Francesca Bartolini
@francescabartolini.bsky.social
Microtubule wrangler by day, flamenco aficionado by night 💃
💊✨ Exciting new collaboration with Laurence Lafanechère’s team (Grenoble)!
Our new study introduces Carba1, a bifunctional carbazole compound that protects against chemotherapy-induced peripheral neuropathy (CIPN) — a major unmet need in cancer therapy.
Our new study introduces Carba1, a bifunctional carbazole compound that protects against chemotherapy-induced peripheral neuropathy (CIPN) — a major unmet need in cancer therapy.
www.science.org
October 29, 2025 at 7:05 PM
💊✨ Exciting new collaboration with Laurence Lafanechère’s team (Grenoble)!
Our new study introduces Carba1, a bifunctional carbazole compound that protects against chemotherapy-induced peripheral neuropathy (CIPN) — a major unmet need in cancer therapy.
Our new study introduces Carba1, a bifunctional carbazole compound that protects against chemotherapy-induced peripheral neuropathy (CIPN) — a major unmet need in cancer therapy.
Reposted by Francesca Bartolini
Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1...
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social
August 28, 2025 at 7:03 AM
Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1...
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social
so many stories in one short clip!
This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.
August 20, 2025 at 2:33 PM
so many stories in one short clip!
Reposted by Francesca Bartolini
🚨
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...
August 19, 2025 at 3:32 PM
🚨
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.
▶️ www.biorxiv.org/content/10.1...
Reposted by Francesca Bartolini
Nominate a deserving early-career investigator today for a chance to compete for a $100,000, 2-year grant!
Support the next generation of Alzheimer’s researchers.
Nominate ➡️ airtable.com/appjJE7FUGZY...
#CCAD2026 #AlzheimersResearch #EarlyCareerScientists #ResearchFunding
Support the next generation of Alzheimer’s researchers.
Nominate ➡️ airtable.com/appjJE7FUGZY...
#CCAD2026 #AlzheimersResearch #EarlyCareerScientists #ResearchFunding
May 13, 2025 at 9:59 PM
Nominate a deserving early-career investigator today for a chance to compete for a $100,000, 2-year grant!
Support the next generation of Alzheimer’s researchers.
Nominate ➡️ airtable.com/appjJE7FUGZY...
#CCAD2026 #AlzheimersResearch #EarlyCareerScientists #ResearchFunding
Support the next generation of Alzheimer’s researchers.
Nominate ➡️ airtable.com/appjJE7FUGZY...
#CCAD2026 #AlzheimersResearch #EarlyCareerScientists #ResearchFunding
Reposted by Francesca Bartolini
LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data
LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data https://www.biorxiv.org/content/10.1101/2025.04.28.650893v1
May 1, 2025 at 6:55 PM
LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data
Reposted by Francesca Bartolini
Today, the 25th of April, in Italy 🇮🇹 we celebrate the #Liberation from NaziFascism. We celebrate to remember the people of the resistance, we celebrate to remember that we kicked fascists' asses once and we can do it again.
April 25, 2025 at 9:37 AM
Today, the 25th of April, in Italy 🇮🇹 we celebrate the #Liberation from NaziFascism. We celebrate to remember the people of the resistance, we celebrate to remember that we kicked fascists' asses once and we can do it again.
Reposted by Francesca Bartolini
Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 22, 2025 at 1:02 AM
Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Francesca Bartolini
Our PhD student Louis Romette is optimizing long-term live-cell imaging. He just casually dropped this 65-hour movie of a growing neuron (div 3 to 6) with knocked-in actin 🔥🕶️ #realtimemicroscopy
April 17, 2025 at 1:30 PM
Our PhD student Louis Romette is optimizing long-term live-cell imaging. He just casually dropped this 65-hour movie of a growing neuron (div 3 to 6) with knocked-in actin 🔥🕶️ #realtimemicroscopy
Reposted by Francesca Bartolini
A blood test biomarker for early detection of Parkinson's disease when there are no symptoms @natureaging.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments - Nature Aging
Madrer et al. identify a Parkinson’s disease–specific increase in transfer RNA (tRNA) fragments in human blood, cerebrospinal fluid and postmortem brain tissue, demonstrating the ability of blood-base...
www.nature.com
April 11, 2025 at 1:56 PM
A blood test biomarker for early detection of Parkinson's disease when there are no symptoms @natureaging.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Happy to share the latest paper of my postdoc JieJia Teoh from his old lab. Super lucky to have you join our MT family JJ!
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy
Gain-of-function variants in the GRIN2D gene cause a severe developmental and epileptic encephalopathy. Teoh et al. generate a mouse model with the V664I v
academic.oup.com
April 12, 2025 at 3:11 PM
Happy to share the latest paper of my postdoc JieJia Teoh from his old lab. Super lucky to have you join our MT family JJ!
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Reposted by Francesca Bartolini
We have a new review out! In this Microscopy & Microanalysis piece, Louisa Mezache and I survey some of the latest commercially available microscope technologies: Nikon NSPARC, Re-scan Gaia, CSR Biotech MI-SIM, refinements to STED, SMLM from Bruker and Abbelight… Check it out with free access:
Advancing Super-Resolution Microscopy: Recent Innovations in Commercial Instruments
Abstract. Super-resolution microscopy techniques have accelerated scientific progress, enabling researchers to explore cellular structures and dynamics wit
academic.oup.com
April 9, 2025 at 3:47 PM
We have a new review out! In this Microscopy & Microanalysis piece, Louisa Mezache and I survey some of the latest commercially available microscope technologies: Nikon NSPARC, Re-scan Gaia, CSR Biotech MI-SIM, refinements to STED, SMLM from Bruker and Abbelight… Check it out with free access:
Happy to share this fabulous collaboration with Laurence Lafanechere et al. in which we demonstrate that in addition to synergizing with taxanes, Carba1 remarkably protects neurons from CIPN by stimulating NAD biosynthesis through activation of NAMPT!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Preventing neuropathy and improving anti-cancer chemotherapy with a carbazole-based compound
Advances in cancer treatment have led to a steady increase in the rate of disease remission. However, while many treatment-related adverse effects gradually resolve after therapy, chemotherapy-induced...
