Fergus O'Farrell
@fergusofarrell.bsky.social
Doctor (Histopathology Trainee) & Neuroscience postdoc. Neuropathology. Autopsy.
Neuroscience PhD via UCL MBPhD. Neuron-glial-vascular interactions, physiology, literature, classical music, microscopy.
🌿📚🏳️🌈 he/him. Cambridge (and hopefully London again..)
Neuroscience PhD via UCL MBPhD. Neuron-glial-vascular interactions, physiology, literature, classical music, microscopy.
🌿📚🏳️🌈 he/him. Cambridge (and hopefully London again..)
Reposted by Fergus O'Farrell
📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments.
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
July 16, 2025 at 1:10 PM
📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments.
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
Reposted by Fergus O'Farrell
Delighted to share our paper examining synaptic tau in PSP. Many thanks to @robertmcgeachan.bsky.social @clairedurrant1.bsky.social and our many collaborators and funders. And extra special thanks to tissue donors who make this work possible.
📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments.
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
July 17, 2025 at 11:54 AM
Delighted to share our paper examining synaptic tau in PSP. Many thanks to @robertmcgeachan.bsky.social @clairedurrant1.bsky.social and our many collaborators and funders. And extra special thanks to tissue donors who make this work possible.
Medium rare. Vanishingly common. Not rare but not not uncommon.
April 27, 2025 at 10:06 PM
Medium rare. Vanishingly common. Not rare but not not uncommon.
My amazing pal Gene Koh strikes again! #InDel #CancerGenomics #MutationalSignatures @naturegenet.bsky.social
PAPER OUT!! 🥳🎉💃🏻🕺🏻💃🏻🕺🏻
A redefined InDel taxonomy provides insights into mutational signatures @NatureGenet
Brainchild of the amazing #GeneKoh
(Sir Jeffrey Cheah ECR)
Tweetorial below!! 👇
1/n
www.nature.com/articles/s41...
A redefined InDel taxonomy provides insights into mutational signatures @NatureGenet
Brainchild of the amazing #GeneKoh
(Sir Jeffrey Cheah ECR)
Tweetorial below!! 👇
1/n
www.nature.com/articles/s41...
A redefined InDel taxonomy provides insights into mutational signatures - Nature Genetics
This paper describes a framework for classifying small insertions and deletions from genomic data and applies it to a large dataset comprising seven tumor types. The analysis highlights new insertion ...
www.nature.com
April 11, 2025 at 9:34 PM
My amazing pal Gene Koh strikes again! #InDel #CancerGenomics #MutationalSignatures @naturegenet.bsky.social
Prescient urban planners installed this lovely sculpture of the Down Jones index in Cambridge 😌.
#stockmarketcrash
#stockmarketcrash
April 6, 2025 at 12:46 PM
Prescient urban planners installed this lovely sculpture of the Down Jones index in Cambridge 😌.
#stockmarketcrash
#stockmarketcrash
Reposted by Fergus O'Farrell
Today is the 17th BDIAP Approach to Cut-Up Study Day! The study day provides an opportunity for attendees to learn more about how to tackle some of the complex specimens that they may encounter in their departments.
#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation
#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation
March 4, 2025 at 11:14 AM
Today is the 17th BDIAP Approach to Cut-Up Study Day! The study day provides an opportunity for attendees to learn more about how to tackle some of the complex specimens that they may encounter in their departments.
#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation
#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation
Reposted by Fergus O'Farrell
The 10th BDIAP Molecular Pathology Study Day has started!
#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation #HealthcareProfessionals #StudyDay #BookNow
#pathology #histopathology #pathologyeducation #biomedicalscientist #pathologists
#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation #HealthcareProfessionals #StudyDay #BookNow
#pathology #histopathology #pathologyeducation #biomedicalscientist #pathologists
March 3, 2025 at 2:06 PM
The 10th BDIAP Molecular Pathology Study Day has started!
#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation #HealthcareProfessionals #StudyDay #BookNow
#pathology #histopathology #pathologyeducation #biomedicalscientist #pathologists
#PathologyStudyDay #CutUpPathology #MedicalTraining #Pathologist #MedicalEducation #HealthcareProfessionals #StudyDay #BookNow
#pathology #histopathology #pathologyeducation #biomedicalscientist #pathologists
Reposted by Fergus O'Farrell
Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social
Mechanisms of astrocyte aging in reactivity and disease - Molecular Neurodegeneration
Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organis...
molecularneurodegeneration.biomedcentral.com
February 21, 2025 at 12:08 PM
Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social
Reposted by Fergus O'Farrell
Great new work by Brian MacVicar's team, showing that pericytes and perivascular fibroblasts are distinct subpopulations of stromal progenitor cells in the adult brain that coordinate revascularization and scar formation after injury. #cerebrovascular #stroke #pericytes
Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke - Nature Neuroscience
Bernier, Hefendehl et al. describe a stromal progenitor cell population consisting of pericytes, venular smooth muscle cells and perivascular fibroblasts in the adult brain that modify their function ...
