Domainex Limited
@domainex.bsky.social
Domainex is a multi-award winning, integrated drug discovery service provider, with a particular emphasis on small molecule lead generation.
Katie Day will be representing Domainex at the 33rd Protein Structure Determination in Industry Conference in Basel that starts on Sunday.
Don't miss her poster on Sunday evening "Using Direct-to-Biology in a Spectral Shift-PoLiPa Platform to Enable Fast Fragment Follow-Up for A2a Antagonists"
Don't miss her poster on Sunday evening "Using Direct-to-Biology in a Spectral Shift-PoLiPa Platform to Enable Fast Fragment Follow-Up for A2a Antagonists"
November 7, 2025 at 4:44 PM
Katie Day will be representing Domainex at the 33rd Protein Structure Determination in Industry Conference in Basel that starts on Sunday.
Don't miss her poster on Sunday evening "Using Direct-to-Biology in a Spectral Shift-PoLiPa Platform to Enable Fast Fragment Follow-Up for A2a Antagonists"
Don't miss her poster on Sunday evening "Using Direct-to-Biology in a Spectral Shift-PoLiPa Platform to Enable Fast Fragment Follow-Up for A2a Antagonists"
Check out our new blog, lnkd.in/esk6U9_h, by one of our scientists Alicia Overall, to find out about what the #Domainex team got up to at ELRIG.
The blog covers the team of volunteers working as Red Shirts, as well as our science presentations.
The blog covers the team of volunteers working as Red Shirts, as well as our science presentations.
November 7, 2025 at 2:27 PM
Check out our new blog, lnkd.in/esk6U9_h, by one of our scientists Alicia Overall, to find out about what the #Domainex team got up to at ELRIG.
The blog covers the team of volunteers working as Red Shirts, as well as our science presentations.
The blog covers the team of volunteers working as Red Shirts, as well as our science presentations.
Don't miss Jonathan Powell giving a presentation at the RSC BMCS New Approaches to the Treatment of Parkinson's conference.
If you would like to find out more information about how #Domainex can advance your CNS drug discovery project, come speak to us there or get in touch enquiries@domainex.co.uk
If you would like to find out more information about how #Domainex can advance your CNS drug discovery project, come speak to us there or get in touch enquiries@domainex.co.uk
November 5, 2025 at 5:23 PM
Don't miss Jonathan Powell giving a presentation at the RSC BMCS New Approaches to the Treatment of Parkinson's conference.
If you would like to find out more information about how #Domainex can advance your CNS drug discovery project, come speak to us there or get in touch enquiries@domainex.co.uk
If you would like to find out more information about how #Domainex can advance your CNS drug discovery project, come speak to us there or get in touch enquiries@domainex.co.uk
Ray Boffey, CCO, will be at the "Bringing discoveries to life through partnerships and enterprise: How to engage with the Milner Institute" event on 3rd November.
If you are attending, look out for Ray to discuss how Domainex can help with your lead discovery challenges.
If you are attending, look out for Ray to discuss how Domainex can help with your lead discovery challenges.
October 31, 2025 at 4:56 PM
Ray Boffey, CCO, will be at the "Bringing discoveries to life through partnerships and enterprise: How to engage with the Milner Institute" event on 3rd November.
If you are attending, look out for Ray to discuss how Domainex can help with your lead discovery challenges.
If you are attending, look out for Ray to discuss how Domainex can help with your lead discovery challenges.
Our last poster presenter is Holly Madden, a scientist within our assay biology team, who will be at Poster 158.
Holly will be presenting "Using Direct-to-Biology in a Spectral Shift-PoLiPa Platform to Enable Fast Fragment Follow-Up for A2a Antagonists"
Holly will be presenting "Using Direct-to-Biology in a Spectral Shift-PoLiPa Platform to Enable Fast Fragment Follow-Up for A2a Antagonists"
October 17, 2025 at 2:59 PM
Our last poster presenter is Holly Madden, a scientist within our assay biology team, who will be at Poster 158.
Holly will be presenting "Using Direct-to-Biology in a Spectral Shift-PoLiPa Platform to Enable Fast Fragment Follow-Up for A2a Antagonists"
Holly will be presenting "Using Direct-to-Biology in a Spectral Shift-PoLiPa Platform to Enable Fast Fragment Follow-Up for A2a Antagonists"
This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG next week, and up next is Nicholas Bland's poster.
