Eloi Littner
eloilittner.bsky.social
Eloi Littner
@eloilittner.bsky.social
PhD in Biology (Génétique et Génomique)

Evolution of integrons, in the lab of @epcrocha.bsky.social, Microbial evolutionary genomics @pasteur.fr

@EPFL and @Polytechnique alumni
Reposted by Eloi Littner
🎓🏆 Two Institut Pasteur PhD students honored at the 2025 Chancellerie des Universités de Paris Prizes!

👏 @nellsaunders.bsky.social – coronavirus research

👏 Antonin Verdier – optogenetic implant for hearing restoration

Excellence in doctoral research 🌟

www.sorbonne.fr/la-chancelle...
Prix Universitaires - Chancellerie des Universités de Paris - Sorbonne
Les Prix Universitaires de la Chancellerie des Universités de Paris - Sorbonne : prix solennels, prix de thèse en droit et en sciences économiques.
www.sorbonne.fr
October 31, 2025 at 9:47 AM
Reposted by Eloi Littner
October 31, 2025 at 8:08 AM
Reposted by Eloi Littner
🦠💊 L’Institut @pasteur.fr vient de publier un communiqué de presse sur nos récents travaux, qui décrivent une nouvelle piste pour augmenter l’efficacité des antibiotiques. #Pasteurdon #Recherche #Science #AMR

Merci à toutes celles et ceux qui ont contribué.

📘 English version coming soon!
Une piste prometteuse pour augmenter l’efficacité des antibiotiques
Les aminosides sont des antibiotiques efficaces contre de très nombreuses bactéries telles que Escherichia coli, Pseudomonas aeruginosa ou Staphylococcus aureus. Mais jusqu’à présent, personne ne sava...
www.pasteur.fr
October 31, 2025 at 10:37 AM
Reposted by Eloi Littner
Many antiphage systems use NAD+, in many ways.
@hugovaysset.bsky.social reviewed them all!

Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...
The multifaceted roles of NAD+ in bacterial immunity
In this review, Vaysset and Bernheim examine how nicotinamide adenine dinucleotide (NAD+) is a key player in diverse and widespread bacterial antiphage defense systems and phage counterdefense. The au...
www.cell.com
October 17, 2025 at 5:55 PM
On Thursday, October 9th, I successfully defended my PhD in Genetics and Genomics, on the diversity, function and evolution of integron cassettes, at @pasteur.fr. Thanks to my PhD supervisor, @epcrocha.bsky.social and to my jury, headed by Ingrid Lafontaine!
October 18, 2025 at 5:26 PM
Reposted by Eloi Littner
Happy to announce that our comparative metagenomic analysis of the gut microbiota of five honeybee species - spearheaded by @aiswarya.bsky.social - is finally published in a peer-reviewed journal! rdcu.be/eKMCs @fbm-unil.bsky.social @dmf-unil.bsky.social 🧵👇
Evolution of gut microbiota across honeybee species revealed by comparative metagenomics
Nature Communications - Here, the authors perform metagenomic analysis of honeybee gut microbes, uncovering many previously unidentified species and host specific differences in composition and...
rdcu.be
October 14, 2025 at 7:04 PM
Reposted by Eloi Littner
New preprint!

Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠

Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!

An epic effort by Rosanna Wright

www.biorxiv.org/content/10.1...
Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages
Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...
www.biorxiv.org
October 6, 2025 at 6:27 AM
Reposted by Eloi Littner
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
September 25, 2025 at 9:29 PM
Reposted by Eloi Littner
[Podcast] Les chantiers de la recherche | "Génétique : l'ADN des bactéries comme source de savoirs" avec @eloilittner.bsky.social
Génétique : l’ADN des bactéries comme source de savoirs
Un pan de la recherche en génomique se propose d'étudier les bactéries, ces micro-organismes développent des mécanismes de défense particulièrement intéressants.
www.radiofrance.fr
September 15, 2025 at 9:08 AM
Et bien c'est fait ! Première à l'antenne d'une radio nationale, dans la matinale de France Culture ce matin. Merci à Guillaume Erner de m'avoir accueilli, et à Juliette Devaux pour la préparation de l'émission.

www.radiofrance.fr/francecultur...
Génétique : l’ADN des bactéries comme source de savoirs
Un pan de la recherche en génomique se propose d'étudier les bactéries, ces micro-organismes développent des mécanismes de défense particulièrement intéressants.
www.radiofrance.fr
September 15, 2025 at 7:46 AM
Reposted by Eloi Littner
Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...
September 8, 2025 at 8:56 AM
J'aurai la chance de présenter mes travaux de thèse sur France Culture, dans l'émission "Les Chantiers de la Recherche" ce lundi 15 à 6h45, avec Guillaume Erner. Pour les lève-tard, l'émission sera disponible en podcast. Stay tuned !

www.radiofrance.fr/francecultur...
Les Chantiers de la recherche : écouter le podcast et replay | France Culture
Chaque matin, entrez dans les coulisses de la recherche, avec celles et ceux qui la font vivre. Dans un laboratoire, une bibliothèque ou sur un terrain de fouilles, des chercheuses et des chercheurs n...
www.radiofrance.fr
September 13, 2025 at 5:04 PM
Reposted by Eloi Littner
Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social

