Mert Erogul
@erogul1.bsky.social
Metabolic health, geroscience, emergency medicine. Thanks for leaving twitter
Reposted by Mert Erogul
Regardless of the disgraceful nonsense we will likely hear from this administration in the coming days on vaccine “recommendations,” Americas healthcare insurers issued a joint statement tonight saying coverage for Covid and flu shots will remain unchanged from prior years.
Speaks for itself.
Speaks for itself.
September 17, 2025 at 2:45 AM
Regardless of the disgraceful nonsense we will likely hear from this administration in the coming days on vaccine “recommendations,” Americas healthcare insurers issued a joint statement tonight saying coverage for Covid and flu shots will remain unchanged from prior years.
Speaks for itself.
Speaks for itself.
They brought in a guy from his house, the circumstances weren't clear. He was found on the ground, unk downtime but the body was covered in pressure sores. He was emaciated and breathing rapidly through his mouth.
July 14, 2025 at 12:14 AM
They brought in a guy from his house, the circumstances weren't clear. He was found on the ground, unk downtime but the body was covered in pressure sores. He was emaciated and breathing rapidly through his mouth.
Nice write up in the times for the medical storytelling program (airwaystories.com)
Real Doctors of New York Spill Their Guts
www.nytimes.com
June 25, 2025 at 12:06 PM
Nice write up in the times for the medical storytelling program (airwaystories.com)
A pilot of reverse transcriptase inhibitors for the treatment of tau-opathies. Probing the hypothesis that retrotransposons underlie pathophysiology of Alzheimer's. Results are interesting.
A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimer’s disease (ART-AD) - npj Dementia
npj Dementia - A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimer’s disease (ART-AD)
www.nature.com
April 8, 2025 at 1:29 AM
A pilot of reverse transcriptase inhibitors for the treatment of tau-opathies. Probing the hypothesis that retrotransposons underlie pathophysiology of Alzheimer's. Results are interesting.
FDA has ruled that compounded GLP drugs are no longer permitted
Compound versions of GLP-1 drugs for weight loss halted by FDA
ABC News' Dr. Tara Narula shares what patients need to know.
abcnews.go.com
March 12, 2025 at 12:57 AM
FDA has ruled that compounded GLP drugs are no longer permitted
Poor sleep disrupts the glymphatic system in humans, which hastens dementia. Exercise improves glymphatic functioning (at least in mice).
Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults - Molecular Psychiatry
Molecular Psychiatry - Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults
www.nature.com
March 11, 2025 at 9:50 PM
Poor sleep disrupts the glymphatic system in humans, which hastens dementia. Exercise improves glymphatic functioning (at least in mice).
Reposted by Mert Erogul
Study in @nature.com (Nature Medicine) “exposes the #exposome in #aging” by exploring how 164 exposures relate to mortality and age-related disease. How and where we live matters big time! www.nature.com/articles/s43...
Exposing the exposome in aging - Nature Aging
Nature Aging - Exposing the exposome in aging
www.nature.com
March 11, 2025 at 7:24 PM
Study in @nature.com (Nature Medicine) “exposes the #exposome in #aging” by exploring how 164 exposures relate to mortality and age-related disease. How and where we live matters big time! www.nature.com/articles/s43...
Here is a theoretical problem with overdriving anabolism with BCAA supplementation in older adults. It paradoxically causes sarcopenia.
mTOR paradox in sarcopenia via BCAA catabolism
Pathological BCAA accumulation in aged muscle overactivates mTOR and paradoxically contributes to loss of muscle mass and strength by inhibiting autophagy and mitochondrial function.
www.nature.com/articles/s43...
Pathological BCAA accumulation in aged muscle overactivates mTOR and paradoxically contributes to loss of muscle mass and strength by inhibiting autophagy and mitochondrial function.
www.nature.com/articles/s43...
February 13, 2025 at 10:31 PM
Here is a theoretical problem with overdriving anabolism with BCAA supplementation in older adults. It paradoxically causes sarcopenia.
Reposted by Mert Erogul
Update on my life: Last year, I joined my kids' school's PTA, because they needed a treasurer and I'm good enough with numbers. It was a straightforward, self-contained job: balancing the checkbook for an organization that only did a few fundraisers each year.
February 6, 2025 at 5:45 AM
Update on my life: Last year, I joined my kids' school's PTA, because they needed a treasurer and I'm good enough with numbers. It was a straightforward, self-contained job: balancing the checkbook for an organization that only did a few fundraisers each year.
