Aleksandra Filipovska
@filipovskalab.bsky.social
Reposted by Aleksandra Filipovska
Our story about FASTKD5 is now published at @narjournal.bsky.social It was an amazing collaboration with @haukehillen.bsky.social and Toni Barrientos’ labs.
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
FASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites
Abstract. The first post-transcriptional step in mammalian mitochondrial gene expression, required for the synthesis of the 13 polypeptides encoded in mito
doi.org
July 11, 2025 at 4:14 AM
Our story about FASTKD5 is now published at @narjournal.bsky.social It was an amazing collaboration with @haukehillen.bsky.social and Toni Barrientos’ labs.
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
Reposted by Aleksandra Filipovska
A great collaboration combining clinical and research data to describe mutations in FASTKD5 causing Leigh syndrome. Thank you all!
📣New from @hantonicka.bsky.social & co
📄Bi-allelic mutations in FASTKD5 are associated with cytochrome c oxidase deficiency and early- to late-onset Leigh syndrome
📄Bi-allelic mutations in FASTKD5 are associated with cytochrome c oxidase deficiency and early- to late-onset Leigh syndrome
Bi-allelic mutations in FASTKD5 are associated with cytochrome c oxidase deficiency and early- to late-onset Leigh syndrome
Mutations in FASTKD5, which codes for a protein essential for processing the primary
mitochondrial transcript, were identified in subjects who presented with Leigh syndrome
and cytochrome c oxidase de...
www.cell.com
June 10, 2025 at 5:49 PM
A great collaboration combining clinical and research data to describe mutations in FASTKD5 causing Leigh syndrome. Thank you all!
It takes two to TANGO2!
TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermediate filament desmin and its loss models TANGO2-deficiency disorder
Many thanks to our team, collaborators and reviewers
rdcu.be/epI3p
#metabolism
#mitochondria
#genetic disorders
TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermediate filament desmin and its loss models TANGO2-deficiency disorder
Many thanks to our team, collaborators and reviewers
rdcu.be/epI3p
#metabolism
#mitochondria
#genetic disorders
June 7, 2025 at 4:53 AM
It takes two to TANGO2!
TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermediate filament desmin and its loss models TANGO2-deficiency disorder
Many thanks to our team, collaborators and reviewers
rdcu.be/epI3p
#metabolism
#mitochondria
#genetic disorders
TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermediate filament desmin and its loss models TANGO2-deficiency disorder
Many thanks to our team, collaborators and reviewers
rdcu.be/epI3p
#metabolism
#mitochondria
#genetic disorders
Reposted by Aleksandra Filipovska
Reposted by Aleksandra Filipovska
Our paper is finally out: Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...
#mitochondria #cryo-EM
#mitochondria #cryo-EM
Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier
The mitochondrial pyruvate carrier transport mechanism is ΔpH driven and is inhibited competitively by distinct compound classes.
www.science.org
April 18, 2025 at 6:16 PM
Our paper is finally out: Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier | Science Advances www.science.org/doi/10.1126/...
#mitochondria #cryo-EM
#mitochondria #cryo-EM
Reposted by Aleksandra Filipovska
Happy to share out latest collaborative work with the groups of Ricarda Richter-Dennerlein and Peter Rehling just out in
@natcomms.nature.com. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab).
www.nature.com/articles/s41...
@natcomms.nature.com. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab).
www.nature.com/articles/s41...
Coupling of ribosome biogenesis and translation initiation in human mitochondria - Nature Communications
Mitochondrial ribosome biogenesis requires the assistance of multiple assembly factors. Here, the authors provide insights into the essential role of the GTPase MTG3 during small subunit biogenesis an...
www.nature.com
April 17, 2025 at 9:39 AM
Happy to share out latest collaborative work with the groups of Ricarda Richter-Dennerlein and Peter Rehling just out in
@natcomms.nature.com. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab).
www.nature.com/articles/s41...
