Daniele Mattei, PhD
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denjo3.bsky.social
Daniele Mattei, PhD
@denjo3.bsky.social
670 followers 1.2K following 21 posts
Neuroscientist at the Icahn School of Medicine at Mount Sinai Hospital - NYC
Studying the 🧠 's immune system in psychiatric disorders and neurodegeneration
Interested in implementing a circadian perspective in microglia research!
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denjo3.bsky.social
Daniele Mattei, PhD @denjo3.bsky.social · Nov 20
What time do you collect Microglia from preclinical models for downstream analyses? Microglia undergo transcriptional, proteomic and functional adaptations to the wake and sleep phases🧵 shorturl.at/LpEQk
Reposted by Daniele Mattei, PhD
denjo3.bsky.social
Microglia don’t act the same around the clock! Their transcriptional/proteomic/functional programs shift across sleep/wake phases - yet most studies ignore time-of-day. This perspective calls for a circadian rethink in neuroimmunology!
pubmed.ncbi.nlm.nih.gov/40618264/
Rethinking microglia from a circadian perspective in neuroimmunology: New insights - PubMed
Rethinking microglia from a circadian perspective in neuroimmunology: New insights
pubmed.ncbi.nlm.nih.gov
July 12, 2025 at 7:08 PM
denjo3.bsky.social
Microglia don’t act the same around the clock! Their transcriptional/proteomic/functional programs shift across sleep/wake phases - yet most studies ignore time-of-day. This perspective calls for a circadian rethink in neuroimmunology!
pubmed.ncbi.nlm.nih.gov/40618264/
Rethinking microglia from a circadian perspective in neuroimmunology: New insights - PubMed
Rethinking microglia from a circadian perspective in neuroimmunology: New insights
pubmed.ncbi.nlm.nih.gov
July 12, 2025 at 7:08 PM
denjo3.bsky.social
April is #Parkinson's awareness month! PD is the second most common #neurodegenerative disease. Below you see two sections of human midbrain processed in our lab, where you can see the hallmark of PD: #Dopaminergic neuronal death in the SNpc, from where I sort intact #microglia for MultiOmics.
April 15, 2025 at 1:31 PM
Reposted by Daniele Mattei, PhD
denjo3.bsky.social
Maternal immune activation may compromise offspring #neurodevelopment via #glia activation. In this chapter, we discuss the most up-to-date evidence and mechanisms gathered via #COVID_19 and other pandemics, preclinical models and brain-organoid models with integrated #microglia.
shorturl.at/0B8Bw
From womb to world: The interplay between maternal immune activation, neuroglia, and neurodevelopment
This chapter introduces and discusses maternal immune activation (MIA) as a contributing factor in increasing the risk of neurodevelopmental disorders…
shorturl.at
March 29, 2025 at 6:40 PM
Reposted by Daniele Mattei, PhD
denjo3.bsky.social
What time do you collect Microglia from preclinical models for downstream analyses? Microglia undergo transcriptional, proteomic and functional adaptations to the wake and sleep phases🧵 shorturl.at/LpEQk
November 20, 2024 at 2:07 AM
denjo3.bsky.social
Maternal immune activation may compromise offspring #neurodevelopment via #glia activation. In this chapter, we discuss the most up-to-date evidence and mechanisms gathered via #COVID_19 and other pandemics, preclinical models and brain-organoid models with integrated #microglia.
shorturl.at/0B8Bw
From womb to world: The interplay between maternal immune activation, neuroglia, and neurodevelopment
This chapter introduces and discusses maternal immune activation (MIA) as a contributing factor in increasing the risk of neurodevelopmental disorders…
shorturl.at
March 29, 2025 at 6:40 PM
Reposted by Daniele Mattei, PhD
lukensjohnr.bsky.social
Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 @natureneuro.bsky.social
www.nature.com/articles/s41...
Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 - Nature Neuroscience
The authors show that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction occurs at sites of vascul...
www.nature.com
March 6, 2025 at 11:34 PM
Reposted by Daniele Mattei, PhD
macauleylab.bsky.social
Spatial transcriptomic clocks reveal cellproximity effects in brain ageing
December 19, 2024 at 1:35 AM
Reposted by Daniele Mattei, PhD
murphyroyallab.org
Delighted to share an update to our preprint, reviewed at @elife.bsky.social, and now sent back for re-review.
Colossal work by the team and driven home by @mathiasgua.bsky.social
Quick 🧵 of what's new -
www.biorxiv.org/content/10.1...
Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation
Early-life stress can have lifelong consequences, enhancing stress susceptibility and resulting in behavioural and cognitive deficits. While the effects of early-life stress on neuronal function have ...
www.biorxiv.org
December 9, 2024 at 11:19 PM
denjo3.bsky.social
Very interesting study showing how Astrocytes in the cerebellum can regulate aggressive behavior!
"Neuron-glial interactions in the cerebellar vermis may play a role in adjusting Purkinje cell excitability and setting the tone of aggression."
December 5, 2024 at 4:43 AM
Reposted by Daniele Mattei, PhD
annamolofskylab.bsky.social
go.bsky.app/Eaua5Jk my starter for neuroimmunology
November 19, 2024 at 4:50 AM
Reposted by Daniele Mattei, PhD
bowleslab.bsky.social
Finally got this across the finish line!