My Chinese patient has a tattoo on his arm. It says 7-5-1986. I ask him its meaning and he says that he did it himself. I say, but why did you write that date, what is the significance of the date? He says that’s what day it was when he did the tattoo.
February 5, 2025 at 3:37 PM
My Chinese patient has a tattoo on his arm. It says 7-5-1986. I ask him its meaning and he says that he did it himself. I say, but why did you write that date, what is the significance of the date? He says that’s what day it was when he did the tattoo.
Reposted by Mert Erogul
How exercise during pregnancy can improve metabolic health of offspring: a key mediator (Serpina3c) from mother's white adipose tissue gets into fetal circulation, suppresses inflammation, as demonstrated in the mouse model
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
January 31, 2025 at 2:29 PM
How exercise during pregnancy can improve metabolic health of offspring: a key mediator (Serpina3c) from mother's white adipose tissue gets into fetal circulation, suppresses inflammation, as demonstrated in the mouse model
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
A landmark paper claiming that somatic mutations to DNA (due to replicative errors, toxins, radiation, etc.) are the sought after drivers of epigenetic changes and account for the ticking of the clock. If true, then it seriously complicates ambitions to reverse aging with Yamanake Factors.
Somatic mutation as an explanation for epigenetic aging - Nature Aging
Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...
www.nature.com
January 24, 2025 at 12:40 AM
A landmark paper claiming that somatic mutations to DNA (due to replicative errors, toxins, radiation, etc.) are the sought after drivers of epigenetic changes and account for the ticking of the clock. If true, then it seriously complicates ambitions to reverse aging with Yamanake Factors.
Reposted by Mert Erogul
Today we report a new compendium of human gut microbiomes with >168,000 samples
By analyzing this massive dataset, we discovered distinct microbiome patterns across the globe, and show we can predict where a person lives just from their gut bacteria
Now out in Cell:
www.cell.com/cell/fulltex...
By analyzing this massive dataset, we discovered distinct microbiome patterns across the globe, and show we can predict where a person lives just from their gut bacteria
Now out in Cell:
www.cell.com/cell/fulltex...
Integration of 168,000 samples reveals global patterns of the human gut microbiome
The Human Microbiome Compendium is a unified database of publicly available human
gut microbiome 16S samples, built with the integrated data from hundreds of independent
projects. The compendium is us...
www.cell.com
January 22, 2025 at 5:12 PM
Today we report a new compendium of human gut microbiomes with >168,000 samples
By analyzing this massive dataset, we discovered distinct microbiome patterns across the globe, and show we can predict where a person lives just from their gut bacteria
Now out in Cell:
www.cell.com/cell/fulltex...
By analyzing this massive dataset, we discovered distinct microbiome patterns across the globe, and show we can predict where a person lives just from their gut bacteria
Now out in Cell:
www.cell.com/cell/fulltex...
Reposted by Mert Erogul
Reconciling 2 major explanations for #aging, study in Nature Aging @nature.com finds somatic mutations are fundamental driver of aging and #epigenetic changes simply track process. Reversing aging may be harder than previously thought. Time to rethink strategies?
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Somatic mutation as an explanation for epigenetic aging - Nature Aging
Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...
www.nature.com
January 21, 2025 at 10:59 PM
Reconciling 2 major explanations for #aging, study in Nature Aging @nature.com finds somatic mutations are fundamental driver of aging and #epigenetic changes simply track process. Reversing aging may be harder than previously thought. Time to rethink strategies?
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Mert Erogul
It's a new year!
...and a new #MVIF program is out! 🤩
Registration here: cassyni.com/s/mvif-35
⭐️MicroTalks:
Minna Chang
@hariszaf.bsky.social
⭐️ Keynote:
@chmoei.bsky.social
⭐️Selected talks:
Pratyay Sengupta
@fatimacpereira.bsky.social
@cladigar.bsky.social
...and a new #MVIF program is out! 🤩
Registration here: cassyni.com/s/mvif-35
⭐️MicroTalks:
Minna Chang
@hariszaf.bsky.social
⭐️ Keynote:
@chmoei.bsky.social
⭐️Selected talks:
Pratyay Sengupta
@fatimacpereira.bsky.social
@cladigar.bsky.social
January 8, 2025 at 2:53 PM
It's a new year!