doi.org
February 18, 2025 at 1:39 AM
Great new work by Brian MacVicar's team, showing that pericytes and perivascular fibroblasts are distinct subpopulations of stromal progenitor cells in the adult brain that coordinate revascularization and scar formation after injury. #cerebrovascular #stroke #pericytes
This is how post-mortems should be documented 😉. From: Descriptive catalogue of the pathological series in the Hunterian Museum of the Royal College of Surgeons of England (1966) #PathSky
February 17, 2025 at 3:30 PM
This is how post-mortems should be documented 😉. From: Descriptive catalogue of the pathological series in the Hunterian Museum of the Royal College of Surgeons of England (1966) #PathSky
"The drowsy stillness of the afternoon was shattered by what sounded to his strained senses like G.K. Chesterton falling on a sheet of tin." P. G. Wodehouse
February 15, 2025 at 10:14 PM
"The drowsy stillness of the afternoon was shattered by what sounded to his strained senses like G.K. Chesterton falling on a sheet of tin." P. G. Wodehouse
Reposted by Fergus O'Farrell
Today, along with 2,000 other NIH employees, I had to clear out my office 😭
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
February 14, 2025 at 11:31 PM
Today, along with 2,000 other NIH employees, I had to clear out my office 😭
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
Reposted by Fergus O'Farrell
@physoc.bsky.social has a starter pack of physiologists. Hooray!! go.bsky.app/2KU1XD6
February 13, 2025 at 6:57 PM
@physoc.bsky.social has a starter pack of physiologists. Hooray!! go.bsky.app/2KU1XD6
Reposted by Fergus O'Farrell
A Perspective from @sierralab.bsky.social on #microglia as hunters or gatherers of brain synapses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microglia as hunters or gatherers of brain synapses - Nature Neuroscience
How microglia sculpt brain circuits is not clear. Here, the authors propose that their contribution to synapse removal may occur by severing synapses (culling) or collecting synapses shed off by neuro...
www.nature.com
January 14, 2025 at 2:41 PM
A Perspective from @sierralab.bsky.social on #microglia as hunters or gatherers of brain synapses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
2025 resolution: leave the pit that is Cambridge
January 1, 2025 at 3:13 PM
2025 resolution: leave the pit that is Cambridge
Reposted by Fergus O'Farrell
Waking out of my sleep on a sudden, I did with my elbow hit my wife a great blow over her face and nose, which waked her with pain, at which I was sorry, and to sleep again.
January 1, 2025 at 5:09 AM
Waking out of my sleep on a sudden, I did with my elbow hit my wife a great blow over her face and nose, which waked her with pain, at which I was sorry, and to sleep again.
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 13 (ish)
Cancer Ward, Aleksandr Solzhenitsyn
#Books #BookSky #BookChallenge
Day 13 (ish)
Cancer Ward, Aleksandr Solzhenitsyn
January 1, 2025 at 12:11 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 13 (ish)
Cancer Ward, Aleksandr Solzhenitsyn
#Books #BookSky #BookChallenge
Day 13 (ish)
Cancer Ward, Aleksandr Solzhenitsyn
My neuroscience Christmas decorations c. 2013
December 25, 2024 at 11:57 PM
My neuroscience Christmas decorations c. 2013
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 12
War and Peace, Leo Tolstoy
#Books #BookSky #BookChallenge
Day 12
War and Peace, Leo Tolstoy
December 25, 2024 at 11:55 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 12
War and Peace, Leo Tolstoy
#Books #BookSky #BookChallenge
Day 12
War and Peace, Leo Tolstoy
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 11
Vanity Fair, William Makepeace Thackeray
#Books #BookSky #BookChallenge
Day 11
Vanity Fair, William Makepeace Thackeray
December 24, 2024 at 11:32 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 11
Vanity Fair, William Makepeace Thackeray
#Books #BookSky #BookChallenge
Day 11
Vanity Fair, William Makepeace Thackeray
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 10
Middlemarch, George Eliot (Mary Ann Evans)
#Books #BookSky #BookChallenge
Day 10
Middlemarch, George Eliot (Mary Ann Evans)
December 23, 2024 at 6:51 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 10
Middlemarch, George Eliot (Mary Ann Evans)
#Books #BookSky #BookChallenge
Day 10
Middlemarch, George Eliot (Mary Ann Evans)
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 9
A Manual for Cleaning Women, Lucia Berlin
#Books #BookSky #BookChallenge
Day 9
A Manual for Cleaning Women, Lucia Berlin
December 22, 2024 at 10:05 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 9
A Manual for Cleaning Women, Lucia Berlin
#Books #BookSky #BookChallenge
Day 9
A Manual for Cleaning Women, Lucia Berlin
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 8
The Prime of Miss Jean Brodie, Muriel Spark
#Books #BookSky #BookChallenge
Day 8
The Prime of Miss Jean Brodie, Muriel Spark
December 21, 2024 at 7:24 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 8
The Prime of Miss Jean Brodie, Muriel Spark
#Books #BookSky #BookChallenge
Day 8
The Prime of Miss Jean Brodie, Muriel Spark
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 7
The Grapes of Wrath, John Steinbeck
#Books #BookSky #BookChallenge
Day 7
The Grapes of Wrath, John Steinbeck
December 20, 2024 at 7:03 PM
Choose 20 books that have stayed with you or influenced you. One book per day for 20 days, in no particular order. No explanations, no reviews, just covers.
#Books #BookSky #BookChallenge
Day 7
The Grapes of Wrath, John Steinbeck
#Books #BookSky #BookChallenge
Day 7
The Grapes of Wrath, John Steinbeck
Reposted by Fergus O'Farrell
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
rdcu.be
December 18, 2024 at 10:40 PM
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