Erinne Ong
@erinneuro.bsky.social
PhD student @dkfz.bsky.social • interested in neuro-glia-tumor interactions and the circuitry of brain cancer networks 🧠 • 🇵🇭 in 🇩🇪 • science communication, mentorship, & outreach
Reposted by Erinne Ong
Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer Neurogenesis https://www.biorxiv.org/content/10.1101/2025.04.25.650717v1
April 29, 2025 at 8:15 PM
Thalamic NRXN1-Mediated Input to Human Cortical Progenitors Drives Upper Layer Neurogenesis https://www.biorxiv.org/content/10.1101/2025.04.25.650717v1
Reposted by Erinne Ong
I begrudgingly admit that actin is pretty cool 🤩
🎥 Primary mouse myotubes labeled with Lifeact-mScarlet-I3 (cyan) and H2B-mStayGreen (red). #FluorescenceFriday
🎥 Primary mouse myotubes labeled with Lifeact-mScarlet-I3 (cyan) and H2B-mStayGreen (red). #FluorescenceFriday
March 22, 2025 at 5:15 AM
I begrudgingly admit that actin is pretty cool 🤩
🎥 Primary mouse myotubes labeled with Lifeact-mScarlet-I3 (cyan) and H2B-mStayGreen (red). #FluorescenceFriday
🎥 Primary mouse myotubes labeled with Lifeact-mScarlet-I3 (cyan) and H2B-mStayGreen (red). #FluorescenceFriday
Reposted by Erinne Ong
Congratulations to winners of The Brain Prize 2025!
Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience.
Learn more: brainprize.org/winners/canc...
Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience.
Learn more: brainprize.org/winners/canc...
March 5, 2025 at 3:37 PM
Congratulations to winners of The Brain Prize 2025!
Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience.
Learn more: brainprize.org/winners/canc...
Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience.
Learn more: brainprize.org/winners/canc...
Reposted by Erinne Ong
Happy to share our new study on the functional reprogramming of neutrophils in the brain tumor microenvironment by hypoxia-driven lactylation
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
March 2, 2025 at 3:24 PM
Happy to share our new study on the functional reprogramming of neutrophils in the brain tumor microenvironment by hypoxia-driven lactylation
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
@theaacr.bsky.social
@wistar.org
@moffittnews.bsky.social
Reposted by Erinne Ong
Online now: Online now: The kinase RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during central nervous system viral infection
The kinase RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during central nervous system viral infection
How innate immune signaling within neurons influences neurotransmission remains poorly understood. Estevez et al. show that the necroptotic kinase RIPK3 promotes neuronal survival during viral infections of the central nervous system by engaging a…
dlvr.it
February 24, 2025 at 3:48 PM
Online now: Online now: The kinase RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during central nervous system viral infection
Reposted by Erinne Ong
Automatic cell analysis using #AI
Researchers retrained existing AI-based software on over 17,000 microscopy images with over 2 million structures to develop this new model - Segment Anything for Microscopy: www.uni-goettingen.de/en/3240.html...
#NatureMethods research: doi.org/10.1038/s415...
Researchers retrained existing AI-based software on over 17,000 microscopy images with over 2 million structures to develop this new model - Segment Anything for Microscopy: www.uni-goettingen.de/en/3240.html...
#NatureMethods research: doi.org/10.1038/s415...
February 24, 2025 at 11:47 AM
Automatic cell analysis using #AI
Researchers retrained existing AI-based software on over 17,000 microscopy images with over 2 million structures to develop this new model - Segment Anything for Microscopy: www.uni-goettingen.de/en/3240.html...
#NatureMethods research: doi.org/10.1038/s415...
Researchers retrained existing AI-based software on over 17,000 microscopy images with over 2 million structures to develop this new model - Segment Anything for Microscopy: www.uni-goettingen.de/en/3240.html...
#NatureMethods research: doi.org/10.1038/s415...
Reposted by Erinne Ong
White matter (WM) #astrocytes differ significantly from grey matter (GM) astrocytes, with WM
astrocytes in the forebrain exhibiting unique proliferation capacity 🧪🧠
www.nature.com/articles/s41...
astrocytes in the forebrain exhibiting unique proliferation capacity 🧪🧠
www.nature.com/articles/s41...
Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter - Nature Neuroscience
White matter (WM) astrocytes differ significantly from gray matter astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity, which is absent in cerebellar WM, suggestin...
www.nature.com
February 24, 2025 at 8:14 PM
White matter (WM) #astrocytes differ significantly from grey matter (GM) astrocytes, with WM
astrocytes in the forebrain exhibiting unique proliferation capacity 🧪🧠
www.nature.com/articles/s41...
astrocytes in the forebrain exhibiting unique proliferation capacity 🧪🧠
www.nature.com/articles/s41...
Reposted by Erinne Ong
Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social
Mechanisms of astrocyte aging in reactivity and disease - Molecular Neurodegeneration
Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organis...
molecularneurodegeneration.biomedcentral.com
February 21, 2025 at 12:08 PM
Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social
Reposted by Erinne Ong
Just in case you thought that removing DEI criteria would mean that everyone is competing equally: NIH is removing grad students from underrepresented backgrounds from the applicant pool altogether. Their applications will not be considered. Other students, not from these backgrounds, will be.
February 6, 2025 at 7:59 PM
Just in case you thought that removing DEI criteria would mean that everyone is competing equally: NIH is removing grad students from underrepresented backgrounds from the applicant pool altogether. Their applications will not be considered. Other students, not from these backgrounds, will be.
Reposted by Erinne Ong
Really interesting paper 🧪 🤩
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Cancer cells ‘poison’ the immune system with tainted mitochondria
Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.
www.nature.com
January 23, 2025 at 6:41 PM
Really interesting paper 🧪 🤩
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Reposted by Erinne Ong
Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.
Thread below: (1/11)
Thread below: (1/11)
Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease
The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying
cerebral plaque burden depending on the parental source of the transgene. Mice inheriting
the transgene paternally...
www.cell.com
January 20, 2025 at 3:49 PM
Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.
Thread below: (1/11)
Thread below: (1/11)
Out now in @cp-neuron.bsky.social:
We found that the parental source of the transgene influences amyloid plaque load in 5xFAD mice, highlighting the need to clearly report breeding schemes to support the consistency and reproducibility of AD research using this model.
www.cell.com/neuron/fullt...
We found that the parental source of the transgene influences amyloid plaque load in 5xFAD mice, highlighting the need to clearly report breeding schemes to support the consistency and reproducibility of AD research using this model.
www.cell.com/neuron/fullt...
Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease
The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying
cerebral plaque burden depending on the parental source of the transgene. Mice inheriting
the transgene paternally...
www.cell.com
January 20, 2025 at 5:12 PM
Out now in @cp-neuron.bsky.social:
We found that the parental source of the transgene influences amyloid plaque load in 5xFAD mice, highlighting the need to clearly report breeding schemes to support the consistency and reproducibility of AD research using this model.
www.cell.com/neuron/fullt...
We found that the parental source of the transgene influences amyloid plaque load in 5xFAD mice, highlighting the need to clearly report breeding schemes to support the consistency and reproducibility of AD research using this model.
www.cell.com/neuron/fullt...
Reposted by Erinne Ong
new out in Nature: lovely paper www.nature.com/articles/s41...
Brain-wide neuronal circuit connectome of human glioblastoma - Nature
Nature - Brain-wide neuronal circuit connectome of human glioblastoma
www.nature.com
January 16, 2025 at 5:23 PM
new out in Nature: lovely paper www.nature.com/articles/s41...
Reposted by Erinne Ong
For #FluorescenceFriday, tau (blue) and long loops of neurofilament proteins are shown in a primary hippocampal neuron 🔬 #Neuroscience #Microscopy
January 17, 2025 at 9:22 PM
For #FluorescenceFriday, tau (blue) and long loops of neurofilament proteins are shown in a primary hippocampal neuron 🔬 #Neuroscience #Microscopy
Reposted by Erinne Ong
Cool work on the effects of OPC specific deletion of glucocorticoid receptors!
Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior
www.biorxiv.org/content/10.1...
Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior
www.biorxiv.org/content/10.1...
Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior
Early life events shape neuronal networks, and prime juvenile and adult behavior. Severely aversive, early experiences can interfere with brain development and enhance the risk for the onset of psychi...
www.biorxiv.org
December 23, 2024 at 12:34 AM
Cool work on the effects of OPC specific deletion of glucocorticoid receptors!
Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior
www.biorxiv.org/content/10.1...
Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior
www.biorxiv.org/content/10.1...
Reposted by Erinne Ong
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
December 20, 2024 at 9:13 PM
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
Reposted by Erinne Ong
Excited to share our latest article! We find that the brain tumor Glioblastoma has a circadian clock that syncs with its host’s environment. These tumors also hijack the circadian clock and use daily signals, like glucocorticoids, to grow 🧠⏱️ @erikherzog.bsky.social
More: www.cell.com/cancer-cell/...
