Danwei Huangfu
@danweihuangfu.bsky.social
PI @ MSKCC
Stem cell biologist passionate about human development, functional genomics and genomic variations affecting human traits.
www.mskcc.org/huangfu
Stem cell biologist passionate about human development, functional genomics and genomic variations affecting human traits.
www.mskcc.org/huangfu
Pinned
Danwei Huangfu
@danweihuangfu.bsky.social
· May 25
Lab hiking at Mount Beacon. Great views of the Hudson, a few detours off-trail (in true scientific spirit), and just the right amount of rain. many thanks to Denis Torre for organizing. A beautiful sendoff for lab members (Jielin Yan and Sharon Adeniyi) soon setting off on their own paths.
Reposted by Danwei Huangfu
new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4
rdcu.be/eOc0q
rdcu.be/eOc0q
Human DICER1 hotspot mutation induces both loss and gain of miRNA function
Nature Structural & Molecular Biology - Jee et al. study a cancer hotspot allele of DICER1 that disrupts RNaseIIIb activity. Beyond ablating 5p hairpin cleavage, 3p passenger strands are...
rdcu.be
November 10, 2025 at 4:43 PM
new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4
rdcu.be/eOc0q
rdcu.be/eOc0q
As a member of the editorial board for @stemcellreports.bsky.social, I am excited to share that we are looking for submissions in the field of stem cell research! I invite you to submit your work for consideration. invt.io/1bxbz2ji4db @isscr.org #stemcell #DevBio #hPSCs #regeneration
Check out ISSCR's society journal, Stem Cell Reports!
invt.io
October 3, 2025 at 9:42 PM
As a member of the editorial board for @stemcellreports.bsky.social, I am excited to share that we are looking for submissions in the field of stem cell research! I invite you to submit your work for consideration. invt.io/1bxbz2ji4db @isscr.org #stemcell #DevBio #hPSCs #regeneration
Reposted by Danwei Huangfu
Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience
Developmental biologist Maria Jasin wins the 2025 Pearl Meister Greengard Prize - News
Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Awarded annually by ...
www.rockefeller.edu
September 12, 2025 at 1:24 PM
Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience
Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose, & treat cancer.
bit.ly/3WUiuo1
bit.ly/3WUiuo1
September 11, 2025 at 9:04 PM
Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose, & treat cancer.
bit.ly/3WUiuo1
bit.ly/3WUiuo1
Congratulations to #MSKPostdoc Denis Torre
on being awarded the Damon Runyon Fellowship! 👏👏👏
Keep up the good work!
@damonrunyon.org @mskeducation.bsky.social
on being awarded the Damon Runyon Fellowship! 👏👏👏
Keep up the good work!
@damonrunyon.org @mskeducation.bsky.social
New Discoveries and Honors in Cancer Research | Damon Runyon
www.damonrunyon.org
September 5, 2025 at 9:26 PM
Congratulations to #MSKPostdoc Denis Torre
on being awarded the Damon Runyon Fellowship! 👏👏👏
Keep up the good work!
@damonrunyon.org @mskeducation.bsky.social
on being awarded the Damon Runyon Fellowship! 👏👏👏
Keep up the good work!
@damonrunyon.org @mskeducation.bsky.social
Reposted by Danwei Huangfu
📢 Interested in #AI + #PrecisionMedicine?
The NIH PRIMED-AI program has forecasted several new #funding opportunities — covering AI frameworks, validation centers, academic-industry partnerships & more!
📝 FOAs expected soon — stay tuned & start planning!
🔗 More information: dknet.org/about/dknetn...
The NIH PRIMED-AI program has forecasted several new #funding opportunities — covering AI frameworks, validation centers, academic-industry partnerships & more!
📝 FOAs expected soon — stay tuned & start planning!
🔗 More information: dknet.org/about/dknetn...
June 11, 2025 at 10:45 PM
📢 Interested in #AI + #PrecisionMedicine?
The NIH PRIMED-AI program has forecasted several new #funding opportunities — covering AI frameworks, validation centers, academic-industry partnerships & more!
