Damien Levard
@damlev.bsky.social
PhD | Neuroimmunology | Blood & Brain Institute @ Caen Normandie | Université de Caen Normandie
#Brain #Macrophages #Stroke 🧠🔬🥼 | Random sports enthusiast 🥋🏃🏻
#Brain #Macrophages #Stroke 🧠🔬🥼 | Random sports enthusiast 🥋🏃🏻
Niche-specific dermal macrophage loss promotes skin capillary ageing
Niche-specific dermal macrophage loss promotes skin capillary ageing - Nature
Capillary-associated macrophages are selectively lost over time, contributing to impaired vascular repair and reduced tissue perfusion in older mice.
www.nature.com
October 21, 2025 at 8:33 PM
Niche-specific dermal macrophage loss promotes skin capillary ageing
www.nature.com/articles/s41...
A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting
A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting
A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting - Nature Neuroscience
The authors describe a mechanism for the clearance of macromolecules from cerebrospinal fluid in which macromolecules traverse from periarterial to perivenous spaces, at sites where intersecting lepto...
www.nature.com
June 10, 2025 at 9:46 AM
www.nature.com/articles/s41...
A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting
A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting
Reposted by Damien Levard
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature
Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.
www.nature.com
February 26, 2025 at 5:10 PM
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immune conversations at the border: meningeal immunity in health and disease
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Frontiers | Immune conversations at the border: meningeal immunity in health and disease
www.frontiersin.org
February 12, 2025 at 3:28 PM
Immune conversations at the border: meningeal immunity in health and disease
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
The immunology of stroke and dementia: Immunity www.cell.com/immunity/ful...
The immunology of stroke and dementia
Ischemic stroke and vascular cognitive impairment are global health threats. Recent
research has uncovered a previously underappreciated dynamic interplay between brain-resident,
meningeal, and system...
www.cell.com
January 15, 2025 at 11:33 AM
The immunology of stroke and dementia: Immunity www.cell.com/immunity/ful...
Reposted by Damien Levard
— Franz Kafka, 1912
January 7, 2025 at 4:23 PM
— Franz Kafka, 1912
« L’expérimentation animale n’est pas toujours nécessaire mais demeure indispensable »
www.lemonde.fr/sciences/art...
www.lemonde.fr/sciences/art...
« L’expérimentation animale n’est pas toujours nécessaire mais demeure indispensable »
TRIBUNE. Dans une tribune au « Monde », un collectif de 2 829 chercheurs et universitaires, dont huit présidents d’université, dénonce les contrevérités avancées par des parlementaires pour taxer les ...
www.lemonde.fr
December 11, 2024 at 9:52 AM
« L’expérimentation animale n’est pas toujours nécessaire mais demeure indispensable »
www.lemonde.fr/sciences/art...
www.lemonde.fr/sciences/art...
Every day a new role for macrophages 🤩
Macrophages excite muscle spindles with glutamate to bolster locomotion
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Macrophages excite muscle spindles with glutamate to bolster locomotion - Nature
A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...
www.nature.com
December 4, 2024 at 5:26 PM
Every day a new role for macrophages 🤩
La recherche biomédicale française mérite mieux qu’une nouvelle taxe.
Aujourd’hui, elle a besoin de votre soutien pour se faire entendre :
forms.office.com/pages/respon...
Aujourd’hui, elle a besoin de votre soutien pour se faire entendre :
forms.office.com/pages/respon...
Microsoft Forms
forms.office.com
November 28, 2024 at 12:53 PM
La recherche biomédicale française mérite mieux qu’une nouvelle taxe.
Aujourd’hui, elle a besoin de votre soutien pour se faire entendre :
forms.office.com/pages/respon...
Aujourd’hui, elle a besoin de votre soutien pour se faire entendre :
forms.office.com/pages/respon...
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology
Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...
www.nature.com
November 26, 2024 at 9:06 AM
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Damien Levard
Vous parlez français🇫🇷? Vous avez entre 18 et 85 ans ? Vous avez un ordinateur portable💻?
Alors vous pourrez nous aider à faire avancer la recherche sur la perception du temps⏰en faisant ce bref questionnaire en ligne🌐
Pour participer👉🏻 bit.ly/3CunJEA
Merci !
Alors vous pourrez nous aider à faire avancer la recherche sur la perception du temps⏰en faisant ce bref questionnaire en ligne🌐
Pour participer👉🏻 bit.ly/3CunJEA
Merci !
November 16, 2024 at 12:00 PM
Vous parlez français🇫🇷? Vous avez entre 18 et 85 ans ? Vous avez un ordinateur portable💻?
Alors vous pourrez nous aider à faire avancer la recherche sur la perception du temps⏰en faisant ce bref questionnaire en ligne🌐
Pour participer👉🏻 bit.ly/3CunJEA
Merci !
Alors vous pourrez nous aider à faire avancer la recherche sur la perception du temps⏰en faisant ce bref questionnaire en ligne🌐
Pour participer👉🏻 bit.ly/3CunJEA
Merci !
Reposted by Damien Levard
🧠 barriers & neurovasculature starter pack - please reply here if you are not on it yet & would like to be added 😊 go.bsky.app/RB6RXKy
November 15, 2024 at 3:30 AM
🧠 barriers & neurovasculature starter pack - please reply here if you are not on it yet & would like to be added 😊 go.bsky.app/RB6RXKy
Check out the @TrendsNeuro Spotlight on our recent paper uncovering the role of CNS-associated macrophages in ischemic stroke. Huge thanks to the Louise McCullough group for highlighting our work!
www.cell.com/trends/neuro...
www.cell.com/trends/neuro...
CAMs in command: aging brain macrophages fine-tune stroke immune responses
Central nervous system-associated macrophages (CAMs) are a unique subset of immune
cells located at the interface between the blood and the brain parenchyma. In a recent
study in mice, Levard and coll...
www.cell.com
November 15, 2024 at 9:16 AM
Check out the @TrendsNeuro Spotlight on our recent paper uncovering the role of CNS-associated macrophages in ischemic stroke. Huge thanks to the Louise McCullough group for highlighting our work!
www.cell.com/trends/neuro...
www.cell.com/trends/neuro...
Very happy to share our paper published in @NatureNeuro, investigating the role of CNS border-associated macrophages in stroke-induced neuroinflammation during aging! 🤩
www.nature.com/articles/s41...
@BbCaen @Inserm @Universite_Caen @Cyceron14 @InsermNordOuest
www.nature.com/articles/s41...
@BbCaen @Inserm @Universite_Caen @Cyceron14 @InsermNordOuest
Central nervous system-associated macrophages modulate the immune response following stroke in aged mice - Nature Neuroscience
How aging influences peripheral immune cell infiltration and the role of these cells following traumatic injury of the CNS is unclear. Here, the authors show that aging transforms CNS-associated macro...
www.nature.com
November 15, 2024 at 9:11 AM
Very happy to share our paper published in @NatureNeuro, investigating the role of CNS border-associated macrophages in stroke-induced neuroinflammation during aging! 🤩
www.nature.com/articles/s41...
@BbCaen @Inserm @Universite_Caen @Cyceron14 @InsermNordOuest
www.nature.com/articles/s41...
@BbCaen @Inserm @Universite_Caen @Cyceron14 @InsermNordOuest