Freddy Benning
@fmcbenning.bsky.social
Mitochondria | structural biology | molecular assemblies | eukaryogenesis
Pinned
Freddy Benning
@fmcbenning.bsky.social
· May 16
Meet Friederike Benning, PhD, the newest Jim and Virginia Stowers Fellow! Her research dives into the complexity of energy generation in evolution to reveal how bacteria build membranes to survive in extreme environments. 🦠
Learn more: bit.ly/3SCZQiM
Learn more: bit.ly/3SCZQiM
I’m thrilled to share that I will join @stowersinstitute.bsky.social this fall to explore the evolution and design of bioenergetic membranes in bacteria.
Out in print! Using ancestral sequence reconstruction 🦖, in vivo characterization, and 🔬 analysis, we identified key residues in the mitochondrial protein #Mic60 that affect #respiration in #yeast.
Since the preprint, we added some cool findings. 🧵⬇️
onlinelibrary.wiley.com/doi/10.1002/...
Since the preprint, we added some cool findings. 🧵⬇️
onlinelibrary.wiley.com/doi/10.1002/...
Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast
In eukaryotes, cellular respiration takes place in the cristae of mitochondria. The mitochondrial inner membrane protein Mic60, a core component of the mitochondrial contact site and cristae organizi...
onlinelibrary.wiley.com
June 23, 2025 at 9:44 PM
Out in print! Using ancestral sequence reconstruction 🦖, in vivo characterization, and 🔬 analysis, we identified key residues in the mitochondrial protein #Mic60 that affect #respiration in #yeast.
Since the preprint, we added some cool findings. 🧵⬇️
onlinelibrary.wiley.com/doi/10.1002/...
Since the preprint, we added some cool findings. 🧵⬇️
onlinelibrary.wiley.com/doi/10.1002/...
I’m thrilled to share that I will join @stowersinstitute.bsky.social this fall to explore the evolution and design of bioenergetic membranes in bacteria.
Meet Friederike Benning, PhD, the newest Jim and Virginia Stowers Fellow! Her research dives into the complexity of energy generation in evolution to reveal how bacteria build membranes to survive in extreme environments. 🦠
Learn more: bit.ly/3SCZQiM
Learn more: bit.ly/3SCZQiM
May 16, 2025 at 12:57 PM
I’m thrilled to share that I will join @stowersinstitute.bsky.social this fall to explore the evolution and design of bioenergetic membranes in bacteria.
Reposted by Freddy Benning
We’re proud to welcome two bold scientific minds to the Institute! Arvind Pillai, PhD, joins as Assistant Investigator exploring protein #evolution and design. Friederike Benning, PhD, joins as Stowers Fellow studying membrane complexity in #bacteria.
Read more: bit.ly/3SCZQiM
Read more: bit.ly/3SCZQiM
May 15, 2025 at 1:33 PM
We’re proud to welcome two bold scientific minds to the Institute! Arvind Pillai, PhD, joins as Assistant Investigator exploring protein #evolution and design. Friederike Benning, PhD, joins as Stowers Fellow studying membrane complexity in #bacteria.
Read more: bit.ly/3SCZQiM
Read more: bit.ly/3SCZQiM
Reposted by Freddy Benning
Congrats Chen and colleagues (with shoutout to @myfry.bsky.social for connecting our labs)! JCI - SARM1 loss protects retinal ganglion cells in a mouse model of Autosomal Dominant Optic Atrophy www.jci.org/articles/vie...
JCI -
SARM1 loss protects retinal ganglion cells in a mouse model of Autosomal Dominant Optic Atrophy
www.jci.org
May 10, 2025 at 2:52 PM
Congrats Chen and colleagues (with shoutout to @myfry.bsky.social for connecting our labs)! JCI - SARM1 loss protects retinal ganglion cells in a mouse model of Autosomal Dominant Optic Atrophy www.jci.org/articles/vie...