📝 FOAs expected soon — stay tuned & start planning!
🔗 More information: dknet.org/about/dknetn...
The NIH PRIMED-AI program has forecasted several new #funding opportunities — covering AI frameworks, validation centers, academic-industry partnerships & more!
📝 FOAs expected soon — stay tuned & start planning!
🔗 More information: dknet.org/about/dknetn...
Reposted by Danwei Huangfu
Traveling to the @isscr.org meeting in HK soon? Feeling like browsing through important #StemCell work published during the past year on your way there? Take a look at our collection of papers published across @natureportfolio.nature.com during the past 12 months!
www.nature.com/collections/...
www.nature.com/collections/...
A year of stem cell and developmental biology
In recent years, the field of stem cell and developmental biology has seen remarkable breakthroughs that have deepened our understanding of how organisms ...
www.nature.com
June 7, 2025 at 11:53 AM
Traveling to the @isscr.org meeting in HK soon? Feeling like browsing through important #StemCell work published during the past year on your way there? Take a look at our collection of papers published across @natureportfolio.nature.com during the past 12 months!
www.nature.com/collections/...
www.nature.com/collections/...
Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells: Stem Cell Reports www.cell.com/stem-cell-re...
Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells
Huangfu and colleagues identified two NANOG enhancers from a CRISPR interference (CRISPRi)
screen in hESCs. Heterozygous deletions of either enhancer significantly lowered NANOG
expression, reduced hE...
www.cell.com
June 2, 2025 at 11:22 PM
Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells: Stem Cell Reports www.cell.com/stem-cell-re...
Lab hiking at Mount Beacon. Great views of the Hudson, a few detours off-trail (in true scientific spirit), and just the right amount of rain. many thanks to Denis Torre for organizing. A beautiful sendoff for lab members (Jielin Yan and Sharon Adeniyi) soon setting off on their own paths.
May 25, 2025 at 2:43 PM
Lab hiking at Mount Beacon. Great views of the Hudson, a few detours off-trail (in true scientific spirit), and just the right amount of rain. many thanks to Denis Torre for organizing. A beautiful sendoff for lab members (Jielin Yan and Sharon Adeniyi) soon setting off on their own paths.
Reposted by Danwei Huangfu
🎓 Congratulations to the 14 scientists who graduated from the Gerstner Sloan Kettering Graduate School of Biomedical Sciences (GSK) this year!
Learn more about this year's GSK graduates and their accomplishments: bit.ly/3SGB1T8
Learn more about this year's GSK graduates and their accomplishments: bit.ly/3SGB1T8
May 19, 2025 at 8:55 PM
🎓 Congratulations to the 14 scientists who graduated from the Gerstner Sloan Kettering Graduate School of Biomedical Sciences (GSK) this year!
Learn more about this year's GSK graduates and their accomplishments: bit.ly/3SGB1T8
Learn more about this year's GSK graduates and their accomplishments: bit.ly/3SGB1T8
Hosted Ben Stanger for a seminar and in addition to a great presentation (I'm expecting that!), I also received a surprise!
Thanks @benstanger01.bsky.social
Thanks @benstanger01.bsky.social
May 16, 2025 at 2:16 AM
Hosted Ben Stanger for a seminar and in addition to a great presentation (I'm expecting that!), I also received a surprise!
Thanks @benstanger01.bsky.social
Thanks @benstanger01.bsky.social
Congratulations to our 2025 graduates! So inspired @carolynbertozzi.bskyverified.social commencement speech. @mskeducation.bsky.social
Congratulations to Dr. Jielin Yan and Dr. Samual Kaplan. So very proud of your accomplishments!
Congratulations to Dr. Jielin Yan and Dr. Samual Kaplan. So very proud of your accomplishments!
May 15, 2025 at 7:53 PM
Congratulations to our 2025 graduates! So inspired @carolynbertozzi.bskyverified.social commencement speech. @mskeducation.bsky.social
Congratulations to Dr. Jielin Yan and Dr. Samual Kaplan. So very proud of your accomplishments!
