Dev Majumdar
@devdoot.bsky.social
Immunology & RNA Biology at the University of Vermont. Troubleshooting biology is my happy place. http://biolab.dev // It's all fun and games and "Reg, transporting really is the safest way to travel" until somebody gets bitten by quasi-energy microbes.
KOSMOS, this week's buzzy AI scientist, posits that a coding mutation in a well-studied diabetes-related protein is functioning instead by mutated/cryptic exonic TFBS. Plausible, and totally fine to hypothesize; and word salad for an AI preprint is fine too. But horizon farther away than I thought.
November 10, 2025 at 2:02 PM
KOSMOS, this week's buzzy AI scientist, posits that a coding mutation in a well-studied diabetes-related protein is functioning instead by mutated/cryptic exonic TFBS. Plausible, and totally fine to hypothesize; and word salad for an AI preprint is fine too. But horizon farther away than I thought.
Quite possibly the best thing you'll read all month.
Control of gene output by intron RNA structure https://www.biorxiv.org/content/10.1101/2025.11.08.687378v1
November 10, 2025 at 4:36 AM
Quite possibly the best thing you'll read all month.
"…Every time you flush the toilet, you may very well be feeding engineered reactor ecosystems that inspired discovery of the domain Archaea and cultivation of syntrophic archaea closely related to our ancestors".
we're following closely... 👏👏👏
glad to see an "update" to > smallthingsconsidered.blog/schaechter/2...
glad to see an "update" to > smallthingsconsidered.blog/schaechter/2...
November 8, 2025 at 1:42 PM
"…Every time you flush the toilet, you may very well be feeding engineered reactor ecosystems that inspired discovery of the domain Archaea and cultivation of syntrophic archaea closely related to our ancestors".
Reposted by Dev Majumdar
🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...
Junior Group Leader for RNA-Biology, RNA-Technology or RNA-Medicine (f/m/d) - Würzburg (Stadt), Bayern (DE) job with Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) | 12844907
#RNAexcellence Junior Group Leader Positions (f/m/d) Job advertisement no.: 089/2025 Starting date: As soon as possible. The con...
www.nature.com
October 27, 2025 at 9:55 PM
🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...
Reposted by Dev Majumdar
Random grant writing tip.
I generally use 'drawing canvas' to insert figures. This keeps the legends and everything together. But there is one problem, text boxes inside the drawing canvas cannot cross the edge and text boxes are always bigger than the text.
I generally use 'drawing canvas' to insert figures. This keeps the legends and everything together. But there is one problem, text boxes inside the drawing canvas cannot cross the edge and text boxes are always bigger than the text.
October 25, 2025 at 6:36 PM
Random grant writing tip.
I generally use 'drawing canvas' to insert figures. This keeps the legends and everything together. But there is one problem, text boxes inside the drawing canvas cannot cross the edge and text boxes are always bigger than the text.
I generally use 'drawing canvas' to insert figures. This keeps the legends and everything together. But there is one problem, text boxes inside the drawing canvas cannot cross the edge and text boxes are always bigger than the text.
Reposted by Dev Majumdar
In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org
@scienceimmuno.bsky.social @lji.org
Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates
Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.
www.science.org
October 20, 2025 at 2:42 PM
In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org
@scienceimmuno.bsky.social @lji.org
Reposted by Dev Majumdar
Vermont still has robust local and state news coverage which makes a real difference when scandals like this break: vtdigger.org/2025/10/17/o...
Orleans County senator resigns following leaked racist group chat - VTDigger
Sen. Sam Douglass apologized for the offense his comments caused and described hateful comments he’d received since news first broke. He released a long statement late Friday afternoon.
vtdigger.org
October 17, 2025 at 10:15 PM
Vermont still has robust local and state news coverage which makes a real difference when scandals like this break: vtdigger.org/2025/10/17/o...
Maybe AI can help us to imagine a future where sort by price is possible on Fisher. How a billion dollar middleman can have such an unusable website in 2025... I just don't get it. share.google/RTKfr8eZ3AXF...