Reposted by Freddy Benning
🚨👉 Please check our recent work on bacterial cell division. In situ Cryo-ET reveals the cellular function of the penicillin binding protein 1b supported by AFM, live-cell imaging, in silico AlphaFold proteome screen and TIRFM. Hope you enjoy the read! #teamtomo #cryo-ET ❄️🔬🐎 big thanks to the team!
The aPBP-type cell wall synthase PBP1b plays a specialized role in fortifying the Escherichia coli division site against osmotic rupture https://www.biorxiv.org/content/10.1101/2025.04.02.646830v1
April 3, 2025 at 9:08 AM
Reposted by Freddy Benning
Interested in learning more about genome editing tool dev & their application to treat human diseases? 🧬 🏥
We're hiring graduating seniors who are seeking ~2 years of post-bac research experience.
If you're interested in gaining experience in next gen medicines, please reach out and apply!
Link 👇
We're hiring graduating seniors who are seeking ~2 years of post-bac research experience.
If you're interested in gaining experience in next gen medicines, please reach out and apply!
Link 👇
Research Technician I - Center for Genomic Medicine
Site: The General Hospital Corporation At Mass General Brigham, we know it takes a surprising range of talented professionals to advance our mission—from doctors, nurses, business people and tech expe...
massgeneralbrigham.wd1.myworkdayjobs.com
March 13, 2025 at 4:39 PM
Interested in learning more about genome editing tool dev & their application to treat human diseases? 🧬 🏥
We're hiring graduating seniors who are seeking ~2 years of post-bac research experience.
If you're interested in gaining experience in next gen medicines, please reach out and apply!
Link 👇
We're hiring graduating seniors who are seeking ~2 years of post-bac research experience.
If you're interested in gaining experience in next gen medicines, please reach out and apply!
Link 👇
Great summary of our recent preprint by Barbora from @prelights.bsky.social. #mitochondria #cristae #respiration #asr
A new #preLight has appeared! ✨🔔
Barbora highlights a preprinted study from the Chao Lab (@lukechao.bsky.social) in which the structure-function relationship at the site of cellular respiration is under review. 👀
Check it out! ⬇️
prelights.biologists.com/highlights/a...
Barbora highlights a preprinted study from the Chao Lab (@lukechao.bsky.social) in which the structure-function relationship at the site of cellular respiration is under review. 👀
Check it out! ⬇️
prelights.biologists.com/highlights/a...
Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast - preLights
In this preprint the structure-function relationship at the site of cellular respiration is under review.
prelights.biologists.com
March 11, 2025 at 1:07 PM
Great summary of our recent preprint by Barbora from @prelights.bsky.social. #mitochondria #cristae #respiration #asr
How do baculoviruses protect their genome?
Delighted to present our findings in print!
We use cryo-EM to determine the structure of a baculoviral nucleocapsid. We show how the tiny capsid protein VP39 assembles into a giant nucleocapsid.❄️🔬
www.nature.com/articles/s41...
Delighted to present our findings in print!
We use cryo-EM to determine the structure of a baculoviral nucleocapsid. We show how the tiny capsid protein VP39 assembles into a giant nucleocapsid.❄️🔬
www.nature.com/articles/s41...
Helical reconstruction of VP39 reveals principles for baculovirus nucleocapsid assembly - Nature Com...
Baculoviruses are used as insecticides, gene therapy tools, and protein production vectors. Here, the authors report the structure of the Autographa californica MNPV nucleocapsid and its fold conserva...
www.nature.com
January 8, 2024 at 9:44 AM
How do baculoviruses protect their genome?
Delighted to present our findings in print!
We use cryo-EM to determine the structure of a baculoviral nucleocapsid. We show how the tiny capsid protein VP39 assembles into a giant nucleocapsid.❄️🔬
www.nature.com/articles/s41...
Delighted to present our findings in print!
We use cryo-EM to determine the structure of a baculoviral nucleocapsid. We show how the tiny capsid protein VP39 assembles into a giant nucleocapsid.❄️🔬
www.nature.com/articles/s41...