Congratulations to Dr. Jielin Yan and Dr. Samual Kaplan. So very proud of your accomplishments!
Reposted by Danwei Huangfu
Reposted by Danwei Huangfu
One of these studies from @mskcancercenter.bsky.social and the result of the long term commitment to basic stem cell investigation by Lorenz Studer and Viviane Tabar at MSK. Very exciting!
Two new studies suggest that Parkinson's disease can potentially be treated with stem cells placed in a patient's brain.
Stem cells to treat Parkinson's? Two small studies hint at success
Two new studies suggest that Parkinson's disease can potentially be treated with stem cells placed in a patient's brain.
www.npr.org
April 17, 2025 at 10:45 AM
One of these studies from @mskcancercenter.bsky.social and the result of the long term commitment to basic stem cell investigation by Lorenz Studer and Viviane Tabar at MSK. Very exciting!
Reposted by Danwei Huangfu
Calling all students in NIDDK relevant disease research fields! 🔬📊 Ready to explore data management, #FAIR data, rigor and reproducibility, and #datascience? The dkNET Summer of Data program offers training to boost your research skills.
Apply now! ✨ dknet.org/about/Summer...
Apply now! ✨ dknet.org/about/Summer...
March 13, 2025 at 1:33 AM
Calling all students in NIDDK relevant disease research fields! 🔬📊 Ready to explore data management, #FAIR data, rigor and reproducibility, and #datascience? The dkNET Summer of Data program offers training to boost your research skills.
Apply now! ✨ dknet.org/about/Summer...
Apply now! ✨ dknet.org/about/Summer...
Reposted by Danwei Huangfu
exciting news for our scientific community! www.nygenome.org/news-events/...
Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center - March 27, 2025
Read about Bing Ren Appointed Scientific Director and Chief Executive Officer of the New York Genome Center at the New York Genome Center on March 27, 2025
www.nygenome.org
March 27, 2025 at 7:26 PM
exciting news for our scientific community! www.nygenome.org/news-events/...
Reposted by Danwei Huangfu
Can you explain your doctoral research through interpretive dance?
The deadline for submissions to the 17th annual #DanceYourPhD competition is this week. Submit by 28 March for a chance to win $2000: scim.ag/4gKMnz9
The deadline for submissions to the 17th annual #DanceYourPhD competition is this week. Submit by 28 March for a chance to win $2000: scim.ag/4gKMnz9
March 24, 2025 at 3:40 PM
Can you explain your doctoral research through interpretive dance?
The deadline for submissions to the 17th annual #DanceYourPhD competition is this week. Submit by 28 March for a chance to win $2000: scim.ag/4gKMnz9
The deadline for submissions to the 17th annual #DanceYourPhD competition is this week. Submit by 28 March for a chance to win $2000: scim.ag/4gKMnz9
Congratulations to Dr. Jielin Yan #GSK for successfully defending her PhD dissertation! And a refreshing perspective on a non-monotonic relationship between academic freedom and scientific growth. Check out her preprint here on the discovery of NANOG enhancers www.biorxiv.org/content/10.1....
March 21, 2025 at 2:26 AM
Congratulations to Dr. Jielin Yan #GSK for successfully defending her PhD dissertation! And a refreshing perspective on a non-monotonic relationship between academic freedom and scientific growth. Check out her preprint here on the discovery of NANOG enhancers www.biorxiv.org/content/10.1....
Reposted by Danwei Huangfu
Tom Maniatis coming in hot in @CellCellPress
to spell out in no uncertain terms what cutting indirect cost rates to 15% will cost science.
And a call to action: "A united front...is essential to preventing this devastating policy from taking effect." 💯
www.cell.com/cell/fulltex...
to spell out in no uncertain terms what cutting indirect cost rates to 15% will cost science.
And a call to action: "A united front...is essential to preventing this devastating policy from taking effect." 💯
www.cell.com/cell/fulltex...