...and a new #MVIF program is out! 🤩
Registration here: cassyni.com/s/mvif-35
⭐️MicroTalks:
Minna Chang
@hariszaf.bsky.social
⭐️ Keynote:
@chmoei.bsky.social
⭐️Selected talks:
Pratyay Sengupta
@fatimacpereira.bsky.social
@cladigar.bsky.social
...and a new #MVIF program is out! 🤩
Registration here: cassyni.com/s/mvif-35
⭐️MicroTalks:
Minna Chang
@hariszaf.bsky.social
⭐️ Keynote:
@chmoei.bsky.social
⭐️Selected talks:
Pratyay Sengupta
@fatimacpereira.bsky.social
@cladigar.bsky.social
Reposted by Mert Erogul
Price gouging by the ‘Big 3 PBMs’—Caremark Rx (CVS), Express Scripts (ESI), and OptumRx —marked up numerous specialty generic drugs at their pharmacies by **thousands of percent***, and many by hundreds of percent—resulting in 📌 $7.3 billion📌 in excess revenue.
www.ftc.gov/news-events/...
www.ftc.gov/news-events/...
January 15, 2025 at 12:53 AM
Price gouging by the ‘Big 3 PBMs’—Caremark Rx (CVS), Express Scripts (ESI), and OptumRx —marked up numerous specialty generic drugs at their pharmacies by **thousands of percent***, and many by hundreds of percent—resulting in 📌 $7.3 billion📌 in excess revenue.
www.ftc.gov/news-events/...
www.ftc.gov/news-events/...
Oscillations in gut microbiota
composition regulate the diurnal
rhythmicity of HPA axis function, which leads to altered stress responsivity across
the day.
composition regulate the diurnal
rhythmicity of HPA axis function, which leads to altered stress responsivity across
the day.
www.cell.com
January 15, 2025 at 3:01 AM
Oscillations in gut microbiota
composition regulate the diurnal
rhythmicity of HPA axis function, which leads to altered stress responsivity across
the day.
composition regulate the diurnal
rhythmicity of HPA axis function, which leads to altered stress responsivity across
the day.
Reposted by Mert Erogul
Redefining obesity, report of a new commission, to override current BMI categories and better define features and pathophysiologic consequences of pre-clinical and clinical obesity
www.thelancet.com/journals/lan... open-access
www.thelancet.com/journals/lan... open-access
January 14, 2025 at 11:38 PM
Redefining obesity, report of a new commission, to override current BMI categories and better define features and pathophysiologic consequences of pre-clinical and clinical obesity
www.thelancet.com/journals/lan... open-access
www.thelancet.com/journals/lan... open-access
Move over #Horvath. #Histone specific epigenetic changes highly predictive of aging, rivaling CpG methylation sites. They typically specify genes important to the aging process. www.science.org/doi/10.1126/...
Histone mark age of human tissues and cell types
Histone mark age predictors will complement cytosine methylation-based clocks in aging and rejuvenation studies.
www.science.org
January 3, 2025 at 3:35 AM
Move over #Horvath. #Histone specific epigenetic changes highly predictive of aging, rivaling CpG methylation sites. They typically specify genes important to the aging process. www.science.org/doi/10.1126/...
Reposted by Mert Erogul
Our assessment of a person's epigenetic ("biological") age has been centered on DNA methylation. A new report shows that a set of 7 histone markers has comparable accuracy and also uncovers new pathways of aging biology
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 1, 2025 at 8:36 PM
Our assessment of a person's epigenetic ("biological") age has been centered on DNA methylation. A new report shows that a set of 7 histone markers has comparable accuracy and also uncovers new pathways of aging biology
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mert Erogul
Our lab's latest study, spearheaded by a fantastic colleague, Colleen, reveals that the blood glucose-lowering effect of metformin requires the inhibition of mitochondrial ETC complex I. www.science.org/doi/10.1126/....
An insightful focus by Prof. Doug Green: bit.ly/41Hc4fX
An insightful focus by Prof. Doug Green: bit.ly/41Hc4fX
Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
www.science.org
December 18, 2024 at 7:07 PM
Our lab's latest study, spearheaded by a fantastic colleague, Colleen, reveals that the blood glucose-lowering effect of metformin requires the inhibition of mitochondrial ETC complex I. www.science.org/doi/10.1126/....
An insightful focus by Prof. Doug Green: bit.ly/41Hc4fX
An insightful focus by Prof. Doug Green: bit.ly/41Hc4fX
Reposted by Mert Erogul
December 18, 2024 at 7:39 PM
Nuclear kappa beta receptor ligand administration (RANKL) regrows thymus and restores immune function in mice. A potential cure for immune senescence.
RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice
RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.
www.science.org
December 5, 2024 at 4:29 PM
Nuclear kappa beta receptor ligand administration (RANKL) regrows thymus and restores immune function in mice. A potential cure for immune senescence.