti...
PDE3 and PDE4 contribute to inflammation and airway smooth muscle contraction, that is evident in conditions such as COPD. Dual inhibition of these enzymes may provide clinical benefit to a broad range of patients with COPD and represents a promising new treatment strategy. doi.org/10.15326/jco...
January 31, 2025 at 6:59 AM
PDE3 and PDE4 contribute to inflammation and airway smooth muscle contraction, that is evident in conditions such as COPD. Dual inhibition of these enzymes may provide clinical benefit to a broad range of patients with COPD and represents a promising new treatment strategy. doi.org/10.15326/jco...
Proposal for the management of cardiovascular risk factors and disease in patients with COPD doi.org/10.1080/1477...
January 24, 2025 at 6:44 PM
Proposal for the management of cardiovascular risk factors and disease in patients with COPD doi.org/10.1080/1477...
Impact of home non-invasive ventilation in chronic hypercapnic respiratory failure due to COPD. Initiation of home noninvasive ventilation in hypercapnic chronic obstructive pulmonary disease: when, where, and how? - PubMed (nih.gov)
December 23, 2024 at 10:50 AM
Impact of home non-invasive ventilation in chronic hypercapnic respiratory failure due to COPD. Initiation of home noninvasive ventilation in hypercapnic chronic obstructive pulmonary disease: when, where, and how? - PubMed (nih.gov)
Patient-reported outcome measures (PROMs) are poorly related to clinical measures in severe asthma, but PROMs are prone to changes in usual care, with exacerbations playing a key role. doi.org/10.1186/s129... #asthma
December 23, 2024 at 10:26 AM
Patient-reported outcome measures (PROMs) are poorly related to clinical measures in severe asthma, but PROMs are prone to changes in usual care, with exacerbations playing a key role. doi.org/10.1186/s129... #asthma
Our latest study is now online in @JAMA Network Open, reporting on the limited estimative performance of exacerbation (ECOPD) history categories by GOLD. Novel cutoffs are suggested in the paper. doi:10.1001/jamanetworkopen.2024.45488
December 19, 2024 at 11:09 AM
Our latest study is now online in @JAMA Network Open, reporting on the limited estimative performance of exacerbation (ECOPD) history categories by GOLD. Novel cutoffs are suggested in the paper. doi:10.1001/jamanetworkopen.2024.45488
Low birth weight is associated with increased risk of COPD, but also has interactions with maternal smoking, older age and passive smoking. Low birth weight and smoking during pregnancy have a joint effect.
bmjopenrespres.bmj.com/content/11/1...
bmjopenrespres.bmj.com/content/11/1...
December 16, 2024 at 7:20 PM
Low birth weight is associated with increased risk of COPD, but also has interactions with maternal smoking, older age and passive smoking. Low birth weight and smoking during pregnancy have a joint effect.
bmjopenrespres.bmj.com/content/11/1...
bmjopenrespres.bmj.com/content/11/1...
Procalcitonin-guided antibiotic therapy for patients with exacerbations of COPD significantly reduced the rate of antibiotic prescriptions without negatively affecting treatment success rate or other outcomes. doi.org/10.1016/j.cm... @cmijournal.bsky.social
December 12, 2024 at 1:37 PM
Procalcitonin-guided antibiotic therapy for patients with exacerbations of COPD significantly reduced the rate of antibiotic prescriptions without negatively affecting treatment success rate or other outcomes. doi.org/10.1016/j.cm... @cmijournal.bsky.social
Several interesting points in this figure: 1) ex-smokers with COPD are less likely to have cough or phlegm than current smokers; 2) more extensive mucus plugging is associated with lower percentage of patients without these symptoms #COPDGene journal.chestnet.org/article/S001... #chest
December 12, 2024 at 7:48 AM
Several interesting points in this figure: 1) ex-smokers with COPD are less likely to have cough or phlegm than current smokers; 2) more extensive mucus plugging is associated with lower percentage of patients without these symptoms #COPDGene journal.chestnet.org/article/S001... #chest