Safeguarding the future of biomedical science in the United States
NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical
infrastructure supporting groundbreaking biomedical research in the United States.
This policy jeopardizes Americ...
www.cell.com
March 1, 2025 at 9:29 PM
Tom Maniatis coming in hot in @CellCellPress
to spell out in no uncertain terms what cutting indirect cost rates to 15% will cost science.
And a call to action: "A united front...is essential to preventing this devastating policy from taking effect." 💯
www.cell.com/cell/fulltex...
to spell out in no uncertain terms what cutting indirect cost rates to 15% will cost science.
And a call to action: "A united front...is essential to preventing this devastating policy from taking effect." 💯
www.cell.com/cell/fulltex...
Reposted by Danwei Huangfu
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
www.nytimes.com/2025/03/01/u...
March 1, 2025 at 6:07 PM
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
www.nytimes.com/2025/03/01/u...
Reposted by Danwei Huangfu
#ISSCR joined hundreds of biomedical research organizations to urge House and Senate appropriators to support robust funding for NIH & avoid drastic measures that will slow scientific progress and weaken the U.S. research ecosystem. www.isscr.org/isscr-news/t...
The ISSCR Signs on to Coalition Letter in Support of NIH — International Society for Stem Cell Research
The ISSCR joined with Research!America, hundreds of biomedical research organizations, and thousands of private citizens from the U.S. scientific community to urge House and Senate appropriators to av...
www.isscr.org
February 26, 2025 at 8:27 PM
#ISSCR joined hundreds of biomedical research organizations to urge House and Senate appropriators to support robust funding for NIH & avoid drastic measures that will slow scientific progress and weaken the U.S. research ecosystem. www.isscr.org/isscr-news/t...
Reposted by Danwei Huangfu
I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
Graduate Reductions Across Biomedical Sciences (2025)
docs.google.com
February 22, 2025 at 1:23 PM
I created a brief spreadsheet of reductions I've heard of so far. Any additions you know of (especially if you have the links/receipts) would be great: docs.google.com/spreadsheets...
Reposted by Danwei Huangfu
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization
event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene.
The use of a small-molecule c...
www.cell.com
February 21, 2025 at 5:31 PM
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
💊 Drug development relies on understanding gene function.
However, we still don’t know what most genes actually do.
Excited to be part of the #MorPhiC consortium, working to close this knowledge gap. #ScienceMatters #CRISPR #FunctionalGenomics #iPSC
Check out 👇
www.nature.com/articles/s41...
However, we still don’t know what most genes actually do.
Excited to be part of the #MorPhiC consortium, working to close this knowledge gap. #ScienceMatters #CRISPR #FunctionalGenomics #iPSC
Check out 👇
www.nature.com/articles/s41...
MorPhiC Consortium: towards functional characterization of all human genes - Nature
This Perspective discusses strategies and challenges for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Consortium as it aims to catalogue the molecular and cellular phenotypes associated...
www.nature.com
February 20, 2025 at 5:10 AM
💊 Drug development relies on understanding gene function.
However, we still don’t know what most genes actually do.
Excited to be part of the #MorPhiC consortium, working to close this knowledge gap. #ScienceMatters #CRISPR #FunctionalGenomics #iPSC
Check out 👇
www.nature.com/articles/s41...
However, we still don’t know what most genes actually do.
Excited to be part of the #MorPhiC consortium, working to close this knowledge gap. #ScienceMatters #CRISPR #FunctionalGenomics #iPSC
Check out 👇
www.nature.com/articles/s41...
Reposted by Danwei Huangfu
Whenever you hear someone sneer about scientific research that seems useless to them — “they’re studying the spit of lizards?!” — remind them that’s exactly how we got Ozempic.
globalnews.ca/news/9793403...
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 5:38 PM
Whenever you hear someone sneer about scientific research that seems useless to them — “they’re studying the spit of lizards?!” — remind them that’s exactly how we got Ozempic.
globalnews.ca/news/9793403...
globalnews.ca/news/9793403...