@natcomms.nature.com. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab).
www.nature.com/articles/s41...
Reposted by Aleksandra Filipovska
Explore current research to better understand the roles of #mitochondria in our cells at the EMBO | FEBS Lecture Course "The evolving role of mitochondria in metabolism" in Belgrade, Serbia, 14–18 Sep
Deadline: 1 Jun
meetings.embo.org/event/25-mit...
#EMBOmitochondria25 #metabolism #EMBOevents 🧪
Deadline: 1 Jun
meetings.embo.org/event/25-mit...
#EMBOmitochondria25 #metabolism #EMBOevents 🧪
The evolving role of mitochondria in metabolism
The history of mitochondria begins with their recognition as distinct cellular organelles in 1888 by Walther Flemming and the introduction of the term mitochondrion from the Greek roots meaning ‘thre…
meetings.embo.org
April 11, 2025 at 2:04 PM
Explore current research to better understand the roles of #mitochondria in our cells at the EMBO | FEBS Lecture Course "The evolving role of mitochondria in metabolism" in Belgrade, Serbia, 14–18 Sep
Deadline: 1 Jun
meetings.embo.org/event/25-mit...
#EMBOmitochondria25 #metabolism #EMBOevents 🧪
Deadline: 1 Jun
meetings.embo.org/event/25-mit...
#EMBOmitochondria25 #metabolism #EMBOevents 🧪
Reposted by Aleksandra Filipovska
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Small molecules restore mutant mitochondrial DNA polymerase activity - Nature
An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.
www.nature.com
April 9, 2025 at 4:30 PM
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Aleksandra Filipovska
It is believed that proton conductance by the mitochondrial uncoupling protein (UCP1) is inhibited specifically by purine nucleotides, but we show that pyrimidine nucleotides also inhibit UCP1 with similar affinities in a pH-dependent manner. #mitochondria
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
February 28, 2025 at 4:59 PM
It is believed that proton conductance by the mitochondrial uncoupling protein (UCP1) is inhibited specifically by purine nucleotides, but we show that pyrimidine nucleotides also inhibit UCP1 with similar affinities in a pH-dependent manner. #mitochondria
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Ready to make breakthroughs in gene editing and mitochondrial biology in sunny Western Australia? Join our vibrant team as a Research Associate or Research Fellow. Expertise in cryo-EM, cell imaging, or mammalian genetic screens is highly desirable
staff.curtin.edu.au/explore-care...
staff.curtin.edu.au/explore-care...
February 12, 2025 at 10:19 PM
Ready to make breakthroughs in gene editing and mitochondrial biology in sunny Western Australia? Join our vibrant team as a Research Associate or Research Fellow. Expertise in cryo-EM, cell imaging, or mammalian genetic screens is highly desirable
staff.curtin.edu.au/explore-care...
staff.curtin.edu.au/explore-care...
Reposted by Aleksandra Filipovska
Another fantastic piece of work from Carlos Moraes' group. Using mitochondrial DdCBE base editors to correct a pathogenic mutation in our heteroplasmic m.5024C>T mice. 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Correcting a pathogenic mitochondrial DNA mutation by base editing in mice
A mitochondrial DNA editor can make compensatory corrections for a pathological mitochondrial DNA mutation in mice.
www.science.org
January 30, 2025 at 11:20 AM
Another fantastic piece of work from Carlos Moraes' group. Using mitochondrial DdCBE base editors to correct a pathogenic mutation in our heteroplasmic m.5024C>T mice. 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice!
academic.oup.com/nar/article/...
#RNA
#mitochondria
#mtDNA
academic.oup.com/nar/article/...
#RNA
#mitochondria
#mtDNA
December 28, 2024 at 2:43 AM
New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice!
academic.oup.com/nar/article/...
#RNA
#mitochondria
#mtDNA
academic.oup.com/nar/article/...
#RNA
#mitochondria
#mtDNA