Francesca Chandler
@francescachandler.bsky.social
Pinned
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology
The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...
www.nature.com
Very happy to share the work from my PhD is out today in @naturesmb.bsky.social !
Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...
Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...
Reposted by Francesca Chandler
A fully narrated animation by our amazing friends at Phospho Biomedical Animation is linked below. Worth a watch.
youtu.be/wuFVeW6eCPg?...
youtu.be/wuFVeW6eCPg?...
Molecular Glues: drugging the undruggable
YouTube video by Phospho Biomedical Animation
youtu.be
March 17, 2025 at 8:58 PM
A fully narrated animation by our amazing friends at Phospho Biomedical Animation is linked below. Worth a watch.
youtu.be/wuFVeW6eCPg?...
youtu.be/wuFVeW6eCPg?...
Reposted by Francesca Chandler
Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.
rdcu.be/edRwF
rdcu.be/edRwF
March 17, 2025 at 8:58 PM
Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.
rdcu.be/edRwF
rdcu.be/edRwF
Very happy to share the work from my PhD is out today in @naturesmb.bsky.social !
Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...
Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology
The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...
www.nature.com
March 17, 2025 at 5:39 PM
Very happy to share the work from my PhD is out today in @naturesmb.bsky.social !
Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...
Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...