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🚨 Are heme-dependent aromatic amino acid oxygenases just peroxidases in oxygenase clothing? 🧪🧥
New in @ACSCatalysis reveals a free radical mechanism in TyrH catalysis — the first direct evidence of a peroxidase-like mechanism in this enzyme superfamily.
HPPA tells all.
doi.org/10.1021/acsc...
New in @ACSCatalysis reveals a free radical mechanism in TyrH catalysis — the first direct evidence of a peroxidase-like mechanism in this enzyme superfamily.
HPPA tells all.
doi.org/10.1021/acsc...
Substrate Analogs Implicate a Free Radical Pathway in Tyrosine Hydroxylase Catalysis
Heme-dependent tyrosine hydroxylases (TyrH) are critical enzymes in catecholamine biosynthesis, yet the role of the substrate’s α-amino group in their monooxygenation mechanism has been unclear. Usin...
pubs.acs.org
October 23, 2025 at 12:52 AM
🚨 Are heme-dependent aromatic amino acid oxygenases just peroxidases in oxygenase clothing? 🧪🧥
New in @ACSCatalysis reveals a free radical mechanism in TyrH catalysis — the first direct evidence of a peroxidase-like mechanism in this enzyme superfamily.
HPPA tells all.
doi.org/10.1021/acsc...
New in @ACSCatalysis reveals a free radical mechanism in TyrH catalysis — the first direct evidence of a peroxidase-like mechanism in this enzyme superfamily.
HPPA tells all.
doi.org/10.1021/acsc...