Thermo Fisher Scientific to Accelerate Life Science Breakthroughs with OpenAI
WALTHAM, Mass., October 16, 2025--Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, announced plans to further increase the impact of Thermo Fisher’s proven growth strate...
share.google
October 17, 2025 at 1:55 AM
Maybe AI can help us to imagine a future where sort by price is possible on Fisher. How a billion dollar middleman can have such an unusable website in 2025... I just don't get it. share.google/RTKfr8eZ3AXF...
Reposted by Dev Majumdar
We are recuiting a postdoc to join us at The University of Oslo. The candidate will investigate how T cells in the Germinal Center shape B cell and antibody quality. The projects include intravital 2-photon microscopy!
www.jobbnorge.no/en/available...
www.jobbnorge.no/en/available...
October 13, 2025 at 8:44 PM
We are recuiting a postdoc to join us at The University of Oslo. The candidate will investigate how T cells in the Germinal Center shape B cell and antibody quality. The projects include intravital 2-photon microscopy!
www.jobbnorge.no/en/available...
www.jobbnorge.no/en/available...
Reposted by Dev Majumdar
Lost Science is a new NYT series of accounts from scientists who have lost their jobs or funding. You can send your story to the Times here www.nytimes.com/2025/10/08/c...
October 10, 2025 at 8:38 AM
Lost Science is a new NYT series of accounts from scientists who have lost their jobs or funding. You can send your story to the Times here www.nytimes.com/2025/10/08/c...
Reposted by Dev Majumdar
Different results in different labs looking at activation of heterotrimeric G proteins. Was traced to use of dispo. plastic tubes v. reusable glass tubes (Fl) washed with Alconox detergent (Al). This led to groundbreaking biochemical and structural studies, such as pubmed.ncbi.nlm.nih.gov/7969474/
September 28, 2025 at 1:59 AM
Different results in different labs looking at activation of heterotrimeric G proteins. Was traced to use of dispo. plastic tubes v. reusable glass tubes (Fl) washed with Alconox detergent (Al). This led to groundbreaking biochemical and structural studies, such as pubmed.ncbi.nlm.nih.gov/7969474/
Reposted by Dev Majumdar
For last 10 years - we have worked with thousands of organizations around the world helping support them in integrating foldscope programs.
To bring in a new cohort of organizations - we are re-launching “fast and curious” 2025 edition - apply and get a Foldscope trainer and Foldscopes for free!
To bring in a new cohort of organizations - we are re-launching “fast and curious” 2025 edition - apply and get a Foldscope trainer and Foldscopes for free!
🔬 Free microscopes + teacher training!
📅 Applications are now open. To apply, visit www.foldscope.com or scan the QR code (video)
✉️ Any questions? Email us at training@foldscope.com
#stem #education #science #teachers #training #free #microscopy #educators #professionaldevelopment #microscope
📅 Applications are now open. To apply, visit www.foldscope.com or scan the QR code (video)
✉️ Any questions? Email us at training@foldscope.com
#stem #education #science #teachers #training #free #microscopy #educators #professionaldevelopment #microscope
September 22, 2025 at 2:19 AM
For last 10 years - we have worked with thousands of organizations around the world helping support them in integrating foldscope programs.
To bring in a new cohort of organizations - we are re-launching “fast and curious” 2025 edition - apply and get a Foldscope trainer and Foldscopes for free!
To bring in a new cohort of organizations - we are re-launching “fast and curious” 2025 edition - apply and get a Foldscope trainer and Foldscopes for free!
Reposted by Dev Majumdar
Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."
September 7, 2025 at 8:04 PM
Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."
Otoh, srbc gcs are the best gcs.
Irving Kriesberg, Red Sheep, 1951 #artbots #moma
https://botfrens.com/collections/14377/contents/1134931
https://botfrens.com/collections/14377/contents/1134931
September 5, 2025 at 8:45 AM
Otoh, srbc gcs are the best gcs.
Reposted by Dev Majumdar
RNA Canada ARN is thrilled to share two RNA-themed escape games, created in collaboration with students at the University of Toronto at Scarborough, as part of their coursework with Dr. Aarthi Ashok! www.rnacanada.ca/rna-canada-a...