This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
September 9, 2025 at 5:11 AM
Reposted by Eloi Littner
A new theme issue of #PhilTransB examines the evolutionary history of bacterial immune systems, their modes of action, and the patterns how different bacterial immune systems are distributed across different ecosystems. Read: buff.ly/Z4qdxY1
September 5, 2025 at 4:01 PM
Reposted by Eloi Littner
At last ! A tool specifically for phage-plasmid hunters. Check tyPPing by @karinailchenko.bsky.social and @eugenpfeifer.bsky.social
🚨 New preprint! 🧬

𝐏𝐡𝐚𝐠𝐞-𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 (𝐏-𝐏𝐬) are fascinating elements: both 𝐭𝐞𝐦𝐩𝐞𝐫𝐚𝐭𝐞 𝐩𝐡𝐚𝐠𝐞𝐬 and 𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 ➡️ tricky to detect.

We present 𝐭𝐲𝐏𝐏𝐢𝐧𝐠 — the first 𝐢𝐝𝐞𝐧𝐭𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐜𝐥𝐚𝐬𝐬𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐭𝐨𝐨𝐥 🛠️designed specifically for P-Ps:
✅ Accurate
✅ Sensitive
✅ Easy to use

📖 www.biorxiv.org/content/10.1...
Efficient detection and typing of phage-plasmids
Phage-plasmids are temperate phages that replicate as plasmids during lysogeny. Despite their high diversity, they carry genes similar to phages and plasmids. This leads to gene exchanges, and to the ...
www.biorxiv.org
September 3, 2025 at 2:00 PM
Reposted by Eloi Littner
We are very proud of our researchers Beatrice Baragli, Jerome Beetz, Jacqueline Degen, Mona Garvert, Jake Greenfield, and Jens Hör: They have been awarded prestigious ERC Starting Grants worth €1.5 million. Congratulations! @erc.europa.eu #ERCStG
➡️ www.uni-wuerzburg.de/en/news-and-...
September 4, 2025 at 10:10 AM
Reposted by Eloi Littner
Congratulations to our #HIRI group leader and JMU junior professor @jenshoer.bsky.social on receiving a 1.5 million euro #ERCStG from @erc.europa.eu! In his RIBO-PHAGE project, he will study phages—viruses that infect bacteria—with RNA genomes. 🥳👏 @helmholtzhzi.bsky.social @uni-wuerzburg.de
September 4, 2025 at 10:32 AM
Reposted by Eloi Littner
I'm really happy to have been granted an @erc.europa.eu Starting Grant! We'll study the molecular principles of RNA phages—from infection to replication to bacterial immunity. Interested in joining? Feel free to reach out! Formal job ads to follow.

More info here:

tinyurl.com/RIBO-PHAGE

#ERCStG
1.5 million euros for research into “bacterial killers”
ERC Starting Grant awarded to Jens Hör from the Helmholtz Institute Würzburg
www.helmholtz-hiri.de
September 4, 2025 at 10:42 AM
Reposted by Eloi Littner
Preprint: We discovered phage proteins that sequester diverse immune signaling molecules, including cUMP, cCMP, and N7-cADPR

The first viral sponges to inhibit Pycsar and type IV Thoeris

Congrats to talented leading author Romi Hadary! Read her thread to learn more about our findings
August 25, 2025 at 1:00 PM
Reposted by Eloi Littner
Mind-blowing tour-de-force for synthetic biology and immunity 🤯
Congrats @garbjeremy.bsky.social and @soreklab.bsky.social 🤩
Preprint: De-novo design of proteins that inhibit bacterial defenses

Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications

Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵
Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection
Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...
www.biorxiv.org
September 2, 2025 at 12:57 PM
Reposted by Eloi Littner
Im Kampf gegen multiresistente Keime können #Bakteriophagen eine weitere Waffe sein. Für sein Projekt "RIBO-PHAGE" erhält @jenshoer.bsky.social, Nachwuchsgruppenleiter @helmholtz-hiri.bsky.social, nun einen #ERCStG des @erc.europa.eu!🎉 Herzlichen Glückwunsch!
www.helmholtz-hzi.de/media-center...
September 4, 2025 at 10:03 AM
Reposted by Eloi Littner
Super excited to receive the ERC starting grant to explore what phage-bacteria interactions can teach us on host-pathogen conflicts 🤩 I'm immensely grateful to my wonderful team and to present and past mentors 🙏
📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 11:40 AM
Reposted by Eloi Littner
👏 Huge congrats to @audeber.bsky.social, group leader and head of our Molecular Diversity of Microbes lab, on being named a 2025 Vallee Scholar! Her pioneering work on ancestral immunity opens new perspectives for biomedical innovation. 🔬🌍

@valleefoundation.bsky.social

#Science #Immunity
September 2, 2025 at 9:44 AM
Reposted by Eloi Littner
Very happy to see this one out: doi.org/10.1093/molbev/msaf192
Here, we assessed the contribution of natural transformation to the acquisition of novel genes. See preprint thread. @molbioevol.bsky.social #microsky #evobio
August 27, 2025 at 1:37 PM
Reposted by Eloi Littner
Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...
July 23, 2025 at 7:35 AM