www.biorxiv.org
March 20, 2025 at 1:45 PM
Happy to share this fabulous collaboration with Laurence Lafanechere et al. in which we demonstrate that in addition to synergizing with taxanes, Carba1 remarkably protects neurons from CIPN by stimulating NAD biosynthesis through activation of NAMPT!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. In this study, we demonstrate t...
www.science.org
March 7, 2025 at 2:18 PM
Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Reposted by Francesca Bartolini
@michellemonje.bsky.social at @stanfordmedicine.bsky.social and Frank Winkler at Heidelberg University have won the 2025 @brainprize.bsky.social from the Lundbeck Foundation for their work in cancer neuroscience.
By @sydneywyatt.bsky.social
#neuroskyence
www.thetransmitter.org/community/20...
By @sydneywyatt.bsky.social
#neuroskyence
www.thetransmitter.org/community/20...
2025 Brain Prize honors pair of cancer neuroscientists
Michelle Monje and Frank Winkler share the $1.4 million award for their discovery of synapses between brain cancer cells and neurons.
www.thetransmitter.org
March 5, 2025 at 3:10 PM
@michellemonje.bsky.social at @stanfordmedicine.bsky.social and Frank Winkler at Heidelberg University have won the 2025 @brainprize.bsky.social from the Lundbeck Foundation for their work in cancer neuroscience.
By @sydneywyatt.bsky.social
#neuroskyence
www.thetransmitter.org/community/20...
By @sydneywyatt.bsky.social
#neuroskyence
www.thetransmitter.org/community/20...
Very interesting new cell biology linking the blood-borne hormone osteocalcin to the renewal of a primary cilia-autophagy axis in hippocampal neurons!
rdcu.be/ebez3
rdcu.be/ebez3
A primary cilia–autophagy axis in hippocampal neurons is essential to maintain cognitive resilience
Nature Aging - Exploring the molecular mechanisms by which the blood-borne factor osteocalcin promotes cognitive resilience, Rivagorda, Romeo-Guitart et al. identify a primary cilia axis through...
rdcu.be
February 25, 2025 at 3:59 PM
Very interesting new cell biology linking the blood-borne hormone osteocalcin to the renewal of a primary cilia-autophagy axis in hippocampal neurons!
rdcu.be/ebez3
rdcu.be/ebez3
Reposted by Francesca Bartolini
Your Action Is Needed!
Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy
www.ascb.org/science-poli...
Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy
www.ascb.org/science-poli...
February 5, 2025 at 3:39 PM
Your Action Is Needed!
Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy
www.ascb.org/science-poli...
Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy
www.ascb.org/science-poli...
Reposted by Francesca Bartolini
Alzheimer's Association Research Fellowship (AARF)
Alzheimer's Association Clinician Scientist Fellowship to Promote Diversity (AACSF-D)
LOI deadline: Feb 27, 2025
Max Award: 200K-250K
#medsky #academicsky 🧪
www.alz.org/research/for...
Alzheimer's Association Clinician Scientist Fellowship to Promote Diversity (AACSF-D)
LOI deadline: Feb 27, 2025
Max Award: 200K-250K
#medsky #academicsky 🧪
www.alz.org/research/for...
February 2, 2025 at 9:31 PM
Alzheimer's Association Research Fellowship (AARF)
Alzheimer's Association Clinician Scientist Fellowship to Promote Diversity (AACSF-D)
LOI deadline: Feb 27, 2025
Max Award: 200K-250K
#medsky #academicsky 🧪
www.alz.org/research/for...
Alzheimer's Association Clinician Scientist Fellowship to Promote Diversity (AACSF-D)
LOI deadline: Feb 27, 2025
Max Award: 200K-250K
#medsky #academicsky 🧪
www.alz.org/research/for...
Cell Bio 2024 mini symposium on synaptic microtubules: every talk was engaging, thought-provoking, and left a great impression on everyone who attended. We've already received so much positive feedback! I love this bunch and can't wait to do this again!👇👇
December 17, 2024 at 4:36 PM
Cell Bio 2024 mini symposium on synaptic microtubules: every talk was engaging, thought-provoking, and left a great impression on everyone who attended. We've already received so much positive feedback! I love this bunch and can't wait to do this again!👇👇
Reposted by Francesca Bartolini
Help choose JCB’s cover of the year! 🔬 Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. 🗓️ Voting closes on Friday, December 20! Have your say in celebrating the beauty of science 👉 https://buff.ly/3BdttSI #CellBio2024
December 4, 2024 at 3:07 PM
Help choose JCB’s cover of the year! 🔬 Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. 🗓️ Voting closes on Friday, December 20! Have your say in celebrating the beauty of science 👉 https://buff.ly/3BdttSI #CellBio2024
I'm excited to share an invitation to the Science Art Show & Reception that Beata is organizing after her subgroup session. The event will take place near the conference venue directly after our subgroup (6:30-10:30 pm). Pls RSVP and join the fun!👇👇👇
December 6, 2024 at 4:46 PM
I'm excited to share an invitation to the Science Art Show & Reception that Beata is organizing after her subgroup session. The event will take place near the conference venue directly after our subgroup (6:30-10:30 pm). Pls RSVP and join the fun!👇👇👇