RNA Canada ARN Online Escape Games! - RNA Canada ARN
RNA Canada ARN is thrilled to share two RNA-themed escape games, created in collaboration with students at the University of Toronto at Scarborough, as part of their coursework with Dr. Aarthi Ashok. ...
www.rnacanada.ca
August 25, 2025 at 7:02 PM
RNA Canada ARN is thrilled to share two RNA-themed escape games, created in collaboration with students at the University of Toronto at Scarborough, as part of their coursework with Dr. Aarthi Ashok! www.rnacanada.ca/rna-canada-a...
Reposted by Dev Majumdar
We’ve got a good mix of exciting talks on various aspects of how RNA biology both influences and is controlled by tumorigenesis, and we’d love to have more folks join our effort to continue cross-pollinating these exciting fields! Abstract deadline is Aug 25th
August 12, 2025 at 9:08 PM
We’ve got a good mix of exciting talks on various aspects of how RNA biology both influences and is controlled by tumorigenesis, and we’d love to have more folks join our effort to continue cross-pollinating these exciting fields! Abstract deadline is Aug 25th
Reposted by Dev Majumdar
fascinated by this plot for listing permutations (namely, the orders in which four introns can be spliced from a given RNA transcript) and denoting their frequencies with line thickness and shade. It avoids needing to enumerate all 4! permutations. from Choquet et al. 2023 (Nat. Struct. Mol. Biol.)
August 5, 2025 at 5:21 PM
fascinated by this plot for listing permutations (namely, the orders in which four introns can be spliced from a given RNA transcript) and denoting their frequencies with line thickness and shade. It avoids needing to enumerate all 4! permutations. from Choquet et al. 2023 (Nat. Struct. Mol. Biol.)
Reposted by Dev Majumdar
New from our lab in @narjournal.bsky.social:
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
July 31, 2025 at 2:27 AM
New from our lab in @narjournal.bsky.social:
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution.
doi.org/10.1093/nar/... 1/5
Reposted by Dev Majumdar
SCIENTIFIC RESEARCH SAVE LIVES: Last Thursday night, I was talking on the phone with my 87-year-old mother, and she had a SEIZURE WHILE ON THE PHONE! Rushed to the ER, had stroke symptoms that were reversed by a dose of the latest version of tissue plasminogen activator (clot-dissolving drug). 1/2
July 29, 2025 at 10:45 PM
SCIENTIFIC RESEARCH SAVE LIVES: Last Thursday night, I was talking on the phone with my 87-year-old mother, and she had a SEIZURE WHILE ON THE PHONE! Rushed to the ER, had stroke symptoms that were reversed by a dose of the latest version of tissue plasminogen activator (clot-dissolving drug). 1/2
Reposted by Dev Majumdar
Wadsworth is awesome - if this describes you, strongly consider applying
The Wadsworth Center is expanding it's research focus on #virology /vector-borne diseases!
www.asmcareerconnections.org/job/research-scientist-5-g-31/78488664/
This is a unicorn assistant prof equivalent position with 12-month hard money salary and no teaching commitments (!)
Reposts appreciated 🙏
www.asmcareerconnections.org/job/research-scientist-5-g-31/78488664/
This is a unicorn assistant prof equivalent position with 12-month hard money salary and no teaching commitments (!)
Reposts appreciated 🙏
July 26, 2025 at 12:23 AM
Wadsworth is awesome - if this describes you, strongly consider applying
If we are all just NPCs living in the world of billionaires, the glass half full view is that one of them truly values basic science. Howard Hughes couldn't tell you about CD47. Good interview. @ashleevance.bsky.social
Priscilla Chan's Multi-Billion Dollar Quest to End Disease
YouTube video by Core Memory
www.youtube.com
July 25, 2025 at 1:34 PM
If we are all just NPCs living in the world of billionaires, the glass half full view is that one of them truly values basic science. Howard Hughes couldn't tell you about CD47. Good interview. @ashleevance.bsky.social
Reposted by Dev Majumdar
Reposted by Dev Majumdar
I used Veo 3 to solve Shakespearean tragedies as pictured in classical art. (sound on)
July 9, 2025 at 9:38 PM
I used Veo 3 to solve Shakespearean tragedies as pictured in classical art. (sound on)
Publish the data, overlook the code? Glam gonna glam.
July 17, 2025 at 2:38 PM
Publish the data, overlook the code? Glam gonna glam.