More: www.cell.com/cancer-cell/...
Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host
Gonzalez-Aponte et al. identify daily glucocorticoid receptor signaling as an intrinsic driver of glioblastoma (GBM) progression and a synchronizer of tumor clock gene expression to the host. This work provides an intrinsic circadian driver, and therapeutic target, to slow GBM growth, and offers considerations for glucocorticoid use in the clinic.
www.cell.com
December 12, 2024 at 4:48 PM
Excited to share our latest article! We find that the brain tumor Glioblastoma has a circadian clock that syncs with its host’s environment. These tumors also hijack the circadian clock and use daily signals, like glucocorticoids, to grow 🧠⏱️ @erikherzog.bsky.social
More: www.cell.com/cancer-cell/...
More: www.cell.com/cancer-cell/...
Reposted by Erinne Ong
The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging.
www.nature.com/articles/nbt...
www.nature.com/articles/nbt...
December 11, 2024 at 8:32 PM
The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging.
www.nature.com/articles/nbt...
www.nature.com/articles/nbt...
Reposted by Erinne Ong
#flourescent(almost)friday
(make sure to full screen this!) Some hippocampal neurons and dendritic arbors visualized from mCherry with a 3.6x objective in a SmartSPIM using iDisco.
(make sure to full screen this!) Some hippocampal neurons and dendritic arbors visualized from mCherry with a 3.6x objective in a SmartSPIM using iDisco.
December 5, 2024 at 6:50 PM
#flourescent(almost)friday
(make sure to full screen this!) Some hippocampal neurons and dendritic arbors visualized from mCherry with a 3.6x objective in a SmartSPIM using iDisco.
(make sure to full screen this!) Some hippocampal neurons and dendritic arbors visualized from mCherry with a 3.6x objective in a SmartSPIM using iDisco.
Reposted by Erinne Ong
Programming tissue-sensing T cells that deliver therapies to the brain
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 5, 2024 at 7:56 PM
Programming tissue-sensing T cells that deliver therapies to the brain
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Erinne Ong
What a great initiative! 👉 Highlighting an outstanding paper by another researcher. 👉 Below is a must-read by @jgrutzendler.bsky.social and team 👇
www.science.org/doi/full/10....
www.science.org/doi/full/10....
December 5, 2024 at 11:04 PM
What a great initiative! 👉 Highlighting an outstanding paper by another researcher. 👉 Below is a must-read by @jgrutzendler.bsky.social and team 👇
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Erinne Ong
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease - Nature Communications
The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...
www.nature.com
December 6, 2024 at 6:44 AM
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
Reposted by Erinne Ong
Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in @science.org. Exciting time for axon scientists!
December 2, 2024 at 10:33 AM
Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in @science.org. Exciting time for axon scientists!
Reposted by Erinne Ong
Which one are you?
Among scientists are collectors, classifiers, and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics.
–Peter Medawar
Among scientists are collectors, classifiers, and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics.
–Peter Medawar
November 29, 2024 at 11:47 PM
Which one are you?
Among scientists are collectors, classifiers, and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics.
–Peter Medawar
Among scientists are collectors, classifiers, and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics.
–Peter Medawar
Reposted by Erinne Ong
🚀 It's #FluorescenceFriday, and commissural axons are coming at you!
🧪🔬 15-hour time-lapse of chick commissural axons navigating and crossing the CNS midline (and reverse).
One stack taken every 10 minutes. Pixels were color-coded in the z-axis.
#LiveImaging #Neuroscience #Science #Microscopy 🧠✨
🧪🔬 15-hour time-lapse of chick commissural axons navigating and crossing the CNS midline (and reverse).
One stack taken every 10 minutes. Pixels were color-coded in the z-axis.
#LiveImaging #Neuroscience #Science #Microscopy 🧠✨
November 29, 2024 at 7:20 AM
🚀 It's #FluorescenceFriday, and commissural axons are coming at you!
🧪🔬 15-hour time-lapse of chick commissural axons navigating and crossing the CNS midline (and reverse).
One stack taken every 10 minutes. Pixels were color-coded in the z-axis.
#LiveImaging #Neuroscience #Science #Microscopy 🧠✨
🧪🔬 15-hour time-lapse of chick commissural axons navigating and crossing the CNS midline (and reverse).
One stack taken every 10 minutes. Pixels were color-coded in the z-axis.
#LiveImaging #Neuroscience #Science #Microscopy 🧠✨