Diana Giron
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dianagironce.bsky.social
Diana Giron
@dianagironce.bsky.social
140 followers 150 following 1 posts
Experimental Medicine PhD Student at University of British Columbia and BCCHR | Studying #immunology #organoids #IBD & #microbes
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Reposted by Diana Giron
brucevallance.bsky.social
🚨 We’re featured in @CBCNews!
Our team is using organoids to study how microbes interact with the gut mucus layer, and how this relationship impacts diseases like IBD 💩🔬
📰 Read the full story: www.cbc.ca/news/health/...
#Microbiome #GutHealth #Organoids #IBD
How much does your gut health impact your overall health? A lot, doctors say | CBC News
Doctors are tapping into to the emerging field of the gut microbiome to try to treat some diseases differently.
www.cbc.ca
June 2, 2025 at 10:10 PM
Reposted by Diana Giron
brucevallance.bsky.social
New paper from our lab! We developed an organoid-based air-liquid interface (ALI) model that produces physiologically relevant intestinal mucus and discovered that EspC has a mucinolytic superpower which enables C. rodentium to degrade mucus. 🧫🦠https://pmc.ncbi.nlm.nih.gov/articles/PMC12054374/
Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus
Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined. F...
pmc.ncbi.nlm.nih.gov
May 8, 2025 at 11:45 PM
Reposted by Diana Giron
tpelaseyed.bsky.social
🎄 Santa came early this year!🎄

We’re unwrapping an exciting discovery from our lab that reveals the critical role of the transmembrane mucin MUC17 in protecting the small intestine against bacterial challenges.

insight.jci.org/articles/vie...

#mucins #glycotime #Crohns #gut
JCI Insight - MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease
insight.jci.org
December 22, 2024 at 11:43 AM
Reposted by Diana Giron
barrallab.bsky.social
Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out!
@vivianlilab.bsky.social @kingscollegelondon.bsky.social

www.cell.com/cell-reports...
IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells
The crosstalk between immune and epithelial cells is vital to maintain intestinal homeostasis. Lebrusant-Fernandez et al. identify NKT cells in the small intestine as key regulators of epithelial biol...
www.cell.com
November 24, 2024 at 11:00 AM