Nick will be presenting "Unlocking RNA as a Drug Target: Novel Hit Discovery Strategies for Small Molecule Binders"
Nick will be presenting "Unlocking RNA as a Drug Target: Novel Hit Discovery Strategies for Small Molecule Binders"
October 15, 2025 at 3:47 PM
This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG next week, and up next is Nicholas Bland's poster.
Nick will be presenting "Unlocking RNA as a Drug Target: Novel Hit Discovery Strategies for Small Molecule Binders"
Nick will be presenting "Unlocking RNA as a Drug Target: Novel Hit Discovery Strategies for Small Molecule Binders"
This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG.
Next up is Phil, who is presenting poster "Molecular Matchmakers: Finding the Perfect Glue".
The poster will detail our cell-free hit finding cascade to detect and characterise molecular glue activity.
Next up is Phil, who is presenting poster "Molecular Matchmakers: Finding the Perfect Glue".
The poster will detail our cell-free hit finding cascade to detect and characterise molecular glue activity.
October 14, 2025 at 3:39 PM
This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG.
Next up is Phil, who is presenting poster "Molecular Matchmakers: Finding the Perfect Glue".
The poster will detail our cell-free hit finding cascade to detect and characterise molecular glue activity.
Next up is Phil, who is presenting poster "Molecular Matchmakers: Finding the Perfect Glue".
The poster will detail our cell-free hit finding cascade to detect and characterise molecular glue activity.
This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG next week.
First up is Kamini Magon, who is presenting a poster titled "Development of C5aR1 negative allosteric modulators with potential benefits for neuroinflammation".
First up is Kamini Magon, who is presenting a poster titled "Development of C5aR1 negative allosteric modulators with potential benefits for neuroinflammation".
October 13, 2025 at 3:49 PM
This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG next week.
First up is Kamini Magon, who is presenting a poster titled "Development of C5aR1 negative allosteric modulators with potential benefits for neuroinflammation".
First up is Kamini Magon, who is presenting a poster titled "Development of C5aR1 negative allosteric modulators with potential benefits for neuroinflammation".
Are you heading to ELRIG next week? Get in touch to set up a meeting with our team, and keep an eye on our socials next week to find out more about our scientists who will be attending alongside our commercial team.
October 10, 2025 at 3:21 PM
Are you heading to ELRIG next week? Get in touch to set up a meeting with our team, and keep an eye on our socials next week to find out more about our scientists who will be attending alongside our commercial team.
Don't miss Tayo Alleyne-Weir's talk at the Annual GCI/ITC Community Meeting in Basel today.
His presentation, 'Harnessing Biophysical Methods for Hit Discovery and Validation at Domainex', will cover a case study for a difficult tpd project.
His presentation, 'Harnessing Biophysical Methods for Hit Discovery and Validation at Domainex', will cover a case study for a difficult tpd project.
September 29, 2025 at 3:51 PM
Don't miss Tayo Alleyne-Weir's talk at the Annual GCI/ITC Community Meeting in Basel today.
His presentation, 'Harnessing Biophysical Methods for Hit Discovery and Validation at Domainex', will cover a case study for a difficult tpd project.
His presentation, 'Harnessing Biophysical Methods for Hit Discovery and Validation at Domainex', will cover a case study for a difficult tpd project.
Chris Miller and Andrew Ratcliffe are at Booth 513 at #DOT2025, drop by to find out more about how we can drive your lead discovery project forward.
We'd also be delighted to discuss our #D2B services, highlighted during our talk. Looking forward to a day of good discussions.
We'd also be delighted to discuss our #D2B services, highlighted during our talk. Looking forward to a day of good discussions.
September 24, 2025 at 3:34 PM
FBLD Conference starts on Sunday in Cambridge and the #Domainex team are looking forward to attending.
Visit us at Booth 6 to catch up with Ray, Anna, Philip, Tom and Gang about our approach to fragment lead discovery and our expertise in applying our services to fragment based projects.
Visit us at Booth 6 to catch up with Ray, Anna, Philip, Tom and Gang about our approach to fragment lead discovery and our expertise in applying our services to fragment based projects.
September 19, 2025 at 3:06 PM
FBLD Conference starts on Sunday in Cambridge and the #Domainex team are looking forward to attending.