We made an isogenic panel of MAPT splicing mutation iPSCs that express high levels of endogenous 4R tau...

...and saw some cool stuff!
👇👇👇
tinyurl.com/38e5d6d2

Big thanks to supporters RCFneuro, Brightfocus, AFTD & UKDRI!
November 28, 2024 at 3:47 PM
Reposted by Daniele Mattei, PhD
bowleslab.bsky.social
Abstract submission for Stem Cell Models of Neurodegeneration 2025 is open until January 31st 2025! Come register and share your work with us!

scmnd.com

We look forward to hosting you in Edinburgh next year :-)

#neuroscience #iPSC #neurodegeneration #stemcells #dementia #organoids
November 25, 2024 at 8:03 PM
denjo3.bsky.social
Microglia are key players in neurodevelopment. It is thus essential to include them in brain organoids to study neurodevelopment, especially to study prenatal immune activation and how it impacts such a delicate process. Thrilled to have participated to this beautiful study. shorturl.at/7M9DU
Microglia undergo molecular and functional adaptations to dark and light phases in male laboratory mice
Microglia are increasingly recognized to contribute to brain health and disease. Preclinical studies using laboratory rodents are essential to advance…
shorturl.at
November 25, 2024 at 10:50 PM
Reposted by Daniele Mattei, PhD
sethabramson.bsky.social
I feel seen
November 24, 2024 at 4:56 PM
Reposted by Daniele Mattei, PhD
denjo3.bsky.social
Any researcher here also looking into glia circadian differences in disease models? Eager to connect amd discuss! We study glia in disease and physiology, but mostly during rodent's sleep phase, as they're often hosted in a light:dark cycle. Hence, are we looking at only half of the picture?
November 21, 2024 at 4:13 PM
Reposted by Daniele Mattei, PhD
derubeislab.bsky.social
We are recruiting a postdoc!

Have expertise in RNA biology and want to apply it to neuro and neurodev disorders? Then apply 👇🏼

📌 $73,588 💰
📌 access to postdoc housing 🏠
📌 Support for internationals 🌍
📌 Awesome view 😅

🙏 RT

labs.icahn.mssm.edu/derubeislab/...
November 23, 2024 at 4:55 AM
Reposted by Daniele Mattei, PhD
nicola-fattorelli.bsky.social
Hi Bluesky 🦋 I’m Nico, a microglia enthusiast based in VIB, Belgium 🧠 if you are curious about the science we do, take a look at our latest work! Here we use xenotransplantation models to map the spectrum of human microglia responses to Alzheimer’s disease pathology www.nature.com/articles/s41...
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology - Nature Neuroscience
Human microglia transplanted in the mouse brain mount a multipronged response to amyloid-β pathology, displaying unique transcriptional states. Alzheimer’s disease risk genes are differentially regula...
www.nature.com
November 16, 2024 at 11:22 PM
denjo3.bsky.social
Any researcher here also looking into glia circadian differences in disease models? Eager to connect amd discuss! We study glia in disease and physiology, but mostly during rodent's sleep phase, as they're often hosted in a light:dark cycle. Hence, are we looking at only half of the picture?
November 21, 2024 at 4:13 PM
denjo3.bsky.social
What time do you collect Microglia from preclinical models for downstream analyses? Microglia undergo transcriptional, proteomic and functional adaptations to the wake and sleep phases🧵 shorturl.at/LpEQk
November 20, 2024 at 2:07 AM
Reposted by Daniele Mattei, PhD
sainthoax.bsky.social
arriving to bluesky after shedding all the bots and naz*s
November 17, 2024 at 2:14 AM
Reposted by Daniele Mattei, PhD
macauleylab.bsky.social
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model

www.cell.com/cell-reports...
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model
Cankar et al. report that sleep loss suppresses NREM norepinephrine oscillations in a murine model of Alzheimer’s disease along with a parallel buildup of amyloid-β. Thus, overexpression of amyloid-β ...
www.cell.com
November 15, 2024 at 7:29 PM