Visit us at Booth 6 to catch up with Ray, Anna, Philip, Tom and Gang about our approach to fragment lead discovery and our expertise in applying our services to fragment based projects.
Visit us at Booth 6 to catch up with Ray, Anna, Philip, Tom and Gang about our approach to fragment lead discovery and our expertise in applying our services to fragment based projects.
At #Domainex, we are continuously expanding our computational chemistry toolkit to better guide molecular design and selection. Find out more in our latest blog:
www.domainex.co.uk/news/new-pre...
#CADD #ComputationalChemistry #CompChem
www.domainex.co.uk/news/new-pre...
#CADD #ComputationalChemistry #CompChem
September 12, 2025 at 10:15 AM
At #Domainex, we are continuously expanding our computational chemistry toolkit to better guide molecular design and selection. Find out more in our latest blog:
www.domainex.co.uk/news/new-pre...
#CADD #ComputationalChemistry #CompChem
www.domainex.co.uk/news/new-pre...
#CADD #ComputationalChemistry #CompChem
Have you noticed a discrepancy in compound turnover between liver microsomes and hepatocytes, with accelerated degradation observed in hepatocyte incubations? This could be due to metabolism by aldehyde oxidase. Find out more:
www.domainex.co.uk/services/ald...
#ADME #Metabolism
www.domainex.co.uk/services/ald...
#ADME #Metabolism
September 10, 2025 at 10:31 AM
Have you noticed a discrepancy in compound turnover between liver microsomes and hepatocytes, with accelerated degradation observed in hepatocyte incubations? This could be due to metabolism by aldehyde oxidase. Find out more:
www.domainex.co.uk/services/ald...
#ADME #Metabolism
www.domainex.co.uk/services/ald...
#ADME #Metabolism
Laura Lemel and Alec O'Keeffe are attending the GPCR-UK Network Meeting today. If you are there, make sure to catch up with them about how Domainex can support your GPCR project.
You can also find out more information on our website lnkd.in/ejJp-VCz or get in touch via enquiries@domainex.co.uk
You can also find out more information on our website lnkd.in/ejJp-VCz or get in touch via enquiries@domainex.co.uk
September 9, 2025 at 12:50 PM
Laura Lemel and Alec O'Keeffe are attending the GPCR-UK Network Meeting today. If you are there, make sure to catch up with them about how Domainex can support your GPCR project.
You can also find out more information on our website lnkd.in/ejJp-VCz or get in touch via enquiries@domainex.co.uk
You can also find out more information on our website lnkd.in/ejJp-VCz or get in touch via enquiries@domainex.co.uk
Jason is attending the International Reid Bioanalytical Forum this week. He will be presenting a poster on 'The characterisation of irreversible and reversible covalent fragments using LC-MS workflows'.
Catch up with Jason at the event, or get in touch with our team at enquiries@domainex.co.uk.
Catch up with Jason at the event, or get in touch with our team at enquiries@domainex.co.uk.
September 9, 2025 at 8:53 AM
Jason is attending the International Reid Bioanalytical Forum this week. He will be presenting a poster on 'The characterisation of irreversible and reversible covalent fragments using LC-MS workflows'.
Catch up with Jason at the event, or get in touch with our team at enquiries@domainex.co.uk.
Catch up with Jason at the event, or get in touch with our team at enquiries@domainex.co.uk.
Our #chemists have prepared a white paper describing how they have adopted high-throughput experimentation #HTE as part of their standard way of working and regularly use it to troubleshoot problematic reactions. A copy can be downloaded from our website:
www.domainex.co.uk/sites/defaul...
www.domainex.co.uk/sites/defaul...
September 5, 2025 at 1:07 PM
Our #chemists have prepared a white paper describing how they have adopted high-throughput experimentation #HTE as part of their standard way of working and regularly use it to troubleshoot problematic reactions. A copy can be downloaded from our website:
www.domainex.co.uk/sites/defaul...
www.domainex.co.uk/sites/defaul...
The #Domainex team are looking forward to attending the FBLD Conference later this month in Cambridge.
We are looking forward to connecting with the fragments community. Get in touch with us if you would like to set up a meeting.
We are looking forward to connecting with the fragments community. Get in touch with us if you would like to set up a meeting.
September 5, 2025 at 12:14 PM
The #Domainex team are looking forward to attending the FBLD Conference later this month in Cambridge.
We are looking forward to connecting with the fragments community. Get in touch with us if you would like to set up a meeting.
We are looking forward to connecting with the fragments community. Get in touch with us if you would like to set up a meeting.
Domainex will be at the RSC BMCS/SCI Medicinal Chemistry Symposium in Cambridge later this month. This is a great event to bring together experts in chemistry, with a focus on first disclosures and new strategies in the field.
Don't miss our posters which are focusing on our D2B platform.
Don't miss our posters which are focusing on our D2B platform.
September 2, 2025 at 4:31 PM
Domainex will be at the RSC BMCS/SCI Medicinal Chemistry Symposium in Cambridge later this month. This is a great event to bring together experts in chemistry, with a focus on first disclosures and new strategies in the field.
Don't miss our posters which are focusing on our D2B platform.
Don't miss our posters which are focusing on our D2B platform.
As we head out of summer and into September, a busy conference season is upon us. The Domainex team have a busy few months of conferences ahead, with poster presentations and talks at events both in the UK and US.
Details of the events are on our website lnkd.in/eqUy8H6E.
Details of the events are on our website lnkd.in/eqUy8H6E.
September 1, 2025 at 1:41 PM
As we head out of summer and into September, a busy conference season is upon us. The Domainex team have a busy few months of conferences ahead, with poster presentations and talks at events both in the UK and US.
Details of the events are on our website lnkd.in/eqUy8H6E.
Details of the events are on our website lnkd.in/eqUy8H6E.
#Domainex is delighted to announce it has joined forces with Pharmacelera to accelerate the discovery of molecules targeting transmembrane proteins.
Find out more:
www.domainex.co.uk/news/domaine...
Find out more:
www.domainex.co.uk/news/domaine...
August 27, 2025 at 7:09 AM
#Domainex is delighted to announce it has joined forces with Pharmacelera to accelerate the discovery of molecules targeting transmembrane proteins.
Find out more:
www.domainex.co.uk/news/domaine...
Find out more:
www.domainex.co.uk/news/domaine...
In our latest blog, you can find out more about the Trek to Remember hike for
#AlzheimersSociety some of the #Domainex team participated in earlier this month.
www.domainex.co.uk/news/trek-re...
Congratulations to the two teams for completing the hike and raising over £4,000.
#AlzheimersSociety some of the #Domainex team participated in earlier this month.
www.domainex.co.uk/news/trek-re...
Congratulations to the two teams for completing the hike and raising over £4,000.
August 22, 2025 at 9:08 AM
In our latest blog, you can find out more about the Trek to Remember hike for
#AlzheimersSociety some of the #Domainex team participated in earlier this month.
www.domainex.co.uk/news/trek-re...
Congratulations to the two teams for completing the hike and raising over £4,000.
#AlzheimersSociety some of the #Domainex team participated in earlier this month.
www.domainex.co.uk/news/trek-re...
Congratulations to the two teams for completing the hike and raising over £4,000.
Have you got a molecular glue programme that you need support for? If so, get in touch with Domainex to find out how we can assist.
Find out more on our website: www.domainex.co.uk/services/mol...
Find out more on our website: www.domainex.co.uk/services/mol...
August 21, 2025 at 3:59 PM
Have you got a molecular glue programme that you need support for? If so, get in touch with Domainex to find out how we can assist.
Find out more on our website: www.domainex.co.uk/services/mol...
Find out more on our website: www.domainex.co.uk/services/mol...
Are you thinking of pursuing a #prodrug strategy for your drug discovery programme? If so, get in touch with #Domainex to find out how we can help or take a look at our new webpage for more information:
www.domainex.co.uk/services/pro...
#DrugDiscovery #LeadDiscovery #Prodrugs
www.domainex.co.uk/services/pro...
#DrugDiscovery #LeadDiscovery #Prodrugs
August 20, 2025 at 11:10 AM
Are you thinking of pursuing a #prodrug strategy for your drug discovery programme? If so, get in touch with #Domainex to find out how we can help or take a look at our new webpage for more information:
www.domainex.co.uk/services/pro...
#DrugDiscovery #LeadDiscovery #Prodrugs
www.domainex.co.uk/services/pro...
#DrugDiscovery #LeadDiscovery #Prodrugs